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https://www.readbyqxmd.com/read/30335188/efficacy-of-a-survivorship-focused-consultation-versus-a-time-controlled-rehabilitation-consultation-in-patients-with-lymphoma-a-cluster-randomized-controlled-trial
#1
Patricia A Parker, Smita C Banerjee, Matthew J Matasar, Carma L Bylund, Madeline Rogers, Kara Franco, Elizabeth Schofield, Yuelin Li, Tomer T Levin, Paul B Jacobsen, Alan B Astrow, Howard Leventhal, Steven Horwitz, David Kissane
BACKGROUND: Survivors of cancer often describe a sense of abandonment after treatment along with heightened uncertainty and limited knowledge of what lies ahead. This study examined the efficacy of a survivorship care plan (SCP) intervention to help physicians to address survivorship issues through communication skills training plus a new consultation focused on the use of an SCP for patients with Hodgkin lymphoma and diffuse large B-cell lymphoma. METHODS: This 4-site cluster randomized trial examined the efficacy of a survivorship planning consultation (SPC) in patients who achieved complete remission after the completion of first-line therapy (for the SPC, physicians received communication skills training and, using an SCP, applied those skills in a survivorship-focused office visit) versus a control arm in which physicians were trained in and subsequently provided a time-controlled, manualized wellness rehabilitation consultation (WRC) focused only on discussion of healthy nutrition and exercise as rehabilitation after chemotherapy...
October 18, 2018: Cancer
https://www.readbyqxmd.com/read/30334969/gene-pair-based-prognostic-signature-for-colorectal-colon-cancer
#2
Peng Shu, Jianping Wu, Yao Tong, Chunxia Xu, Xingguo Zhang
BACKGROUND: The identification of high-risk colorectal cancer (CRC) patient is key to individualized treatment after surgery and reliable prognostic biomarkers are needed identifying high-risk CRC patients. METHODS: We developed a gene pair based prognostic signature that could can the prognosis risk in patients with CRC. This study retrospectively analyzed 4 public CRC datasets, and 1123 patients with CRC were divided into a training cohort (n = 300) and 3 independent validation cohorts (n = 507, 226, and 90 patients)...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334944/an-unusual-location-of-squamous-cell-carcinoma-and-a-rare-cutaneous-infection-caused-by-serratia-marcescens-on-the-tumoral-tissue-a-case-report
#3
Nurhayat Ozkan Sevencan, Elcin Kal Cakmakliogullari, Aysegul Ertinmaz Ozkan, Burcak Kayhan
RATIONALE: Serratia marcescens (S. marcescens) is an opportunistic pathogen of the Enterobacteriaceae family. Although S. marcescens is known to cause sepsis, meningitis, endocarditis, urinary system and ocular infections, skin infections are sporadic. Squamous cell carcinoma (SCC) is the most aggressive skin cancer type that is often located in the head and neck region, and rarely in the scalp tissue. PATIENT CONCERNS: An 89-years-old male patient was diagnosed with SCC three years ago...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30334557/mirna-182-5p-via-hif2%C3%AE-contributes-to-arsenic-carcinogenesis-evidence-from-human-renal-epithelial-cells
#4
Xin Fang, Ru Sun, Yuxin Hu, Huihui Wang, Yi Guo, Bei Yang, Jingbo Pi, Yuanyuan Xu
Chronic exposure to high levels of arsenic has been associated with high risks for many cancers, including renal cell carcinoma (RCC). However the underlying mechanisms are not clear. In the present study, chronic arsenite exposure (2 μM or 5 μM, 30 weeks) induced malignant transformation of HK-2 human renal epithelial cells as indicated by elevated colony formation (6.2- and 5.4-fold increase, respectively), secreted MMP-9 activity (10.1- and 11.3-fold increase, respectively) and proliferation rate (1.2- and 1...
