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Surface Modification

Kumiko Miyajima, Yuki Miwa, Yoshitaka Kitamoto
Porous FePt microcapsules are fabricated for use in bead-based immunoassay technologies, that generally use magnetic spheres to immobilize biomolecules on their surface. The magnetic capsules can be used to carry assay reagents to reduce the time required to perform immunoassay processes, and microsize capsules are easier to manipulate magnetically than nanosize ones. Silica particles of approximately 2.5 μm diameter are used as templates and modified with poly(ethyleneimine) (PEI), which enables FePt nanoparticles to accumulate selectively on the template particles and an FePt shell to be formed by a polyol process...
October 3, 2018: Colloids and Surfaces. B, Biointerfaces
Sanjay Tiwari, Pratap Bahadur
Hyaluronic acid (HA) is a high molecular weight, non-sulfated anionic polysaccharide from glycosamine glycan family. It is a versatile biomaterial that binds to specific cell receptor CD44 (frequently over-expressed on the tumor cell surface) and is useful in skin rejuvenation, drug delivery, tissue engineering and molecular imaging due to its biodegradable, non-toxic, biocompatible, non-immunogenic and non-inflammatory characteristics. It can be chemically modified by cross-linking, grafting, linking with hydrophobic substances and drugs, or through polyion complex formation with oppositely charged polysaccharides, proteins or surfactants...
October 12, 2018: International Journal of Biological Macromolecules
Yi Zhang, Zongliang Wang, Yu Wang, Linlong Li, Zhenxu Wu, Yoshihiro Ito, Xiaoyu Yang, Peibiao Zhang
The highly damaging state of spinal cord injuries has provided much inspiration for the design of surface modification of the implants that can promote nerve regeneration and functional reconstruction. DOPA-IGF-1, a new recombinant protein designed in our previous study exhibited strong binding affinity to titanium and significantly enhanced the growth of NIH3T3 cells on the surface of titanium with the same biological activity as IGF-1. In this paper, surface modification of PLGA films with recombinant DOPA-IGF-1 was performed to promote the paracrine activity of human umbilical cord mesenchymal stem cells (hUCMSCs) by secreting neurotrophic factors...
October 12, 2018: Journal of Pharmaceutical Sciences
Amir Solomonica, Tawfiq Choudhury, Rodrigo Bagur
The Lotus valve system (Boston Scientific, Marlborough, Massachusetts, USA) consists of a braided wire Nitinol™ frame with three bovine pericardial leaflets. The valve is deployed by controlled mechanical expansion which allows recapturing/repositioning and full retrievability. Areas covered:While this system offers a unique seal, which conforms to irregular surfaces, thereby minimizing paravalvular leak, its main downfall is a high rate of new pacemaker implantation. This had been partially addressed with the design of the Depth Guard™ mechanism to optimize deployment by early anchoring and limiting the depth of implant...
October 15, 2018: Expert Review of Medical Devices
Martin Pendola, Gaurav Jain, Yu-Chieh Huang, Denis Gebauer, John Spencer Evans
The formation of the sea urchin spicule involves the stabilization and transformation of amorphous calcium carbonate (ACC) and assembly of ACC nanoparticle precursors into a mesoscale single crystal of fracture-resistant calcite. This process of particle assembly or attachment is under the control of a family of proteins known as the spicule matrix [ Strongylocentrotus purpuratus (SpSM)] proteome. Recently, two members of this proteome, SpSM50 and the glycoprotein SpSM30B/C-G (in recombinant forms), were found to interact together via SpSM30B/C-G oligosaccharide-SpSM50 protein interactions to form hybrid protein hydrogels with unique physical properties...
September 30, 2018: ACS Omega
Paolo Macor, Sara Capolla, Francesco Tedesco
Deposits of complement components have been documented in several human tumors suggesting a potential involvement of the complement system in tumor immune surveillance. In vitro and in vivo studies have revealed a double role played by this system in tumor progression. Complement activation in the cancer microenvironment has been shown to promote cancer growth through the release of the chemotactic peptide C5a recruiting myeloid suppressor cells. There is also evidence that tumor progression can be controlled by complement activated on the surface of cancer cells through one of the three pathways of complement activation...
2018: Frontiers in Immunology
Quang Nghia Pham, Kieu The Loan Trinh, Nguyen Khoi Song Tran, Tae-Sik Park, Nae Yoon Lee
We fabricate a three-dimensional (3D) microdevice operated with minimal peripheral accessories, including a portable pump for semi-automated sample delivery and a single heater for temperature control, for performing reverse transcription polymerase chain reaction (RT-PCR) integrated with a downstream fluorescence detection module for semi-quantitative assessment of gene expression. The microdevice was fabricated by wrapping a polytetrafluoroethylene (PTFE) tube around a pre-designed polycarbonate mold to create a seamless microchannel for both the reverse transcription (RT) of RNA and the amplification of complementary DNA...
