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https://www.readbyqxmd.com/read/30535707/description-of-ovariectomy-protocol-in-mice
#1
Vanessa R Souza, Eduardo Mendes, Mateus Casaro, Ana Tada F B Antiorio, Fernando A Oliveira, Caroline M Ferreira
Estrogen and ovarian function decline are relevant characteristics of menopause period. Numerous physiological, metabolic and immunological alterations in the female body occur in the menopause period and some of these changes remain uncertain. The animal model that mimics menopause phase is an important approach to better comprehend the biological process involved in this period of women life. Ovariectomy is a procedure where ovaries are surgically excised and have been a valuable tool for understanding estrogen deficiency through animal experiments...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30530271/ovarian-protection-with-gonadotropin-releasing-hormone-agonists-during-chemotherapy-in-cancer-patients-from-biological-evidence-to-clinical-application
#2
REVIEW
Matteo Lambertini, Florence Horicks, Lucia Del Mastro, Ann H Partridge, Isabelle Demeestere
Survivorship issues are an area of crucial importance to be addressed as early as possible by all health care providers dealing with cancer patients. In women diagnosed during their reproductive years, the possible occurrence of chemotherapy-induced premature ovarian insufficiency (POI) is of particular concern being associated with important menopause-related symptoms, psychosocial issues as well as infertility. Temporary ovarian suppression by administering a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been studied to reduce the gonadotoxic impact of chemotherapy thus diminishing the chance of developing POI...
December 1, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/30526173/gynecologists-are-afraid-of-prescribing-hormone-replacement-to-endometrial-ovarian-cancer-survivors-despite-national-guidelines-a-survey-in-sweden
#3
Sandra Halldorsdottir, Hanna Dahlstrand, Karin Stålberg
BACKGROUND: Prolonged survival in ovarian and endometrial cancer patients increases the importance of paying attention to quality of life. Hormone replacement therapy (HRT) after gynecologic cancer has been controversial. With this survey, we sought to describe Swedish gynecologists' and gynecologic oncologists' attitudes towards prescribing HRT to these cancer survivors and see if prescribing practice is consistent with the available evidence and national guidelines. MATERIAL AND METHODS: A web-based survey containing three hypothetical cases with a total of 15 questions was distributed to gynecologists and gynecologic oncologists in Sweden...
December 10, 2018: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/30521462/-the-role-of-testosterone-in-the-improvement-of-sexual-desire-in-postmenopausal-women-an-evidence-based-clinical-review
#4
REVIEW
Maria Gouveia, Raquel Sanches, Sara Andrade, Sara Carmona, Carolina Ferreira
INTRODUCTION: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire. MATERIAL AND METHODS: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms 'testosterone', 'androgens', 'libido', 'sexual dysfunctions' and 'menopause'...
November 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/30516646/management-of-intracranial-haemorrhage-unruptured-aneurysms-and-arteriovenous-malformations-during-and-after-pregnancy
#5
Monica Acciarresi, Riccardo Altavilla, Maria G Mosconi, Valeria Caso
PURPOSE OF REVIEW: The absolute risk of pregnancy-associated intracranial haemorrhage (ICH) has been reported to be relatively low and often associated with high risks of life-long disabilities and mortality. The aim of this narrative review was obtaining a better understanding of the current management practices for ICH, unruptured aneurysms and/or arteriovenous malformations during pregnancy, as well as the effects of future pregnancies, and the uses of oral contraceptive or HRT. RECENT FINDING: General guidelines for the management of ICH are used for pregnant women but additional expedient and thorough evaluation of foetal viability and its gestational age are requested...
November 30, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/30513889/green-tea-consumption-and-risk-of-breast-cancer-and-recurrence-a-systematic-review-and-meta-analysis-of-observational-studies
#6
REVIEW
Vincenza Gianfredi, Daniele Nucci, Angela Abalsamo, Mattia Acito, Milena Villarini, Massimo Moretti, Stefano Realdon
Breast cancer (BC) is the most common cancer in women and several factors are involved in its onset. Green tea (GT) has been shown to have potential beneficial effects on different types of cancer. The aim of this review was to evaluate the association between GT regular consumption and risk of BC in women. The risk of BC recurrence and risk of BC in relation to menopausal status were also evaluated. A literature search of PubMed, Scopus, and Web of Science was conducted. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to perform the systematic review and meta-analysis...
