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Dermatology guidelines

Hannah Trøstrup, Steen H Matzen
INTRODUCTION: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence. PRESENTATION OF CASE: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. The patient was referred to the Department of Plastic Surgery and Breast Surgery after primary excision in a private practice setting of a general surgeon...
November 27, 2018: International Journal of Surgery Case Reports
Chloe Ekelem, Margit Juhasz, Pooja Khera, Natasha Atanaskova Mesinkovska
Importance: Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety of systemic pathways, including the immune system, in low doses of 1.5 to 4.0 mg/d. This phenomenon has piqued the interest of researchers and practitioners in regard to low-dose naltrexone's potential in the treatment of several autoimmune conditions...
November 28, 2018: JAMA Dermatology
J-M Amici
The incidence of basal cell carcinoma (BCC) is increasing as the population is aging and doubles every ten years. Surgery is the first-line treatment of BCC. Dermatological surgery is an oncological skin surgery whose first objective is to obtain a complete resection of the tumor. Its aim is also to reconstruct the defect using the optimal repair technique for the best cosmetic and scarring outcome and without functional impairment. The dermatological approach with the "oncological reading" of cutaneous tumors constitutes the essential preliminary time to the diagnosis of BCC and the identification of its limits...
November 2018: Annales de Dermatologie et de Vénéréologie
Faraz M Ali, Nutjaree Johns, Sam Salek, Andrew Y Finlay
Skin conditions may have a major impact on the psychologic well-being of patients, ranging from depression to anxiety. The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life tool in dermatology, though it has yet to be correlated with psychiatric measures used in clinical therapeutic trials. We conducted a systematic review to determine whether there is any correlation between the DLQI and psychiatric measure scores, potentially allowing the DLQI to be used as a surrogate measure for depression or psychiatric screening...
November 2018: Clinics in Dermatology
Antonia Reimer, Leena Bruckner-Tuderman, Hagen Ott
BACKGROUND: Rare diseases affect approximately 30 million people in the European Union and present a major health issue. Over 1000 rare skin diseases are known, many of which are of genetic origin and manifest in childhood. One of these diseases is epidermolysis bullosa (EB), a genodermatosis presenting with skin fragility and blistering. With an estimate of up to 2000 affected individuals in Germany, many of these children, but only two specialist centres, the question arose where and how health care for this rare disease is provided...
November 8, 2018: Orphanet Journal of Rare Diseases
Birgitte Skjærbæk Aggerholm, Mads Kirchheiner Rasmussen, Mette Meinert
In this case report a 42-year-old woman presented with a long history of hidrosadenitis suppurativa (HS). Due to recurrent abscesses and post-operative complications, she underwent 69 operations in general anaesthesia as well as numerous incisions in local anaesthesia in 2013-2017. The abscesses were repeatedly treated with simple incisions, although a Danish guideline from 2016 does not recommend this procedure as treatment of patients with HS, since there is a high rate of recurrence. This illustrates the necessity of increasing knowledge of the treatment of HS...
November 5, 2018: Ugeskrift for Laeger
Steven Chow, Chew Swee Seow, Maria Victoria Dizon, Kiran Godse, Henry Foong, Vicheth Chan, Tran Hau Khang, Leihong Xiang, Syarief Hidayat, M Yulianto Listiawan, Danang Triwahyudi, Srie Prihianti Gondokaryono, Endang Sutedja, Inne Arline Diana, Oki Suwarsa, Hartati Purbo Dharmadji, Agnes Sri Siswati, Retno Danarti, Retno Soebaryo, Windy Keumala Budianti
Background: Atopic dermatitis (AD) is a common skin condition among Asians. Recent studies have shown that Asian AD has a unique clinical and immunologic phenotype compared with European/American AD. Objective: The Asian Academy of Dermatology and Venereology Expert Panel on Atopic Dermatitis developed this reference guide to provide a holistic and evidence-based approach in managing AD among Asians. Methods: Electronic searches were performed to retrieve relevant systematic reviews and guidelines on AD...
