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National lipid Association

J Thereaux, T Lesuffleur, S Czernichow, A Basdevant, S Msika, D Nocca, B Millat, A Fagot-Campagna
BACKGROUND: Few studies have assessed changes in antihypertensive and lipid-lowering therapy after bariatric surgery. The aim of this study was to assess the 6-year rates of continuation, discontinuation or initiation of antihypertensive and lipid-lowering therapy after bariatric surgery compared with those in a matched control group of obese patients. METHODS: This nationwide observational population-based cohort study used data extracted from the French national health insurance database...
October 16, 2018: British Journal of Surgery
Chau L B Ho, Enayet K Chowdhury, Monique Breslin, Jenny Doust, Christopher M Reid, Lindon M H Wing, Mark R Nelson
BACKGROUND: There is currently insufficient evidence to support the use of lipid-lowering drug treatment (LLT) for primary prevention of cardiovascular disease (CVD) in the elderly. OBJECTIVES: We examined the relationship of early initiation of LLT with short- and long-term all-cause and CVD mortality in persons older than 65 years in this post hoc study from the Second Australian National Blood Pressure study (ANBP2). METHODS: This was an in- and post-trial observational study...
September 6, 2018: Journal of Clinical Lipidology
Omer Shahab, Rakesh Biswas, James Paik, Haley Bush, Pegah Golabi, Zobair M Younossi
Dyslipidemia is one of the common risk factors for NAFLD and is associated with cardiovascular (CV) mortality, which is the most common cause of death in NAFLD. Lipid-lowering agents (LLAs) are used to reduce CV events in the general population. Our aim was to assess whether the use of LLAs in patients with NAFLD can reduce the risk of CV mortality. We used the third National Health and Nutrition Examination Survey mortality linked files. Mortality was determined from the National Death Index records through 2011...
October 2018: Hepatology communications
M-H Kim, H-N Kim, W-S Choi
BACKGROUNDS AND AIMS: We aimed to reveal the association between subclinical inflammation and metabolic risk factors and to determine the difference in the association between normal-weight and obese Korean individuals. METHODS AND RESULTS: Data collected from the Korean National Health and Nutrition Examination Survey (KNHANES) 2015, conducted from January to December 2015, were analyzed. Overall, 4620 subjects were examined and divided into two subgroups: 2987 and 1633 subjects in the normal-weight and obese groups, respectively...
June 25, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Melanie M Mott, Megan A McCrory, Linda G Bandini, Howard J Cabral, Stephen R Daniels, Martha R Singer, Lynn L Moore
OBJECTIVE: Longitudinal data on cardiometabolic effects of egg intake during adolescence are lacking. The current analyses aim to evaluate the impact of usual adolescent egg consumption on lipid levels, fasting glucose, and insulin resistance during late adolescence (age 17-20 years). METHODS: Data from 1392 girls, aged 9 to 10 at baseline and followed for 10 years, in the National Heart, Lung, and Blood Institute's National Growth and Health Study were used to examine the association between usual egg intake alone and in combination with other healthy lifestyle factors and late adolescent lipid levels, fasting glucose, and insulin resistance, measured as homeostasis model assessment of insulin resistance (HOMA-IR)...
October 3, 2018: Journal of the American College of Nutrition
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Jacqueline Honerlaw, David R Gagnon, Scott L DuVall, Jin Li, Gina M Peloso, Mark Chaffin, Aeron M Small, Jie Huang, Hua Tang, Julie A Lynch, Yuk-Lam Ho, Dajiang J Liu, Connor A Emdin, Alexander H Li, Jennifer E Huffman, Jennifer S Lee, Pradeep Natarajan, Rajiv Chowdhury, Danish Saleheen, Marijana Vujkovic, Aris Baras, Saiju Pyarajan, Emanuele Di Angelantonio, Benjamin M Neale, Aliya Naheed, Amit V Khera, John Danesh, Kyong-Mi Chang, Gonçalo Abecasis, Cristen Willer, Frederick E Dewey, David J Carey, John Concato, J Michael Gaziano, Christopher J O'Donnell, Philip S Tsao, Sekar Kathiresan, Daniel J Rader, Peter W F Wilson, Themistocles L Assimes
The Million Veteran Program (MVP) was established in 2011 as a national research initiative to determine how genetic variation influences the health of US military veterans. Here we genotyped 312,571 MVP participants using a custom biobank array and linked the genetic data to laboratory and clinical phenotypes extracted from electronic health records covering a median of 10.0 years of follow-up. Among 297,626 veterans with at least one blood lipid measurement, including 57,332 black and 24,743 Hispanic participants, we tested up to around 32 million variants for association with lipid levels and identified 118 novel genome-wide significant loci after meta-analysis with data from the Global Lipids Genetics Consortium (total n > 600,000)...
