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https://www.readbyqxmd.com/read/30508603/in-vitro-analysis-of-synthetic-peptides-in-blocking-the-entry-of-dengue-virus
#1
Asnet Mary John, Akanitt Jittmittraphap, Siriporn Chattanadee, A Alwin Prem Anand, R Shenbagarathai, Pornsawan Leaungwutiwong
Dengue fever is the most prevalent arthropod-borne viral disease, and no specific therapeutic or promising antiviral drug is available for its treatment. Peptide inhibitors are less toxic than synthetic compounds and have found proven effective against viral infections. Here, three peptides that mimic part of the E protein of the dengue virus (DENV) were synthesized and evaluated for their inhibitory activity against four serotypes of DENV in African green monkey kidney (Vero) and rhesus macaque (Macaca mulatta) monkey kidney (LLC-MK2) cell lines...
November 30, 2018: Virus Research
https://www.readbyqxmd.com/read/30507199/maximum-caliber-can-build-and-infer-models-of-oscillation-in-a-three-gene-feedback-network
#2
Taylor Firman, Anar Amgalan, Kingshuk Ghosh
Single-cell protein expression time trajectories provide rich temporal data quantifying cellular variability and its role in dictating fitness. However, theoretical models to analyze and fully extract information from these measurements remain limited for three reasons: i) gene expression profiles are noisy, rendering models of averages inapplicable, ii) experiments typically measure only a few protein species while leaving other molecular actors -- necessary to build traditional bottom-up models -- unnoticed, and iii) measured data is in fluorescence, not particle number...
December 3, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/30503941/phytoestrogens-and-their-synthetic-analogues-as-substrate-mimic-inhibitors-of-cyp1b1
#3
Mohd Usman Mohd Siddique, Tabassum Khair Barbhuiya, Barij Nayan Sinha, Venkatesan Jayaprakash
Phytoestrogens are class of natural compounds that shares structural similarity with estrogen and has the capacity to alter the fertilization in mammals. Till early 1990s, the natural phytoestrogens as well as their synthetic analogues were explored for their fertility modulating activity. During late 1990s, two findings renewed the interest on phytoestrogens as means to control hormone induced cancer: (i) revelation of overexpression of CYP1B1 in breast & ovarian cancer and (ii) protection offered by alphanapthoflavone (ANF) against hormone induced cancer...
November 17, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30500412/young-spontaneously-hypertensive-rats-shrs-display-prodromal-schizophrenia-like-behavioral-abnormalities
#4
Suzy Tamie Niigaki, Fernanda Fiel Peres, Lizia Ferreira, Tania Libanio, Douglas Albuquerque Gouvea, Raquel Levin, Valeria Almeida, Neide Derci Silva, Mariana Cepollaro Diana, Mayra Akimi Suiama, Mariana Bendlin Calzavara, Vanessa Costhek Abilio
The Spontaneously Hypertensive Rat (SHR) strain has been suggested as an animal model of schizophrenia, considering that adult SHRs display behavioral abnormalities that mimic the cognitive, psychotic and negative symptoms of the disease and are characteristic of its animal models. SHRs display: (I) deficits in fear conditioning and latent inhibition (modeling cognitive impairments), (II) deficit in prepulse inhibition of startle reflex (reflecting a deficit in sensorimotor gating, and associated with psychotic symptoms), (III) diminished social behavior (modeling negative symptoms) and (IV) hyperlocomotion (modeling the hyperactivity of the dopaminergic mesolimbic system/ psychotic symptoms)...
November 28, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30489320/novel-plag1-gene-rearrangement-distinguishes-a-subset-of-uterine-myxoid-leiomyosarcoma-from-other-uterine-myxoid-mesenchymal-tumors
#5
Javier A Arias-Stella, Ryma Benayed, Esther Oliva, Robert H Young, Lien N Hoang, Cheng-Han Lee, Achim A Jungbluth, Denise Frosina, Robert A Soslow, Cristina R Antonescu, Marc Ladanyi, Sarah Chiang
Genetic alterations in uterine myxoid leiomyosarcoma are unknown. We investigate the clinicopathologic features of 19 uterine tumors previously diagnosed as myxoid leiomyosarcomas in which tumoral RNA was subjected to targeted RNA sequencing. PLAG1, BCOR, BCORL1, HMGA2, and ALK break-apart fluorescence in situ hybridization (FISH) and BCOR, PLAG1, and ALK immunohistochemistry were performed in cases which failed or lacked fusions by sequencing. The diagnosis of myxoid leiomyosarcoma was confirmed in 15 cases after exclusion of 4 tumors with BCOR and ALK rearrangements...