October 18, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/30334367/maternal-embryonic-leucine-zipper-kinase-a-novel-biomarker-and-a-potential-therapeutic-target-of-cervical-cancer
#5
Juan Wang, Yamei Wang, Fangrong Shen, Yanting Xu, Yinghui Zhang, Xinwei Zou, Jinhua Zhou, Youguo Chen
Maternal embryo leucine zipper kinase (MELK) is highly expressed in a variety of malignant tumors and involved in cell cycle regulation, cell proliferation, apoptosis, tumor formation etc However, the biological effects of MELK in cervical cancer are still uninvestigated. This study aimed to explore the expression of MELK in cervical cancer, as well as its effects on the proliferation, apoptosis, DNA damage repair on cervical cancer cell line in vitro and to provide novel ideas for further improving the clinical efficacy of cervical cancer...
October 18, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30334298/mir-34b-c-5p-and-the-neurokinin-1-receptor-regulate-breast-cancer-cell-proliferation-and-apoptosis
#6
Lufang Zhang, Lushan Wang, Dong Dong, Zhiyong Wang, Wei Ji, Man Yu, Fei Zhang, Ruifang Niu, Yunli Zhou
OBJECTIVES: MiR-34 is a tumour suppressor in breast cancer. Neurokinin-1 receptor (NK1R), which is the predicted target of the miR-34 family, is overexpressed in many cancers. This study investigated the correlation and clinical significance of miR-34 and NK1R in breast cancer. MATERIALS AND METHODS: Western blotting, quantitative reverse transcription-PCR (qRT-PCR) and luciferase assays were conducted to analyse the regulation of NK1R by miR-34 in MDA-MB-231, MCF-7, T47D, SK-BR-3 and HEK-293 T cells...
October 17, 2018: Cell Proliferation
https://www.readbyqxmd.com/read/30334194/aso-author-reflections-primary-tumor-location-and-long-term-survival-after-hepatic-resection-for-metastatic-colon-cancer
#7
John M Creasy, Michael I D'Angelica
No abstract text is available yet for this article.
October 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30334162/vascular-anatomy-of-the-transverse-mesocolon-and-bidirectional-laparoscopic-d3-lymph-node-dissection-for-patients-with-advanced-transverse-colon-cancer
#8
Takashi Ueki, Shuntato Nagai, Tatsuya Manabe, Ryo Koba, Kinuko Nagayoshi, Masafumi Nakamura, Masao Tanaka
Laparoscopic D3 lymph node dissection for transverse colon cancer is technically demanding because of complicated anatomy. Here, we reviewed the vascular structure of the transverse mesocolon, explored the extent of the base of the transverse mesocolon, and evaluated the feasibility and oncological safety of D3 lymph node dissection. We retrospectively reviewed the clinical records of 42 patients with advanced transverse colon cancer who underwent curative surgery and D3 dissection at Kyushu University Hospital between January 2008 and December 2015...
October 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30334065/microrna-429-regulates-the-expression-of-chmp5-in-the-inflammatory-colitis-and-colorectal-cancer-cells
#9
Ji-Su Mo, Seol-Hee Han, Ki-Jung Yun, Soo-Cheon Chae
OBJECTIVE AND DESIGN: MicroRNAs (miRNAs) play an important role in the pathogenesis of human diseases by regulating the expression of target genes in specific cells or tissues. In this study, we analyzed the association between the MIR429 and its target gene, charged multivesicular body protein 5 (CHMP5), in human colon cancer cells and in a DSS-induced colitis mouse model. MATERIALS AND METHODS: A luciferase reporter system was used to confirm the effect of MIR429 on CHMP5 expression...
