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follicular development

Wen-Peng Zhao, Hong-Wei Wang, Jing Liu, Zi-Hao Zhang, Shi-Quan Zhu, Bian-Hua Zhou
Excessive fluoride intake has a strong female reproductive toxicity, which can result in follicular developmental dysplasia and decrease oocytes developmental potential. The underlying mechanisms of fluoride-induced mitochondrial dysfunction in ovarian granulosa cells remain largely unknown. In this study, the ultrastructure changes of mitochondria and DNA damage in ovarian granulosa cells were observed under transmission electron microscope and TUNEL staining. Then, the ATP content and ROS level in granulosa cells were measured...
October 8, 2018: Chemosphere
Kuixing Zhang, Daniel Farrell, Deepa Jeyakumar, Susan O'Brien, Xiaohui Zhao, Sherif A Rezk
Although rare cases of prolymphocytic transformation from splenic B-cell lymphomas and follicular lymphoma have been reported, prolymphocytic transformation from lymphoplasmacytic lymphoma has not been previously reported. We report a case of 76-year old male patient with a history of Waldenström's Macroglobulinemia diagnosed in 2010 and treated with infusion chemotherapy. He was in clinical remission for 5years. In 2016, he presented with diffuse lymphadenopathy and a head and neck lymph node biopsy showed lymphoplasmacytic lymphoma...
October 17, 2018: Human Pathology
Nadezda Abramova, Julie Hubbard, Joan Schertz, Emilia Richter
INTRODUCTION: Recombinant human luteinizing hormone (r-hLH) is used in a fixed-ratio combination with recombinant human follicle-stimulating hormone (r-hFSH) for the stimulation of follicular development. OBJECTIVE: The objective of this article was to conduct a review of safety data to evaluate the risks of r-hFSH/r-hLH treatment. METHODS: Data were retrieved from the Global Safety Database (Merck KGaA, Darmstadt, Germany) including reports from healthcare professionals, patients, health authorities, clinical trials, non-interventional studies, and the literature...
October 19, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Guan-Yun Long, Jie-Ying Yang, Jin-Jie Xu, Yan-Hong Ni, Xiao-Ling Zhou, Jia-Yi Ma, Yu-Cai Fu, Li-Li Luo
Previous studies have proposed that caloric restriction (CR) regulates many cell functions and prolongs the lifespan of an organism. Our previous studies proposed that CR also prevents follicular activation and preserves the ovarian reserve in mice by activating SIRT1. To test if SIRT1 preserves the ovarian reserve and prolongs the ovarian longevity, we generated SIRT1 knock-in mice that can overexpress SIRT1 in oocytes of the mouse. Ovaries of the mice at ages 35 days and 15 months were collected, and the follicular development and follicular reserve were examined...
October 16, 2018: Gene
Samantha A Chalmers, Elizabeth Glynn, Sayra J Garcia, Mark Panzenbeck, Josephine Pelletier, Janice Dimock, Elise Seccareccia, Todd Bosanac, Sara Khalil, Christian Harcken, Deborah Webb, Gerald Nabozny, Jay S Fine, Donald Souza, Elliott Klein, Leal Herlitz, Meera Ramanujam, Chaim Putterman
Lupus nephritis is a common disease manifestation of SLE, in which immune complex deposition and macrophage activation are important contributors to disease pathogenesis. Bruton's tyrosine kinase (BTK) plays an important role in both B cell and FcgammaR mediated myeloid cell activation. In the current study, we examined the efficacy of BI-BTK-1, a recently described irreversible BTK inhibitor, in the classical NZB × NZW F1 (NZB/W) and MRL/lpr spontaneous mouse models of SLE. NZB/W mice were randomly assigned to a treatment (0...
October 16, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Piotr Pawlak, Ewelina Warzych, Adam Cieslak, Natalia Malyszka, Eliza Maciejewska, Zofia Eliza Madeja, Dorota Lechniak
Oocyte and embryo developmental competence are shaped by multiple extrinsic and intrinsic factors. One of the most extensive research areas in the last decade is the regulation of lipid metabolism in oocytes and embryos of different species. We hypothesized that differences in developmental competence of oocytes and embryos between prepubertal and cyclic gilts may arise due to distinct fatty acid profiles in follicular fluid. We found that supplementation of oocyte maturation media with follicular fluid from prepubertal pigs affected quality and development of embryos from prepubertal pigs while embryos of cyclic pigs were not affected...