October 1, 2018: Nature Genetics
Maha Saber-Ayad, Shaista Manzoor, Ahmed El Serafi, Ibrahim Mahmoud, Sarah Hammoudeh, Aghila Rani, Salah Abusnana, Nabil Sulaiman
BACKGROUND: Fat mass and obesity-associated protein gene variants have shown diverse influence on body weight and metabolism across different populations. Overweight, obesity and metabolic syndrome are multifactorial major health problems in the UAE and worldwide. Insulin resistance represents the link between overweight and development of metabolic syndrome and type 2 diabetes mellitus. We investigated two (FTO) variants in Emirati population, in relation to insulin resistance and different parameters of metabolic syndrome...
September 29, 2018: Gene
Nay Chi Htun, Hitomi Suga, Shino Imai, Wakana Shimizu, Kazuko Ishikawa-Takata, Hidemi Takimoto
BACKGROUND AND OBJECTIVES: Little is known about the association between dietary patterns and cardiovascular disease risk factors among Japanese adults based on nationally representative data. This study aimed to explore the association between dietary patterns and hypertension or blood lipid profiles among Japanese people. METHODS AND STUDY DESIGN: De-identified Japan National Health and Nutrition Survey (NHNS) 2012 data with a total of 8721 subjects (3524 men and 5197 women) aged 40-74 years were used...
2018: Asia Pacific Journal of Clinical Nutrition
T E Strandberg, K Räikkönen, V Salomaa, A Strandberg, H Kautiainen, M Kivimäki, K Pitkälä, J Huttunen
OBJECTIVES: In a 5-year multifactorial risk reduction intervention for healthy men with at least one cardiovascular disease (CVD) risk factor, mortality was unexpectedly higher in the intervention than the control group during the first 15-year follow-up. In order to find explanations for the adverse outcome, we have extended mortality follow-up and examined in greater detail baseline characteristics that contributed to total mortality. DESIGN: Long-term follow-up of a controlled intervention trial...
2018: Journal of Nutrition, Health & Aging
Olivier S Descamps, Olivier Van Caenegem, Michel P Hermans, Jean-Luc Balligand, Christophe Beauloye, Antoine Bondue, Stéphane Carlier, Emilie Castermans, Fabien Chenot, Marc Claeys, Christophe De Block, Anne de Leener, Antoine De Meester, Fabian Demeure, Herbert De Raedt, Walter Desmet, Ivan Elegeert, Michel Guillaume, Etienne Hoffer, Raymond Kacenelenbogen, Patrizio Lancellotti, Michel Langlois, Attilio Leone, Ann Mertens, Nicolas Paquot, Olivier Vanakker, Jean-Louis Vanoverschelde, Ann Verhaegen, Pieter Vermeersch, Caroline Wallemacq, Ernst Rietzschel
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is an autosomal dominant lipoprotein disorder characterized by significant elevation of low-density lipoprotein cholesterol (LDL-C) and markedly increased risk of premature cardiovascular disease (CVD). Because of the very high coronary artery disease risk associated with this condition, the prevalence of FH among patients admitted for CVD outmatches many times the prevalence in the general population. Awareness of this disease is crucial for recognizing FH in the aftermath of a hospitalization of a patient with CVD, and also represents a unique opportunity to identify relatives of the index patient, who are unaware they have FH...
October 2018: Atherosclerosis
Susan Smolinske, Robert S Hoffman, Eric Villeneuve, Lotte C G Hoegberg, Sophie Gosselin
OBJECTIVE: Although anecdotal reports suggest that intravenous lipid emulsion (ILE) therapy is effective in a large variety of overdoses, the few controlled human trials published to date yielded disappointing results. Because of potential publication biases, there are few reports concerning the failure of ILE. The primary aim of this study was to identify fatal poisoning cases in the American Association of Poison Control Centers (AAPCC) National Poison Data System (NPDS) in which ILE was administered...
September 27, 2018: Clinical Toxicology
Petroula Proitsi, Diana Kuh, Andrew Wong, Jane Maddock, Rebecca Bendayan, Wahyu Wulaningsih, Rebecca Hardy, Marcus Richards
Maintenance of healthy cognitive ageing is vital for independence and wellbeing in the older general population. We investigated the association between blood metabolites and cognitive function and decline. Participants from the MRC National Survey of Health and Development (NSHD, the British 1946 birth cohort) were studied; 233 nuclear magnetic resonance circulating metabolite measures were quantified in 909 men and women at ages 60-64. Short-term and delayed verbal memory and processing speed were concurrently assessed and these tests were repeated at age 69...
