keyword
https://read.qxmd.com/read/38544315/prevalence-of-occupational-hypersensitivity-pneumonitis-a-systematic-review-and-meta-analysis
#1
REVIEW
Xinliang Zhang, Bukhtiyarov Igor, Dudnik Elena, Rumyantseva Olga, Oleg Glazachev
In this meta-analysis, we aimed to evaluate the prevalence of occupational hypersensitivity pneumonitis (OHP) among different occupations globally. Our search was conducted on MEDLINE via PubMed, Scopus, Web of Science, and Cochrane CENTRAL from inception to September 2023. Eligible studies were observational in nature and focused on several specific occupations. A total of 46 articles were included (n = 2,826,420 participants). The overall prevalence of OHP was found to be 4.2% (95% CI: 2.1% to 8...
March 27, 2024: International Journal of Environmental Health Research
https://read.qxmd.com/read/38540667/the-role-of-lung-microbiome-in-fibrotic-interstitial-lung-disease-a-systematic-review
#2
REVIEW
Ruxandra Puiu, Nicoleta Stefania Motoc, Sergiu Lucaciu, Maria Victoria Ruta, Ruxandra-Mioara Rajnoveanu, Doina Adina Todea, Milena Adina Man
Interstitial Lung Disease (ILD) involves lung disorders marked by chronic inflammation and fibrosis. ILDs include pathologies like idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD (CTD-ILD), hypersensitivity pneumonitis (HP) or sarcoidosis. Existing data covers pathogenesis, diagnosis (especially using high-resolution computed tomography), and treatments like antifibrotic agents. Despite progress, ILD diagnosis and management remains challenging with significant morbidity and mortality...
February 20, 2024: Biomolecules
https://read.qxmd.com/read/38536984/one-step-forward-in-understanding-sleep-in-hypersensitivity-pneumonitis-patients
#3
EDITORIAL
Paulo Mateus Madureira Soares Mariano, Pedro Rodrigues Genta
No abstract text is available yet for this article.
March 22, 2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536981/relative-incidence-of-interstitial-lung-diseases-in-brazil
#4
JOURNAL ARTICLE
Simone Lobo Krupok Matias, Carlos Alberto de Castro Pereira, Maria Raquel Soares, Flávia Castro Velasco Fernandes, Maria Auxiliadora Carmo Moreira, Fernanda Maciel de Aguiar Baptista, Tarciane Aline Prata, Gediel Cordeiro Junior, Eliane Viana Mancuzo
OBJECTIVE: To assess the relative frequency of incident cases of interstitial lung diseases (ILDs) in Brazil. METHODS: This was a retrospective survey of new cases of ILD in six referral centers between January of 2013 and January of 2020. The diagnosis of ILD followed the criteria suggested by international bodies or was made through multidisciplinary discussion (MDD). The condition was characterized as unclassifiable ILD when there was no specific final diagnosis following MDD or when there was disagreement between clinical, radiological, or histological data...
2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38535033/pulmonary-adverse-events-in-cancer-immunotherapy-case-studies-of-ct-patterns
#5
JOURNAL ARTICLE
Giorgio Bocchini, Maria Chiara Imperato, Tullio Valente, Salvatore Guarino, Roberta Lieto, Candida Massimo, Emanuele Muto, Federica Romano, Mariano Scaglione, Giacomo Sica, Davide Vitagliano Torre, Salvatore Masala, Marialuisa Bocchino, Gaetano Rea
Immune-checkpoint inhibitors have profoundly changed cancer treatment, improving the prognosis of many oncologic patients. However, despite the good efficacy of these drugs, their mechanism of action, which involves the activation of the immune system, can lead to immune-related adverse events, which may affect almost all organs. Pulmonary adverse events are relatively common, and potentially life-threatening complications may occur. The diagnosis is challenging due to the wide and non-specific spectrum of clinical and radiological manifestations...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38501183/nationwide-study-of-the-epidemiology-diagnosis-and-treatment-of-hypersensitivity-pneumonitis-in-korea
#6
JOURNAL ARTICLE
Hae In Jung, Dal Ri Nam, Seung-Hun You, Jae-Woo Jung, Kang-Mo Gu, Sun-Young Jung
BACKGROUND: Hypersensitivity pneumonitis (HP) is a condition with an uncertain global incidence, and information on its diagnosis and management is limited. This study aimed to address these knowledge gaps. METHODS: This study utilized customized claims data from the Health Insurance Review and Assessment Service (HIRA) in South Korea from January 2010, to December 2021. Patients with HP were identified based on the diagnosis code (International Classification of Diseases, 10th Revision, J67) between 2011 and 2020...
