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msc immunomodulation mir

Joonhong Park, Sikyoung Jeong, Kicheol Park, Keumjin Yang, Soyoung Shin
Immunomodulatory or immunosuppressive properties of bone marrow-derived mesenchymal stem cells (BM-MSCs) facilitate the treatment of acute respiratory distress syndrome and acute lung injury (ALI). Dysregulated miRNA (miRNA or miR) expression associated with the effects of BM-MSCs was assessed in a rat model of lipopolysaccharide (LPS)-induced ALI. The present study performed biochemical tests to assess five analytes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, blood urea nitrogen (BUN), and creatinine (CREA)...
June 2018: Experimental and Therapeutic Medicine
Michael Spinosa, Guanyi Lu, Gang Su, Sai Vineela Bontha, Ricardo Gehrau, Morgan D Salmon, Joseph R Smith, Mark L Weiss, Valeria R Mas, Gilbert R Upchurch, Ashish K Sharma
The formation of an abdominal aortic aneurysm (AAA) is characterized by inflammation, macrophage infiltration, and vascular remodeling. In this study, we tested the hypothesis that mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) immunomodulate aortic inflammation, to mitigate AAA formation via modulation of microRNA-147. An elastase-treatment model of AAA was used in male C57BL/6 wild-type (WT) mice. Administration of EVs in elastase-treated WT mice caused a significant attenuation of aortic diameter and mitigated proinflammatory cytokines, inflammatory cell infiltration, an increase in smooth muscle cell α-actin expression, and a decrease in elastic fiber disruption, compared with untreated mice...
May 29, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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