September 26, 2018: Translational Psychiatry
Piers Blackett, Minu George, Don P Wilson
Pediatric lipid screening and management with the aim of reducing and preventing adult disease is an internationally accepted concept, and guidelines have been published in several countries. However, implementation by the practicing pediatric community in the United States has been less than expected and delays have been attributed to uncertainty among providers. Reduced screening rates have also been reported for conditions contributing to arterial wall pathology such as obesity, hypertension, and prediabetes despite accumulating evidence that detection and intervention can lead to risk reversal...
August 29, 2018: Journal of Clinical Lipidology
Jimin Lee, Sukhyang Lee
STUDY OBJECTIVE: Patients with coronary heart disease (CHD) frequently use the combination of a statin and renin-angiotensin-aldosterone system (RAAS) blocker- an angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB)-to control lipid levels and blood pressure, respectively, and the use of ARBs is increasing in Korean patients. Few studies are available, however, that have compared combination therapy with statin-ACEIs versus statin-ARBs. The objective of this study was to evaluate whether ARBs are associated with a reduced risk of major adverse cardiovascular and cerebrovascular events (MACCEs) compared with ACEIs when used in combination with statins in patients with established CHD...
September 17, 2018: Pharmacotherapy
Jianati Anniwaer, Meng-Zhuang Liu, Ke-Dong Xue, Abuduzhayier Maimaiti, Aersilan Xiamixiding
PURPOSE: Although hyperhomocysteinemia (Hhcy) is a risk factor for cerebral infarction, its effect on recurrent cerebral infarction is less-defined. We aimed to investigate the association of Hhcy and increased risk of recurrent cerebral infarct. MATERIALS AND METHODS: From 2011-2013, we recruited 231 primary cerebral infarct patients that were divided to a Hhcy group (n = 105) and a control group (n = 126) according to plasma homocysteinemia (Hcy) levels exceeding 15μmol/L...
September 14, 2018: International Journal of Neuroscience
Kai-Hung Cheng, Jr-Rung Lin, Craig S Anderson, Wen-Ter Lai, Tsong-Hai Lee
Background: Low lipid level is associated with better cardiovascular outcome. However, lipid paradox indicating low lipid level having worse outcomes could be seen under acute injury in some diseases. The present study was designed to clarify the prognostic significance of acute-phase lipid levels within 1 day after admission for stroke on mortality in first-ever statin-naïve acute ischemic stroke (IS) and hemorrhagic stroke (HS). Methods: This observational study was conducted using the data collected from Stroke Registry In Chang-Gung Healthcare System (SRICHS) between 2009 and 2012...
2018: Frontiers in Neurology
Yan Wang, Jun Zhang, Yanrong Ma, Xiangxin Song, Suli Li, Xianqin Zhan, Lan Wu
BACKGROUND: This study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance. METHODS: Participants' data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson's correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics. RESULTS: HOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0...
September 7, 2018: Lipids in Health and Disease
Piyushkumar A Mundra, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Kaushala S Jayawardana, Corey Giles, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Gerard Wong, Bronwyn A Kingwell, John Simes, Andrew M Tonkin, Peter J Meikle
BACKGROUND: Plasma lipidomic measures may enable improved prediction of cardiovascular outcomes in secondary prevention. The aim of this study is to determine the association of plasma lipidomic measurements with cardiovascular events and assess their potential to predict such events. METHODS: Plasma lipids (n = 342) were measured in a retrospective subcohort (n = 5,991) of the LIPID study. Proportional hazards regression was used to identify lipids associated with future cardiovascular events (nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death) and cardiovascular death...
September 6, 2018: JCI Insight
(no author information available yet)
According to the national survey data over the past five years, there are about 50.16 million elderly diabetic patients (≥60 years old) in China. With the increase in the total number of the elderly, this number will be expected to increase. Among the elderly patients, most of them are newly diagnosed, and are associated with a number of risk factors for cardiovascular diseases at the time of initial diagnosis. Those who were with young-onset have a long-term clinical course, and often complicated with diabetic chronic complications and potential organ dysfunctions...
September 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
F D H Olalere, B O Okusanya, B A Oye-Adeniran
OBJECTIVE: This was to determine the serum lipid profile of preeclamptic women and their association with severity of preeclampsia. METHODS: This was a case control study conducted at the Lagos University Teaching Hospital, Lagos, Nigeria. Blood samples for serum lipid estimation were collected after an overnight fast. The National Cholesterol Education Program - Adult Treatment Panel (ATP) III criteria were used to define dyslipidemia. RESULTS: Two hundred forty women participated in the study...
September 3, 2018: Journal of Maternal-fetal & Neonatal Medicine
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