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Yang Yu, Lihe Yan, Mengmeng Yue, Huanhuan Xu
Reduced graphene oxide (rGO) functionalized with silver nanoparticles (Ag NPs) is prepared using a femtosecond laser ablation in liquids method. By ablating the mixed aqueous solutions of silver nitrate and graphene oxide (GO) using femtosecond laser pulses, Ag ions and GO are simultaneously reduced and well-dispersed Ag NPs supported on rGO are obtained. The effect of laser power, irritation time and Ag ion concentration on the optical property and morphology of the products are systematically studied. The nonlinear optical responses of the functionalized graphene are studied using a nanosecond Z-scan technique...
July 2018: Royal Society Open Science
Bjarki Gudmundsson, Hans G Thormar, Albert Sigurdsson, Wendy Dankers, Margret Steinarsdottir, Stefan Hermanowicz, Stefan Sigurdsson, David Olafsson, Anna M Halldorsdottir, Stephen Meyn, Jon J Jonsson
DNA damage assays have various limitations in types of lesions detected, sensitivity, specificity and samples that can be analyzed. The Northern Lights Assay (NLA) is based on 2D Strandness-Dependent Electrophoresis (2D-SDE), a technique that separates nucleic acids based on length, strandness, structure and conformation changes induced by damage. NLA is run on a microgel platform in 20-25 min. Each specimen is analyzed in pairs of non-digested DNA to detect single- and double-stranded breaks (DSBs) and Mbo I-digested DNA to detect other lesions...
July 24, 2018: Nucleic Acids Research
James M Wainaina, Elijah Ateka, Timothy Makori, Monica A Kehoe, Laura M Boykin
Sweet potato is a major food security crop within sub-Saharan Africa where 90% of Africa production occurs. One of the major limitations of sweet potato production are viral infections. In this study, we used a combination of whole genome sequences from a field isolate obtained from Kenya and those available in GenBank. Sequences of four sweet potato viruses: Sweet potato feathery mottle virus ( SPFMV ), Sweet potato virus C ( SPVC ), Sweet potato chlorotic stunt viru s ( SPCSV ), Sweet potato chlorotic fleck virus ( SPCFV ) were obtained from the Kenyan sample...
2018: PeerJ
Ryan A Hill, Marc H Weber, Rick M Debbout, Scott G Leibowitz, Anthony R Olsen
Natural and human-related landscape features influence the ecology and water quality of lakes. Summarizing these features in a hydrologically meaningful way is critical to understanding and managing lake ecosystems. Such summaries are often done by delineating watershed boundaries of individual lakes. However, many technical challenges are associated with delineating hundreds or thousands of lake watersheds at broad spatial extents. These challenges can limit the application of analyses and models to new, unsampled locations...
June 1, 2018: Freshwater Science (Print)
Ann R Strom, William T N Culp, Brian C Leonard, Jonathan D Dear, Erik R Wisner, Lynelle R Johnson, David J Maggs
OBJECTIVE To describe and evaluate outcomes of a multidisciplinary, minimally invasive approach combining lacrimoscopy and fluoroscopically guided stenting for management of nasolacrimal apparatus (NLA) obstruction in dogs. DESIGN Prospective, nonrandomized clinical trial. ANIMALS 16 client-owned dogs with confirmed NLA obstruction. PROCEDURES Dogs underwent CT contrast dacryocystorhinography, rhinoscopy, and lacrimoscopy. Whenever possible, the NLA was stented, typically with fluoroscopic guidance. RESULTS Median duration of clinical signs prior to treatment was 3...
June 15, 2018: Journal of the American Veterinary Medical Association
Takashi Ikeda, Hiroki Ishihara, Toshio Takagi, Tsunenori Kondo, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe
BACKGROUND: According to the Response Evaluation Criteria in Solid Tumors (RECIST) classification, progressive disease (PD) is defined as target lesion growth (TLG), unequivocal non-target lesion growth (NTLG), or new lesion appearance (NLA). The prognostic impact of the components of PD in tyrosine kinase inhibitor (TKI) therapy for metastatic renal cell carcinoma (mRCC) remains unknown. OBJECTIVE: We retrospectively evaluated the prognostic impact of these PD components on survival in patients with mRCC after first-line TKI therapy...
June 2018: Targeted Oncology
Amreen Mughal, Chengwen Sun, Stephen T O'Rourke
Apelin increases coronary blood flow, cardiac contractility, and cardiac output. Based on these favorable hemodynamic effects, apelin and apelin-like analogs are being developed for treating heart failure and related disorders; however, the molecular mechanisms underlying apelin-induced coronary vasodilation are unknown. This study aimed to elucidate the signaling pathways by which apelin causes smooth muscle relaxation in coronary arteries. Receptors for apelin (APJ receptors) were expressed in coronary arteries, as determined by Western blot and polymerase chain reaction analyses...
