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Glucosamine chondroitin

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https://www.readbyqxmd.com/read/30255058/combining-a-joint-health-supplement-with-tibial-plateau-leveling-osteotomy-in-dogs-with-cranial-cruciate-ligament-rupture-an-exploratory-controlled-trial
#1
Filippo M Martini, Anna Brandstetter de Bellesini, Alda Miolo, Laura Del Coco, Francesco P Fanizzi, Antonio Crovace
Canine cranial cruciate ligament rupture (CrCLR) is a very common pathology. Surgical stabilization is the first choice treatment, although it does not fully eliminate the increased risk of osteoarthritis. This preliminary study was carried out to explore whether a newly formulated joint health supplement would benefit metabolic, clinical and radiographic changes in dogs with CrCLR surgically treated with tibial plateau leveling osteotomy (TPLO). Besides chondroitin sulfate and glucosamine hydrochloride, the studied supplement contained anti-inflammatory and antioxidant ingredients, the main ones being N-palmitoyl-D-glucosamine (Glupamid®) and quercetin...
December 2017: International Journal of Veterinary Science and Medicine
https://www.readbyqxmd.com/read/30232562/natural-products-for-promoting-joint-health-and-managing-osteoarthritis
#2
REVIEW
Yves Henrotin, Ali Mobasheri
PURPOSE OF REVIEW: Osteoarthritis, the most common joint disease, is associated with substantial medical costs, lost productivity, and reduced quality of life. However, available pharmaceutical treatments have limitations in terms of efficacy and long-term safety. RECENT FINDINGS: In vitro evidence suggests that some natural products may possess anti-inflammatory and anti-oxidative properties and may inhibit the release of key osteoarthritis-related cytokines. There is, therefore, ongoing interest in identifying natural products that safely promote joint health and treat osteoarthritis...
September 19, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/30216397/purl-time-to-stop-glucosamine-and-chondroitin-for-knee-oa
#3
Corey Lyon, Rebecca Mullen, Drew Ashby
Prior studies provided conflicting results regarding the efficacy of these medications. This study offers evidence for discontinuing them.
September 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/30122200/daily-oral-supplementation-with-collagen-peptides-combined-with-vitamins-and-other-bioactive-compounds-improves-skin-elasticity-and-has-a-beneficial-effect-on-joint-and-general-wellbeing
#4
Anna Czajka, Ewa M Kania, Licia Genovese, Andrea Corbo, Giovanni Merone, Cecilia Luci, Sara Sibilla
Aging is a multifactorial and natural process that causes physiological changes in organs, tissues and cells over time. In the skin and cartilage, aging leads to a decrease in the synthesis and changes in the arrangement of proteoglycans and collagen, in addition to the loss of glycosaminoglycans, which are responsible for the integrity and health of these tissues. We hypothesized that daily oral supplementation with a liquid nutraceutical containing hydrolyzed fish collagen, vitamins, antioxidants and other active ingredients could improve skin texture and elasticity, and in addition have a protective effect on joint health...
September 2018: Nutrition Research
https://www.readbyqxmd.com/read/30086786/impact-of-oral-osteoarthritis-therapy-usage-among-other-risk-factors-on-knee-replacement-a-nested-case-control-study-using-the-osteoarthritis-initiative-cohort
#5
Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using the Osteoarthritis Initiative (OAI) database. METHODS: In this nested case-control design study, participants who had a KR after cohort entry were defined as "cases" and were matched with up to four controls for age, gender, income, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, Kellgren-Lawrence grade, and duration of follow up...
August 7, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29980200/effectiveness-and-safety-of-glucosamine-and-chondroitin-for-the-treatment-of-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#6
REVIEW
Xiaoyue Zhu, Lingli Sang, Dandong Wu, Jiesheng Rong, Liying Jiang
OBJECTIVE: To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine. METHODS: We searched electronic database including PubMed, Embase, Cochrane Library, and the reference lists of relevant articles published from inception to May 22, 2018. An updated meta-analysis was performed to assess the effectiveness of these slow-acting drugs for osteoarthritis...
July 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29975014/natural-product-dietary-supplement-use-by-individuals-with-rheumatoid-arthritis-a-scoping-review
#7
Janel C DeSalvo, Meghan B Skiba, Carol L Howe, Karen E Haiber, Janet L Funk
OBJECTIVE: Natural-product dietary supplements (NDS), defined as non-mineral, non-vitamin, ingested natural product-derived substances, are the most frequently used CAM modality in the United States, with musculoskeletal disease being the most frequent reason for their use. Because NDS usage is frequently unreported and individuals with RA may be at higher risk for NDS-related side effects due the underlying nature of the disease and frequent use of complex pharmaceutical regimens, a scoping review of the literature was undertaken to examine population-based patterns of NDS use for RA self-management...
