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https://www.readbyqxmd.com/read/28340348/the-evolutionary-pathway-to-virulence-of-an-rna-virus
#1
Adi Stern, Ming Te Yeh, Tal Zinger, Matt Smith, Caroline Wright, Guy Ling, Rasmus Nielsen, Andrew Macadam, Raul Andino
Paralytic polio once afflicted almost half a million children each year. The attenuated oral polio vaccine (OPV) has enabled world-wide vaccination efforts, which resulted in nearly complete control of the disease. However, poliovirus eradication is hampered globally by epidemics of vaccine-derived polio. Here, we describe a combined theoretical and experimental strategy that describes the molecular events leading from OPV to virulent strains. We discover that similar evolutionary events occur in most epidemics...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28335014/impact-of-high-intensity-polio-eradication-activities-on-children-s-routine-immunization-status-in-northern-india
#2
Marco J Haenssgen
The objective of this article is to analyse and quantify the side effects of the Polio Eradication Initiative on routine immunization performance in India. Past studies have faced methodological challenges in assessing these side effects. This article offers a methodological alternative for health policy analysts. The research uses secondary household survey data from the Indian District-Level Household and Facility Survey (DLHS), focusing on children aged 10-30 months in the Northern Indian states of Uttar Pradesh (n = 34 327) and Bihar (n = 20 525)...
March 16, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28331440/polio-eradication-in-pakistan-call-for-alliance
#3
EDITORIAL
Syed Uzair Mahmood, Syed Ahsanuddin Ahmed, Maria Shoaib, Tooba Khan, Maham Majeed
No abstract text is available yet for this article.
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28301394/effects-on-the-anti-abo-titers-of-military-blood-donors-from-a-predeployment-vaccination-program
#4
Olle Berséus
BACKGROUND: The use of blood group O as "universal blood" for emergency whole blood transfusions carries the risk for a hemolytic transfusion reaction mediated by incompatible A-/B-antibodies. This risk can be minimized by assuring that the donor has a low titer of anti-A and anti-B. The level of these naturally occurring antibodies have been shown to be increased by vaccination with most biologically derived vaccines. This boostering effect has been investigated for the new generation of vaccines...
March 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28299161/healthcare-professionals-awareness-knowledge-attitudes-perceptions-and-beliefs-about-ebola-at-gondar-university-hospital-northwest-ethiopia-a-cross-sectional-study
#5
Tamrat Befekadu Abebe, Akshaya Srikanth Bhagavathula, Yonas Getaye Tefera, Akram Ahmad, Muhammad Umair Khan, Sewunet Admasu Belachew, Brandon Brown, Tadesse Melaku Abegaz
A poor understanding of Ebola Virus Disease (EVD) among Health Care Professionals (HCPs) may put our lives at risk. We aimed to assess the awareness, knowledge, attitudes, perceptions, beliefs of HCPs towards Ebola at Gondar University Hospital (GUH) in Northwest Ethiopia. We conducted a hospital based, cross-sectional survey among 245 randomly selected HCPs working at GUH from August-October, 2015. A validated, self-administered questionnaire was used to collect the data. We calculated descriptive statistics with P<0...
December 31, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28288747/mobile-phone-delivered-reminders-and-incentives-to-improve-childhood-immunisation-coverage-and-timeliness-in-kenya-m-simu-a-cluster-randomised-controlled-trial
#6
Dustin G Gibson, Benard Ochieng, E Wangeci Kagucia, Joyce Were, Kyla Hayford, Lawrence H Moulton, Orin S Levine, Frank Odhiambo, Katherine L O'Brien, Daniel R Feikin
BACKGROUND: As mobile phone access continues to expand globally, opportunities exist to leverage these technologies to support demand for immunisation services and improve vaccine coverage. We aimed to assess whether short message service (SMS) reminders and monetary incentives can improve immunisation uptake in Kenya. METHODS: In this cluster-randomised controlled trial, villages were randomly and evenly allocated to four groups: control, SMS only, SMS plus a 75 Kenya Shilling (KES) incentive, and SMS plus 200 KES (85 KES = USD$1)...
April 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28284678/analysis-of-the-effects-of-individual-and-community-level-factors-on-childhood-immunization-in-malawi
#7
Peter Austin Morton Ntenda, Kun-Yang Chuang, Fentanesh Nibret Tiruneh, Ying-Chih Chuang
BACKGROUND: Empirical evidence regarding the relationship between childhood immunization and individual- and community-level factors in low-income countries has received little attention. We compared the trends and the effects of a wide range of individual- and community-level socioeconomic factors on the likelihood of a child being immunized between 2004 and 2010 in Malawi. METHODS: We used data from the 2004 and 2010 Malawi Demographic and Health Survey and applied generalized estimating logistic regression equation to analyze data respectively on 2042 and 3496 children aged 12-23months...