November 27, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/30450898/pitfalls-in-the-abts-peroxidase-activity-test-interference-of-photochemical-processes
#6
Andrea Liberato, M Jesús Fernández-Trujillo, Ángeles Máñez, Marcelino Maneiro, Laura Rodríguez-Silva, Manuel G Basallote
ABTS (2,2'-azinobis(3-ethylbenzothiazoline)-6-sulfonic acid) oxidation to form its radical cation in the presence of H2 O2 is frequently used as a test for determining the peroxidase activity of enzyme mimics. Detailed studies using salen-type Mn(III) complexes show that photochemical processes involving H2 O2 , ABTS, and the complex itself can lead to erroneous results. The capability of the complexes to act as • OH scavengers can be also relevant when the mechanism of their biological activity is considered...
November 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30448294/il-15-improves-skeletal-muscle-oxidative-metabolism-and-glucose-uptake-in-association-with-increased-respiratory-chain-supercomplex-formation-and-ampk-pathway-activation
#7
L Nadeau, D A Patten, A Caron, L Garneau, E Pinault-Masson, M Foretz, P Haddad, B G Anderson, L S Quinn, K Jardine, M W McBurney, E E Pistilli, M E Harper, C Aguer
BACKGROUND: IL-15 is believed to play a role in the beneficial impact of exercise on muscle energy metabolism. However, previous studies have generally used supraphysiological levels of IL-15 that do not represent contraction-induced IL-15 secretion. METHODS: L6 myotubes were treated acutely (3 h) and chronically (48 h) with concentrations of IL-15 mimicking circulating (1-10 pg/ml) and muscle interstitial (100 pg/ml -20 ng/ml) IL-15 levels with the aim to better understand its autocrine/paracrine role on muscle glucose uptake and mitochondrial function...
November 15, 2018: Biochimica et biophysica acta. General subjects
https://www.readbyqxmd.com/read/30445910/cdss-rm-a-clinical-decision-support-system-reference-model
#8
Dimitrios Zikos, Nailya DeLellis
Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The objective of this paper is to introduce a high level reference model that is intended to be used as a foundation to design successful and contextually relevant CDSS systems. The paper begins by introducing the information flow, use, and sharing characteristics in a hospital setting, and then it outlines the referential context for the model, which are clinical decisions in a hospital setting...
November 16, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/30445365/shock-absorbing-ability-in-healthy-and-damaged-cartilage-bone-under-high-rate-compression
#9
Shaktivesh, Fatemeh Malekipour, Peter V S Lee
Articular cartilage is a soft tissue that distributes the loads in joints and transfers the compressive load to the underlying bone. At high rate and magnitudes of mechanical loading, cartilage and subchondral bone together are susceptible to damage. In addition, any disruption to the cartilage's structure, caused by injury, trauma or disorder such as osteoarthritis (OA), can alter the mechanism of load transfer from the cartilage to the underlying bone. Changes in the cartilage structure can also alter the ability of cartilage-bone to absorb and dissipate the impact energy...