August 2018: Journal of Pharmacology and Experimental Therapeutics
Kyung-Hoon Han, Young-Sam Park, Doo-Hee Cho, Yoonjay Han, Jonghee Lee, Byounggon Yu, Nam Sung Cho, Jeong-Ik Lee, Jang-Joo Kim
Recently, we have addressed that a formation mechanism of a nanolens array (NLA) fabricated by using a maskless vacuum deposition is explained as the increase in surface tension of organic molecules induced by their crystallization. Here, as another research using finite difference time domain simulations, not electric field intensities but transmitted energies of electromagnetic waves inside and outside top-emitting blue organic light-emitting diodes (TOLEDs), without and with NLAs, are obtained, to easily grasp the effect of NLA formation on the light extraction of TOLEDs...
June 6, 2018: ACS Applied Materials & Interfaces
Farnaz Malekifard, Minoo Ahmadpour
Giardia duodenalis is one of the most prevalent intestinal protozoa infecting humans and domestic animals. The aim of this study was to identify subspecies of G. duodenalis by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method from fecal samples of naturally infected cattle in the Urmia, West Azerbaijan province, Iran. Overall, 246 fecal specimens were collected from the cattle (diarrheic and healthy) and microscopically examined for G. duodenalis. The PCR-RFLP analysis of glutamate dehydrogenase (gdh) locus was used to identify the genotypes found in cattle...
2018: Veterinary Research Forum
Nan Zhang, Sun Wang, Lin-Feng Fan, Xiao-Min Chen, Xiao-Xin Li
PURPOSE: To compare the changes of soft tissues before and after treatment of functional and skeletal Angle class Ⅲ malocclusion with FRⅢ appliance. METHODS: Thirty patients with functional and skeletal Angel Class Ⅲ malocclusion were selected and treated with FRⅢ appliance,SPSS 22 software package was used to analyzed soft tissue changes before and after treatment. RESULTS: After treatment, FCA,NLA, Pog labial angle,upper lip to E line were increased significantly (P<0...
December 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Lara RodrÍguez-Zamora, Harald K Engan, Angelica Lodin-Sundström, Fanny Schagatay, Xavier Iglesias, Ferran A Rodríguez, Erika Schagatay
A number of competitive water sports are performed while breath-holding (apnea). Such performances put large demands on the anaerobic system, but the study of lactate accumulation in apneic sports is limited. We therefore aimed to determine and compare the net lactate accumulation (NLA) during competition events in six disciplines of competitive freediving (FD) and three disciplines of synchronized swimming (SSW). The FD disciplines were: static apnea (STA; n = 14); dynamic apnea (DYN; n = 19); dynamic apnea no fins (DNF; n = 16); constant weight (CWT; n = 12); constant weight no fins (CNF; n = 8); free immersion (FIM; n =10)...
January 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Matthew E Levy, Alan E Greenberg, Manya Magnus, Naji Younes, Amanda Castel
Statin coverage has been examined among HIV-infected patients using Adult Treatment Panel III (ATP III) and American College of Cardiology/American Heart Association (ACC/AHA) guidelines, although not with newer National Lipid Association (NLA) guidelines. We investigated statin eligibility, prescribing practices, and therapeutic responses using these three guidelines. Sociodemographic, clinical, and laboratory data were collected between 2011 and 2016 for HIV-infected outpatients enrolled in the DC Cohort, a multi-center, prospective, observational study in Washington, DC...
February 2018: AIDS Patient Care and STDs
Cori Russell, Samip Sheth, Douglas Jacoby
PURPOSE OF REVIEW: We provide an overview of our current understanding of combination lipid-lowering therapies intended for dyslipidemia treatment and cardiovascular disease prevention. First, we analyze recent statin and non-statin combination therapy guidelines and clinical studies since the publication of 2013 American College of Cardiology Cholesterol Guidelines. Second, we examine the clinical utility of non-statin agents alone and in combination in terms of LDL-C lowering and ASCVD risk reduction...
