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lawrence h young

Anna R Kahkoska, Scott Isom, Jasmin Divers, Elizabeth J Mayer-Davis, Lawrence Dolan, Amy S Shah, Maryam Afkarian, David J Pettitt, Jean M Lawrence, Santica Marcovina, Sharon H Saydah, Dana Dabelea, David M Maahs, Amy K Mottl
AIMS: To determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression. METHODS: Data from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later)...
October 4, 2018: Journal of Diabetes and its Complications
J Narbutt, P A Philipsen, G I Harrison, K A Morgan, K P Lawrence, K A Baczynska, K Grys, M Rogowski-Tylman, I Olejniczak-Staruch, A Tewari, M Bell, C O'Connor, H C Wulf, A Lesiak, A R Young
BACKGROUND: Sun protection factor (SPF) is assessed with sunscreen applied at 2mg/cm2 . People typically apply ~0·8mg/cm2 and use sunscreen daily for holidays. Such use typically results in erythema that is a risk factor for skin cancer. OBJECTIVES: To determine if (i) typical sunscreen use resulted in erythema, epidermal DNA damage and photoimmunosuppression during a sunny holiday, (ii) optimal sunscreen use inhibited erythema and (iii) erythema is a biomarker for photoimmunosuppression in a laboratory study...
October 11, 2018: British Journal of Dermatology
Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R Robertson, Jason M Torres, N William Rayner, Anthony J Payne, Valgerdur Steinthorsdottir, Robert A Scott, Niels Grarup, James P Cook, Ellen M Schmidt, Matthias Wuttke, Chloé Sarnowski, Reedik Mägi, Jana Nano, Christian Gieger, Stella Trompet, Cécile Lecoeur, Michael H Preuss, Bram Peter Prins, Xiuqing Guo, Lawrence F Bielak, Jennifer E Below, Donald W Bowden, John Campbell Chambers, Young Jin Kim, Maggie C Y Ng, Lauren E Petty, Xueling Sim, Weihua Zhang, Amanda J Bennett, Jette Bork-Jensen, Chad M Brummett, Mickaël Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon L R Kardia, Florian Kronenberg, Kristi Läll, Ching-Ti Liu, Adam E Locke, Jian'an Luan, Ioanna Ntalla, Vibe Nylander, Sebastian Schönherr, Claudia Schurmann, Loïc Yengo, Erwin P Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C Florez, Ian Ford, Oscar H Franco, Timothy M Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T Hattersley, Christian Herder, M Arfan Ikram, Martin Ingelsson, Marit E Jørgensen, Torben Jørgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L Mohlke, Andrew D Morris, Girish Nadkarni, James S Pankow, Annette Peters, Naveed Sattar, Alena Stančáková, Konstantin Strauch, Kent D Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R Witte, Josée Dupuis, Patricia A Peyser, Eleftheria Zeggini, Ruth J F Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S Collins, J Wouter Jukema, Colin N A Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Köttgen, Goncalo R Abecasis, James B Meigs, Jerome I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J Wareham, Kari Stefansson, Anna L Gloyn, Andrew P Morris, Michael Boehnke, Mark I McCarthy
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency <5%, 14 with estimated allelic odds ratio >2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence)...
October 8, 2018: Nature Genetics
Theodore S Jardetzky, Jerry H Brown, Joan C Gorga, Lawrence J Stern, Robert G Urban, Young-In Chi, Cynthia Stauffacher, Jack L Strominger, Don C Wiley
No abstract text is available yet for this article.
October 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Ulf Büntgen, Lukas Wacker, J Diego Galván, Stephanie Arnold, Dominique Arseneault, Michael Baillie, Jürg Beer, Mauro Bernabei, Niels Bleicher, Gretel Boswijk, Achim Bräuning, Marco Carrer, Fredrik Charpentier Ljungqvist, Paolo Cherubini, Marcus Christl, Duncan A Christie, Peter W Clark, Edward R Cook, Rosanne D'Arrigo, Nicole Davi, Ólafur Eggertsson, Jan Esper, Anthony M Fowler, Ze'ev Gedalof, Fabio Gennaretti, Jussi Grießinger, Henri Grissino-Mayer, Håkan Grudd, Björn E Gunnarson, Rashit Hantemirov, Franz Herzig, Amy Hessl, Karl-Uwe Heussner, A J Timothy Jull, Vladimir Kukarskih, Alexander Kirdyanov, Tomáš Kolář, Paul J Krusic, Tomáš Kyncl, Antonio Lara, Carlos LeQuesne, Hans W Linderholm, Neil J Loader, Brian Luckman, Fusa Miyake, Vladimir S Myglan, Kurt Nicolussi, Clive Oppenheimer, Jonathan Palmer, Irina Panyushkina, Neil Pederson, Michal Rybníček, Fritz H Schweingruber, Andrea Seim, Michael Sigl, Olga Churakova Sidorova, James H Speer, Hans-Arno Synal, Willy Tegel, Kerstin Treydte, Ricardo Villalba, Greg Wiles, Rob Wilson, Lawrence J Winship, Jan Wunder, Bao Yang, Giles H F Young
Though tree-ring chronologies are annually resolved, their dating has never been independently validated at the global scale. Moreover, it is unknown if atmospheric radiocarbon enrichment events of cosmogenic origin leave spatiotemporally consistent fingerprints. Here we measure the 14 C content in 484 individual tree rings formed in the periods 770-780 and 990-1000 CE. Distinct 14 C excursions starting in the boreal summer of 774 and the boreal spring of 993 ensure the precise dating of 44 tree-ring records from five continents...
