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National lipid Association

Mousa Abujbara, Anwar Batieha, Yousef Khader, Hashem Jaddou, Mohammed El-Khateeb, Kamel Ajlouni
Background: Dyslipidemia is one of the major modifiable risk factors for the development of cardiovascular disease and type two diabetes mellitus. Knowing the current prevalence of dyslipidemia is an important step for increasing awareness of the problem and for proper planning of health programs for prevention of its negative clinical effects. Methods: A national population based household sample was selected from north, middle, and south regions of Jordan in 2017...
2018: Journal of Lipids
Zhi Luo, Shujin Li, Irfan Muhammad, Md Rezaul Karim, Yongyan Song
BACKGROUND: Previous studies have investigated the associations of paraoxonase 1 (PON1) rs854560 polymorphism with plasma lipid levels, but the results are inconclusive. This meta-analysis aimed to clarify the associations of the rs854560 polymorphism with plasma lipid levels. METHODS: A comprehensive search of the literature was carried out by using the databases which include Medline, Google Scholar, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database up till August 2018...
December 3, 2018: Lipids in Health and Disease
Ting-Chun Lin, Yen-Kuang Lin, Chin-I Chen, Lung Chan, Nai-Fang Chi, Rey-Yue Yuan, Jau-Jiuan Sheu, Chun-Ren Wei, Jui-Ping Tsai, Tu-Hsueh Yeh
Background: This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods: We retrospectively analyzed consecutive ischemic stroke patients who were treated with intravenous tissue plasminogen activator between January 2007 and January 2017. Lipid levels on admission, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels, as well as potential predictors of sICH were tested using univariate and multivariate analyses...
2018: PeerJ
Amna Umer, Candice Hamilton, Roger A Edwards, Lesley Cottrell, Peter Giacobbi, Kim Innes, Collin John, George A Kelley, William Neal, Christa Lilly
Introduction The immediate benefits of breastfeeding are well-established but the long-term health benefits are less well-known. West Virginia (WV) has a higher prevalence of cardiovascular disease (CVD) and lower breastfeeding rates compared to national averages. There is a paucity of research examining the relationship between breastfeeding and subsequent childhood CVD risk factors, an issue of particular relevance in WV. Methods This study used longitudinally linked data from three cross-sectional datasets in WV (N = 11,980)...
November 29, 2018: Maternal and Child Health Journal
Sofia Axia Karlsson, Stefan Franzén, Ann-Marie Svensson, Mervete Miftaraj, Björn Eliasson, Karolina Andersson Sundell
BACKGROUND: Management of type 2 diabetes mellitus (T2DM) encompasses intensive glycaemic control, along with treatment of comorbidities and complications to handle the increased risk of cardiovascular disease (CVD). Improved control of LDL-cholesterol (LDL-C) with lipid-lowering medications is associated with reduced CVD risk in T2DM patients. Thus, treatment guidelines recommend lipid-lowering medications for T2DM patients with LDL-C above risk-associated thresholds. This study aimed to assess healthcare provider adherence to guidelines regarding lipid-lowering medication prescription among T2DM patients and to analyse factors associated with lipid-lowering medication prescription...
November 28, 2018: BMC Health Services Research
A E de Wit, E J Giltay, M K de Boer, F J Bosker, R C van der Mast, H C Comijs, R C Oude Voshaar, R A Schoevers
OBJECTIVES: Older age and Major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and Metabolic Syndrome (MetS) in men, though associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. METHODS: In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons (NESDO) were included...
November 26, 2018: International Journal of Geriatric Psychiatry
Sonia Cortassa, Viviane Caceres, Carlo G Tocchetti, Michel Bernier, Rafael de Cabo, Nazareno Paolocci, Steven J Sollott, Miguel A Aon
KEY POINTS: Hearts from type 2 diabetic animals display perturbations in excitation-contraction coupling, impairing myocyte contractility and delaying relaxation, along with altered substrate consumption patterns. Under high glucose and β-adrenergic stimulation conditions, palmitate can, at least in part, offset left ventricle (LV) dysfunction in hearts from diabetic mice improving contractility and relaxation while restoring coronary perfusion pressure. Fluxome calculations of central catabolism in diabetic hearts show that, in presence of palmitate, there is a metabolic remodeling involving tricarboxylic acid cycle, polyol and pentose phosphate pathways, leading to improved redox balance in cytoplasmic and mitochondrial compartments...