October 16, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/30443239/cerebral-hemodynamics-in-speech-related-cortical-areas-articulation-learning-involves-the-inferior-frontal-gyrus-ventral-sensory-motor-cortex-and-parietal-temporal-sylvian-area
#10
Naomi Nakamichi, Kouichi Takamoto, Hiroshi Nishimaru, Kumiko Fujiwara, Yusaku Takamura, Jumpei Matsumoto, Makoto Noguchi, Hisao Nishijo
Although motor training programs have been applied to childhood apraxia of speech (AOS), the neural mechanisms of articulation learning are not well understood. To this aim, we recorded cerebral hemodynamic activity in the left hemisphere of healthy subjects ( n = 15) during articulation learning. We used near-infrared spectroscopy (NIRS) while articulated voices were recorded and analyzed using spectrograms. The study consisted of two experimental sessions (modified and control sessions) in which participants were asked to repeat the articulation of the syllables "i-chi-ni" with and without an occlusal splint...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30441549/predictive-value-of-prothrombin-time-for-all-cause-mortality-in-acute-myocardial-infarction-patients
#11
Xurong Wang, Runge Chen, Ye Li, Fen Miao
Acute myocardial infarction (AMI) is a serious cardiovascular disease caused by acute or persistent ischemic and anoxia of the coronary artery. A more practical and effective risk model is still remained to be established for AMI patients. This study aims to investigate the predictive value of prothrombin time (PT) in AMI patients. In this study, 2734 AMI patients available in the public MIMIC III clinical database were investigated, with 629 deaths occurring within 2-year follow-up. More than 20 risk factors including demographics, clinical disease history, laboratory test information, surgery history, and mediation information were analyzed as potential predictors for all-cause mortality in AMI patients...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30441014/severity-classification-of-chronic-obstructive-pulmonary-disease-and-asthma-with-heart-rate-and-spo2-sensors
#12
Tasnuba Siddiqui, Bashir I Morshed
Asthma and Chronic Obstructive Pulmonary Disease are chronic and long-term lung diseases. Disease monitoring with minimal sensors with high efficacy can make the disease control simple and practical for patients. We propose a model for the severity assessment of the diseases through wearables and compatible with mobile health applications, using only heart rate and SpO2 (from pulse oximeter sensor). Patient data were obtained from the MIMIC- III Waveform Database Matched Subset. The dataset consists of 158 subjects...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/30429994/selective-c-h-halogenation-over-hydroxylation-by-non-heme-iron-iv-oxo
#13
Sujoy Rana, Jyoti Prasad Biswas, Asmita Sen, Martin Clémancey, Geneviève Blondin, Jean-Marc Latour, Gopalan Rajaraman, Debabrata Maiti
Non-heme iron based halogenase enzymes promote selective halogenation of the sp3 -C-H bond through iron(iv)-oxo-halide active species. During halogenation, competitive hydroxylation can be prevented completely in enzymatic systems. However, synthetic iron(iv)-oxo-halide intermediates often result in a mixture of halogenation and hydroxylation products. In this report, we have developed a new synthetic strategy by employing non-heme iron based complexes for selective sp3 -C-H halogenation by overriding hydroxylation...
October 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/30424236/formation-of-branched-and-chained-alginate-microfibers-using-theta-glass-capillaries
#14
Keigo Nishimura, Yuya Morimoto, Nobuhito Mori, Shoji Takeuchi
This study proposes a microfluidic spinning method to form alginate microfibers with branched and chained structures by controlling two streams of a sodium alginate solution extruded from a theta-glass capillary (a double-compartmented glass capillary). The two streams have three flow regimes: (i) a combined flow regime (single-threaded stream), (ii) a separated flow regime (double-threaded stream), and (iii) a chained flow regime (stream of repeating single- and double-threaded streams). The flow rate of the sodium alginate solution and the tip diameter of the theta-glass capillary are the two parameters which decide the flow regime...
June 17, 2018: Micromachines
https://www.readbyqxmd.com/read/30411243/mean-arterial-pressure-and-mortality-in-patients-with-distributive-shock-a-retrospective-analysis-of-the-mimic-iii-database
#15
Jean-Louis Vincent, Nathan D Nielsen, Nathan I Shapiro, Margaret E Gerbasi, Aaron Grossman, Robin Doroff, Feng Zeng, Paul J Young, James A Russell
BACKGROUND: Maintenance of mean arterial pressure (MAP) at levels sufficient to avoid tissue hypoperfusion is a key tenet in the management of distributive shock. We hypothesized that patients with distributive shock sometimes have a MAP below that typically recommended and that such hypotension is associated with increased mortality. METHODS: In this retrospective analysis of the Medical Information Mart for Intensive Care (MIMIC-III) database from Beth Israel Deaconess Medical Center, Boston, USA, we included all intensive care unit (ICU) admissions between 2001 and 2012 with distributive shock, defined as continuous vasopressor support for ≥ 6 h and no evidence of low cardiac output shock...
