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Diabetes insulin and antidiabetic oral drugs guidelines

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https://www.readbyqxmd.com/read/30106222/disease-characteristics-and-treatment-of-patients-with-diabetes-mellitus-attending-government-health-services-in-indonesia-peru-romania-and-south-africa
#1
Nanny N M Soetedjo, Susan M McAllister, Cesar Ugarte-Gil, Adela G Firanescu, Katharina Ronacher, Bachti Alisjahbana, Anca L Costache, Carlos Zubiate, Stephanus T Malherbe, Raspati C Koesoemadinata, Yoko V Laurence, Fiona Pearson, Sarah Kerry-Barnard, Rovina Ruslami, David A J Moore, Mihai Ioana, Leanie Kleynhans, Hikmat Pernama, Philip C Hill, Maria Mota, Gerhard Walzl, Hazel M Dockrell, Julia A Critchley, Reinout van Crevel
OBJECTIVE: To describe the characteristics and management of Diabetes mellitus (DM) patients from low- and middle-income countries (LMIC). METHODS: We systematically characterized consecutive DM patients attending public health services in urban settings in Indonesia, Peru, Romania and South Africa, collecting data on DM treatment history, complications, drug treatment, obesity, HbA1c, and cardiovascular risk profile; and assessing treatment gaps against relevant national guidelines...
August 14, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/30023075/goal-study-clinical-and-non-clinical-predictive-factors-for-achieving-glycemic-control-in-people-with-type-2-diabetes-in-real-clinical-practice
#2
Abdulqawi Al Mansari, Youssef Obeid, Najmul Islam, Mohammed Fariduddin, Ahmed Hassoun, Khier Djaballah, Mojtaba Malek, Dror Dicker, Tirthankar Chaudhury
Objective: The American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/30020738/costs-associated-with-long-acting-insulin-analogues-in-patients-with-diabetes
#3
Berhanu Alemayehu, Jessica Speiser, Lisa Bloudek, Evelyn Sarnes
OBJECTIVES: The objective of this literature review was to evaluate the costs associated with the use of long-acting insulin analogues (LAIAs) compared with non-LAIA agents, including human insulin, oral antidiabetic drugs, and other injectable therapies, in the treatment of patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). STUDY DESIGN: A systematic review of the medical literature (MEDLINE, EMBASE, Cochrane, EconLit) conducted from 2004 to 2016. METHODS: The review protocol was developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
July 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29696567/factors-influencing-the-prescribing-preferences-of-physicians-for-drug-naive-patients-with-type-2-diabetes-mellitus-in-the-real-world-setting-in-japan-insight-from-a-web-survey
#4
Hiroki Murayama, Kota Imai, Masato Odawara
INTRODUCTION: The Japanese guidelines for type 2 diabetes mellitus (T2DM) emphasize individualization of treatment based on patient need and encourage physicians to select an appropriate oral antidiabetes drug (OAD). However, limited evidence is available on the factors influencing the selection by physicians (diabetes specialists and nonspecialists) of the first-line OAD to treat drug-naive patients with T2DM. A survey was designed to explore the treatment factors and patient characteristics that influence physicians when they choose an initial OAD to prescribe to a drug-naive patient with T2DM in a real-world setting in Japan...
June 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29675797/treatment-intensification-in-type-2-diabetes-a-real-world-study-of-2-oad-regimens-glp-1-ras-or-basal-insulin
#5
Lawrence Blonde, Denis Raccah, Elisheva Lew, Juliana Meyers, Elena Nikonova, Mayank Ajmera, Keith L Davis, Monica Bertolini, Bruno Guerci
INTRODUCTION: Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result in uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among patients with uncontrolled T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin in a real-world setting. METHODS: Adults with T2D on OAD monotherapy were identified in the MarketScan claims database (2007-2014)...
