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Glucosamine chondroitin

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https://www.readbyqxmd.com/read/30086786/impact-of-oral-osteoarthritis-therapy-usage-among-other-risk-factors-on-knee-replacement-a-nested-case-control-study-using-the-osteoarthritis-initiative-cohort
#1
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative (OAI) database. METHODS: In this nested case-control design study, participants who had a KR after cohort entry were defined as "cases" and were matched with up to four controls for age, gender, income, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, Kellgren-Lawrence grade, and duration of follow up...
August 7, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29980200/effectiveness-and-safety-of-glucosamine-and-chondroitin-for-the-treatment-of-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Xiaoyue Zhu, Lingli Sang, Dandong Wu, Jiesheng Rong, Liying Jiang
OBJECTIVE: To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. METHODS: We searched electronic database including PubMed, Embase, Cochrane Library, and the reference lists of relevant articles published from inception to May 22, 2018. An updated meta-analysis was performed to assess the effectiveness of these slow-acting drugs for osteoarthritis...
July 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29975014/natural-product-dietary-supplement-use-by-individuals-with-rheumatoid-arthritis-a-scoping-review
#3
Janel C DeSalvo, Meghan B Skiba, Carol L Howe, Karen E Haiber, Janet L Funk
OBJECTIVE: Natural-product dietary supplements (NDS), defined as non-mineral, non-vitamin, ingested natural product-derived substances, are the most frequently used CAM modality in the United States, with musculoskeletal disease being the most frequent reason for their use. Because NDS usage is frequently unreported and individuals with RA may be at higher risk for NDS-related side effects due the underlying nature of the disease and frequent use of complex pharmaceutical regimens, a scoping review of the literature was undertaken to examine population-based patterns of NDS use for RA self-management...
July 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29947998/effect-of-glucosamine-and-chondroitin-sulfate-in-symptomatic-knee-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#4
REVIEW
Mario Simental-Mendía, Adriana Sánchez-García, Félix Vilchez-Cavazos, Carlos A Acosta-Olivo, Víctor M Peña-Martínez, Luis E Simental-Mendía
Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS)...
August 2018: Rheumatology International
https://www.readbyqxmd.com/read/29940912/heparan-sulfate-proteoglycans-undergo-differential-expression-alterations-in-left-sided-colorectal-cancer-depending-on-their-metastatic-character
#5
Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón, Luis M Quirós
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of expression of HSPGs in left sided colorectal cancer (LSCRC), both metastatic and non-metastatic, and the results are also compared with those previously obtained for right sided tumors (RSCRCs). METHODS: Eighteen LSCRCs were studied using qPCR to analyze the expression of both the proteoglycan core proteins and the enzymes involved in heparan sulfate chain biosynthesis...
June 25, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29938530/anti-inflammatory-effect-of-carprofen-is-enhanced-by-avocado-soybean-unsaponifiables-glucosamine-and-chondroitin-sulfate-combination-in-chondrocyte-microcarrier-spinner-culture
#6
Mark W Grzanna, Erica J Secor, Lowella V Fortuno, Angela Y Au, Carmelita G Frondoza
Objective Osteoarthritis is a painful, chronic joint disease affecting man and animals with no known curative therapies. Palliative nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but they cause adverse side effects prompting the search for safer alternatives. To address this need, we evaluated the anti-inflammatory activity of avocado/soybean unsaponifiables (ASU), glucosamine (GLU), and chondroitin sulfate (CS) with or without the NSAID carprofen. Design Canine chondrocytes were propagated in microcarrier spinner culture and incubated with (1) control medium, (2) ASU (8...
June 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29771395/glucosamine-and-chondroitin-sulfate-what-has-been-learned-since-the-glucosamine-chondroitin-arthritis-intervention-trial
#7
Nicholas DiNubile
Glucosamine and chondroitin sulfate, alone or in combination, are used worldwide by individuals suffering from osteoarthritis pain. They are by prescription in some countries but are available as over-the-counter dietary supplements in other countries, such as the United States. The inconclusive results of the National Institutes of Health-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) did little to clarify the efficacy of these agents. However, some newer studies have provided a better perspective on the potential benefits that they can offer...