October 2018: Asia Pacific Allergy
L Kandolf Sekulovic, J Guo, S Agarwala, A Hauschild, G McArthur, G Cinat, A Wainstein, C Caglevic, P Lorigan, H Gogas, M Alvarez, R Duncombe, C Lebbe, K Peris, P Rutkowski, A Stratigos, A-M Forsea, L De La Cruz Merino, M Kukushkina, R Dummer, C Hoeller, C Gorry, L Bastholt, D Herceg, B Neyns, R Vieira, P Arenberger, M Bylaite-Bucinskiene, N Babovic, M Banjin, K Putnik, V Todorovic, K Kirov, J Ocvirk, A Zhukavets, A Ymeri, I Stojkovski, C Garbe
According to data from recent studies from Europe, a large percentage of patients have restricted access to innovative medicines for metastatic melanoma. Melanoma World Society and European Association of Dermato-oncology conducted a Web-based survey on access to first-line recommended treatments for metastatic melanoma by current guidelines (National Comprehensive Center Network, European Society for Medical Oncology [ESMO] and European Organization for Research and Treatment of Cancer/European Association of Dermato-oncology/European dermatology Forum) among melanoma experts from 27 European countries, USA, China, Australia, Argentina, Brazil, Chile and Mexico from September 1st, 2017 to July 1st, 2018...
October 30, 2018: European Journal of Cancer
Clothilde Börjesson, Elisabeth Guinard, Marie Tauber, Maria-Polina Konstantinou, Cristina B Livideanu, Juliette Mazereeuw-Hautier, Nicolas Meyer, Carle Paul
Compounded topical preparations (CTP) were used to treat psoriasis until the last century and have disappeared from guidelines. The present authors report two severe psoriasis patients who were treated with CTP. A man had psoriasis with a PASI of 23 and a body surface area (BSA) of 43%. He had been using daily for several weeks a CTP including minoxidil, clobetasol propionate and hydroxyprogesterone formulated in an alcohol based vehicle. A woman suffered from psoriasis with an annular inflammatory pattern and a central healing...
November 2, 2018: Dermatologic Therapy
Juliana Cassol-Spanemberg, María-Eugenia Rodríguez-de Rivera-Campillo, Eva-María Otero-Rey, Albert Estrugo-Devesa, Enric Jané-Salas, José López-López
Background: Oral lichen planus (OLP) is one of the most common dermatological diseases which are present in the oral cavity. It is a chronic autoimmune, mucocutaneous disease that affects the oral mucosa as well as the skin, genital mucosa and other sites. Objective: Review the relevant information to OLP and its relationship with systemic diseases. Material and Methods: Searches were carried out in the Medline/PubMed, Lilacs, Bireme, BVS, and SciELO databases by using key-words...
September 2018: Journal of Clinical and Experimental Dentistry
Nancy S Younis, Nourah Yousef Al-Harbi
BACKGROUND: Acne vulgaris, a chronic inflammatory disease, is among the most common dermatologic conditions worldwide. In Saudi Arabia, Isotretinoin is commonly used to treat mild acne even without prescription. OBJECTIVE: To explore the practice and knowledge of community in Saudi Arabia regarding dispensing, counseling practices, and safety of isotretinoin-containing products. METHODS: A cross-sectional survey, using a self-administered questionnaire, was conducted in 3 sections: demographics, self-medication attitude (in the form of self Isotretinoin use), and identifying the side effects associated with the use of isotretinoin...
October 31, 2018: Therapeutic Innovation & Regulatory Science
Meth Ruvinda Delpachitra, Clare Heal, Jennifer Banks, Pranav Divakaran, Mrinal Pawar
OBJECTIVE: To identify patient- and procedure-related risk factors for surgical site infection following minor dermatological surgery. DATA SOURCES: The MEDLINE, Cumulative Index of Nursing and Allied Health Literature, Informit, and Scopus databases were searched for relevant literature on patient populations receiving minor surgery, where risk factors for surgical site infection were explicitly stated. STUDY SELECTION: Studies involving major dermatological surgery were excluded...