March 7, 2018: Current Atherosclerosis Reports
Sungmi Park, Benjamin J Bivona, Lisa M Harrison-Bernard
We have previously reported significant increases in neuronal nitric oxide synthase (NOS) immunostaining in renal arterioles of angiotensin type 1A receptor (AT1A) knockout mice, and in arterioles and macula densa cells of AT1A/AT1B knockout mice. The contribution of nitric oxide derived from endothelial and macula densa cells in the maintenance of afferent arteriolar tone and acetylcholine-induced vasodilation was functionally determined in kidneys of wild-type, AT1A, and AT1A/AT1B knockout mice. Acetylcholine-induced changes in arteriolar diameters of in vitro blood-perfused juxtamedullary nephrons were measured during control conditions, in the presence of the nonspecific NOS inhibitor, Nω -nitro-l-arginine methyl ester (NLA), or the highly selective neuronal NOS inhibitor, N5 -(1-imino-3-butenyl)-l-ornithine (VNIO)...
June 1, 2018: American Journal of Physiology. Renal Physiology
Jie Li, Yuting Huang, Yixin Zhang, Zheming Pu
Background: Rhinoplasty maneuvers to lengthen the nose include placing an alloplastic implant, caudally rotating the lower lateral cartilage (LLC), and stretching the soft tissue skin envelope (STSE) downward. Tissue tension associated with these procedures can result in implant extrusion or tip retraction. Objectives: The authors performed rhinoplasty with implantation of porous polyethylene (Medpor). The Medpor device enabled transfer of tension from the LLC and STSE to the juncture of the septal cartilage and upper lateral cartilage (ULC), thereby stabilizing the nasal structures...
April 6, 2018: Aesthetic Surgery Journal
So Young Choi, Su Jin Kim, Ho Yun Lee, Dong Sik Chang, Myoung Su Choi
BACKGROUND: The positioning of the nasal tip is as esthetically important as the tip projection when rhinoplasty is being considered. It is not uncommon for Asians to have a protruding upper lip and teeth that affect the nasolabial angle (NLA). This study aimed to find the preferred NLA according to the degree of upper lip protrusion in an Asian population. METHODS: A left-side lateral photograph of each participant was used for simulation of six different tip angles by using a photoshop program...
January 1, 2018: American Journal of Rhinology & Allergy
M Ruscica, C Macchi, C Pavanello, A Corsini, A Sahebkar, C R Sirtori
Statins, the most widely used drugs in the Western world, have become a pivotal component in the primary and secondary prevention of vascular diseases. Although benefits have been well documented in younger-than-75-year-old individuals, the value of statins in people aged >75years and over is controversial. The CTT meta-analysis calculated an absolute risk reduction of 0.6%/year per 38.7mg/dl reduction in LDL-C levels in patients aged >75years, that would translate into a number needed to treat of 167...
April 2018: European Journal of Internal Medicine
Jian Yang, Lan Wang, Chuanzao Mao, Honghui Lin
BACKGROUND: Phosphate (Pi), an essential mineral nutrient for plant development and reproduction, is one of the main components of fertilizers in modern agriculture. Previous research demonstrated that AtNLA1 mediates ubiquitination of Pi transporters in the plasma membrane and triggers their endocytosis and degradation in Arabidopsis. In this study, we researched the function of NLA homologous proteins in Pi homeostasis in rice. FINDINGS: Two OsNLA homologs from rice (Oryza sativa L...
December 28, 2017: Rice
M Sina, E Dirandeh, H Deldar, B Shohreh
This study was undertaken to determine the effect of inflammatory status on different patterns of postpartum luteal activity and reproductive performance of Holstein cows during early lactation. The cows (n = 75) averaged 3.4 ± 1.2 (mean ± SEM) in parity and 3.1 ± 0.2 (mean ± SEM) in body condition score at calving. Transrectal ultrasonography was performed twice weekly from day 10-60 postpartum to consider ovarian dynamics. Plasma concentrations of progesterone (P4) and estradiol (E2) were measured twice weekly and plasma levels of tumor necrosis factor alpha (TNF-α) and lipopolysacchride binding protein (LBP) were measured weekly (week 3-6 postpartum)...
March 1, 2018: Theriogenology
Wei-Yi Lin, Yen-Yu Lin, Su-Fen Chiang, Cueihuan Syu, Li-Ching Hsieh, Tzyy-Jen Chiou
Unlike most ancient microRNAs, which conservatively target homologous genes across species, microRNA827 (miR827) targets two different types of SPX (SYG1/PHO81/XPR1)-domain-containing genes, NITROGEN LIMITATION ADAPTATION (NLA) and PHOSPHATE TRANSPORTER 5 (PHT5), in Arabidopsis thaliana and Oryza sativa to regulate phosphate (Pi) transport and storage, respectively. However, how miR827 shifted its target preference and its evolutionary history are unknown. Based on target prediction analysis, we found that in most angiosperms, miR827 conservatively targets PHT5 homologs, but in Brassicaceae and Cleomaceae it preferentially targets NLA homologs, and we provide evidence for the transition of target preference during Brassicales evolution...
March 2018: New Phytologist
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