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Satoru Takahashi

Yu-Hsin Chang, Susumu Nishimura, Hisashi Oishi, Vincent P Kelly, Akihiro Kuno, Satoru Takahashi
During the maturation of transfer RNA (tRNA), a variety of chemical modifications can be introduced at specific nucleotide positions post-transcriptionally. 5-Methyluridine (m5 U) is one of the most common and conserved modifications from eubacteria to eukaryotes. Although TrmA protein in Escherichia coli and Trm2p protein in Saccharomyces cerevisiae, which are responsible for the 5-methylation of uracil at position 54 (m5 U54) on tRNA, are well characterized, the biological function of the U54 methylation responsible enzyme in mammalian species remains largely unexplored...
November 28, 2018: Biochemical and Biophysical Research Communications
Tatsurou Serita, Mizuki Miyahara, Toshiyuki Tanimizu, Shohei Takahashi, Satoru Oishi, Taikai Nagayoshi, Ryuhei Tsuji, Hirofumi Inoue, Mariko Uehara, Satoshi Kida
Magnesium (Mg2+ ) is an essential mineral for maintaining biological functions. One major action of Mg2+ in the brain is modulating the voltage-dependent blockade of N-methyl-D-aspartate type glutamate receptors, thereby controlling their opening, which is crucial for synaptic plasticity. Therefore, Mg2+ has been shown to play critical roles in learning and memory, and synaptic plasticity. However, the effects of dietary Mg2+ deficiency (MgD) on learning and memory and the morphology of neurons contributing to memory performance have not been examined in depth...
November 27, 2018: Brain Research Bulletin
Sariya Mapoung, Shugo Suzuki, Satoshi Fuji, Aya Naiki-Ito, Hiroyuki Kato, Supachai Yodkeeree, Chitchamai Ovatlarnporn, Satoru Takahashi, Pornngarm Limtrakul Dejkriengkraikul
Many prostate cancer patients develop resistance to the treatment called castration-resistant prostate cancer (CRPC), which is the major cause of recurrence and death. In this study, four cyclohexanone curcumin analogs were synthesized. Additionally, their anti-cancer progression activity on CRPC cell lines, PC3 and PLS10 cells, was examined. We first determined their anti-metastasis property and found that 2,6-bis-(4-hydroxy-3-methoxy-benzylidene)-cyclohexanone (2A) and 2,6-bis-(3,4-dihydroxy-benzylidene)-cyclohexanone (2F) exhibited higher anti-invasion properties against CRPC cells than curcumin...
November 30, 2018: Cancer Science
Akira Ohtsuru, Sanae Midorikawa, Tetsuya Ohira, Satoru Suzuki, Hideto Takahashi, Michio Murakami, Hiroki Shimura, Takashi Matsuzuka, Seiji Yasumura, Shin-Ichi Suzuki, Susumu Yokoya, Yuko Hashimoto, Akira Sakai, Hitoshi Ohto, Shunichi Yamashita, Koichi Tanigawa, Kenji Kamiya
Importance: Ultrasonographic (US) screening for thyroid cancer was performed in the Fukushima Health Management Survey after the 2011 Fukushima Daiichi nuclear power station accident. Clinical characteristics of thyroid cancers screened by US among children and young adults during the first 5 years after the accident were analyzed. Objectives: To evaluate the number of detected thyroid cancers by age group within 5 years of the Fukushima Daiichi nuclear power station accident and to compare the basic clinical characteristics and demographic patterns in first- and second-round examinations...
November 29, 2018: JAMA Otolaryngology—Head & Neck Surgery
Toshiya Kuno, Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Takuji Tanaka, Satoru Takahashi, Hideki Mori
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) is known to possess potentials to prevent chemical carcinogenesis in multiple organs of rodents. In the present study, possible chemopreventive effect of FBRA against spontaneous occurrence of lymphomas was examined using female AKR/NSlc mice. Four-week-old female AKR/ NSlc mice were divided into three groups, and fed diets containing FBRA for 26 weeks at a dose level 0% (Group 1), 5% (Group 2) or 10% (Group 3). At the termination of experiment, the incidence of thymic malignant lymphoma of Group 3 was significantly lower than of Group 1 (p < 0...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Kazuko Omodaka, Shigeto Maekawa, Guangzhou An, Satoru Tsuda, Yukihiro Shiga, Naoko Takada, Tsutomu Kikawa, Hidetoshi Takahashi, Hideo Yokota, Masahiro Akiba, Toru Nakazawa
PURPOSE: To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma. METHODS: This retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2...