July 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29713967/effects-of-glucosamine-in-patients-with-osteoarthritis-of-the-knee-a-systematic-review-and-meta-analysis
#8
Toru Ogata, Yuki Ideno, Masami Akai, Atsushi Seichi, Hiroshi Hagino, Tsutomu Iwaya, Toru Doi, Keiko Yamada, Ai-Zhen Chen, Yingzi Li, Kunihiko Hayashi
Osteoarthritis (OA) of the knee is one of the main causes of mobility decline in the elderly. Non-surgical treatments such as administration of supplements to strengthen the joint cartilage matrix have become popular not only for pain relief but also for joint preservation. Glucosamine has been used in many countries based on the increasing evidence of its effectiveness for OA. Although there are many previous studies and systematic reviews, the findings vary and different conclusions have been drawn. We aimed to review recent randomized controlled trials on glucosamine for knee OA to reveal up-to-date findings about this supplement...
April 30, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#9
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29595285/-nutraceuticals-in-therapy-of-knee-osteoarthritis-orthopaedic-view
#10
Jiří Gallo
Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger patients without an extensive and serious impairment. Implantation of TKR (total knee replacement) is usually indicated in more advanced stages. One of the pillars of conservative therapy is analgesics and non-steroidal antirheumatic drugs. A specific group consists of perorally administered drugs for suppression of symptoms or even deceleration of knee osteoarthrosis...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29564812/negative-electron-transfer-dissociation-sequencing-of-3-o-sulfation-containing-heparan-sulfate-oligosaccharides
#11
Jiandong Wu, Juan Wei, John D Hogan, Pradeep Chopra, Apoorva Joshi, Weigang Lu, Joshua Klein, Geert-Jan Boons, Cheng Lin, Joseph Zaia
Among dissociation methods, negative electron transfer dissociation (NETD) has been proven the most useful for glycosaminoglycan (GAG) sequencing because it produces informative fragmentation, a low degree of sulfate losses, high sensitivity, and translatability to multiple instrument types. The challenge, however, is to distinguish positional sulfation. In particular, NETD has been reported to fail to differentiate 4-O- versus 6-O-sulfation in chondroitin sulfate decasaccharide. This raised the concern of whether NETD is able to differentiate the rare 3-O-sulfation from predominant 6-O-sulfation in heparan sulfate (HS) oligosaccharides...
June 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29525231/effect-of-an-oral-joint-supplement-when-compared-to-carprofen-in-the-management-of-hip-osteoarthritis-in-working-dogs
#12
João Carlos Alves, Ana Margarida Santos, Patrícia Isabel Jorge
The goal of this study was to evaluate the effectiveness of an oral joint supplement in working dogs with hip osteoarthritis compared with a positive control group (CG). Fifteen animals were divided in treatment group (TG, n = 10) and CG (n = 5). To TG a commercially available joint supplement, containing glucosamine HCl, chondroitin sulphate, and hyaluronic acid was given for 40 days and a 70-day course of a placebo, to be administered as if it was carprofen. The CG received carprofen for 70 days, and a placebo to be administered as the joint supplement...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29488228/cytochrome-p450-2c9-natural-antiarthritic-interactions-evaluation-of-inhibition-magnitude-and-prediction-from-in-vitro-data
#13
Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compounds with human hepatic cytochrome P450 (CYP) enzymes is limited. This study aimed to examine the modulatory effects of these compounds on CYP2C9, a major CYP isoform, using in vitro biochemical assay and in silico models. Utilizing valsartan hydroxylase assay as probe, all forms of glucosamine and chondroitin exhibited IC50 values beyond 1000 μM, indicating very weak potential in inhibiting CYP2C9...
April 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29465368/comparative-effectiveness-of-glucosamine-chondroitin-acetaminophen-or-celecoxib-for-the-treatment-of-knee-and-or-hip-osteoarthritis-a-network-meta-analysis
#14
Xiaoyue Zhu, Dandong Wu, Lingli Sang, Yidan Wang, Yi Shen, Xun Zhuang, Minjie Chu, Liying Jiang
OBJECTIVES: To compare the efficacies of oral glucosamine, chondroitin, the combination of glucosamine and chondroitin, acetaminophen and celecoxib on the treatment of knee and/or hip osteoarthritis. METHODS: We searched electronic databases including PubMed, Embase, and Cochrane Library and the reference lists of relevant articles published from inception to October 23, 2017. A Bayesian hierarchical random effects model was used to examine the overall effect size among mixed multiple interventions...
July 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29398161/analgesic-use-and-risk-for-acute-coronary-events-in-patients-with-osteoarthritis-a-population-based-nested-case-control-study
#15
Caridad Pontes, Josep Ramon Marsal, Josep Maria Elorza, Maria Aragón, Daniel Prieto-Alhambra, Rosa Morros
PURPOSE: Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management. We studied the existing association between the use of different OA drug therapies and the risk for acute coronary events. METHODS: A cohort of patients with clinically diagnosed OA (according to ICD-10 codes) was identified in the SIDIAP database. Within the cohort, cases with incident acute coronary events (acute myocardial infarction or unstable angina) between 2008 and 2012 were identified using ICD-10 codes and data from hospital admission...
