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https://www.readbyqxmd.com/read/28532531/determinants-of-successful-vitamin-a-supplementation-coverage-among-children-aged-6-59-months-in-thirteen-sub-saharan-african-countries
#1
Amynah Janmohamed, Rolf Dw Klemm, David Doledec
OBJECTIVE: Vitamin A supplementation (VAS) for children aged 6-59 months occurs regularly in most sub-Saharan African countries. The present study aimed to explore child, household and delivery platform factors associated with VAS coverage and identify barriers to compliance in thirteen African countries. DESIGN: We pooled data (n ~60 000) from forty-four household coverage surveys and used bivariate and multivariable regression analyses to assess the effects of supplementation strategy, rural v...
May 23, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28530339/-health-scares-a-chronicle-unnecessary-anxiety
#2
REVIEW
Iftach Sagy, Dan Greenberg, Alan Jotkowitz, Leonid Barski, Victor Novack
A health scare is an event characterized by fear of catastrophic consequences with little actual results. Regardless of these negligible results, the health, social and economic impacts of such events may be significant. Health scares are spread throughout four major groups: the media, relevant medical experts, policy makers and the public at large. In this review, we described two recent cases in Israel: the case of Eltroxin exchange that occurred in Israel as well as other countries, in addition to the polio virus spread in sewage, in the context of health scares...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28528761/responding-to-a-cvdpv1-outbreak-in-ukraine-implications-challenges-and-opportunities
#3
Nino Khetsuriani, Ihor Perehinets, Dorit Nitzan, Dragoslav Popovic, Thomas Moran, Vusala Allahverdiyeva, Shahin Huseynov, Eugene Gavrilin, Liudmyla Slobodianyk, Olha Izhyk, Anna Sukhodolska, Sahar Hegazi, Katerina Bulavinova, Sergei Platov, Patrick O'Connor
BACKGROUND: The European Region, certified polio-free in 2002, remains at risk of wild poliovirus reintroduction and emergence of circulating vaccine-derived polioviruses (cVDPV) until global polio eradication is achieved, as demonstrated by the cVDPV1 outbreak in Ukraine in 2015. METHODS: We reviewed epidemiologic, clinical and virology data on cVDPV cases, surveillance and immunization coverage data, and reports of outbreak-related surveys, country missions, and expert group meetings...
May 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28524217/-importance-of-enteroviruses-in-neuropaediatrics-from-polioviruses-to-other-enteroviruses
#4
M Cabrerizo, Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus
Enteroviruses are among the most common human viruses around the world. More than 100 different serotypes that can cause a range of clinical pathologies have been identified, although the most frequent are those that affect the central nervous system, such as aseptic meningitis, encephalitis or paralysis, which in some cases can be very severe or even fatal. In recent years, enterovirus outbreaks associated to new diseases have been reported all over the world, and as a result some serotypes have been considered 'emerging' pathogens...
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28512076/considering-the-public-in-public-health-popular-resistance-to-the-smallpox-eradication-programme-in-india
#5
Luke Juran, Jennifer Trivedi, Korine N Kolivras
Public health initiatives, including large-scale vaccination and disease eradication programmes, regularly pit the rights of the individual against broader benefits to society. At times, the public resists such initiatives, with the World Health Organisation's Smallpox Eradication Programme (SEP) in India being a case in point. Here, we critically investigate resistance to smallpox vaccines in India and argue that while the SEP successfully eradicated a global killer; individuals were stripped of human rights through coercion, forcible vaccination and quarantine...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28512071/ethical-and-legal-challenges-of-vaccines-and-vaccination-reflections
#6
Amar Jesani, Veena Johari
Vaccines and vaccination have emerged as key medical scientific tools for prevention of certain diseases. Documentation of the history of vaccination shows that the initial popular resistance to universal vaccination was based on false assumptions and eventually gave way to acceptance of vaccines and trust in their ability to save lives. The successes of the global eradication of smallpox, and now of polio, have only strengthened the premier position occupied by vaccines in disease prevention. However, the success of vaccines and public trust in their ability to eradicate disease are now under challenge, as increasing numbers of people refuse vaccination, questioning the effectiveness of vaccines and the need to vaccinate...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28510687/massive-polio-vaccination-drive-in-african-nations
#7
M J Friedrich
No abstract text is available yet for this article.
May 16, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28505244/the-influence-of-maternally-derived-antibody-and-infant-age-at-vaccination-on-infant-vaccine-responses-an-individual-participant-meta-analysis
#8
Merryn Voysey, Dominic F Kelly, Thomas R Fanshawe, Manish Sadarangani, Katherine L O'Brien, Rafael Perera, Andrew J Pollard
Importance: The design of infant immunization schedules requires an understanding of the factors that determine the immune response to each vaccine antigen. Data Sources: Deidentified individual participant data from GlaxoSmithKline clinical trials were obtained through Clinical Study Data Request. The data were requested on January 2, 2015, and final data were received on April 11, 2016. Study Selection: Immunogenicity trials of licensed or unlicensed vaccines administered to infants were included if antibody concentrations in infants were measured prior to the first dose of vaccine...