2018: PloS One
Satoru Takahashi, Takahiro Yamauchi, Toshihiro Yamamura, Takahiro Ogishima, Toshinari Arai
Background: Chronic subdural hematoma (CSDH) is a disorder that is commonly seen in routine neurosurgery. Although risk factors for recurrence have been studied, the findings are inconsistent. Furthermore, bilateral CSDHs are operated unilaterally or bilaterally depending on symptoms or hematoma volume. Although there are cases in which hematomas on nonoperated side in unilaterally operated bilateral CSDHs requiring for additional operation, little have been studied on the effect of the surgical selection...
October 2018: Asian Journal of Neurosurgery
Takuya Azami, Ken Matsumoto, Hyojung Jeon, Tsuyoshi Waku, Masafumi Muratani, Hitoshi Niwa, Satoru Takahashi, Masatsugu Ema
Mouse embryonic stem cells (ESCs) are pluripotent stem cells, which have the ability to differentiate into all three germ layers: mesoderm, endoderm, and ectoderm. Proper levels of phosphorylated extracellular signal-regulated kinase (pERK) are critical for maintaining pluripotency, as elevated pERK evoked by fibroblast growth factor (FGF) receptor activation results in differentiation of ESCs, while, conversely, reduction of pERK by a MEK inhibitor maintains a pluripotent ground state. However, mechanisms underlying proper control of pERK levels in mouse ESCs are not fully understood...
2018: PloS One
Satoru Nagase, Tsuyoshi Ohta, Fumiaki Takahashi, Takayuki Enomoto
AIM: To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2015 and the Annual Treatment Report for 2010 on the outcomes of patients who started treatment in 2010. METHODS: The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment was initiated in 2015 were analyzed retrospectively...
November 13, 2018: Journal of Obstetrics and Gynaecology Research
Satoru Takahashi, Sei Komatsu, Tomoki Ohara, Mitsuhiko Takewa, Yasuyuki Toyama, Chikao Yutani, Kazuhisa Kodama
A 73-year-old man reporting severe chest and back pain for 20 min was admitted to our hospital. The pain occurred 3 days before admission. Computed tomography angiography showed a hazy-surfaced low-density area in the aortic arch with aneurysmal formation of unknown etiology. It was inconclusive whether the aortic change was acute or chronic because no previous information was available. To investigate the etiology, non-obstructive angioscopy (NOA) was performed. A fissure with blood flow was detected at the surface of the low-density area and active subintimal blood flow was demonstrated on NOA...
November 2018: Journal of Cardiology Cases
Takuya Matsumoto, Shingo Iwano, Nobunori Takahashi, Shuji Asai, Tatsuo Watanabe, Nobuyuki Asai, Yasumori Sobue, Satoru Ito, Naoki Ishiguro, Toshihisa Kojima
OBJECTIVE: This study aimed to assess the association between chest computed tomography (CT) findings and incidence of respiratory adverse events (RAEs), and to detect risk factors for RAEs, in RA patients treated with long-term biological therapy. METHODS: Clinical and radiological data of 332 RA patients who were treated with biological disease-modifying antirheumatic drugs were collected. CT data were assessed by an experienced radiologist. Patients were categorized into the interstitial lung disease (ILD) group (n = 29), airway disease (AD) group (n = 76), co-existing ILD and AD (Co-existing) group (n = 6), and the group without detectable change (WDC, n = 221) based on CT findings and scores...
November 8, 2018: International Journal of Rheumatic Diseases
Siamak Yousefi, Ebrahim Yousefi, Hidenori Takahashi, Takahiko Hayashi, Hironobu Tampo, Satoru Inoda, Yusuke Arai, Penny Asbell
We developed an unsupervised machine learning algorithm and applied it to big corneal parameters to identify and monitor keratoconus stages. A big dataset of corneal swept source optical coherence tomography (OCT) images of 12,242 eyes acquired from SS-1000 CASIA OCT Imaging Systems in multiple centers across Japan was assembled. A total of 3,156 eyes with valid Ectasia Status Index (ESI) between zero and 100% were selected for the downstream analysis. Four hundred and twenty corneal topography, elevation, and pachymetry parameters (excluding ESI Keratoconus indices) were selected...
2018: PloS One
Satoru Mitsuboshi, Naoki Tsuruma, Kazuya Watanabe, Shigehiro Takahashi, Manami Nakashita, Atsuko Ito, Kenichi Kobayashi, Masami Tsugita
We hypothesized that quick Sequential Organ Failure Assessment (qSOFA) would be associated with 30-day mortality in bacteremia caused by extended-spectrum β-lactamase (ESBL)-producing bacteria and might be a selection criterion for the use of carbapenem as initial empirical therapy. A multicenter retrospective study was conducted in six hospitals. All patients who had bacteremia due to ESBL-producing bacteria were included in the study. Multivariable logistic regression analysis was performed to analyze 30-day mortality as the main outcome...
