keyword
MENU ▼
Read by QxMD icon Read
search

Satoru Takahashi

keyword
https://www.readbyqxmd.com/read/30341734/comparative-pulmonary-toxicity-of-a-dwcnt-and-mwcnt-7-in-rats
#1
Ahmed M El-Gazzar, Mohamed Abdelgied, David B Alexander, William T Alexander, Takamasa Numano, Masaaki Iigo, Aya Naiki, Satoru Takahashi, Hiroshi Takase, Akihiko Hirose, Jun Kannno, Osama Saeid Elokle, Ashraf Mohamed Nazem, Hiroyuki Tsuda
Very little is known about the in vivo toxicity of inhaled double-walled carbon nanotubes (DWCNTs). In the present study, we compared the pulmonary toxicity of DWCNT to MWCNT-7, a well-known multi-walled carbon nanotube. Rats were divided into six groups: untreated, vehicle, low-dose DWCNT, high-dose DWCNT, low-dose MWCNT-7, and high-dose MWCNT-7. The test materials were administered by intra-tracheal intra-pulmonary spraying (TIPS) every other day for 15 days: the low-dose and high-dose groups were administered final total doses of 0...
October 19, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/30334618/feasibility-of-early-multimodal-interventions-for-elderly-patients-with-advanced-pancreatic-and-non-small-cell-lung-cancer
#2
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30307946/thermodynamic-and-computational-analyses-reveal-the-functional-roles-of-the-galloyl-group-of-tea-catechins-in-molecular-recognition
#3
Tomoya Takahashi, Satoru Nagatoishi, Daisuke Kuroda, Kouhei Tsumoto
Catechins, biologically active polyphenols in green tea, exhibit various biological activities, such as anticancer and antiviral activities, arising from interactions with functional proteins. However, the molecular details of these interactions remain unclear. In this study, we investigated the interactions between human serum albumin (HSA) and various catechins, including some with a galloyl group, by means of isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and docking simulations...
2018: PloS One
https://www.readbyqxmd.com/read/30302793/adalimumab-treatment-in-japanese-patients-with-generalized-pustular-psoriasis-results-of-an-open-label-phase-3-study
#4
Akimichi Morita, Fumikazu Yamazaki, Takashi Matsuyama, Kenzo Takahashi, Satoru Arai, Akihiko Asahina, Shinichi Imafuku, Hidemi Nakagawa, Yuichi Hasegawa, David Williams, Naoto Matsuda, Susumu Kitamura
A phase 3, multicenter, open-label, 52-week study investigated the efficacy and safety of adalimumab 80 mg at week 0 followed by adalimumab 40 mg every other week (option to escalate to 80 mg when necessary) in Japanese patients with generalized pustular psoriasis (GPP). Adults (aged 15-75 years) with GPP, total skin score (overall erythema area, erythema area with pustules, and edema area) of 3 or more, and erythema with pustules (skin score, ≥1) based on the 2014 Japanese Dermatological Association severity index of GPP were enrolled...
October 10, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/30300887/hyperbaric-oxygen-therapy-as-concurrent-treatment-with-systemic-steroids-for-idiopathic-sudden-sensorineural-hearing-loss-a-comparison-of-three-different-steroid-treatments
#5
Seiji Hosokawa, Kumiko Hosokawa, Goro Takahashi, Ken-Ichi Sugiyama, Hiroshi Nakanishi, Satoru Takebayashi, Hiroyuki Mineta
We analyzed 356 patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and systemic steroids (n = 161), systemic steroids alone (n = 160), or intratympanic and systemic steroids (n = 35). The main outcome measure was the hearing recovery rate. The effect of other variables, including the initial averaged 5-frequency hearing level, patient age, interval between the onset of symptoms and treatment, presence of vertigo as a complication, presence of diabetes mellitus, smoking history, and presence of hypertension, on the hearing recovery rate was also evaluated...