December 3, 2018: Nutrients
https://www.readbyqxmd.com/read/30505220/discordant-interpretation-of-serial-bone-mineral-density-measurements-by-dual-energy-x-ray-absorptiometry-using-vendor-s-and-institutional-least-significant-changes-serious-impact-on-decision-making
#7
Nosheen Fatima, Maseeh Uz Zaman, Sadaf Saleem, Noureen Hameed, Jamila Bano
Meaningful change in bone mineral density (BMD) should be equal or higher than institutional least significant change (LSC). But some facilities use vendor's LSC which is discouraged by International Society for Clinical Densitometry (ISCD). The aim of this study was to find the impact of scan interpretation upon interval BMD changes using vendors and institutional LSCs. This prospective study was conducted at Joint Commission International-accredited facility of Pakistan from April-June 2017 using Hologic Discovery-A scanner...
October 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/30498423/intraductal-papilloma-without-atypia-on-image-guided-breast-biopsy-upgrade-rates-to-carcinoma-at-surgical-excision
#8
Doris Leithner, Benjamin Kaltenbach, Petra Hödl, Volker Möbus, Volker Brandenbusch, Stephan Falk, Clara Park, Thomas J Vogl, Markus Müller-Schimpfle
Background: The management of intraductal papilloma without atypia (IDP) in breast needle biopsy remains controversial. This study investigates the upgrade rate of IDP to carcinoma and clinical and radiologic features predictive of an upgrade. Methods: Patients with a diagnosis of IDP on image-guided (mammography, ultrasound, magnetic resonance imaging) core needle or vacuum-assisted biopsy and surgical excision of this lesion at a certified breast center between 2007 and 2017 were included in this institutional review board-approved retrospective study...
October 2018: Breast Care
https://www.readbyqxmd.com/read/30487320/-secondary-osteoporosis-clinical-approach-to-secondary-osteoporosis
#9
Yasuhiro Takeuchi
Osteoporosis is deterioration of bone integrity caused by bone loss(bone mineral density decrease)due to failure of coupling of bone resorption and bone formation. Various pathophysiological conditions other than natural menopause or aging are involved in the development of osteoporosis. When there is a specific cause of the disease, it is referred to as secondary osteoporosis. Secondary osteoporosis is usually thought to lead to an increased risk of fracture by causing a decrease in bone mineral density. It has also should be noted that in patients receiving corticosteroids, bone mineral density independent fracture risk increases...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/30473125/no-366-gynaecologic-management-of-hereditary-breast-and-ovarian-cancer
#10
Michelle Jacobson, Marcus Bernardini, Mara L Sobel, Raymond H Kim, Jeanna McCuaig, Lisa Allen
OBJECTIVE: This Committee Opinion outlines the gynaecologic management recommendations for women diagnosed with hereditary breast and ovarian cancer syndrome (HBOC) with respect to screening, contraception, chemoprophylaxis, fertility considerations, risk-reducing surgery, and post-oophorectomy care. INTENDED USERS: This Committee Opinion is designed for gynaecologic oncologists, general gynaecologists, family physicians, genetic counsellors, registered nurses, nurse practitioners, residents, and health care providers...
November 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/30461101/lived-experiences-and-quality-of-life-after-gynaecological-cancer-an-integrative-review
#11
REVIEW
Ragnhild J Tveit Sekse, Gail Dunberger, Mette Linnet Olesen, Maria Østerbye, Lene Seibaek
AIM AND OBJECTIVES: To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. BACKGROUND: While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalization has become shorter in relation to treatment. This has increased the need for follow-up and rehabilitation. DESIGN: Integrative literature review using the Equator PRISMA guidelines...
November 21, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/30456205/evaluation-of-knowledge-perception-and-risk-awareness-about-breast-cancer-and-its-treatment-outcome-among-university-of-gondar-students-northwest-ethiopia
#12
Begashaw Melaku Gebresillassie, Eyob Alemayehu Gebreyohannes, Sewunet Admasu Belachew, Yohannes Kelifa Emiru
Background: Breast cancer is among the most common life-threatening public health problems of global concern including Ethiopia. Knowledge and awareness about the disease will help to reduce the number of cases who present at late stages of the disease. The objective of this survey was to assess the knowledge, perception and risk awareness about breast cancer among female medical and health science students of University of Gondar, Ethiopia. Methods: A cross sectional survey was conducted from May 03 to June 01, 2017 at University of Gondar, Ethiopia...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/30453418/-chinese-guideline-on-menopause-management-and-menopause-hormone-therapy-2018
#13
(no author information available yet)
No abstract text is available yet for this article.
November 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/30452294/what-should-guide-our-patient-management-of-vulvovaginal-atrophy
#14
M Shapiro
Genitourinary syndrome of menopause including vulvovaginal atrophy is commonly experienced by postmenopausal women, reducing their quality of life. The aim of this review is to assess current treatment options within the framework of recent management guidelines. Recommendations include use of treatments addressing both symptoms and the underlying pathophysiology, and proactive patient discussion. Both prescription and non-prescription options are recognized, including non-hormone-based approaches. Local therapy is preferable in the primary treatment of genitourinary syndrome of menopause symptoms as risk of adverse events is reduced, although long-term safety data are limited...
