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Colon* And Cancer

Man Kyu Shim, Jooho Park, Hong Yeol Yoon, Sangmin Lee, Wooram Um, Jong-Ho Kim, Sun-Woong Kang, Joung-Wook Seo, Soo-Wang Hyun, Jae Hyung Park, Youngro Byun, Ick Chan Kwon, Kwangmeyung Kim
Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition...
December 11, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Daniel Triner, Samantha N Devenport, Sadeesh K Ramakrishnan, Xiaoya Ma, Ryan A Frieler, Joel K Greenson, Naohiro Inohara, Gabriel Nunez, Justin A Colacino, Richard M Mortensen, Yatrik M Shah
BACKGROUND & AIMS: Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors, are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are under way in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis. METHODS: Colitis-associated colon cancer was induced mice with conditional deletion of neutrophils (LysMCre;Mcl1fl/fl ) and wild-type littermates (LysMCre;Mcl1+/+ , control mice) by administration of azoxythmethane and/or dextran sulfate sodium...
December 11, 2018: Gastroenterology
Malwina Michalak, Uwe Warnken, Martina Schnölzer, Hans-Joachim Gabius, Jürgen Kopitz
Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our pilot study, we tested galectin-4 (gal-4) that is a growth inhibitor for colon cancer cells (CRC), here working with the LS 180 line. In order to cover monitoring of short- and long-term effects stable isotope labeling by amino acids in cell culture-based quantitative phosphoproteomic analyses were conducted on LS 180 cell preparations collected 1 and 72 h after adding gal-4 to the culture medium...
December 14, 2018: IUBMB Life
Giuseppe Vanella, Livia Archibugi, Serena Stigliano, Gabriele Capurso
PURPOSE OF REVIEW: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. RECENT FINDINGS: Moderate alcohol intake increases the risk of esophageal squamous cell carcinoma and colorectal cancer...
December 12, 2018: Current Opinion in Gastroenterology
Pan Pan, Jianhua Yu, Li-Shu Wang
PURPOSE OF REVIEW: Colorectal cancer (CRC) is one of the most common cancers and the fourth leading cause of cancer-related deaths worldwide. Diet has a significant impact on the risk of developing CRC, but though processed meat is a known positive contributor, the effects of other dietary components are largely mixed. This review focuses on dietary patterns to describe the complexity of dietary diversity and overall food consumption and to examine the relationship between dietary patterns and risk of CRC...
December 12, 2018: Current Opinion in Gastroenterology
Sunny C Lin, Scott E Regenbogen, John M Hollingsworth, Russell Funk, Julia Adler-Milstein
PURPOSE: To improve care coordination for complex cancers, it is critical to establish a more nuanced understanding of the types of providers involved. As the number of provider types increases, strategies to support cancer care coordination must adapt to a greater variety of information needs, communication styles, and treatment strategies. METHODS: We categorized providers into 11 types, using National Provider Identifier specialties. Using Medicare claims, we counted the number of unique combinations of provider types billed during preoperative, operative, and postdischarge care for colon cancer surgery and assessed how this count varies across hospitals...
December 14, 2018: Journal of Oncology Practice
Derek Weycker, Mark Bensink, Alexander Lonshteyn, Robin Doroff, David Chandler
BACKGROUND: Guidelines recommend primary prophylactic use of colony-stimulating factor (PP-CSF) when risk of febrile neutropenia (FN)-based on chemotherapy and patient risk factors-is high. Whether and how PP-CSF use may have changed over time (e.g., due to guideline revisions, increasing use of myelosuppressive regimens, controversy regarding inappropriate CSF use), and whether there has been a concomitant change in the incidence of FN, is unknown. METHODS: A retrospective cohort design and data from two US healthcare claims repositories were employed...