November 21, 2018: Journal of Physiology
Ping Zeng, Xiang Zhou
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disorder that is predicted to increase across the globe by ~70% in the following decades. Understanding the disease causal mechanism underlying ALS and identifying modifiable risks factors for ALS hold the key for the development of effective preventative and treatment strategies. Here, we investigate the causal effects of four blood lipid traits that include high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG) on the risk of ALS...
November 16, 2018: Human Molecular Genetics
Huifeng Jin, Jessie Nicodemus-Johnson
Dyslipidemia is a precursor to a myriad of cardiovascular diseases in the modern world. Age, gender, and diet are known modifiers of lipid levels, however they are not frequently investigated in subset analyses. Food and nutrient intakes from National Health and Nutrition Examination Study 2001⁻2013 were used to assess the correlation between lipid levels (high-density lipoprotein (HDL) cholesterol, triglycerides (TG), low-density lipoprotein (LDL) cholesterol, and total cholesterol (TC):HDL cholesterol ratio) and nutritional intake using linear regression...
November 14, 2018: Nutrients
Pooneh Angoorani, Majid Khademian, Hanieh-Sadat Ejtahed, Ramin Heshmat, Mohammad Esmaeil Motlagh, Mahya Vafaeenia, Gita Shafiee, Armita Mahdivi-Gorabi, Mostafa Qorbani, Roya Kelishadi
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7-18 years...
November 14, 2018: Lipids in Health and Disease
Ram B Jain, Alan Ducatman
Data from National Health and Nutrition Examination Survey (NHANES) for 2005-2014 for those aged ≥20 years fasting for ≥8 h (N = 3629) were analyzed to evaluate the role that gender and obesity play in defining correlations between selected perfluoroalkyl substances (PFAS) and total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides. PFAS considered for analyses were: perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA), perfluorohexane sulfonate (PFHxS), perfluoroundecanoic acid (PFUnDA), and 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (Me-FOSAA)...
October 29, 2018: Science of the Total Environment
Torfinn S Madssen, Inger Thune, Vidar G Flote, Steinar Lundgren, Gro F Bertheussen, Hanne Frydenberg, Erik Wist, Ellen Schlichting, Hartmut Schäfer, Hans E Fjøsne, Riyas Vettukattil, Jon Lømo, Tone F Bathen, Guro F Giskeødegård
BACKGROUND: Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment between recipients and non-recipients of chemotherapy, and describe metabolite profiles associated with treatment-related weight gain. METHODS: This pilot study includes 60 stage I/II breast cancer patients who underwent surgery and were treated according to national guidelines...
October 2018: British Journal of Cancer
Maria Beatriz Trindade de Castro, Diana Barbosa Cunha, Marina Campos Araujo, Ilana Nogueira Bezerra, Amanda Rodrigues Amorim Adegboye, Gilberto Kac, Rosely Sichieri
There is evidence in the general population that adhering to a high protein and low carbohydrate diet may help in losing weight. However, there is little evidence among postpartum women. The aim of this study is to evaluate the effect of a high protein diet on weight loss among postpartum women. A parallel-randomized controlled trial with ninety-four postpartum women was conducted in a maternity ward in Mesquita county (recruitment from February 2009 to December 2010) and in a polyclinic in Rio de Janeiro city (recruitment from December 2010 to December 2011)...