June 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29530386/steroid-induced-hyperglycemia-an-underdiagnosed-problem-or-clinical-inertia-a-narrative-review
#6
REVIEW
Aldo Bonaventura, Fabrizio Montecucco
Corticosteroids are widely diffused drugs. An important side effect is the impairment of glycemic control both in patients with known diabetes and in normoglycemic ones potentially leading to steroid-induced diabetes mellitus (SIDM). In this review based on papers released on PubMed, MEDLINE, and EMBASE from January 2015 to October 2017, we summarized and discussed main updates about the definition, the diagnosis, and the pathophysiology of steroid-induced hyperglycemia (SIH), with a look to new therapies. Main alterations responsible for the diabetogenic effect of corticosteroids are a negative impact on insulin sensitivity along with a derangement on insulin secretion, explaining the typical post-prandial hyperglycemia linked to the promotion of gluconeogenesis...
May 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29508275/eadsg-guidelines-insulin-therapy-in-diabetes
#7
Bahendeka Silver, Kaushik Ramaiya, Swai Babu Andrew, Otieno Fredrick, Sarita Bajaj, Sanjay Kalra, Bavuma M Charlotte, Karigire Claudine, Anthony Makhoba
A diagnosis of diabetes or hyperglycemia should be confirmed prior to ordering, dispensing, or administering insulin (A). Insulin is the primary treatment in all patients with type 1 diabetes mellitus (T1DM) (A). Typically, patients with T1DM will require initiation with multiple daily injections at the time of diagnosis. This is usually short-acting insulin or rapid-acting insulin analogue given 0 to 15 min before meals together with one or more daily separate injections of intermediate or long-acting insulin...
April 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29406841/slow-titration-and-delayed-intensification-of-basal-insulin-among-patients-with-type-2-diabetes
#8
Michelle Mocarski, Jason Yeaw, Victoria Divino, Mitch DeKoven, German Guerrero, Jakob Langer, Brian Larsen Thorsted
BACKGROUND: Clinical inertia in type 2 diabetes mellitus (T2DM) refers to the failure of clinicians to intensify therapy when indicated. Many T2DM patients remain suboptimally controlled after initiating basal insulin. OBJECTIVE: To examine the prevalence of patients treated with basal insulin but in poor glycemic control (hemoglobin A1c [A1c] ≥ 7%) after initiation and subsequent treatment intensification patterns and glycemic outcomes in a real-world setting...
April 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27580306/a-novel-option-for-prandial-insulin-therapy-inhaled-insulin
#9
REVIEW
George Dailey, Aakif Ahmad, Sarit Polsky, Viral Shah
Many adults with type 2 diabetes (T2D) do not achieve or maintain glycemic targets on oral antidiabetes drugs (OADs) alone and require insulin therapy. Although initiating basal insulin is common when treatment needs to be intensified, individualization of therapy (in line with current guidelines) may lead more health care professionals (HCPs) to add rapid-acting insulin (RAI) to OAD regimens for treatment of postprandial hyperglycemia to achieve glycated hemoglobin (A1C) targets. HCPs and patients are concerned about the burden associated with injections...