December 14, 2018: Current Medical Research and Opinion
Cuixia Liu, Guifeng Yang, Ni Liu, Zhenping Zhou, Bole Cao, Peng Zhou, Bin Yang
<i>Background:</i> Gastric cancer is one of the most common cancers and is the second leading cause of cancer mortality worldwide. The present study aimed to investigate the potential biological effect of long non-coding RNA (lncRNA) BNC2-AS1 on the proliferation, migration, and invasion of cervical cancer cells. <i>Methods:</i> BNC2-AS1 small interfering RNA (siRNA) was transfected into SGC7901 and BGC823 gastric cancer cell lines, with negative siRNA serving as a control. A reverse transcription-quantitative polymerase chain reaction assay was performed to confirm the knockdown of BNC2-AS1...
October 31, 2018: Clinical Laboratory
Akira Horiuchi, Tamaki Ikuse, Naoki Tanaka
Colonoscopy has been shown to reduce the risk of colon cancer by enabling the removal of precancerous lesions. Although the cold snare and hot snare polypectomy have similar retrieval rates and complete resection rates, the rates of delayed bleeding tend to be lower with cold snare polypectomy than with hot snare polypectomy, especially for patients taking antithrombotic agents. However, among cold snares there may be differences in terms of the completeness of polyp excision, as complete removal appears more likely with thin-wire dedicated cold snares compared to the traditional, thick-wire cold snares...
December 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Chengzhi Wang, Manyi Yang, Jinfeng Zhao, Xia Li, Xiangcheng Xiao, Yang Zhang, Xin Jin, Mingmei Liao
OBJECTIVE: Glycochenodeoxycholate acid (GCDA) is a toxic component in bile salts. It plays an important role in the development and progression of liver cancer. In this study, we investigated the underlying mechanism of GCDA in hepatocarcinogenesis and chemotherapy resistance. MATERIALS AND METHODS: Cell proliferation was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and clonality by Ki-67 and colony-formation assay. Apoptosis was examined by flow cytometry...
December 12, 2018: Journal of Cellular Physiology
Shuichi Nakamura, Kenji Nakai, Momoko Sakata, Yoshio Nagaoka, Kozue Yoshida, Uichiro Katsumata, Toshimi Chiba, Keiji Matsubayashi
Lactococcus garvieae is a well-known fish pathogen that has low virulence in humans and is rarely isolated from the blood cultures of endocarditis patients. We describe herein the first reported case of transfusion-transmitted L. garvieae sepsis caused by a contaminated platelet concentrate from a donor who consumed raw octopus before blood donation. Retrospective examination of the laboratory results of the index donor revealed that his haemoglobin levels had been steadily decreasing, which led to the detection of a latent colon cancer...
December 12, 2018: Vox Sanguinis
Ketra Rice, Krishna Sharma, Chunyu Li, Lynn Butterly, Joanne Gersten, Amy DeGroff
BACKGROUND: Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Screening Program implemented a patient navigation (PN) intervention to increase colonoscopy screening among low-income patients in health centers in New Hampshire. In the current study, the authors examined the cost-effectiveness of this intervention...
December 12, 2018: Cancer
Ye Jin, Yang Liu, Lei Zhao, Fuya Zhao, Jing Feng, Shengda Li, Huinan Chen, Jiayu Sun, Biqiang Zhu, Rui Geng, Yunwei Wei
BACKGROUND: Colorectal cancer (CRC) is a common disease worldwide that is strongly associated with the gut microbiota. However, little is known regarding the gut microbiota after surgical treatment. METHODS: 16S rRNA gene sequencing was used to evaluate differences in gut microbiota among colorectal adenoma patients, CRC patients, CRC postoperative patients and healthy controls by comparing gut microbiota diversity, overall composition and taxonomic signature abundance...