October 30, 2018: Advances in Skin & Wound Care
Filomena Russo, Martina Vispi, Riccardo Sirna, Virginia Mancini, Giovanni Bagnoni, Laura Bartoli, Mauro Bellini, Luca Brandini, Marzia Caproni, Antonio Castelli, Roberto Cecchi, Aldo Cuccia, Michele Fimiani, Marta Grazzini, Franco Marsili, Carlo Mazzatenta, Maria Chiara Niccoli, Salvatore Panduri, Camilla Peccianti, Silvia Pecenco, Nicola Pimpinelli, Francesca Prignano, Federica Ricceri, Marco Romanelli, Susanna Rossari, Franca Taviti, Walter Volpi, Michele Pellegrino
Psoriasis (PSO) is traditionally defined as an immune-mediated, inflammatory dermatological disease characterized by a chronic-relapsing course and associated with multifactorial inheritance (genetic predisposition and influence of various environmental factors). Considered until recently a dermatological disease only, today PSO is correctly known as a systemic one because of the involvement of multiple organs with important impact on social life and relationships.1 PSO is found in the 0.3-4,6% of the world's population, while its prevalence in the Italian population is estimated at 2...
October 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Sara Anvari, Jennifer Miller, Chih-Yin Yeh, Carla M Davis
Food allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fc ε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non-IgE-mediated food allergy which is more delayed in onset...
October 29, 2018: Clinical Reviews in Allergy & Immunology
Christos C Zouboulis, André Nogueira da Costa
BACKGROUND: Despite existing guidelines and methods for standardized clinical photography in dermatology and plastic surgery, human skin exhibits exquisite site-specific morphologies and functions, and each body region can exhibit an individual pathologic phenotype. The aim of this work was to develop a standardized, representative and reproducible documentation of the multilocular hidradenitis suppurativa/acne inversa (HS) lesions, a disease mostly occurring in skin folds. METHOD: Optimal body positions for medical photography of candidate areas for HS involvement were evaluated...
October 26, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
Kamber Loren Hart, Roy Howard Perlis, Clifford Scott Perlis
No abstract text is available yet for this article.
October 24, 2018: Journal of the American Academy of Dermatology
Jianbo Li, Yue Jin, Huiyan Fu, Yihui Huang, Xianqin Wang, Yunfang Zhou
Gelsenicine was one of indole alkaloids isolated Gelsemium elegans Benth. In recent years, the role of Gelsemium elegans Benth preparations in anti-tumor, analgesic, dilatation and dermatological treatment has attracted attention, and it has been applied clinically, but it is easy to cause poisoning. An UPLC-MS/MS method was established to determine the gelsenicine in the mouse blood, and the pharmacokinetics of gelsenicine after intravenous (0.1 mg/kg) and intragastric (0.5, 1 mg/kg) administration was studied...
October 26, 2018: Biomedical Chromatography: BMC
Jakob D Wikstrom, Lena Lundeberg, Margareta Frohm-Nilsson, Ada Girnita
Although clinical guidelines exist, the management of patients with cutaneous melanoma (CM) is a complex process that may vary between different care providers with potential dysfunctions ultimately mirrored in the overall patient satisfaction. The aim of the present study was to investigate the CM management as related to lead times, surgical quality and diagnosis communication with the hypothesis that the care may differ between providers and disparities may impact patient satisfaction. Medical records of 181 patients were retrospectively analyzed with parallel patient satisfaction evaluation by telephone interviews...
2018: PloS One
Annarosa Floreani, Nora Cazzagon
Patients with PBC have at least 60% of probability to have an autoimmune extrahepatic condition. The pathogenesis of these conditions includes a common mechanism involving both innate and adaptive immune responses targeting cholangiocytes and different extrahepatic tissues. The recent EASL guidelines recommend the management of these conditions, although detailed practical treatments have not been indicated. Autoimmune extrahepatic conditions may include: rheumatologic, endocrine, pulmonary, gastrointestinal, dermatologic diseases...
June 2018: Best Practice & Research. Clinical Gastroenterology
Rachela Bleuel, Bernadette Eberlein
Affecting 0.5 % of the world's population, vitiligo is an acquired skin disorder that poses major challenges in terms of dermatological care. Characterized by patchy depigmentation, the disease is frequently associated with cosmetic disfigurement and considerable psychological distress. The primary pathophysiological causes for the loss of functional melanocytes are thought to include genetic predisposition, autoimmune mechanisms, and oxidative stress. The present article highlights treatment recommendations contained in the European guidelines as well as those provided by recent reviews on vitiligo...
November 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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