May 15, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28495264/community-engagement-and-integrated-health-and-polio-immunisation-campaigns-in-conflict-affected-areas-of-pakistan-a-cluster-randomised-controlled-trial
#9
Muhammad Atif Habib, Sajid Soofi, Simon Cousens, Saeed Anwar, Najib Ul Haque, Imran Ahmed, Noshad Ali, Rehman Tahir, Zulfiqar A Bhutta
BACKGROUND: Pakistan faces huge challenges in eradicating polio due to widespread poliovirus transmission and security challenges. Innovative interventions are urgently needed to strengthen community buy-in, to increase the coverage of oral polio vaccine (OPV) and other routine immunisations, and to enhance immunity through the introduction of inactivated polio vaccine (IPV) in combination with OPV. We aimed to evaluate the acceptability and effect on immunisation coverage of an integrated strategy for community engagement and maternal and child health immunisation campaigns in insecure and conflict-affected polio-endemic districts of Pakistan...
June 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28492720/association-between-language-and-hearing-disorders-risk-identification
#10
Alessandra Giannella Samelli, Silmara Rondon-Melo, Camila Maia Rabelo, Daniela Regina Molini-Avejonas
OBJECTIVE: To identify children at risk for hearing and/or language disorders and to investigate the association between these risks by conducting pre-validated hearing and language screenings. METHODS: The study was conducted during a polio vaccination campaign in August of 2013 in basic health units in western São Paulo. Parents of children between 2 and 5 years of age were asked to complete two screening tools: a hearing questionnaire (regarding hearing development) and a language production and comprehension scale (including the major language development milestones)...
April 2017: Clinics
https://www.readbyqxmd.com/read/28492113/health-research-and-safeguards-the-south-african-journey
#11
Amaboo Dhai
Health research, as a social good, needs to be conducted in the interests of the common good. Because of the unfortunate exploitation of research participants globally, safeguards for protections are necessary. Most international codes and guidelines originated as responses to the abuse and mistreatment of research subjects. By the 1890s, antivivisectionists were already calling for laws to protect children, as a result of the increasing numbers of institutionalised children being subjected to vaccine experiments in Europe and the USA...
April 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28488995/written-reminders-increase-vaccine-coverage-in-danish-children-evaluation-of-a-nationwide-intervention-using-the-danish-vaccination-register-2014-to-2015
#12
Camilla Hiul Suppli, Mette Rasmussen, Palle Valentiner-Branth, Kåre Mølbak, Tyra Grove Krause
We evaluated a national intervention of sending written reminders to parents of children lacking childhood vaccinations, using the Danish Vaccination Register (DDV). The intervention cohort included the full birth cohort of 124,189 children born in Denmark who reached the age of 2 and 6.5 years from 15 May 2014 to 14 May 2015. The reference cohort comprised 124,427 children who reached the age of 2 and 6.5 years from 15 May 2013 to 14 May 2014. Vaccination coverage was higher in the intervention cohort at 2...
April 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28479621/increased-immunization-coverage-addresses-the-equity-gap-in-nepal
#13
Ashish Kc, Viktoria Nelin, Hendrikus Raaijmakers, Hyung Joon Kim, Chahana Singh, Mats Målqvist
OBJECTIVE: To compare immunization coverage and equity distribution of coverage between 2001 and 2014 in Nepal. METHODS: We used data from the Demographic and Health Surveys carried out in 2001, 2006 and 2011 together with data from the 2014 Multiple Indicator Cluster Survey. We calculated the proportion, in mean percentage, of children who had received bacille Calmette-Guérin (BCG) vaccine, three doses of polio vaccine, three doses of diphtheria-pertussis-tetanus (DPT) vaccine and measles vaccine...
April 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28479178/needle-adapters-for-intradermal-administration-of-fractional-dose-of-inactivated-poliovirus-vaccine-evaluation-of-immunogenicity-and-programmatic-feasibility-in-pakistan
#14
Ali Faisal Saleem, Ondrej Mach, Mohammad T Yousafzai, Asia Khan, William C Weldon, M Steven Oberste, Roland W Sutter, Anita K M Zaidi
Administration of 1/5th dose of Inactivated poliovirus vaccine intradermally (fIPV) provides similar immune response as full-dose intramuscular IPV, however, fIPV administration with BCG needle and syringe (BCG NS) is technically difficult. We compared immune response after one fIPV dose administered with BCG NS to administration with intradermal devices, referred to as Device A and B; and assessed feasibility of conducting a door-to-door vaccination campaign with fIPV. In Phase I, 452 children 6-12months old from Karachi were randomized to receive one fIPV dose either with BCG NS, Device A or Device B in a health facility...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28469988/polio-in-syria-problem-still-not-solved
#15
Ahmad Al-Moujahed, Fares Alahdab, Heba Abolaban, Leo Beletsky
The reappearance of polio in Syria in mid-2013, 18 years after it was eliminated from the country, manifests the public health catastrophe brought on by the civil war. Among the lessons learned, this outbreak emphasizes the importance of increasing the international financial and logistical support for vaccine and immunization efforts, especially in countries suffering from conflicts. The lack of access to polio accredited laboratory or outright lack of laboratories in settings of conflict should be recognized allowing international surveillance to be strengthened by supplementing the laboratory definition with the clinical definition...