November 19, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30407085/optimizing-quality-of-life-in-perimenopause-lessons-from-the-east
#15
X Wang, S Ran, Q Yu
As global life expectancy improves, women are expected to spend more than one-third of their lives in the status of menopause. In China, many women suffer from menopausal symptoms during this period, which impacts their well-being and quality of life. However, most Chinese women simply endure menopausal symptoms. Since the Chinese Menopause Society was founded in 1999, several versions of the guidelines for menopause management and menopausal hormone therapy (MHT) have been published; international cooperation has strengthened; menopause-related activities have been advocated; and popular knowledge of menopause and MHT has gradually improved...
November 8, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30399025/assessment-of-nams-members-prescription-patterns-of-hormone-therapy-before-and-after-the-2016-nams-annual-meeting
#16
Lindsay P Bonnett, Xuezhi Jiang, JoAnn V Pinkerton, Peter F Schnatz
OBJECTIVE: Hormone therapy (HT) prescription patterns have varied enormously over time and across specialties. The present study attempts to look at practice variation in specific controversial scenarios and to determine if attendance at The North American Menopause Society (NAMS) 2016 Annual Meeting, where the draft of the 2017 NAMS HT Position Statement was presented, had any impact on members' HT prescribing patterns. METHODS: An anonymous survey with 11 case scenarios was sent to all NAMS members before and after the 2016 NAMS Annual Meeting...
November 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30385358/-contraception-and-cancer-cngof-contraception-guidelines
#17
D Pragout, V Laurence, H Baffet, B Raccah-Tebeka, C Rousset-Jablonski
OBJECTIVES: To synthesize knowledge on cancer risks related to hormonal contraception and to propose recommendations on contraception during treatment and after cancer. METHODS: A systematic review of the literature about hormonal contraception and cancer was conducted on PubMed/Medline and the Cochrane Library. RESULTS: Overall, there is no increase in cancer (all types together) incidence or mortality among hormonal contraceptive users. Estroprogestin combined contraceptive use is associated with an increased risk of breast cancer (during use), and with a reduced risk of endometrial, ovarian, lymphatic or hematopoietic cancers that persist after discontinuation, and a decreased risk of colorectal cancer...
October 29, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/30376664/preventing-ovarian-failure-associated-with-chemotherapy
#18
Wanyuan Cui, Catharyn Stern, Martha Hickey, Fiona Goldblatt, Antoinette Anazodo, William S Stevenson, Kelly-Anne Phillips
Alkylating chemotherapy is often used to treat pre-menopausal women for various malignancies and autoimmune diseases. Chemotherapy-associated ovarian failure is a potential consequence of this treatment which can cause infertility, and increases the risk of other long term adverse health sequelae. Randomised trials, predominantly of women undergoing alkylating chemotherapy for breast cancer, have shown evidence for the efficacy of gonadotropin-releasing hormone agonists (GnRHa) in preventing chemotherapy-associated ovarian failure...
November 5, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30358729/association-between-the-vaginal-microbiota-menopause-status-and-signs-of-vulvovaginal-atrophy
#19
Rebecca M Brotman, Michelle D Shardell, Pawel Gajer, Doug Fadrosh, Kathryn Chang, Michelle I Silver, Raphael P Viscidi, Anne E Burke, Jacques Ravel, Patti E Gravitt
OBJECTIVE: The vaginal microbiota helps protect the female genital tract from disease. We sought to describe the composition of the vaginal microbiota in premenopausal, perimenopausal, and postmenopausal women and to explore the association between the microbiota and vulvovaginal atrophy (VVA). METHODS: Eighty-seven women (aged 35-60 y) were classified as premenopausal (n = 30), perimenopausal (n = 29), or postmenopausal (n = 28) according to Stages of Reproductive Aging Workshop guidelines...
November 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30348046/managing-vulvovaginal-atrophy-after-breast-cancer
#20
Jenifer Sassarini, Mahesh Perera, Keith Spowart, Kay McAllister, Judith Fraser, Ros Glasspool, Rosie Harrand, Marina Chitoni, Sheila Stallard, Mary-Ann Lumsden
Cancer treatment may result in loss of ovarian function through surgical removal of the ovaries, chemotherapy or radiation. While menopausal symptoms, such as hot flushes, night sweats, sleep disturbance, memory concerns and mood issues can be extremely bothersome to some women going through menopause naturally, women who undergo an induced menopause usually experience more sudden and severe symptoms. Pain and vaginal dryness can occur whether a woman has a sexual partner or not. In women with breast cancer, the aetiology of impaired sexual functioning, and lowered sexual desire, is often multifactorial, and may be related to physical and/or psychological reasons...
October 23, 2018: Post Reproductive Health
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