October 9, 2018: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/30292262/sub-solid-nodule-detectability-in-seven-observers-of-seventy-nine-clinical-cases-comparison-between-ultra-low-dose-chest-digital-tomosynthesis-with-iterative-reconstruction-and-chest-radiography-by-receiver-operating-characteristics-analysis
#6
Yukihiro Nagatani, Masashi Takahashi, Mitsuru Ikeda, Norihisa Nitta, Katsunori Miyata, Jun Hanaoka, Yasutaka Nakano, Satoru Matsuo, Yuto Hamada, Akinaga Sonoda, Hideji Otani, Noritoshi Ushio, Shinichi Ohta, Yoko Murakami, Chiaki Kaneko, Akitoshi Inoue, Tetsuo Kida, Kiyoshi Murata
PURPOSE: To compare sub-solid nodules detectability (SSND) between ultra-low-dose chest digital tomosynthesis (ULD-CDT) with/without iterative reconstruction (IR) and chest radiography (CR) by using low-dose computed tomography (LDCT) as the standard of reference (SOR). MATERIALS AND METHODS: Institutional Review Board approved this study and written informed consent was obtained. In a single visit, 79 subjects underwent ULD-CDT at 120 kV and 10 mA, CR and LDCT (effective dose: 0...
October 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30266983/a-novel-irfp-incorporated-in-vivo-murine-atherosclerosis-imaging-system
#7
Kaushalya Kulathunga, Michito Hamada, Yukiko Hiraishi, Mao Otake, Mai Thi Nhu Tran, Olivia Cheng, Junko Tanaka, Tomoki Sakasai, Shota Sakaguchi, Yuka Sugiyama, Bernd K Fleischmann, Satoru Takahashi, Yoshihiro Miwa
By using near-infrared fluorescent protein (iRFP)-expressing hematopoietic cells, we established a novel, quantitative, in vivo, noninvasive atherosclerosis imaging system. This murine atherosclerosis imaging approach targets macrophages expressing iRFP in plaques. Low-density lipoprotein receptor-deficient (LDLR-/- ) mice transplanted with beta-actin promoter-derived iRFP transgenic (TG) mouse bone marrow (BM) cells (iRFP → LDLR-/- ) were used. Atherosclerosis was induced by a nonfluorescent 1.25% cholesterol diet (HCD)...
September 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30254177/a-single-phosphorylation-site-of-sik3-regulates-daily-sleep-amounts-and-sleep-need-in-mice
#8
Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa
Sleep is an evolutionally conserved behavior from vertebrates to invertebrates. The molecular mechanisms that determine daily sleep amounts and the neuronal substrates for homeostatic sleep need remain unknown. Through a large-scale forward genetic screen of sleep behaviors in mice, we previously demonstrated that the Sleepy mutant allele of the Sik3 protein kinase gene markedly increases daily nonrapid-eye movement sleep (NREMS) amounts and sleep need. The Sleepy mutation deletes the in-frame exon 13 encoding a peptide stretch encompassing S551, a known PKA recognition site in SIK3...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30251915/immunological-properties-of-neural-crest-cells-derived-from-human-induced-pluripotent-stem-cells
#9
Shota Fujii, Satoru Yoshida, Emi Inagaki, Shin Hatou, Kazuo Tsubota, Masayo Takahashi, Shigeto Shimmura, Sunao Sugita
Collecting sufficient quantities of primary neural crest cells (NCCs) for experiments is difficult, as NCCs are embryonic transient tissue that basically does not proliferate. We successfully induced NCCs from human induced pluripotent stem cells (iPSCs) in accordance with a previously described method with some modifications. The protocol used in this study efficiently produced large amounts of iPSC-derived NCCs (iPSC-NCCs). Many researchers have recently produced large amounts of iPSC-NCCs and used these to examine the physiological properties, such as migratory activity, and the potential for medical uses such as wound healing...
September 25, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/30249946/household-income-relationship-with-health-services-utilization-and-healthcare-expenditures-in-people-aged-75-years-or-older-in-japan-a-population-based-study-using-medical-and-long-term-care-insurance-claims-data
#10
Shota Hamada, Hideto Takahashi, Nobuo Sakata, Boyoung Jeon, Takahiro Mori, Katsuya Iijima, Satoru Yoshie, Tatsuro Ishizaki, Nanako Tamiya
BACKGROUND: This study aimed to determine whether there are disparities in healthcare services utilization according to household income among people aged 75 years or older in Japan. METHODS: We used data on medical and long-term care (LTC) insurance claims and on LTC insurance premiums and needs levels for people aged 75 years or older in a suburban city. Data on people receiving public welfare were not available. Participants were categorized according to household income level using LTC insurance premiums data...