April 2017: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/28468861/detection-of-emerging-vaccine-related-polioviruses-by-deep-sequencing
#16
Malaya K Sahoo, Marisa Holubar, ChunHong Huang, Alisha Mohamed-Hadley, Yuanyuan Liu, Jesse J Waggoner, Stephanie B Troy, Lourdes Garcia-Garcia, Leticia Ferreyra-Reyes, Yvonne Maldonado, Benjamin A Pinsky
Oral poliovirus vaccine (OPV) can mutate to regain neurovirulence. To date, evaluation of these mutations has primarily been performed on culture-enriched isolates using conventional Sanger sequencing. We therefore developed a culture-independent, deep sequencing method targeting the 5' untranslated region (UTR) and P1 genomic region to characterize vaccine-related poliovirus variants. Error analysis of the deep sequencing method demonstrated reliable detection of poliovirus mutations at levels <1%, depending on read depth...
May 3, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28459105/crude-childhood-vaccination-coverage-in-west-africa-trends-and-predictors-of-completeness
#17
Jacob S Kazungu, Ifedayo M O Adetifa
Background: Africa has the lowest childhood vaccination coverage worldwide. If the full benefits of childhood vaccination programmes are to be enjoyed in sub-Saharan Africa, all countries need to improve on vaccine delivery to achieve and sustain high coverage. In this paper, we review trends in vaccination coverage, dropouts between vaccine doses and explored the country-specific predictors of complete vaccination in West Africa.  Methods: We utilized datasets from the Demographic and Health Surveys Program, available for Benin, Burkina Faso, The Gambia, Ghana, Guinea, Cote d'Ivoire, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone and Togo, to obtain coverage for Bacillus Calmette-Guerin, polio, measles, and diphtheria, pertussis and tetanus (DPT) vaccines in children aged 12 - 23 months...
February 15, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28456205/water-isotope-effect-on-the-thermostability-of-a-polio-viral-rna-hairpin-a-metadynamics-study
#18
Arup K Pathak, Tusar Bandyopadhyay
Oral polio vaccine is considered to be the most thermolabile of all the common childhood vaccines. Despite heavy water (D2O) having been known for a long time to stabilise attenuated viral RNA against thermodegradation, the molecular underpinnings of its mechanism of action are still lacking. Whereas, understanding the basis of D2O action is an important step that might reform the way other thermolabile drugs are stored and could possibly minimize the cold chain problem. Here using a combination of parallel tempering and well-tempered metadynamics simulation in light water (H2O) and in D2O, we have fully described the free energy surface associated with the folding/unfolding of a RNA hairpin containing a non-canonical basepair motif, which is conserved within the 3'-untranslated region of poliovirus-like enteroviruses...
April 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28455172/inactivated-polio-vaccines-from-three-different-manufacturers-have-equivalent-safety-and-immunogenicity-when-given-as-1-or-2-additional-doses-after-bivalent-opv-results-from-a-randomized-controlled-trial-in-latin-america
#19
Eduardo Lopez-Medina, Mario Melgar, James T Gaensbauer, Ananda S Bandyopadhyay, Bhavesh R Borate, William C Weldon, Ricardo Rüttimann, Joel Ward, Ralf Clemens, Edwin J Asturias
BACKGROUND: Since April 2016 inactivated poliovirus vaccine (IPV) has been the only routine source of polio type 2 protection worldwide. With IPV supply constraints, data on comparability of immunogenicity and safety will be important to optimally utilize available supplies from different manufacturers. METHODS: In this multicenter phase IV study, 900 Latin American infants randomly assigned to six study groups received three doses of bOPV at 6, 10 and 14weeks and either one IPV dose at 14weeks (groups SP-1, GSK-1 and BBio-1) or two IPV doses at 14 and 36weeks (groups SP-2, GSK-2 and BBio-2) from three different manufacturers...
April 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28454675/maximising-the-impact-of-inactivated-polio-vaccines
#20
Elizabeth B Brickley, Peter F Wright
No abstract text is available yet for this article.
April 25, 2017: Lancet Infectious Diseases
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