February 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29391578/possible-role-of-chondroitin-sulphate-and-glucosamine-for-primary-prevention-of-colorectal-cancer-results-from-the-mcc-spain-study
#16
Gemma Ibáñez-Sanz, Anna Díez-Villanueva, Laura Vilorio-Marqués, Esther Gracia, Nuria Aragonés, Rocío Olmedo-Requena, Javier Llorca, Juana Vidán, Pilar Amiano, Pilar Nos, Guillermo Fernández-Tardón, Ricardo Rada, María Dolores Chirlaque, Elisabet Guinó, Verónica Dávila-Batista, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Benito Mirón-Pozo, Trinidad Dierssen-Sotos, Jaione Etxeberria, Amaia Molinuevo, Begoña Álvarez-Cuenllas, Manolis Kogevinas, Marina Pollán, Victor Moreno
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29359666/enhancing-the-intestinal-permeation-of-the-chondroprotective-nutraceuticals-glucosamine-sulphate-and-chondroitin-sulphate-using-conventional-and-modified-liposomes
#17
Ahmed M Agiba, Maha Nasr, Sameh Abdel-Hamid, Ahmed B Eldin, Ahmed S Geneidi
BACKGROUND: Liposomes are promising systems for the delivery of macromolecules and poorly absorbed drugs, owing to their ability to compartmentalize drugs, their biodegradability and biocompatibility. OBJECTIVE: The aim of the present study was to formulate and evaluate conventional and modified glucosamine sulphate (GluS) and chondroitin sulphate (CS) liposomal formulations, to enhance their oral permeation for the treatment of osteoarthritis (OA). METHOD: Liposomal formulations were prepared by the thin-film hydration method using two types of phospholipids; Epikuron 200© and Epikuron 200© SH, and three permeation enhancers; poloxamer 407, cetylpyridinium chloride, and sodium deoxycholate...
2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29341524/-what-s-new-in-ambulatory-general-internal-medicine%C3%A2
#18
Annick Gerber, Camille Buffle Genecand, Thierry Mach, David Schrumpf, Ana Rita Forte Marques, Jean Dupraz, Thomas Schmid
Many treatments are used every day in general medicine without any evidence of their efficacy. This last year, three randomised studies tried to prove the clinical utility of chondroitin/glucosamine in arthritis, cranberry in urinary infections, and acupuncture in migraine. Screening and management of prostate cancer are still controversial. Two recent studies help us advising our patients on this difficult topic. Muscle side effects from statins are well known and have been widely relayed by the press these last years, although myopathies are rare in clinical trials...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29196833/chondroitin-sulfate-and-glucosamine-sulfate-associated-to-photobiomodulation-prevents-degenerative-morphological-changes-in-an-experimental-model-of-osteoarthritis-in-rats
#19
Marcella Sanches, Lívia Assis, Cyntia Criniti, Danilo Fernandes, Carla Tim, Ana Claudia Muniz Renno
The aim of this study was to compare the effects of combined treatment with chondroitin sulfate and glucosamine sulfate (CS/Gl) and photobiomodulation (PBM) on the degenerative process related to osteoarthritis (OA) in the articular cartilage in rats. Forty male Wistar rats were randomly divided into four groups: OA control group (CG); OA animals submitted to PBM treatment (PBM); OA animals submitted to CS/Gl treatment (CS/Gl); OA submitted to CS/GS associated with PBM treatments (GS/Gl + PBM). The CS/Gl started 48 h after the surgery, and they were performed for 29 consecutive days...
April 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29177637/inappropriate-claims-from-non-equivalent-medications-in-osteoarthritis-a-position-paper-endorsed-by-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-osteoarthritis-and-musculoskeletal-diseases-esceo
#20
REVIEW
Olivier Bruyère, Cyrus Cooper, Nasser M Al-Daghri, Elaine M Dennison, René Rizzoli, Jean-Yves Reginster
Osteoarthritis (OA) is a progressive joint disease, that occurs frequently in the aging population and is a major cause of disability worldwide. Both glucosamine and chondroitin are biologically active molecules that are substrates for proteoglycan, an essential component of the cartilage matrix. Evidence supports the use of glucosamine and chondroitin as symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) with impact on OA symptoms and disease-modifying effects in the long term. Glucosamine and chondroitin are administered in exogenous form as a sulfate salt and multiple formulations of these agents are available, both as prescription-grade products and nutritional supplements...
February 2018: Aging Clinical and Experimental Research
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