September 22, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/30238687/androgen-responsive-trim36-enhances-tumor-suppressive-effect-by-regulating-apoptosis-related-pathway-in-prostate-cancer
#11
Naoki Kimura, Yuta Yamada, Ken-Ichi Takayama, Tetsuya Fujimura, Satoru Takahashi, Haruki Kume, Satoshi Inoue
Tripartite motif 36 (TRIM36) belongs to the TRIM family, most members of which are involved in ubiquitination and degradation of target proteins by functioning as E3 ubiquitin ligases. The function of TRIM36 has not been well documented, and therefore we investigated the clinical significance and function of TRIM36 in human prostate cancer (PC). Multivariate logistic regression analysis showed that TRIM36 immunoreactivity was an independent predictor of cancer-specific survival of PC patients. Gain-of-function study revealed that overexpression of TRIM36 suppressed cell proliferation and migration of LNCaP, 22Rv1, and DU145 cells...
September 20, 2018: Cancer Science
https://www.readbyqxmd.com/read/30211061/urethral-diverticulum-carcinoma-in-females-a-case-series-and-review-of-the-english-and-japanese-literature
#12
REVIEW
Eabhann O'Connor, Domniki Iatropoulou, Sho Hashimoto, Satoru Takahashi, Daniel Heffernan Ho, Tamsin Greenwell
The aims of our study were to describe our case series of three urethral diverticulum carcinomas (UDC) in women and to review the literature on UDC in females to determine patient characteristics, presenting symptoms and outcomes along with optimal investigations and treatment modalities. A literature search was performed utilizing Medline, EMBASE and the Cochrane library for all papers including case reports on UDC in women published to date. The results along with those of our three cases are detailed. A total of 126 cases of UDC in women have been reported; 75% adenocarcinoma (Adenoca), 15% transitional cell carcinoma (TCC) and 10% squamous cell carcinoma (SCC)...
August 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/30210446/assessment-of-the-efficacy-of-reogo-j-robotic-training-against-other-rehabilitation-therapies-for-upper-limb-hemiplegia-after-stroke-protocol-for-a-randomized-controlled-trial
#13
Takashi Takebayashi, Kayoko Takahashi, Satoru Amano, Yuki Uchiyama, Masahiko Gosho, Kazuhisa Domen, Kenji Hachisuka
Background: Stroke patients experience chronic hemiparesis in their upper extremities leaving negative effects on quality of life. Robotic therapy is one method to recover arm function, but its research is still in its infancy. Research questions of this study is to investigate how to maximize the benefit of robotic therapy using ReoGo-J for arm hemiplegia in chronic stroke patients. Methods: Design of this study is a multi-center parallel group trial following the prospective, randomized, open-label, blinded endpoint (PROBE) study model...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30179801/laparoscopic-repair-of-acute-small-bowel-obstruction-due-to-left-paraduodenal-hernia-a-case-report
#14
Masakazu Wakabayashi, Satoru Kono, Tomohide Takahashi
INTRODUCTION: Paraduodenal hernia is a rare disease but the most common internal hernia. Laparoscopic repair of paraduodenal hernia is feasible and effective because of its minimal invasiveness and aesthetic advantage. PRESENTATION OF CASE: We report a case of a 79 year-old-man who was admitted with a complaint of recurrent left abdominal pain. Computed tomography revealed an encapsulated cluster of jejunum loops in the left upper quadrant, near the ligament of Treitz and at the dorsal side of the inferior mesenteric vein...
August 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30174471/computed-diffusion-weighted-imaging-in-prostate-cancer-basics-advantages-cautions-and-future-prospects
#15
REVIEW
Yoshiko R Ueno, Tsutomu Tamada, Satoru Takahashi, Utaru Tanaka, Keitaro Sofue, Tomonori Kanda, Munenobu Nogami, Yoshiharu Ohno, Nobuyuki Hinata, Masato Fujisawa, Takamichi Murakami
Computed diffusion-weighted MRI is a recently proposed post-processing technique that produces b-value images from diffusion-weighted imaging (DWI), acquired using at least two different b-values. This article presents an argument for computed DWI for prostate cancer by viewing four aspects of DWI: fundamentals, image quality and diagnostic performance, computing procedures, and future uses.