October 15, 2018: Analyst
Ying Fan, Min Chen, Jinqiang Zhang, Philippe Maincent, Xuefeng Xia, Wen Wu
Intranasal drug delivery is emerging as a reliable and promising pathway to deliver a wide range of therapeutic agents including small and large molecules, peptides and proteins, genes to the central nervous system for the treatment of brain diseases such as Alzheimer's disease, Parkinson's disease, depression, migraine, schizophrenia, and glioma. This presents noninvasive entry into the brain via direct nose-to-brain and/or indirect nose-to-blood-to-brain routes. Several nanocarrier-based strategies have been developed to transport therapeutic agents to the brain including nanoparticles, liposomes, and exosomes following intranasal delivery...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
Mohamed F Attia, Justine Wallyn, Nicolas Anton, Thierry F Vandamme
In the last two decades, nanoparticle contrast agents have emerged as an essential tool for preclinical imaging and diagnosis. Besides their main advantage, related to their size range inhibiting glomerular filtration, they exhibit excellent X-ray attenuation when fabricated with heavy metal and thus high contrast in tomodensitometry. Another strength of inorganic nanoparticles, making them very adaptable to preclinical imaging applications, is the modularity of their surface chemistry, which is compatible with decoration by ligands and biomolecules...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
Yuki Ohmuro-Matsuyama, Takahiro Yamashita, Keiko Gomi, Hideki Yamaji, Hiroshi Ueda
Post-translational modifications, such as phosphorylation, are crucial in the regulation of protein-protein interactions and protein function in cell signaling. Here, we studied the interaction between the transactivation domain peptide of cancer suppressor protein p53 and its negative regulator Mdm2 using a novel protein-protein interaction assay, based on the modified FlimPIA using the streptavidin-biotin interaction to link the p53 peptide and the probe enzyme. We succeeded in detecting an attenuation in the affinity of p53 towards Mdm2 caused by the phosphorylation at Thr18...
October 11, 2018: Analytical Biochemistry
Baranya Murugan, Uma Maheswari Krishnan
Nanotechnology-based interventions have gained popularity in the past decade for cancer therapy owing to their ability to overcome several shortcomings encountered in conventional therapy. Among the various nanoparticles that have been explored as drug carriers, mesoporous silica possesses certain desirable properties such as regulated pore size, high surface area, chemical and thermal stability, amenability for surface modification and biocompatibility. These systems have been widely investigated for site-specific delivery of single and multiple therapeutic agents as well as for imaging and theranostic applications...
October 10, 2018: International Journal of Pharmaceutics
Giorgio Pia, Elisa Sogne, Andrea Falqui, Francesco Delogu
The present study focuses on the modification of surface compositional profiles induced in nanoporous (NP) Au catalysts by the catalytic oxidation of carbon monoxide to carbon dioxide in the presence of oxygen. The phenomenon has deep implications concerning the catalytic behavior of NP Au foams in particular, and more in general for the design of more efficient catalysts. Aimed at gaining deeper insight into the mechanisms governing surface segregation, we exposed NP Au foams containing residual Ag to a mixture of gaseous carbon monoxide and oxygen at different temperature...
October 12, 2018: Scientific Reports
Anna I Kozelskaya, Evgeny N Bolbasov, Alexey S Golovkin, Alexander I Mishanin, Alice N Viknianshchuk, Evgeny V Shesterikov, Аndrey Ashrafov, Vadim A Novikov, Alexander Y Fedotkin, Igor A Khlusov, Sergey I Tverdokhlebov
In this study, thin calcium phosphate (Ca-P) coatings were deposited on zirconia substrates by radiofrequency (RF) magnetron sputtering using different calcium phosphate targets (calcium phosphate tribasic (CPT), hydroxyapatite (HA), calcium phosphate monobasic, calcium phosphate dibasic dehydrate (DCPD) and calcium pyrophosphate (CPP) powders). The sputtering of calcium phosphate monobasic and DCPD powders was carried out without an inert gas in the self-sustaining plasma mode. The physico-chemical, mechanical and biological properties of the coatings were investigated...