March 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28283489/maternal-education-empowerment-economic-status-and-child-polio-vaccination-uptake-in-pakistan-a-population-based-cross-sectional-study
#8
Muhammad Tahir Khan, Sidra Zaheer, Kashif Shafique
OBJECTIVES: To explore the association of maternal education and empowerment with childhood polio vaccination using nationally representative data of Pakistani mothers in a reproductive age group. DESIGN: Cross-sectional. SETTING: Secondary analysis of Pakistan Demographic and Health Survey (PDHS), 2012-2013 data was performed. PARTICIPANTS: Of the 13 558 mothers included in the survey sample, 6982 mothers were able to provide information regarding polio vaccinations...
March 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28283373/dynamics-affecting-the-risk-of-silent-circulation-when-oral-polio-vaccination-is-stopped
#9
J S Koopman, C J Henry, J H Park, M C Eisenberg, E L Ionides, J N Eisenberg
Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissibility, the time from beginning vaccination to reaching low polio levels, and the infection to paralysis ratio (IPR)...
March 1, 2017: Epidemics
https://www.readbyqxmd.com/read/28275258/understanding-perceptions-is-critical-for-all-vaccination-efforts-not-only-polio-eradication
#10
Roy Widdus
Because Pakistan is the country with the most daunting challenges for ending transmission of endemic poliovirus, the work of Habib et al in this issue is critical for achieving polio eradication globally. Understanding why immunization programs are not reaching all children is important for success in reducing spread of all vaccine preventable diseases. The methods and insights are important for public health generalists, not only those employed in the pursuit of polio eradication.
February 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28274276/treatment-with-l-citrulline-in-patients-with-post-polio-syndrome-study-protocol-for-a-single-center-randomised-placebo-controlled-double-blind-trial
#11
Simone Schmidt, Vanya Gocheva, Thomas Zumbrunn, Daniela Rubino-Nacht, Ulrike Bonati, Dirk Fischer, Patricia Hafner
BACKGROUND: Post-polio syndrome (PPS) is a condition that affects polio survivors years after recovery from an initial acute infection by the Poliomyelitis virus. Most often, patients who suffered from polio start to experience gradual new weakening in muscles, a gradual decrease in the size of muscles (muscle atrophy) and fatigue years after the acute illness. L-citrulline is known to change muscular metabolism synthesis by raising nitric oxide (NO) levels and increasing protein synthesis...
March 9, 2017: Trials
https://www.readbyqxmd.com/read/28266226/why-have-the-majority-of-recent-polio-cases-occurred-in-countries-affected-by-islamist-militancy-a-historical-comparative-analysis-of-the-political-determinants-of-polio-in-nigeria-somalia-pakistan-afghanistan-and-syria
#12
Jonathan Kennedy
This article aims to understand why the last few areas where polio remains are affected by armed conflicts involving militant organizations that use Islam to legitimize their activities. The first section critically analyses the argument that Muslims' animosity towards polio vaccination programmes is a consequence of their irrational, backward, anti-Western theology. This argument is depoliticizing, ahistorical and orientalist. Moreover, it does not explain why Islamist militant groups' attitudes to polio vaccination campaigns vary between countries...
March 7, 2017: Medicine, Conflict, and Survival
https://www.readbyqxmd.com/read/28260567/between-securitisation-and-neglect-managing-ebola-at-the-borders-of-global-health
#13
Mark Honigsbaum
In 2014 the World Health Organization (WHO) was widely criticised for failing to anticipate that an outbreak of Ebola in a remote forested region of south-eastern Guinea would trigger a public health emergency of international concern (pheic). In explaining the WHO's failure, critics have pointed to structural restraints on the United Nations organisation and a leadership 'vacuum' in Geneva, among other factors. This paper takes a different approach. Drawing on internal WHO documents and interviews with key actors in the epidemic response, I argue that the WHO's failure is better understood as a consequence of Ebola's shifting medical identity and of triage systems for managing emerging infectious disease (EID) risks...
April 2017: Medical History
https://www.readbyqxmd.com/read/28253229/response-to-a-large-polio-outbreak-in-a-setting-of-conflict-middle-east-2013-2015
#14
Chukwuma Mbaeyi, Michael J Ryan, Philip Smith, Abdirahman Mahamud, Noha Farag, Salah Haithami, Magdi Sharaf, Jaume C Jorba, Derek Ehrhardt
As the world advances toward the eradication of polio, outbreaks of wild poliovirus (WPV) in polio-free regions pose a substantial risk to the timeline for global eradication. Countries and regions experiencing active conflict, chronic insecurity, and large-scale displacement of persons are particularly vulnerable to outbreaks because of the disruption of health care and immunization services (1). A polio outbreak occurred in the Middle East, beginning in Syria in 2013 with subsequent spread to Iraq (2). The outbreak occurred 2 years after the onset of the Syrian civil war, resulted in 38 cases, and was the first time WPV was detected in Syria in approximately a decade (3,4)...