September 6, 2018: Nature Communications
Nijasri C Suwanwela, Christopher L H Chen, Chun Fan Lee, Sherry H Young, San San Tay, Thirugnanam Umapathi, Annabelle Y Lao, Herminigildo H Gan, Alejandro C Baroque Ii, Jose C Navarro, Hui Meng Chang, Joel M Advincula, Sombat Muengtaweepongsa, Bernard P L Chan, Carlos L Chua, Nirmala Wijekoon, H Asita de Silva, John Harold B Hiyadan, Ka Sing Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Narayanaswamy Venketasubramanian
BACKGROUND AND PURPOSE: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional outcomes after stroke. METHODS: Data from the CHInese Medicine NeuroAiD Efficacy on Stroke (CHIMES) and CHIMES-Extension (CHIMES-E) studies were analyzed. CHIMES-E was a 24-month follow-up study of subjects included in CHIMES, a multi-centre, double-blind placebo-controlled trial which randomized subjects with acute ischemic stroke, to either MLC601 or placebo for 3 months in addition to standard stroke treatment and rehabilitation...
2018: Cerebrovascular Diseases
Victor Chedid, Justin Brandler, Priya Vijayvargiya, Seon-Young Park, Lawrence A Szarka, Michael Camilleri
OBJECTIVES: Our aim was to characterize upper gastrointestinal (UGI) symptoms and associations in individuals with diabetes mellitus (DM) who had undergone evaluation of gastric emptying (GE) and accommodation (GA) at a referral center. METHODS: From the Mayo Clinic Rochester electronic medical records of adults with diabetes types 1 and 2 (DM1 and DM2) evaluated between January 1997 and December 2015, we extracted demographics, UGI symptoms, current medications, treatments for diabetes, GE solids by scintigraphy, GA by single photon emission computed tomography (SPECT), and diabetes complications...
August 30, 2018: American Journal of Gastroenterology
Lawrence Mbuagbaw, Amy L Slogrove, Jacqueline Sas, John Lengwe Kunda, Frederick Morfaw, Jackson K Mukonzo, Wei Cao, Gisele Ngomba-Kadima, Moleen Zunza, Pierre Ongolo-Zogo, Philip N Nana, Anne Cockcroft, Neil Andersson, Nelson Sewankambo, Mark F Cotton, Taisheng Li, Taryn Young, Joel Singer, Jean-Pierre Routy, Colin Jd Ross, Kyaw Thin, Lehana Thabane, Aslam H Anis
As a response to the human immunodeficiency virus (HIV) epidemic and part of Canadian Institutes for Health Research's mandate to support international health research capacity building, the Canadian Institutes for Health Research Canadian HIV Trial Network (CTN) developed an international postdoctoral fellowship award under the CTN's Postdoctoral Fellowship Awards Program to support and train young HIV researchers in resource-limited settings. Since 2010, the fellowship has been awarded to eight fellows in Cameroon, China, Lesotho, South Africa, Uganda and Zambia...
2018: HIV/AIDS: Research and Palliative Care
Natalie J Collins, Edwin H G Oei, Janneke L de Kanter, Bill Vicenzino, Kay M Crossley
OBJECTIVE: In adults with persistent patellofemoral pain (PFP), (i) describe the prevalence of radiographic features of patellofemoral osteoarthritis (PFOA); (ii) describe the prevalence of magnetic resonance imaging (MRI) PFOA and compare to age- and sex-matched controls; and (iii) explore radiographic and MRI prevalence across age, sex and body mass index (BMI) groups. METHODS: This cross-sectional study included 84 individuals with PFP ≥3 months duration, and 26 age- and sex-matched controls...