October 11, 2018: Materials
Siqi Qiao, Xiaoyan Peng, Lidan Wang, Shukai Duan, Jin Chu, Pengfei Jia
In this work, we fabricated three carbon nanoplume structured samples under different temperatures using a simple hot filament physical vapor deposition (HFPVD) process, and investigated the role of surface morphology, defects, and graphitic content on relative humidity (RH) sensing performances. The Van der Drift growth model and oblique angle deposition (OAD) technique of growing a large area of uniformly aligned and inclined oblique arrays of carbon nanoplumes (CNPs) on a catalyst-free silicon substrate was demonstrated...
October 11, 2018: Sensors
Jianqiang Wang, Hao Guo, Xiaonan Shi, Zhikan Yao, Weihua Qing, Fu Liu, Chuyang Y Tang
We report a novel membrane surface modification method using a fast polydopamine coating (fPDAc) strategy. Specifically, NaIO4 was introduced in the coating process to accelerate the polydopamine deposition rate. Surface properties and separation performances of fPDAc-coated reverse osmosis membranes were characterized and compared to those obtained using the conventional slow polydopamine coating (sPDAc) strategy. Quartz crystal microbalance measurements showed greatly increased polydopamine deposition rate using the fPDAc method, resulting in a reduction of 97% coating time to reach an areal mass of 2000 ng/cm2 ...
October 6, 2018: Journal of Colloid and Interface Science
Huajun Feng, Qiaoqi Guo, Yingfeng Xu, Ting Chen, Yuyang Zhou, Yigang Wang, Meizhen Wang, Dongsheng Shen
The concept of photocatalytic CO2 conversion provides simultaneous solutions for global warming mitigation and fuels generation, which, however, is limited by the unsatisfactory photoconversion efficiency. Despite light harvesting and charge separation, enhancing adsorption of CO2 via surface modification could be an efficient way to improve CO2 photoconversion efficiency. Herein, we doped nonpolar carbon quantum dots (denoted as CQDs) on g-C3N4 to construct a metal-free heterojunction photocatalyst (denoted as CQDs/g-C3N4)...
October 12, 2018: ChemSusChem
Anastasios Stergiou, Nikos Tagmatarchis
Molybdenum disulfide (MoS2) nanosheets have attracted great scientific interest for their remarkable electronic and optical properties. During the last few years significant progress on exfoliation methods of those nanosheets allowed the development of surface functionalization in covalent or non-covalent fashion. Markedly, the chemical modification allows tailoring and tuning the optical and electronic characteristics of MoS2, opening new avenues for the potentiality of MoS2-based hybrids in diverse technological fields...
October 12, 2018: Chemistry: a European Journal
Shuanhong Ma, Changyou Yan, Meirong Cai, Jun Yang, Xiaolong Wang, Feng Zhou, Weimin Liu
The development of versatile generalized strategies for easy surface modification is of immense scientific interest. Herein, a novel mechanism to form functional hydrogel coatings on a wide variety of substrate materials including polymers, polymeric resins, ceramics, and intermetallic compounds, enabling easy change of the surface wettability and lubrication property, is reported. In situ polymerization and hydrogel coating formation is initiated by free radicals generated through the redox reaction between Fe2+ and S2 O8 2- at the solid-liquid interface, which shows controllable growth kinetics...
October 11, 2018: Advanced Materials
Abdulaziz Almalik, Ibrahim Alradwan, Majed A Majrashi, Bashayer A Alsaffar, Abdulmalek T Algarni, Mohammed S Alsuabeyl, Haitham Alrabiah, Nicola Tirelli, Ali H Alhasan
In recent years, nanotechnology has been proven to offer promising biomedical applications for in vivo diagnostics and drug delivery, stressing the importance of thoroughly investigating the biocompatibility of potentially translatable nanoparticles (NPs). Herein, we report the cellular responses of uncoated chitosan NPs (CS NPs) and hyaluronic acid-coated chitosan NPs (HA-CS NPs) when introduced into Chinese hamster ovary cells (CHO-K1) in a dose-dependent manner (2.5, 0.25, 0.025, 0.0025, and 0.00025 mg mL-1 ) at two time points (24 and 48 h)...
September 1, 2018: Toxicology Research
Matthew Du, Luis A Martínez-Martínez, Raphael F Ribeiro, Zixuan Hu, Vinod M Menon, Joel Yuen-Zhou
Strong-coupling between light and matter produces hybridized states (polaritons) whose delocalization and electromagnetic character allow for novel modifications in spectroscopy and chemical reactivity of molecular systems. Recent experiments have demonstrated remarkable distance-independent long-range energy transfer between molecules strongly coupled to optical microcavity modes. To shed light on the mechanism of this phenomenon, we present the first comprehensive theory of polariton-assisted remote energy transfer (PARET) based on strong-coupling of donor and/or acceptor chromophores to surface plasmons...
August 28, 2018: Chemical Science
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