November 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27579824/-act-on-threes-paradigm-for-treatment-intensification-of-type-2-diabetes-in-managed-care-results-of-a-randomized-controlled-study-with-an-educational-intervention-targeting-improved-glycemic-control
#10
RANDOMIZED CONTROLLED TRIAL
Nella Bieszk, Shannon L Reynolds, Wenhui Wei, Cralen Davis, Pravin Kamble, Claudia Uribe
BACKGROUND: Clinical inertia, which has been defined as the recognition of a problem with a patient's management but failing to act, is a concern in type 2 diabetes (T2D) because it places the patient at risk of diabetes-related complications. Despite managed care organizations making significant investment in this area, little is known about the impact of educational programs aimed at aligning patients and their physicians with diabetes guidelines and thus overcoming clinical inertia...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27574744/-act-on-threes-paradigm-for-treatment-intensification-of-type-2-diabetes-in-managed-care-results-of-a-randomized-controlled-study-with-an-educational-intervention-targeting-improved-glycemic-control
#11
Nella Bieszk, Shannon L Reynolds, Wenhui Wei, Cralen Davis, Pravin Kamble, Claudia Uribe
BACKGROUND: Clinical inertia, which has been defined as the recognition of a problem with a patient's management but failing to act, is a concern in type 2 diabetes (T2D) because it places the patient at risk of diabetes-related complications. Despite managed care organizations making significant investment in this area, little is known about the impact of educational programs aimed at aligning patients and their physicians with diabetes guidelines and thus overcoming clinical inertia...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27569076/head-and-neck-cancer-patients-impact-of-diabetes-mellitus-on-surgical-outcomes
#12
Chiara Bianchini, Andrea Ciorba, Claudia Aimoni, Virginia Corazzi, Ruggero Ronchin, Francesco Stomeo, Giovanni Scanelli
PURPOSE: Cancer patients with significant comorbidities undergoing major surgical intervention are at high risk for peri/postoperative complications and a prolonged hospital stay. Diabetes mellitus is a prevalent chronic metabolic disease, reported to affect surgery outcomes of malignancies. The purpose of this article was to evaluate the impact of diabetes mellitus on the development of local and systemic complications as well as the length of the hospital stay, after major surgery for Head and Neck (H&N) cancer...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27106272/exenatide-decreases-liver-fat-content-and-epicardial-adipose-tissue-in-patients-with-obesity-and-type-2-diabetes-a-prospective-randomized-clinical-trial-using-magnetic-resonance-imaging-and-spectroscopy
#13
RANDOMIZED CONTROLLED TRIAL
A Dutour, I Abdesselam, P Ancel, F Kober, G Mrad, P Darmon, O Ronsin, V Pradel, N Lesavre, J C Martin, A Jacquier, Y Lefur, M Bernard, B Gaborit
AIM: To conduct a prospective randomized trial to investigate the effect of glucagon-like peptide-1 (GLP-1) analogues on ectopic fat stores. METHODS: A total of 44 obese subjects with type 2 diabetes uncontrolled on oral antidiabetic drugs were randomly assigned to receive exenatide or reference treatment according to French guidelines. Epicardial adipose tissue (EAT), myocardial triglyceride content (MTGC), hepatic triglyceride content (HTGC) and pancreatic triglyceride content (PTGC) were assessed 45 min after a standardized meal with 3T magnetic resonance imaging and proton magnetic resonance spectroscopy before and after 26 weeks of treatment...
September 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27042016/a-set-of-four-simple-performance-measures-reflecting-adherence-to-guidelines-predicts-hospitalization-a-claims-based-cohort-study-of-patients-with-diabetes
#14
Carola A Huber, Michael Brändle, Roland Rapold, Oliver Reich, Thomas Rosemann
BACKGROUND: The link between guideline adherence and outcomes is a highly demanded issue in diabetes care. We aimed to assess the adherence to guidelines and its impact on hospitalization using a simple set of performance measures among patients with diabetes. METHODS: We performed a retrospective cohort study, using health care claims data for adult patients with treated diabetes (2011-2013). Patients were categorized into three drug treatment groups (with oral antidiabetic agents [OAs] only, in combination with insulin, and insulin only)...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/26900098/oral-antidiabetics-use-among-diabetic-type-2-patients-with-chronic-kidney-disease-do-nephrologists-take-account-of-recommendations
#15
MULTICENTER STUDY
Clotilde Muller, Yves Dimitrov, Olivier Imhoff, Sarah Richter, Julien Ott, Thierry Krummel, Dorothée Bazin-Kara, Francois Chantrel, Thierry Hannedouche
BACKGROUND: There is an increasing prevalence of diabetes type 2 and chronic kidney disease, challenging appropriate prescribing of oral anti-diabetic drugs (OADs). METHODS: We have described the practice patterns of 13 nephrologists in 4 centers, in a cohort of 301 consecutive adult type 2 diabetic patients. Among oral anti-diabetic prescriptions, we have detailed drugs dosage for each subject, with 3 different formulae for estimating glomerular filtration rate (GFR) and its adequation according to the latest ERBP recommendations (2015)...