October 17, 2018: Scientific Reports
Toby A Eyre, Graham P Collins, Avinash Gupta, Nicholas Coupe, Semira Sheikh, John Whittaker, Lai Mun Wang, Leticia Campo, Elizabeth Soilleux, Finn Tysoe, Richard Cousins, Nick La Thangue, Lisa K Folkes, Michael R L Stratford, David Kerr, Mark R Middleton
BACKGROUND: In the current study, the authors sought to determine the maximum tolerated dose (MTD) of the novel class 1 selective histone deacetylase inhibitor CXD101 in a dose escalation study in patients with advanced solid tumors or recurrent/refractory lymphoma. METHODS: The authors escalated the dose of CXD101 from 1 mg twice daily orally for 5 days in a 21-day cycle (3+3 design). RESULTS: A total of 39 patients were enrolled, 36 of whom received CXD101...
October 17, 2018: Cancer
Liannv Qiu, Qinhua Yu, Yonglie Zhou, Sujie Zheng, Jiaojiao Tao, Qian Jiang, Guorong Yuan
Non-small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. The interaction between programmed cell death 1 (PD-1) and its ligand, PD-L1, plays important roles in tumor immunology. Follicular helper T (Tfh) cells have characteristically high PD-1 expression; thus, in the present study, we investigated the role of circulating Tfh cells and their correlation with disease-free survival after tumor resection in NSCLC...
October 16, 2018: Cancer Science
Xiao-Jun Chen, Wen-Jun Wu, Qi Zhou, Jin-Ping Jie, Xiong Chen, Fang Wang, Xiao-Hua Gong
Despite the administration of exogenous insulin and other medications used to control many aspects of diabetes mellitus (DM), increased oxidative stress has been increasingly acknowledged in DM development and complications. Therefore, this study aims to investigate the role of advanced glycation end-products (AGEs) in oxidative stress (OS) of thyroid cells in patients with DM. Patients with DM with or without thyroid dysfunction (TD) were enrolled. Thyroid toxic damage was induced by adding AGE-modified bovine serum albumin (AGE-BSA) to normal human thyroid follicular epithelial cells...
October 15, 2018: Journal of Cellular Biochemistry
A Z Szóstek-Mioduchowska, K Lukasik, D J Skarzynski, K Okuda
Transforming growth factor (TGF)-β1 not only regulates cell growth, development, and tissue remodeling, but it also participates in the pathogenesis of tissue fibrosis. In the equine endometrium, the concentration of TGF-β1 is correlated with endometrosis (equine endometrial fibrosis). In other tissues, TGF-β1 induces differentiation of many cell types into myofibroblasts. These cells are characterized by α-smooth muscle actin (α-SMA) expression and an ability to deposit excessive amounts of extracellular matrix (ECM) components...
October 4, 2018: Theriogenology
Long Bai, Hsun-Ming Chang, Yi-Min Zhu, Peter C K Leung
Lysyl oxidase (LOX) is a copper-dependent enzyme that maintains and stabilizes the extracellular matrix (ECM) by catalyzing the cross-linking of elastin and collagen. ECM within the ovarian follicle plays a crucial role in regulating follicular development and oocyte maturation. Bone morphogenetic protein 2 (BMP2) belongs to the BMP subfamily that has been shown to be involved in the process of ovarian folliculogenesis and luteal formation. To date, whether BMP2 regulates the activity of LOX during human follicular development remains to be elucidated...
October 12, 2018: Cellular Signalling
Antigoni Poultsidi, Yiannis Dimopoulos, Ting-Fang He, Triantafyllos Chavakis, Emmanouil Saloustros, Peter P Lee, Constantinos Petrovas
Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B cell responses within the germinal center. Throughout the past decade, numerous studies have revealed the important role of Tfh cells in Human Immunodeficiency Virus (HIV) pathogenesis as well as in the development of neutralizing antibodies post-infection and post-vaccination. It has also been established that tumors influence various immune cell subsets not only in their proximity, but also in draining lymph nodes...
2018: Frontiers in Immunology
Rehana Rehman, Tooba Irfan, Shireen Jawed, Mehwish Hussain, Rabiya Ali
OBJECTIVE: To assess the role of good-quality embryos in acquiring pregnancy after intracytoplasmic sperm injection and to predict factors required for development of embryos. METHODS: The quasi-experimental study was conducted from June 2010 to August 2012 at Islamabad Clinic Serving Infertile Couples and comprised infertile females who received long-term gonadotropin agonist protocol for intracytoplasmic sperm injection. Basal estradiol and antral follicle count was measured at baseline, while estradiol, progesterone and interleukin levels with pre-ovulatory follicle count were evaluated on the ovulation induction day...