October 31, 2018: Japanese Journal of Infectious Diseases
Motoya Kobayashi, Satoshi Kato, Hideki Murakami, Satoru Demura, Katsuhito Yoshioka, Noritaka Yonezawa, Naoki Takahashi, Takaki Shimizu, Hiroyuki Tsuchiya
Tumor excision surgeries of the spine present a distinct challenge regarding the maintenance of spinal cord blood supply because they often require preoperative embolization of segmental arteries, ligation of the corresponding nerve roots, and circumferential exposure of the dural sac. The authors present a case of delayed-onset spinal cord infarction after repeated tumor excision surgeries of the thoracic spine. A 49-year-old man had undergone a left nephrectomy for renal cell carcinoma, 2 pulmonary metastasectomies, and excision of a left sixth rib metastasis before referral to the authors' institution...
October 26, 2018: Orthopedics
Yuki Tsunakawa, Michito Hamada, Yurina Matsunaga, Sayaka Fuseya, Hyojung Jeon, Yuji Wakimoto, Toshiaki Usui, Maho Kanai, Seiya Mizuno, Naoki Morito, Satoru Takahashi
Multicentric carpotarsal osteolysis (MCTO) is a condition involving progressive osteolysis of the carpal and tarsal bones that is associated with glomerular sclerosis and renal failure (MCTO nephropathy). Previous work identified an autosomal dominant missense mutation in the transactivation domain of the transcription factor MAFB as the cause of MCTO. Several methods are currently used for MCTO nephropathy treatment, but these methods are invasive and lead to severe side effects, limiting their use. Therefore, the development of alternative treatments for MCTO nephropathy is required; however, the pathogenesis of MCTO in vivo is unclear without access to a mouse model...
October 26, 2018: Experimental Animals
Ahmed M El-Gazzar, Mohamed Abdelgied, David B Alexander, William T Alexander, Takamasa Numano, Masaaki Iigo, Aya Naiki, Satoru Takahashi, Hiroshi Takase, Akihiko Hirose, Jun Kannno, Osama Saeid Elokle, Ashraf Mohamed Nazem, Hiroyuki Tsuda
Very little is known about the in vivo toxicity of inhaled double-walled carbon nanotubes (DWCNTs). In the present study, we compared the pulmonary toxicity of DWCNT to MWCNT-7, a well-known multi-walled carbon nanotube. Rats were divided into six groups: untreated, vehicle, low-dose DWCNT, high-dose DWCNT, low-dose MWCNT-7, and high-dose MWCNT-7. The test materials were administered by intra-tracheal intra-pulmonary spraying (TIPS) every other day for 15 days: the low-dose and high-dose groups were administered final total doses of 0...
October 19, 2018: Archives of Toxicology
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Tomoya Takahashi, Satoru Nagatoishi, Daisuke Kuroda, Kouhei Tsumoto
Catechins, biologically active polyphenols in green tea, exhibit various biological activities, such as anticancer and antiviral activities, arising from interactions with functional proteins. However, the molecular details of these interactions remain unclear. In this study, we investigated the interactions between human serum albumin (HSA) and various catechins, including some with a galloyl group, by means of isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), and docking simulations...
2018: PloS One
Akimichi Morita, Fumikazu Yamazaki, Takashi Matsuyama, Kenzo Takahashi, Satoru Arai, Akihiko Asahina, Shinichi Imafuku, Hidemi Nakagawa, Yuichi Hasegawa, David Williams, Naoto Matsuda, Susumu Kitamura
A phase 3, multicenter, open-label, 52-week study investigated the efficacy and safety of adalimumab 80 mg at week 0 followed by adalimumab 40 mg every other week (option to escalate to 80 mg when necessary) in Japanese patients with generalized pustular psoriasis (GPP). Adults (aged 15-75 years) with GPP, total skin score (overall erythema area, erythema area with pustules, and edema area) of 3 or more, and erythema with pustules (skin score, ≥1) based on the 2014 Japanese Dermatological Association severity index of GPP were enrolled...
October 10, 2018: Journal of Dermatology
Seiji Hosokawa, Kumiko Hosokawa, Goro Takahashi, Ken-Ichi Sugiyama, Hiroshi Nakanishi, Satoru Takebayashi, Hiroyuki Mineta
We analyzed 356 patients with idiopathic sudden sensorineural hearing loss treated with hyperbaric oxygen therapy and systemic steroids (n = 161), systemic steroids alone (n = 160), or intratympanic and systemic steroids (n = 35). The main outcome measure was the hearing recovery rate. The effect of other variables, including the initial averaged 5-frequency hearing level, patient age, interval between the onset of symptoms and treatment, presence of vertigo as a complication, presence of diabetes mellitus, smoking history, and presence of hypertension, on the hearing recovery rate was also evaluated...
2018: Audiology & Neuro-otology
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