May 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26872083/management-of-diabetes-mellitus-in-individuals-with-chronic-kidney-disease-therapeutic-perspectives-and-glycemic-control
#16
REVIEW
Carolina C R Betônico, Silvia M O Titan, Maria Lúcia C Correa-Giannella, Márcia Nery, Márcia Queiroz
The purpose of this study was to evaluate the therapeutic options for diabetes treatment and their potential side effects, in addition to analyzing the risks and benefits of tight glycemic control in patients with diabetic kidney disease. For this review, a search was performed using several pre-defined keyword combinations and their equivalents: "diabetes kidney disease" and "renal failure" in combination with "diabetes treatment" and "oral antidiabetic drugs" or "oral hypoglycemic agents...
January 2016: Clinics
https://www.readbyqxmd.com/read/26551483/safety-and-effectiveness-of-insulin-detemir-in-combination-with-oral-antidiabetic-agents-in-an-outpatient-specialist-setting-results-of-the-italian-solve%C3%A2-observational-study
#17
S Caputo, A Maran, D Mannino, S Morano, G Lastoria, P Nicoziani
AIM: The addition of basal insulin to oral antidiabetics (OADs) is described by a large number of guidelines and commonly used in clinical practice as a way to start insulin therapy in patients with type 2 diabetes mellitus in order to maximize compliance and minimise the impact of side effects (mainly hypoglycemia and body weight increase). METHODS: SOLVE™ was a 24-week international observational study conducted in 10 countries (including Italy) for the evaluation of the safety and effectiveness of once-daily insulin detemir as add-on therapy in patients with type 2 diabetes mellitus (T2DM) already treated with one or more OADs...
December 2015: Minerva Endocrinologica
https://www.readbyqxmd.com/read/26436350/the-treatment-of-diabetes-mellitus-of-patients-with-chronic-liver-disease
#18
REVIEW
Diego García-Compeán, José A González-González, Fernando J Lavalle-González, Emmanuel I González-Moreno, Héctor J Maldonado-Garza, Jesús Zacarías Villarreal-Pérez
About 80% of patients with liver cirrhosis may have glucose metabolism disorders, 30% show overt diabetes mellitus (DM). Prospective studies have demonstrated that DM is associated with an increased risk of hepatic complications and death in patients with liver cirrhosis. DM might contribute to liver damage by promoting inflammation and fibrosis through an increase in mitochondrial oxidative stress mediated by adipokines. Based on the above mentioned the effective control of hyperglycemia may have a favorable impact on the evolution of these patients...
November 2015: Annals of Hepatology
https://www.readbyqxmd.com/read/26269439/-the-impact-of-glycosylated-hemoglobin-target-value-in-treatment-guidelines-on-glycemic-control-of-type-2-diabetic-in-chinese-cities
#19
Weijun Gu, Linong Ji, Xiaohui Guo, Juming Lu
OBJECTIVE: To investigate the influence of glycosylated hemoglobin Al c (HbA1c) standard value (2007 and 2010 Chinese Diabetes Prevention Guide) on glycemic control and treatment of type 2 diabetic patients in Chinese cities. METHODS: A cross-sectional study was carried out in type 2 diabetes mellitus from outpatients in selected hospitals all over China in 2009 and 2012. Patients treated with oral antidiabetic drugs (OADs), insulin or OAD combined with insulin were enrolled...
March 2015: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/26211282/-glp-1-receptor-agonists-versus-sglt-2-inhibitors-in-obese-type-2-diabetes-patients
#20
REVIEW
Ana Rita Forte Marques, Jaafar Jaafar, Bénédicte de Kalbermatten, Jacques Philippe
Who never had a type 2 obese diabetic patient, treated by several oral antidiabetic drugs and insulin, with consequent weight gain associated with the therapeutic escalation and uncontrolled diabetes? The arrival of GLP-1 agonists and SGLT-2 inhibitors allows to reevaluate the management of these patients, with their favorable effects on glycemic control, weight and the risk of hypoglycemia and their complementary mechanisms to conventional treatments. The vicious cycle of weight gain and increased need of insulin is limited...
June 3, 2015: Revue Médicale Suisse
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