October 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/30333890/relationship-between-ct-signs-and-the-expression-of-mir-146a-in-colon-cancer
#10
Zijian Liu, Yuzhu Li, Quanxiang Luo
Our study investigated the relationship between CT signs of colon cancer and the expression of miR-146a, to evaluate their predictive value in early diagnosis and of colon cancer. A total of 216 patients with colon cancer who were admitted to the Department of Hematology and Oncology in Yingcheng Hospital, the Second Hospital of Shandong University in Zhaoyuan City from January 2013 to March 2017 were selected as the study group. At the same time, 150 patients with benign colitis were also included to serve as the control group...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333881/anti-il-20-monoclonal-antibody-suppresses-hepatocellular-carcinoma-progression
#11
Wen-Zhou Ding, Guo-Yong Han, Hui-Han Jin, Chuan-Fei Zhan, Yuan Ji, Xin-Li Huang
Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In the present study, it was observed that IL-20 mRNA and protein levels were markedly increased in the HCC tissues examined via reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333877/long-noncoding-rna-z38-promotes-cell-proliferation-and-metastasis-and-inhibits-cell-apoptosis-in-human-gastric-cancer
#12
Yang Wang, Chunhui Zheng, Teng Li, Rui Zhang, Yang Wang, Jiaxin Zhang, Qingsi He, Zuocheng Sun, Xinsheng Wang
Gastric cancer is one of the leading causes of cancer-associated mortality and has a high tendency to metastasize, making it a priority to develop novel diagnostic and treatment methods at the early stages. The present study investigated the role of a newly-discovered long non-coding RNA, Z38, in gastric cancer cell proliferation, metastasis and apoptosis. It was observed that Z38 was upregulated in tissues from patients with gastric cancer as well as in cultured gastric cancer cells. Knockdown of Z38 decreased the cell proliferative rate, as evidenced by colony formation assays and cell proliferation assays...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333866/never-in-mitosis-a-related-kinase-8-a-novel-target-of-von-hippel-lindau-tumor-suppressor-protein-promotes-gastric-cancer-cell-proliferation
#13
Xiao-Fei Ding, Jie Chen, Jun Zhou, Guang Chen, Ying-Liang Wu
Previous research has revealed that the von-Hippel-Lindau tumor suppressor protein (pVHL) may downregulate never-in-mitosis A-related kinase 8 (NEK8) via hypoxia-inducible factor-α (HIF-α). The HIF-independent functions of pVHL also serve an important role in its tumor-suppressor action. In the present study, the association between pVHL and NEK8 was demonstrated in the human gastric cancer cell line, SGC-7901, indicating a direct interaction of pVHL with NEK8. Subsequently, it was reported that MG-132, a specific proteasome inhibitor, may attenuate pVHL overexpression-induced reductions in NEK8 protein expression levels...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333860/par4-overexpression-promotes-colorectal-cancer-cell-proliferation-and-migration
#14
Hongshan Zhang, Ping Jiang, Chuanrao Zhang, Siman Lee, Wei Wang, Hao Zou
Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in positive lymph node and poorly differentiated types of cancer. We hypothesized that PAR4 serves a function in the progression of colorectal cancer. In the present study, overexpression of PAR4 in colorectal cancer LoVo cells promoted proliferation, anchorage-independent growth and migration...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333551/web-based-model-for-predicting-time-to-surgery-in-young-patients-with-familial-adenomatous-polyposis-an-internally-validated-study
#15
Shashank Sarvepalli, Carol A Burke, Marc Monachese, Rocio Lopez, Brandie H Leach, Lisa Laguardia, Margaret O'Malley, Matthew F Kalady, James M Church
INTRODUCTION: The timing of prophylactic colorectal surgery in patients with familial adenomatous polyposis (FAP) is based on the immediacy of the colorectal cancer risk. The ability to predict the need for surgery may help patients and their families plan in the context of life events and CRC risk. We created a model to predict the likelihood of surgery within 2 and 5 years of first colonoscopy at our institution. METHODS: A single institution hereditary colorectal syndrome (Cologene™) database was interrogated for all patients with FAP having a deleterious APC mutation...