July 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29947998/effect-of-glucosamine-and-chondroitin-sulfate-in-symptomatic-knee-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#8
REVIEW
Mario Simental-Mendía, Adriana Sánchez-García, Félix Vilchez-Cavazos, Carlos A Acosta-Olivo, Víctor M Peña-Martínez, Luis E Simental-Mendía
Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS)...
August 2018: Rheumatology International
https://www.readbyqxmd.com/read/29940912/heparan-sulfate-proteoglycans-undergo-differential-expression-alterations-in-left-sided-colorectal-cancer-depending-on-their-metastatic-character
#9
Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón, Luis M Quirós
BACKGROUND: Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of expression of HSPGs in left sided colorectal cancer (LSCRC), both metastatic and non-metastatic, and the results are also compared with those previously obtained for right sided tumors (RSCRCs). METHODS: Eighteen LSCRCs were studied using qPCR to analyze the expression of both the proteoglycan core proteins and the enzymes involved in heparan sulfate chain biosynthesis...
June 25, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29938530/anti-inflammatory-effect-of-carprofen-is-enhanced-by-avocado-soybean-unsaponifiables-glucosamine-and-chondroitin-sulfate-combination-in-chondrocyte-microcarrier-spinner-culture
#10
Mark W Grzanna, Erica J Secor, Lowella V Fortuno, Angela Y Au, Carmelita G Frondoza
Objective Osteoarthritis is a painful, chronic joint disease affecting man and animals with no known curative therapies. Palliative nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but they cause adverse side effects prompting the search for safer alternatives. To address this need, we evaluated the anti-inflammatory activity of avocado/soybean unsaponifiables (ASU), glucosamine (GLU), and chondroitin sulfate (CS) with or without the NSAID carprofen. Design Canine chondrocytes were propagated in microcarrier spinner culture and incubated with (1) control medium, (2) ASU (8...
June 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29771395/glucosamine-and-chondroitin-sulfate-what-has-been-learned-since-the-glucosamine-chondroitin-arthritis-intervention-trial
#11
Nicholas DiNubile
Glucosamine and chondroitin sulfate, alone or in combination, are used worldwide by individuals suffering from osteoarthritis pain. They are by prescription in some countries but are available as over-the-counter dietary supplements in other countries, such as the United States. The inconclusive results of the National Institutes of Health-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) did little to clarify the efficacy of these agents. However, some newer studies have provided a better perspective on the potential benefits that they can offer...
July 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29713967/effects-of-glucosamine-in-patients-with-osteoarthritis-of-the-knee-a-systematic-review-and-meta-analysis
#12
Toru Ogata, Yuki Ideno, Masami Akai, Atsushi Seichi, Hiroshi Hagino, Tsutomu Iwaya, Toru Doi, Keiko Yamada, Ai-Zhen Chen, Yingzi Li, Kunihiko Hayashi
Osteoarthritis (OA) of the knee is one of the main causes of mobility decline in the elderly. Non-surgical treatments such as administration of supplements to strengthen the joint cartilage matrix have become popular not only for pain relief but also for joint preservation. Glucosamine has been used in many countries based on the increasing evidence of its effectiveness for OA. Although there are many previous studies and systematic reviews, the findings vary and different conclusions have been drawn. We aimed to review recent randomized controlled trials on glucosamine for knee OA to reveal up-to-date findings about this supplement...
September 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#13
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29595285/-nutraceuticals-in-therapy-of-knee-osteoarthritis-orthopaedic-view
#14
Jiří Gallo
Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger patients without an extensive and serious impairment. Implantation of TKR (total knee replacement) is usually indicated in more advanced stages. One of the pillars of conservative therapy is analgesics and non-steroidal antirheumatic drugs. A specific group consists of perorally administered drugs for suppression of symptoms or even deceleration of knee osteoarthrosis...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29564812/negative-electron-transfer-dissociation-sequencing-of-3-o-sulfation-containing-heparan-sulfate-oligosaccharides
#15
Jiandong Wu, Juan Wei, John D Hogan, Pradeep Chopra, Apoorva Joshi, Weigang Lu, Joshua Klein, Geert-Jan Boons, Cheng Lin, Joseph Zaia
Among dissociation methods, negative electron transfer dissociation (NETD) has been proven the most useful for glycosaminoglycan (GAG) sequencing because it produces informative fragmentation, a low degree of sulfate losses, high sensitivity, and translatability to multiple instrument types. The challenge, however, is to distinguish positional sulfation. In particular, NETD has been reported to fail to differentiate 4-O- versus 6-O-sulfation in chondroitin sulfate decasaccharide. This raised the concern of whether NETD is able to differentiate the rare 3-O-sulfation from predominant 6-O-sulfation in heparan sulfate (HS) oligosaccharides...