September 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/30166199/descriptive-epidemiology-of-varicella-based-on-national-surveillance-data-before-and-after-the-introduction-of-routine-varicella-vaccination-with-two-doses-in-japan-2000-2017
#16
Saeko Morino, Keiko Tanaka-Taya, Hiroshi Satoh, Satoru Arai, Takuri Takahashi, Tomimasa Sunagawa, Kazunori Oishi
Routine childhood immunization using two doses of the varicella vaccine was introduced in Japan in October 2014. In this study, we analyzed the data extracted from national varicella surveillance, including pediatric sentinel surveillance from 2000 to 2017 and hospitalized varicella surveillance from the 38th week of 2014 to the 37th week of 2017. Compared with the 2000-2011 baseline data, the number of varicella cases per sentinel decreased substantially by 76.6% overall and by 88.2% among children aged 1-4 years in 2017...
September 25, 2018: Vaccine
https://www.readbyqxmd.com/read/30153343/high-sensitivity-sulfur-isotopic-measurements-for-antarctic-ice-core-analyses
#17
Kazuya Takahashi, Yoichi Nakai, Yuko Motizuki, Toshiyuki Ino, Shigeru Ito, Satoru B Ohkubo, Takeshi Minami, Yuichi Takaku, Yoshitaka Yamaguchi, Miho Tanaka, Hideaki Motoyama
RATIONALE: Sulfur is widely distributed in nature, and sulfur isotopic measurements have been applied to elucidate the origin and transport of sulfuric compounds in the lithosphere, biosphere, and atmosphere. Analyses of samples containing small amounts of sulfur, such as the Antarctic ice core samples analyzed herein, require a high-sensitivity analytical method. METHODS: We developed a high-sensitivity sulfur isotopic ratio (δ34 S value) analytical system equipped with an elemental analyzer, a cryo-flow device, and an isotope ratio mass spectrometer, and established a measurement and calibration procedure...
August 28, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30146126/de-novo-mutations-activating-germline-tp53-in-an-inherited-bone-marrow-failure-syndrome
#18
Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito
Inherited bone-marrow-failure syndromes (IBMFSs) include heterogeneous genetic disorders characterized by bone-marrow failure, congenital anomalies, and an increased risk of malignancy. Many lines of evidence have suggested that p53 activation might be central to the pathogenesis of IBMFSs, including Diamond-Blackfan anemia (DBA) and dyskeratosis congenita (DC). However, the exact role of p53 activation in each clinical feature remains unknown. Here, we report unique de novo TP53 germline variants found in two individuals with an IBMFS accompanied by hypogammaglobulinemia, growth retardation, and microcephaly mimicking DBA and DC...
September 6, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/30111673/bactericidal-efficacy-of-a-quaternary-ammonium-compound-with-food-additive-grade-calcium-hydroxide-toward-salmonella-infantis-and-escherichia-coli-on-abiotic-carriers
#19
Md Shahin Alam, Satoru Takahashi, Mariko Ito, Miyuki Komura, Mayuko Suzuki, Natthanan Sangsriratanakul, Dany Shoham, Kazuaki Takehara
The bactericidal efficacies of 0.2% food additive grade calcium hydroxide (FdCa(OH)2 ) solution, a quaternary ammonium compound (QAC) diluted at 1:500 (QACx500) and their mixture - Mix500 (FdCa(OH)2 powder added at final concentration 0.2% to QACx500) - were investigated at two different temperatures (room temperature (RT) (25 ± 2°C) and 2°C), using varying contact time, with or without presence of organic materials (5% fetal bovine serum: FBS), either in suspension or on abiotic carrier (steel, rubber and plastic)...
August 16, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/30079806/aberrant-imprinting-in-mouse-trophoblast-stem-cells-established-from-somatic-cell-nuclear-transfer-derived-embryos
#20
Michiko Hirose, Masashi Hada, Satoshi Kamimura, Shogo Matoba, Arata Honda, Kaori Motomura, Narumi Ogonuki, Hossam H Shawki, Kimiko Inoue, Satoru Takahashi, Atsuo Ogura
Although phenotypic abnormalities frequently appear in the placenta following somatic cell nuclear transfer (SCNT), mouse trophoblast stem cells (TSCs) established from SCNT embryos reportedly show no distinct abnormalities compared with those derived from normal fertilization. In this study, we reexamined SCNT-TSCs to identify their imprinting statuses. Placenta-specific maternally imprinted genes (Gab1, Slc38a4, and Sfmbt2) consistently showed biallelic expression in SCNT-TSCs, suggesting their loss of imprinting (LOI)...
August 23, 2018: Epigenetics: Official Journal of the DNA Methylation Society
keyword
keyword
170125
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"