October 2018: JPMA. the Journal of the Pakistan Medical Association
Han-I Wang, Eve Roman, Simon Crouch, Eline Aas, Cathy Burton, Russell Patmore, Alexandra Smith
OBJECTIVES: To use real-world data to develop a flexible generic decision model to predict cost, life expectancy, and quality-adjusted life-years (QALYs) for follicular lymphoma (FL) in the general patient population. METHODS: All patients newly diagnosed with FL in the UK's population-based Haematological Malignancy Research Network ( between 2004 and 2011 were followed until 2015 (N = 740). Treatment pathways, QALYs, and costs were incorporated into a discrete event simulation to reflect patient heterogeneity, including age and disease management...
October 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Nicco Krezdorn, Christine G Lian, Michael Wells, Luccie Wo, Sotirios Tasigiorgos, Shuyen Xu, Thiago J Borges, Rayven M Frierson, Ewelina Stanek, Leonardo V Riella, Bohdan Pomahac, George F Murphy
Face vascularized composite allografts (FVCA) have helped severe patient disfigurement, with acute rejection now largely controlled through iatrogenic immunosuppression. However, little is known regarding the incidence and mechanism(s) of more long-term pathologic alterations in FVCAs that may affect function and graft durability. Protocol surveillance biopsies for up to an 8 year interval in seven patients who received FVCAs at our institution revealed histopathologic evidence of chronic rejection. Clinical manifestations included features of premature aging, mottled leukoderma accentuating suture lines, telangiectasia, and dryness of nasal mucosa...
October 12, 2018: American Journal of Transplantation
Joohyun Hong, Junhun Cho, Young Hye Ko, Seok Jin Kim, Won Seog Kim
The Marginal Zone Lymphoma International Prognostic Index (MALT-IPI) was recently developed for use in patients with mucosa-associated lymphoid tissue (MALT) lymphoma based on age, serum lactate dehydrogenase level, and Ann Arbor stage. In this study, we aimed to validate the MALT-IPI. A total of 455 MALT lymphoma patients were included in this study from between January 2005 and February 2017. Event-free survival (EFS), progression-free survival (PFS), cause-specific survival (CSS), and overall survival (OS) were the primary outcomes...
October 11, 2018: Annals of Hematology
J F Cox, F Navarrete, A Carrasco, J Dorado, F Saravia
This study used a comparative approach to gather clinical information to assess the effect of bovine somatotropin (bST) on follicular dynamics and ovulation in sheep and goats during an interovulatory cycle. The performance of general markers of ovarian function and specific features of follicular dynamics obtained by daily ultrasonography (US) were used to assess the hypothesis that bST, associated with supraphysiological levels of IGF-I, was able to disrupt the follicular dynamics and ovulation in Highlander ewes and Saanen goats...
October 3, 2018: Theriogenology
Stefan Nagel, Roderick A F MacLeod, Corinna Meyer, Maren Kaufmann, Hans G Drexler
Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation. Several members of the NKL subclass are deregulated in T-cell progenitors and support leukemogenesis. We have recently described particular expression patterns of nine NKL homeobox genes in early hematopoiesis and T-cell development. Here, we screened NKL homeobox gene activities in normal B-cell development and extended the NKL-code to include this lymphoid lineage. Analysis of public expression profiling datasets revealed that HHEX and NKX6-3 were the only members differentially active in naïve B-cells, germinal center B-cells, plasma cells and memory B-cells...
2018: PloS One
V Squicciarini, R Riquelme, K Wilsterman, G E Bentley, H E Lara
RFamide-related peptide (RFRP-3) is a regulator of GnRH secretion from the brain, but it can also act in human ovary to influence steroidogenesis. We aimed to study the putative local role of RFRP-3 in the ovary and its potential participation in the development of a polycystic ovary phenotype induced by chronic sympathetic stress (cold stress). We used adult Sprague–Dawley rats divided into control and stressed groups. In both groups, we studied the effect of intraovarian exposure to RFRP-3 on follicular development and plasma ovarian steroid concentrations...
October 1, 2018: Journal of Endocrinology
Warakorn Cheewasopit, Mhairi Laird, Claire Glister, Phil G Knight
Myostatin plays a negative role in skeletal muscle growth regulation but its potential role in the ovary has received little attention. Here, we first examined relative expression of myostatin (MSTN), myostatin receptors (ACVR1B, ACVR2B and TGFBR1) and binding protein, follistatin (FST), in granulosa (GC) and theca (TC) cells of developing bovine follicles. Secondly, using primary GC and TC cultures, we investigated whether myostatin affects steroidogenesis and cell number. Thirdly, effects of gonadotropins and other intrafollicular factors on MSTN expression in GC and TC were examined...
October 1, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
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