June 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29525231/effect-of-an-oral-joint-supplement-when-compared-to-carprofen-in-the-management-of-hip-osteoarthritis-in-working-dogs
#16
RANDOMIZED CONTROLLED TRIAL
João Carlos Alves, Ana Margarida Santos, Patrícia Isabel Jorge
The goal of this study was to evaluate the effectiveness of an oral joint supplement in working dogs with hip osteoarthritis compared with a positive control group (CG). Fifteen animals were divided in treatment group (TG, n = 10) and CG (n = 5). To TG a commercially available joint supplement, containing glucosamine HCl, chondroitin sulphate, and hyaluronic acid was given for 40 days and a 70-day course of a placebo, to be administered as if it was carprofen. The CG received carprofen for 70 days, and a placebo to be administered as the joint supplement...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29488228/cytochrome-p450-2c9-natural-antiarthritic-interactions-evaluation-of-inhibition-magnitude-and-prediction-from-in-vitro-data
#17
Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compounds with human hepatic cytochrome P450 (CYP) enzymes is limited. This study aimed to examine the modulatory effects of these compounds on CYP2C9, a major CYP isoform, using in vitro biochemical assay and in silico models. Utilizing valsartan hydroxylase assay as probe, all forms of glucosamine and chondroitin exhibited IC50 values beyond 1000 μM, indicating very weak potential in inhibiting CYP2C9...
April 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29465368/comparative-effectiveness-of-glucosamine-chondroitin-acetaminophen-or-celecoxib-for-the-treatment-of-knee-and-or-hip-osteoarthritis-a-network-meta-analysis
#18
COMPARATIVE STUDY
Xiaoyue Zhu, Dandong Wu, Lingli Sang, Yidan Wang, Yi Shen, Xun Zhuang, Minjie Chu, Liying Jiang
OBJECTIVES: To compare the efficacies of oral glucosamine, chondroitin, the combination of glucosamine and chondroitin, acetaminophen and celecoxib on the treatment of knee and/or hip osteoarthritis. METHODS: We searched electronic databases including PubMed, Embase, and Cochrane Library and the reference lists of relevant articles published from inception to October 23, 2017. A Bayesian hierarchical random effects model was used to examine the overall effect size among mixed multiple interventions...
July 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29398161/analgesic-use-and-risk-for-acute-coronary-events-in-patients-with-osteoarthritis-a-population-based-nested-case-control-study
#19
Caridad Pontes, Josep Ramon Marsal, Josep Maria Elorza, Maria Aragón, Daniel Prieto-Alhambra, Rosa Morros
PURPOSE: Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management. We studied the existing association between the use of different OA drug therapies and the risk for acute coronary events. METHODS: A cohort of patients with clinically diagnosed OA (according to ICD-10 codes) was identified in the SIDIAP database. Within the cohort, cases with incident acute coronary events (acute myocardial infarction or unstable angina) between 2008 and 2012 were identified using ICD-10 codes and data from hospital admission...
February 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29391578/possible-role-of-chondroitin-sulphate-and-glucosamine-for-primary-prevention-of-colorectal-cancer-results-from-the-mcc-spain-study
#20
Gemma Ibáñez-Sanz, Anna Díez-Villanueva, Laura Vilorio-Marqués, Esther Gracia, Nuria Aragonés, Rocío Olmedo-Requena, Javier Llorca, Juana Vidán, Pilar Amiano, Pilar Nos, Guillermo Fernández-Tardón, Ricardo Rada, María Dolores Chirlaque, Elisabet Guinó, Verónica Dávila-Batista, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Benito Mirón-Pozo, Trinidad Dierssen-Sotos, Jaione Etxeberria, Amaia Molinuevo, Begoña Álvarez-Cuenllas, Manolis Kogevinas, Marina Pollán, Victor Moreno
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated...
February 1, 2018: Scientific Reports
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