March 18, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38497194/assessing-the-effectiveness-and-safety-of-transbronchial-lung-cryobiopsy-utilizing-a-flexible-bronchoscope-with-an-endobronchial-blocker-in-diffuse-parenchymal-lung-lesions
#7
JOURNAL ARTICLE
Deepak Sharma, Vinay V, Jitendra Kumar Saini, Prabhpreet Sethi, Lokender Kumar, Praveen Kumar Dubey
Transbronchial lung cryobiopsy (TBLC) with flexible bronchoscope represents an encouraging modality to obtain a larger size specimen without crush artifact, and a higher diagnostic yield in patients with diffuse parenchymal lung lesions/diseases as compared to conventional transbronchial lung biopsy, and fewer complications as opposed to surgical lung biopsy. Artificial airway is preferred as it provides better airway protection in cases of severe bleeding. Although various researchers have published data on different modalities, the data is not sufficient to standardize a single technique...
March 15, 2024: Monaldi Archives for Chest Disease
https://read.qxmd.com/read/38479405/the-impact-of-hiatus-hernia-in-hypersensitivity-pneumonitis
#8
JOURNAL ARTICLE
David A Heriot, Carmel J W Stock, Zain-Ul-Abideen Mumtaz, R Gisli Jenkins, Felix Chua, Phillip L Molyneaux, Anand Devaraj, Vasilis Kouranos, Athol U Wells, Elizabetta A Renzoni, Simon P G Padley, Sujal R Desai, Peter M George
No abstract text is available yet for this article.
March 13, 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38465164/hypersensitivity-pneumonitis-due-to-living-environmental-pollution-caused-by-masked-musangs
#9
Etaro Hashimoto, Hiroaki Satoh
Hypersensitivity pneumonitis is an allergic disease caused by various factors such as animal proteins and chemicals. The masked musang, a small animal of the Viverridae family native to East Asia, tends to infiltrate spaces like the attics of residences, causing damage through the deposition of excrement and other means. The older Japanese patient had been experiencing cough, shortness of breath, and fever for two months before presenting to our hospital. The symptoms improved upon admission to a local medical facility but deteriorated upon discharge...
February 2024: Curēus
https://read.qxmd.com/read/38460665/the-potential-impact-of-nano-and-microplastics-on-human-health-understanding-human-health-risks
#10
REVIEW
Ewa Winiarska, Marek Jutel, Magdalena Zemelka-Wiacek
Plastics are used all over the world. Unfortunately, due to limited biodegradation, plastics cause a significant level of environmental pollution. The smallest recognized to date are termed nanoplastics (1 nm [nm] up to 1 μm [μm]) and microplastics (1 μm-5 mm). These nano- and microplastics can enter the human body through the respiratory system via inhalation, the digestive tract via consumption of contaminated food and water, or penetration through the skin via cosmetics and clothes contact...
March 7, 2024: Environmental Research
https://read.qxmd.com/read/38454199/pulmonary-function-and-diffusing-capacity-of-carbon-monoxide-in-hypersensitivity-pneumonitis-an-observational-study-of-152-patients
#11
JOURNAL ARTICLE
Sonam Spalgais, Parul Mrigpuri, N Ravishankar, Raj Kumar
OBJECTIVE: Hypersensitivity pneumonitis (HP) is an inflammatory and/or fibrotic lung disease. The restrictive lung function with low diffusing capacity of carbon monoxide (DLCO) is common in interstitial lung diseases (ILD). There are limited data on pulmonary function test (PFT) in HP and its role for diagnosis is questionable. We analyzed the data of 152 HP patients for type of defect, lung volume, and DLCO. MATERIAL AND METHODS: The present study is a retrospective analysis of 152 patients at one of the tertiary chest institutes in India...