August 21, 2018: Arthritis Care & Research
R Agnese, T Aralis, T Aramaki, I J Arnquist, E Azadbakht, W Baker, S Banik, D Barker, D A Bauer, T Binder, M A Bowles, P L Brink, R Bunker, B Cabrera, R Calkins, C Cartaro, D G Cerdeño, Y-Y Chang, J Cooley, B Cornell, P Cushman, P C F Di Stefano, T Doughty, E Fascione, E Figueroa-Feliciano, C Fink, M Fritts, G Gerbier, R Germond, M Ghaith, S R Golwala, H R Harris, Z Hong, E W Hoppe, L Hsu, M E Huber, V Iyer, D Jardin, C Jena, M H Kelsey, A Kennedy, A Kubik, N A Kurinsky, R E Lawrence, J V Leyva, B Loer, E Lopez Asamar, P Lukens, D MacDonell, R Mahapatra, V Mandic, N Mast, E H Miller, N Mirabolfathi, B Mohanty, J D Morales Mendoza, J Nelson, J L Orrell, S M Oser, W A Page, R Partridge, M Pepin, A Phipps, F Ponce, S Poudel, M Pyle, H Qiu, W Rau, A Reisetter, T Reynolds, A Roberts, A E Robinson, H E Rogers, R K Romani, T Saab, B Sadoulet, J Sander, A Scarff, R W Schnee, S Scorza, K Senapati, B Serfass, J So, D Speller, C Stanford, M Stein, J Street, H A Tanaka, D Toback, R Underwood, A N Villano, B von Krosigk, S L Watkins, J S Wilson, M J Wilson, J Winchell, D H Wright, S Yellin, B A Young, X Zhang, X Zhao
We present the first limits on inelastic electron-scattering dark matter and dark photon absorption using a prototype SuperCDMS detector having a charge resolution of 0.1 electron-hole pairs (CDMS HVeV, a 0.93 g CDMS high-voltage device). These electron-recoil limits significantly improve experimental constraints on dark matter particles with masses as low as 1  MeV/c^{2}. We demonstrate a sensitivity to dark photons competitive with other leading approaches but using substantially less exposure (0.49 g d)...
August 3, 2018: Physical Review Letters
Nabil E Boutagy, Jing Wu, Zhengxi Cai, Wenjie Zhang, Carmen J Booth, Tassos C Kyriakides, Daniel Pfau, Tim Mulnix, Zhao Liu, Edward J Miller, Lawrence H Young, Richard E Carson, Yiyun Huang, Chi Liu, Albert J Sinusas
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of 18 F-DHMT, a marker of ROS, for early detection of doxorubicin-induced cardiotoxicity in rats. Echocardiography was performed at baseline and 4, 6, and 8 weeks post-doxorubicin initiation, whereas in vivo superoxide production was measured at 4 and 6 weeks with 18 F-DHMT positron emission tomography. Left ventricular ejection fraction (LVEF) was not significantly decreased until 6 weeks post-doxorubicin treatment, whereas myocardial superoxide production was significantly elevated at 4 weeks...
June 2018: JACC. Basic to Translational Science
Dandan Wang, Xiaoyue Hu, Seung Hee Lee, Feng Chen, Kai Jiang, Zizhuo Tu, Zejian Liu, Jing Du, Li Wang, Chaoying Yin, Yu Liao, Hongcai Shang, Kathleen A Martin, Raimund I Herzog, Lawrence H Young, Li Qian, John Hwa, Yaozu Xiang
Management for patients with diabetes experiencing myocardial infarction remains a challenge. Here the authors show that hyperglycemia- and hyperinsulinemia-induced microRNA-24 (miR-24) reduction and O-GlcNAcylation in the diabetic heart contribute to poor survival and increased infarct size in diabetic myocardial ischemia/reperfusion (I/R). In a mouse model of myocardial I/R, pharmacological or genetic overexpression of miR-24 in hearts significantly reduced myocardial infarct size. Experimental validation revealed that miR-24 targets multiple key proteins, including O-GlcNac transferase, ATG4A, and BIM, to coordinately protect the myocardium from I/R injury...
June 2018: JACC. Basic to Translational Science
Avery C Rossidis, Heron D Baumgarten, Kendall M Lawrence, Patrick E McGovern, Ali Y Mejaddam, Haiying Li, Grace Hwang, Kathleen Young, William H Peranteau, Marcus G Davey, J William Gaynor, Alan W Flake
INTRODUCTION: We have recently developed an extra-uterine environment for neonatal development (EXTEND) capable of supporting premature fetal lambs and have been able to replicate hypoxic in utero conditions by controlling fetal oxygen delivery. In this study, we investigated the fetal mitochondrial response to hypoxia. METHODS: Eight premature fetal lambs were delivered via hysterotomy and transitioned to extra-uterine support for 3 weeks. The lambs were divided into 2 groups: normoxic fetuses which maintained physiologic oxygen delivery and hypoxic fetuses in which oxygen delivery was significantly reduced...