December 10, 2018: Environmental Microbiology
Katarzyna Skonieczna, Arkadiusz Jawień, Andrzej Marszałek, Tomasz Grzybowski
BACKGROUND: p53 is a tumour suppressor protein that is involved in many cancer-related processes. Growing evidence suggests that p53 also plays an important role in mtDNA maintenance. Somatic mitogenome mutations are frequently observed in colorectal cancer cells. Thus, it was important to verify whether somatic mtDNA changes are associated with TP53 mutational status. METHODS: Here, we analysed the TP53 gene in 67 colorectal cancer patients, for whom mitogenome haplotypes were previously described...
December 10, 2018: Journal of Gene Medicine
Shiho Ueda, Hidemi Hayashi, Takako Miyamoto, Shinya Abe, Kana Hirai, Kanji Matsukura, Hideki Yagi, Yuta Hara, Kinji Yoshida, Shogo Okazaki, Masakazu Tamura, Yuki Abe, Toshinori Agatsuma, Shin-Ichiro Niwa, Kazue Masuko, Takashi Masuko
L-type amino-acid transporter 1 (LAT1) disulfide-linked to the CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In this study, we developed novel anti-LAT1 mAbs, and demonstrated the internalization activity, inhibitory effects of amino acid uptake and cell growth and antibody-dependent cellular cytotoxicity, as well as in vivo anti-tumor effects in athymic mice. Furthermore, we examined the reactivity of mAbs with LAT1 of Macaca fascicularis to evaluate possible side effects of anti-human LAT1 mAbs in clinical trials...
December 10, 2018: Cancer Science
Shuang Ma, Wan-Lin Zhang, Bruce D Leckey, Hong-Tao Xu, Lian-He Yang, Endi Wang
BACKGROUND: Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and subsequently up-regulate its expression, and also to attempt to suppress the malignant biological behavior of and enhance the radiosensitivity in lung cancer cells with hypermethylation of the Dab2 gene...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Yanrong Su, Nathan R Hopfinger, Theresa D Nguyen, Thomas J Pogash, Julia Santucci-Pereira, Jose Russo
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is increasing evidence showing that epigenetic mechanisms are involved in the activation of EMT. The objective of this study is to epigenetically reverse the process of EMT in TNBC by using DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi)...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Bing Liu, Shimeng Pan, Yang Xiao, Qianqian Liu, Jingchao Xu, Li Jia
BACKGROUND: Long non-coding RNAs (LncRNAs) emerging as pivotal marker in the procession of cancer, including colorectal cancer (CRC). Abnormal O-glycosylation is a crucial modification during cancer malignancy. The aim of this work is to analyze the alteration of O-glycosylation involved in CRC progression. METHODS: qRT-PCR is utilized to screen the differential linc01296 expression in CRC tissues and cell lines. Functionally, CRC cell proliferation, aggressiveness and apoptosis are measured through relevant experiments, including CCK8 assay, colony formation assay, transwell assay, western blot and flow cytometry...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Jinlan Gao, Chenyang Zhao, Qi Liu, Xiaoyu Hou, Sen Li, Xuesha Xing, Chunhua Yang, Yang Luo
BACKGROUND: Gastric cancer is one of the most common malignant tumors. Cyclin G2 has been shown to be associated with the development of multiple types of tumors, but its underlying mechanisms in gastric tumors is not well-understood. The aim of this study is to investigate the role and the underlying mechanisms of cyclin G2 on Wnt/β-catenin signaling in gastric cancer. METHODS: Real-time PCR, immunohistochemistry and in silico assay were used to determine the expression of cyclin G2 in gastric cancer...
December 14, 2018: Journal of Experimental & Clinical Cancer Research: CR
Anwar Tawfik Amin, Ahmed A S Salem, Abeer Ibrahim
BACKGROUND: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. This study aims at evaluating the post-operative outcomes after multi-visceral resection of locally advanced gastrointestinal cancers. PATIENTS AND METHODS: Ninety patients who underwent extended and multi-visceral resection for GIT cancers invading or adhering to adjacent organs have been included...
December 14, 2018: Journal of Gastrointestinal Cancer
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