March 2024: Thorac Res Pract
https://read.qxmd.com/read/38448221/adaptive-multi-interventional-trial-platform-to-improve-patient-care-for-fibrotic-interstitial-lung-diseases
#12
REVIEW
Leticia Kawano-Dourado, Tejaswini Kulkarni, Christopher J Ryerson, Pilar Rivera-Ortega, Bruno Guedes Baldi, Nazia Chaudhuri, Manuela Funke-Chambour, Anna-Maria Hoffmann-Vold, Kerri A Johannson, Yet Hong Khor, Sydney B Montesi, Lucilla Piccari, Helmut Prosch, María Molina-Molina, Jacobo Sellares Torres, Iazsmin Bauer-Ventura, Sujeet Rajan, Joseph Jacob, Duncan Richards, Lisa G Spencer, Barbara Wendelberger, Tom Jensen, Melanie Quintana, Michael Kreuter, Anthony C Gordon, Fernando J Martinez, Naftali Kaminski, Victoria Cornelius, Roger Lewis, Wendy Adams, Gisli Jenkins
BACKGROUND: Fibrotic interstitial lung diseases (fILDs) are a heterogeneous group of lung diseases associated with significant morbidity and mortality. Despite a large increase in the number of clinical trials in the last 10 years, current regulatory-approved management approaches are limited to two therapies that prevent the progression of fibrosis. The drug development pipeline is long and there is an urgent need to accelerate this process. This manuscript introduces the concept and design of an innovative research approach to drug development in fILD: a global Randomised Embedded Multifactorial Adaptive Platform in fILD (REMAP-ILD)...
March 6, 2024: Thorax
https://read.qxmd.com/read/38431048/adult-respiratory-distress-syndrome-ards-due-to-omeprazole-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-case-report-and-review-of-the-literature
#13
D Díaz Díaz, C Olmos Mata, E Palencia Herrejón, L López Pérez
Eosinophilia in not an uncommon findings in the intensive care unit (ICU); however, DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome, which is characterized by a hypersensitivity reaction to drugs and manifests as eosinophilia, systemic involvement and maculopapular erythematous rash 2-6 weeks after exposure to the offending drug, is an exceptional occurrence. We present the first case described in the literature of DRESS syndrome with pulmonary involvement in the form of interstitial pneumonitis and persistent adult respiratory distress syndrome (ARDS) secondary to proton pump inhibitors (PPI)...
February 29, 2024: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/38423290/respiratory-diseases-associated-with-organic-dust-exposure
#14
JOURNAL ARTICLE
Jill A Poole, Jose L Zamora-Sifuentes, Leticia De Las Vecillas, Santiago Quirce
Organic dusts are complex bioaerosol mixtures comprised of dust and particulate matter of organic origin. These include components from bacteria, fungi, pollen, and viruses to fragments of animals and plants commonplace to several environmental/occupational settings encompassing agriculture/farming, grain processing, waste/recycling, textile, cotton, woodworking, bird breeding, and more. Organic dust exposures are linked to development of chronic bronchitis, chronic obstructive pulmonary disease (COPD), asthma, asthma-like syndrome, byssinosis, hypersensitivity pneumonitis (HP), and idiopathic pulmonary fibrosis (IPF)...
February 27, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38410707/prognostic-factors-of-progressive-fibrotic-hypersensitivity-pneumonitis-a-large-retrospective-multicentre-observational-cohort-study
#15
JOURNAL ARTICLE
Esteban Cano-Jiménez, Ana Villar Gómez, Eduardo Velez Segovia, Myriam Aburto Barrenechea, Jacobo Sellarés Torres, Joel Francesqui, Karina Portillo Carroz, Alan Jhunior Solis Solis, Orlando Acosta Fernández, Ana Belén Llanos González, Jaume Bordas-Martinez, Eva Cabrera Cesar, Eva Balcells Vilarnau, Diego Castillo Villegas, Ana Reyes Pardessus, Coral González Fernández, Marta García Moyano, Amaia Urrutia Gajate, Andrés Blanco Hortas, María Molina-Molina
BACKGROUND: Fibrotic hypersensitivity pneumonitis (fHP) is an immune-mediated interstitial lung disease caused by sensitisation to chronic allergen inhalation. This study aimed to determine prognostic indicators of progression and mortality in fHP. METHODS: This was a retrospective, multicentre, observational, cross-sectional cohort study of consecutive patients diagnosed with fHP from 1 January 2012 to 31 December 2021. Multivariate Cox regression analyses were used to calculate hazard ratios (HRs) with 95% confidence intervals for predictors of progression and survival...