June 28, 2018: Fetal Diagnosis and Therapy
Lawrence H Young, Catherine M Viscoli, Gregory G Schwartz, Silvio E Inzucchi, Jeptha P Curtis, Mark J Gorman, Karen L Furie, Robin Conwit, Erica Spatz, Anne Lovejoy, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Frederick S Ling, Steven E Pfau, Walter N Kernan
Background -The Insulin Resistance Intervention after Stroke (IRIS) trial demonstrated that pioglitazone reduced risk for both cardiovascular events and diabetes in insulin resistant patients. However, concern remains that pioglitazone may increase risk for heart failure (HF) in susceptible individuals. Methods -In IRIS, patients with insulin resistance but without diabetes were randomized to pioglitazone or placebo (1:1) within 180 days of an ischemic stroke or TIA and followed for up to 5 years. To identify patients at higher HF risk with pioglitazone we performed a secondary analysis of IRIS participants without HF history at entry...
June 22, 2018: Circulation
Waqas Rasheed, Apparao Draksharapu, Saikat Banerjee, Victor G Young, Ruixi Fan, Yisong Guo, M Ozerov, Joscha Nehrkorn, J Krzystek, Joshua Telser, Lawrence Que
Oxoiron(IV) units are often implicated as intermediates in the catalytic cycles of non-heme iron oxygenases and oxidases. The most reactive synthetic analogues of these intermediates are supported by tetradentate tripodal ligands with N-methylbenzimidazole or quinoline donors, but their instability precludes structural characterization. Herein we report crystal structures of two [FeIV (O)(L)]2+ complexes supported by pentadentate ligands incorporating these heterocycles, which show longer average Fe-N distances than the complex with only pyridine donors...
July 20, 2018: Angewandte Chemie
Rakesh Chandra, Edward W Fisher, Terry M Jones, David W Kennedy, Dennis H Kraus, John H Krouse, Michael J Link, Lawrence R Lustig, Bert W O'Malley, Jay F Piccirillo, Robert Ruben, Robert T Sataloff, Raj Sindwani, Richard J Smith, Michael G Stewart, Peter C Weber, D Bradley Welling, Robin Youngs
No abstract text is available yet for this article.
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Mary Ann Powles, Andrew Galgoci, Andrew Misura, Lawrence Colwell, Karen H Dingley, Wei Tang, Jin Wu, Timothy Blizzard, Mary Motyl, Katherine Young
The World Health Organization has identified antimicrobial resistance as a global public health threat since the prevalence and spread of antibiotic resistance among bacterial pathogens worldwide are staggering. Carbapenems, such as imipenem and meropenem, have been used to treat multidrug-resistant bacteria; however, since the development of resistance to carbapenems, β-lactam antibiotics in combination with β-lactamase inhibitors (BLI) has been one of the most successful strategies to enhance the activity of β-lactam antibiotics...
August 2018: Antimicrobial Agents and Chemotherapy
Laurel E Cederberg, Mark D Rabinovitch, Jennifer M Grimm-Geris, David O Schmeling, Emma A Filtz, Lawrence M Condon, Henry H Balfour
Background: A potential source of primary Epstein-Barr virus (EBV) infection for young children is parental oral secretions. If parents who identify with racial/ethnic categories other than white have a higher prevalence of oral EBV DNA, this difference could explain why their children acquire primary EBV infection at an earlier age than white children. Methods: To test this hypothesis, we recruited parents who brought their children <8 years old to routine clinic visits and tested their oral washes for EBV DNA by real-time PCR...
May 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Najwa Khuri-Bulos, Lindsey Lawrence, Bhinnata Piya, Li Wang, Christopher Fonnesbeck, Samir Faouri, Asem Shehabi, Sten H Vermund, John V Williams, Natasha B Halasa
OBJECTIVE: To assess virus-specific hospitalisation rates, risk factors for illness severity and seasonal trends in children hospitalised with acute respiratory infections (ARI). DESIGN: Prospective cohort study. SETTING: A government hospital serving low-income and middle-income population in Amman, Jordan. PARTICIPANTS: Children under 2 years of age hospitalised with fever and/or respiratory symptoms (n=3168) from 16 March 2010 to 31 March 2013...
May 20, 2018: BMJ Open
Eric B Rimm, Lawrence J Appel, Stephanie E Chiuve, Luc Djoussé, Mary B Engler, Penny M Kris-Etherton, Dariush Mozaffarian, David S Siscovick, Alice H Lichtenstein
Since the 2002 American Heart Association scientific statement "Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease," evidence from observational and experimental studies and from randomized controlled trials continues to emerge to further substantiate the beneficial effects of seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease. A recent American Heart Association science advisory addressed the specific effect of n-3 polyunsaturated fatty acid supplementation on clinical cardiovascular events...
July 3, 2018: Circulation
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