March 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28250536/adapting-nepal-s-polio-eradication-programme
#15
Krishna P Paudel, Lee M Hampton, Santosh Gurung, Rajendra Bohara, Indra K Rai, Sameer Anaokar, Rachel D Swift, Stephen Cochi
PROBLEM: Many countries have weak disease surveillance and immunization systems. The elimination of polio creates an opportunity to use staff and assets from the polio eradication programme to control other vaccine-preventable diseases and improve disease surveillance and immunization systems. APPROACH: In 2003, the active surveillance system of Nepal's polio eradication programme began to report on measles and neonatal tetanus cases. Japanese encephalitis and rubella cases were added to the surveillance system in 2004...
March 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28248924/microrna-screening-identifies-mir-134-as-a-regulator-of-poliovirus-and-enterovirus-71-infection
#16
Nichole Lynn Orr-Burks, Byoung-Shik Shim, Weilin Wu, Abhijeet A Bakre, Jon Karpilow, Ralph A Tripp
MicroRNAs (miRNAs) regulate virus replication through multiple mechanisms. Poliovirus causes a highly debilitating disease and though global efforts to eradicate polio have sharply decreased polio incidence, unfortunately three countries (Afghanistan, Nigeria and Pakistan) remain polio-endemic. We hypothesize that understanding the host factors involved in polio replication will identify novel prophylactic and therapeutic targets against polio and related viruses. In this data set, employing genome wide screens of miRNA mimics and inhibitors, we identified miRNAs which significantly suppressed polio replication...
March 1, 2017: Scientific Data
https://www.readbyqxmd.com/read/28246672/electronic-alerts-improve-immunization-rates-in-two-month-old-premature-infants-hospitalized-in-the-neonatal-intensive-care-unit
#17
Kimberly D Ernst
OBJECTIVE: To determine if an electronic alert improves 2 month immunization rates in infants remaining hospitalized in the neonatal intensive care unit. METHODS: Institutional Review Board-approved retrospective chart review of 261 infants with birth weights <2 kg and still hospitalized at ≥ 58 days. Charts were reviewed between 2009 and 2013, before and after the 2011 electronic alert was instituted in the electronic medical record from days 56 to 67 to remind providers that immunizations were due...
March 1, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28237501/vaccines-shaping-global-health
#18
Sonia Pagliusi, Ching-Chia Ting, Fernando Lobos
The Developing Countries Vaccine Manufacturers' Network (DCVMN) gathered leaders in immunization programs, vaccine manufacturing, representatives of the Argentinean Health Authorities and Pan American Health Organization, among other global health stakeholders, for its 17th Annual General Meeting in Buenos Aires, to reflect on how vaccines are shaping global health. Polio eradication and elimination of measles and rubella from the Americas is a result of successful collaboration, made possible by timely supply of affordable vaccines...
February 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28237252/effect-of-ebola-virus-disease-on-maternal-and-child-health-services-in-guinea-a-retrospective-observational-cohort-study
#19
Alexandre Delamou, Alison M El Ayadi, Sidikiba Sidibe, Therese Delvaux, Bienvenu S Camara, Sah D Sandouno, Abdoul H Beavogui, Georges W Rutherford, Junko Okumura, Wei-Hong Zhang, Vincent De Brouwere
BACKGROUND: The 2014 west African epidemic of Ebola virus disease posed a major threat to the health systems of the countries affected. We sought to quantify the consequences of Ebola virus disease on maternal and child health services in the highly-affected Forest region of Guinea. METHODS: We did a retrospective, observational cohort study of women and children attending public health facilities for antenatal care, institutional delivery, and immunisation services in six of seven health districts in the Forest region (Beyla, Guéckédou, Kissidougou, Lola, Macenta, and N'Zérékoré)...
April 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28222999/effect-of-stepwise-perinatal-immunization-education-a-cluster-randomized-controlled-trial
#20
Aya Saitoh, Akihiko Saitoh, Isamu Sato, Tomohiro Shinozaki, Hajime Kamiya, Satoko Nagata
BACKGROUND: Perinatal immunization education is important for improving the immunization outcomes of infants; however, the content of educational materials used at each perinatal period has not been carefully evaluated. We hypothesized that stepwise education offered at different perinatal periods would improve infant immunization status and enhance maternal immunization knowledge. METHODS: In this cluster-randomized controlled trial, pregnant women were recruited from nine obstetric sites in Niigata, Japan...
February 17, 2017: Vaccine
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