January 2024: ERJ Open Research
https://read.qxmd.com/read/38399782/predominantly-orphan-secretome-in-the-lung-pathogen-mycobacterium-abscessus-revealed-by-a-multipronged-growth-phase-driven-strategy
#16
JOURNAL ARTICLE
Harish Chandra, Manish K Gupta, Ying-Wai Lam, Jagjit S Yadav
The emerging lung pathogen Mycobacterium abscessus is understudied for its virulence determinants and molecular targets for diagnosis and therapeutics. Here, we report a comprehensive secretome (600 proteins) of this species, which was identified using a multipronged strategy based on genetic/genomic, proteomic, and bioinformatic approaches. In-solution digested bottom-up proteomics from various growth phases identified a total of 517 proteins, while 2D-GE proteomics identified 33 proteins. A reporter-gene-fusion-based genomic library that was custom-generated in this study enabled the detection of 23 secretory proteins...
February 12, 2024: Microorganisms
https://read.qxmd.com/read/38398362/vexas-and-myelodysplastic-syndrome-an-interdisciplinary-challenge
#17
JOURNAL ARTICLE
Virginie Kreutzinger, Anne Pankow, Zhivana Boyadzhieva, Udo Schneider, Katharina Ziegeler, Lars Uwe Stephan, Jan Carl Kübke, Sebastian Schröder, Christian Oberender, Philipp le Coutre, Sebastian Stintzing, Ivan Jelas
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a recently recognized systemic autoinflammatory disease caused by somatic mutations in hematopoietic progenitor cells. This case series of four patients with VEXAS syndrome and comorbid myelodysplastic syndrome (MDS) aims to describe clinical, imaging, and hematologic disease presentations as well as response to therapy. Four patients with VEXAS syndrome and MDS are described. A detailed analysis of imaging features, hemato-oncological presentation including bone marrow microscopy and clinical-rheumatological disease features and treatment outcomes is given...
February 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38396736/differential-immunogenicity-and-lung-disease-inducing-potential-of-mycobacterium-immunogenum-genotypes-and-impact-of-co-exposure-with-pseudomonas-optimizing-a-mouse-model-of-chronic-hypersensitivity-pneumonitis
#18
JOURNAL ARTICLE
Elisabet Johansson, Jagjit S Yadav
Mycobacterium immunogenum (MI) colonizing metalworking fluids (MWFs) has been associated with chronic hypersensitivity pneumonitis (HP) in machinists. However, it is etiologically unclear why only certain mycobacteria-contaminated fluids induce this interstitial lung disease. We hypothesized that this may be due to differential immunogenicity and the HP-inducing potential of MI strains/genotypes as well as the confounding effect of co-inhaled endotoxin-producers. To test this hypothesis, we optimized a chronic HP mouse model in terms of MI antigen dose, timepoint of sacrifice, and form of antigen (cell lysates vs...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38389607/unveiling-the-diagnostic-potential-a-comprehensive-review-of-bronchoalveolar-lavage-in-interstitial-lung-disease
#19
REVIEW
Arman Sindhu, Ulhas Jadhav, Babaji Ghewade, Pankaj Wagh, Pallavi Yadav
This comprehensive review examines the diagnostic potential of bronchoalveolar lavage (BAL) in interstitial lung disease (ILD), emphasizing its accuracy and significance in various ILDs, including idiopathic pulmonary fibrosis (IPF), sarcoidosis, hypersensitivity pneumonitis, and connective tissue disease-associated ILD. The analysis underscores the importance of abnormalities in both cellular and non-cellular components of BAL fluid for precise ILD diagnosis. Recommendations advocate for the integration of BAL into clinical guidelines, a multidisciplinary diagnostic approach, and further standardization of procedures...
January 2024: Curēus
https://read.qxmd.com/read/38384745/steroid-reduction-resistant-pulmonary-involvement-with-sweet-s-syndrome-suspected-of-being-vacuoles-e1-enzyme-x-linked-autoinflammatory-somatic-syndrome-a-case-report
#20
Yuki Amakusa, Tatsuro Suzuki, Masaya Takemura, Tetsuya Oguri
In cases of Sweet's syndrome with pulmonary involvement, fever of unknown origin, and macrocytic anaemia, VEXAS syndrome can be considered in the differential diagnosis. A 67-year-old man who was taking prednisolone for a fever of unknown origin and Sweet's syndrome was referred to us because of an abnormal chest shadow. Computed tomography revealed a nonfibrotic hypersensitivity pneumonitis-like opacity, and blood test results indicated macrocytic anaemia. His pulmonary symptoms spontaneously improved but again exacerbated approximately 1 month later...
February 2024: Respirology Case Reports
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