October 17, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/30333402/prosthetic-valve-endocarditis-caused-by-st8-sccmecivl-type-community-associated-methicillin-resistant-staphylococcus-aureus-a-case-report
#16
Hiroki Kitagawa, Hiroki Ohge, Junzo Hisatsune, Toshiki Kajihara, Keijiro Katayama, Shinya Takahashi, Taijiro Sueda, Motoyuki Sugai
The emergence of a Japan-intrinsic community associated methicillin-resistant Staphylococcus aureus strain (CA-MRSA/J) has been reported. A 70-year-old man with recurrent colon cancer and a history of mitral valve replacement was admitted to the hospital in a state of shock. He was diagnosed with prosthetic valve endocarditis (PVE) caused by MRSA and underwent cardiac surgery. The MRSA isolates belonged to multilocus sequence type 8 and carried staphylococcal cassette chromosome mec IVl and the genes of toxic shock syndrome toxin-1, enterotoxin C, and enterotoxin L...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333251/systematic-identification-of-celastrol-binding-proteins-reveals-that-shoc2-is-inhibited-by-celastrol
#17
Xiao-Pei Huang, Ji-Kuai Chen, Wei Xu, Yi-Fan Dong, Lang Yan, Xiao-Fang Zhang, Ya-Min Pan, Wen-Jun Chang, Jiang-Bo Zhu
Colorectal cancer (CRC) is the third most commonly diagnosed cancer. Celastrol exhibits anti-tumor activities in a variety of cancers. However, the effect of Celastrol on human CRC and the underlying mechanisms still need to be elucidated. This study aimed to use in vitro and in vivo methods to clarify the anti-tumor effect of Celastrol and use protein microarrays to explore its mechanisms. We demonstrated that Celastrol effectively inhibited SW480 CRC cell proliferation. Two weeks of Celastrol gavage significantly inhibited the growth of xenografts in nude mice...
October 17, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30333221/decision-support-and-navigation-to-increase-colorectal-cancer-screening-among-hispanic-patients
#18
Ronald E Myers, Brian Stello, Constantine Daskalakis, Randa Sifri, Evelyn T Gonzalez, Melissa DiCarlo, Melanie B Johnson, Sarah E Hegarty, Kyle Shaak, Alicia Rivera, Lucas Gordils-Molina, Anett Petrich, Beth Careyva, Rosa de-Ortiz, Liselly Diaz
BACKGROUND: Effective strategies are needed to raise colorectal cancer (CRC) screening rates among Hispanics Methods: We surveyed and randomized 400 Hispanic primary care patients either to a Decision Support and Navigation Intervention (DSNI) Group (n=197) or a Standard Intervention (SI) Group (n=203). Both groups received a CRC screening kit (bilingual informational booklet, fecal immunochemical stool blood test (SBT), and colonoscopy screening instructions). The DSNI Group received a telephone contact from a patient navigator...
October 17, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/30333034/comparative-study-between-colonic-metallic-stent-and-anal-tube-decompression-for-japanese-patients-with-left-sided-malignant-large-bowel-obstruction
#19
Satoru Kagami, Kimihiko Funahashi, Mitsunori Ushigome, Junichi Koike, Tomoaki Kaneko, Takamaru Koda, Akiharu Kurihara, Yasuo Nagashima, Yu Yoshino, Mayu Goto, Tetsuo Mikami, Kumiko Chino
BACKGROUND: Surgical management of malignant bowel obstruction carries with high morbidity and mortality. Placement of a trans-anal decompression tube (TDT) has traditionally been used for malignant bowel obstruction as a bridge to surgery. Recently, colonic metallic stent (CMS) as a bridge to surgery for malignant bowel obstruction, particularly left-sided malignant large bowel obstruction (LMLBO) caused by colorectal cancer, has been reported to be both a safe and feasible option. The aim of this retrospective study is to evaluate the clinical effects of CMS for LMLBO as a bridge to surgery compared to TDT...
October 17, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30333033/perspectives-of-primary-care-providers-and-endoscopists-about-current-practices-facilitators-and-barriers-for-preparation-and-follow-up-of-colonoscopy-procedures-a-qualitative-study
#20
Gayle Restall, John R Walker, Celeste Waldman, Kathleen Zawaly, Valerie Michaud, Dana Moffat, Harminder Singh
BACKGROUND: Colonoscopy has become a common medical procedure due to increased use of colonoscopy for evaluation of symptoms, colorectal cancer screening and surveillance of people with higher risks of developing colorectal cancer. Timely access to colonoscopy is essential for diagnosis of colorectal cancer, as well as diagnosis and management of inflammatory bowel disease and gastrointestinal symptoms such as diarrhea. The purpose of this study was to obtain the perspectives of primary care providers and endoscopists about current practices, barriers and facilitators to following recommended practice for preparation and follow-up after colonoscopy...
October 17, 2018: BMC Health Services Research
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