November 8, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/30408752/the-manganese-iii-porphyrin-mntnhex-2-pyp-5-modulates-intracellular-ros-and-breast-cancer-cell-migration-impact-on-doxorubicin-treated-cells
#16
Ana Flórido, Nuno Saraiva, Sara Cerqueira, Nuno Almeida, Maddy Parsons, Ines Batinic-Haberle, Joana P Miranda, João G Costa, Guia Carrara, Matilde Castro, Nuno G Oliveira, Ana S Fernandes
Manganese(III) porphyrins (MnPs) are superoxide dismutase (SOD) mimics with demonstrated beneficial effects in cancer treatment in combination with chemo- and radiotherapy regimens. Despite the ongoing clinical trials, little is known about the effect of MnPs on metastasis, being therefore essential to understand how MnPs affect this process. In the present work, the impact of the MnP MnTnHex-2-PyP5+ in metastasis-related processes was assessed in breast cancer cells (MCF-7 and MDA-MB-231), alone or in combination with doxorubicin (dox)...
October 25, 2018: Redox Biology
https://www.readbyqxmd.com/read/30406910/mhc-class-i-molecules-and-pirb-shape-neuronal-morphology-by-affecting-the-dendritic-arborization-of-cortical-neurons
#17
Yuqing Shen, Huanhuan Zhao, Ping Li, Yaqin Peng, Pengfei Cui, Fengqin Miao, Ying Zhang, Aifeng Zhang, Jianqiong Zhang
Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I proteins aggregate at specific sites in neuronal cell bodies, which overlap with the actin cytoskeleton. Knockout of MHC class I in cultured neurons increases total dendritic length and the number of branch points...
November 8, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/30401937/proteomics-as-a-new-tool-to-study-fingermark-ageing-in-forensics
#18
Stijn Oonk, Tom Schuurmans, Martin Pabst, Louis C P M de Smet, Marcel de Puit
Fingermarks are trace evidence of great forensic importance, and their omnipresence makes them pivotal in crime investigation. Police and law enforcement authorities have exploited fingermarks primarily for personal identification, but crucial knowledge on when fingermarks were deposited is often lacking, thereby hindering crime reconstruction. Biomolecular constituents of fingermark residue, such as amino acids, lipids and proteins, may provide excellent means for fingermark age determination, however robust methodologies or detailed knowledge on molecular mechanisms in time are currently not available...
November 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30384009/mimicking-salmochelin-s1-and-the-interactions-of-its-fe-iii-complex-with-periplasmic-iron-siderophore-binding-proteins-ceue-and-vctp
#19
Ellis J Wilde, Elena V Blagova, Thomas J Sanderson, Daniel J Raines, Ross P Thomas, Anne Routledge, Anne-Kathrin Duhme-Klair, Keith S Wilson
A mimic of the tetradentate stealth siderophore salmochelin S1, was synthesised, characterised and shown to form Fe(III) complexes with ligand-to-metal ratios of 1:1 and 3:2. Circular dichroism spectroscopy confirmed that the periplasmic binding proteins CeuE and VctP of Campylobacter jejuni and Vibrio cholerae, respectively, bind the Fe(III) complex of the salmochelin mimic by preferentially selecting Λ-configured Fe(III) complexes. Intrinsic fluorescence quenching studies revealed that VctP binds Fe(III) complexes of the mimic and structurally-related catecholate ligands, such as enterobactin, bis(2, 3-dihydroxybenzoyl-l-serine) and bis(2, 3-dihydroxybenzoyl)-1, 5-pentanediamine with higher affinity than does CeuE...
October 19, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/30376033/water-dispersed-two-dimensional-ultrathin-fe-iii-modified-covalent-triazine-framework-nanosheets-peroxidase-like-activity-and-colorimetric-biosensing-applications
#20
Linjing Su, Zhi Zhang, Yuhao Xiong
Peroxidase mimics have attracted increasing attention as emerging artificial enzymes due to their promising applications in many fields, including bionanotechnology, sustainable chemistry, and environmental remediation. Although many types of peroxidase mimics have been successfully exploited in the past decade, the development of an innovative peroxidase mimic that does not contain noble metals, but exhibits remarkable peroxidase-like activity and low cytotoxicity still remains a major challenge in this field...
November 8, 2018: Nanoscale
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