October 31, 2018: Maternal & Child Nutrition
Runqi Wangqin, Daniel T Laskowitz, Yongjun Wang, Zixiao Li, Yilong Wang, Liping Liu, Li Liang, Roland A Matsouaka, Jeffrey L Saver, Gregg C Fonarow, Deepak L Bhatt, Eric E Smith, Lee H Schwamm, Janet Prvu Bettger, Adrian F Hernandez, Eric D Peterson, Ying Xian
Background Adherence to evidence-based guidelines is an important quality indicator; yet, there is lack of assessment of adherence to performance measures in acute ischemic stroke for most world regions. Methods and Results We analyzed 19 604 patients with acute ischemic stroke in the China National Stroke Registry and 194 876 patients in the Get With The Guidelines--Stroke registry in the United States from June 2012 to January 2013. Compared with their US counterparts, Chinese patients were younger, had a lower prevalence of comorbidities, and had similar median, lower mean, and less variability in National Institutes of Health Stroke Scale (median 4 [25th percentile-75th percentile, 2-7], mean 5...
October 16, 2018: Journal of the American Heart Association
Xingxing Song, Weijing Wang, Zongyao Li, Dongfeng Zhang
BACKGROUND: As an essential trace element, copper has been considered to play an important role in lipid metabolism. However, the associations of serum copper with lipid concentration and dyslipidemia are still controversial. METHODS: We used the 2011-2014 National Health and Nutrition Examination Survey to examine the relationship between serum copper and lipid concentration among participants aged 20 years and older. Multivariate linear regression was conducted to estimate the differences in the level of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol...
October 26, 2018: Annals of Nutrition & Metabolism
Slaven Pikija, Laszlo K Sztriha, Monika Killer-Oberpfalzer, Friedrich Weymayr, Constantin Hecker, Christian Ramesmayer, Larissa Hauer, Johann Sellner
The contribution of lipids, including low- and high-density lipoprotein cholesterol (LDL-C and HDL-C, respectively) and triglycerides (TG), to stroke outcomes is still debated. We sought to determine the impact of LDL-C concentrations on the outcome of patients with ischemic stroke in the anterior circulation who received treatment with endovascular thrombectomy (EVT). We performed a retrospective analysis of consecutive patients with acute ischemic stroke treated at a tertiary center between 2012 and 2016...
October 23, 2018: Molecular Neurobiology
J Thereaux, T Lesuffleur, S Czernichow, A Basdevant, S Msika, D Nocca, B Millat, A Fagot-Campagna
BACKGROUND: Few studies have assessed changes in antihypertensive and lipid-lowering therapy after bariatric surgery. The aim of this study was to assess the 6-year rates of continuation, discontinuation or initiation of antihypertensive and lipid-lowering therapy after bariatric surgery compared with those in a matched control group of obese patients. METHODS: This nationwide observational population-based cohort study used data extracted from the French national health insurance database...
October 16, 2018: British Journal of Surgery
Chau L B Ho, Enayet K Chowdhury, Monique Breslin, Jenny Doust, Christopher M Reid, Lindon M H Wing, Mark R Nelson
BACKGROUND: There is currently insufficient evidence to support the use of lipid-lowering drug treatment (LLT) for primary prevention of cardiovascular disease (CVD) in the elderly. OBJECTIVES: We examined the relationship of early initiation of LLT with short- and long-term all-cause and CVD mortality in persons older than 65 years in this post hoc study from the Second Australian National Blood Pressure study (ANBP2). METHODS: This was an in- and post-trial observational study...
September 6, 2018: Journal of Clinical Lipidology
Omer Shahab, Rakesh Biswas, James Paik, Haley Bush, Pegah Golabi, Zobair M Younossi
Dyslipidemia is one of the common risk factors for NAFLD and is associated with cardiovascular (CV) mortality, which is the most common cause of death in NAFLD. Lipid-lowering agents (LLAs) are used to reduce CV events in the general population. Our aim was to assess whether the use of LLAs in patients with NAFLD can reduce the risk of CV mortality. We used the third National Health and Nutrition Examination Survey mortality linked files. Mortality was determined from the National Death Index records through 2011...
October 2018: Hepatology communications
M-H Kim, H-N Kim, W-S Choi
BACKGROUNDS AND AIMS: We aimed to reveal the association between subclinical inflammation and metabolic risk factors and to determine the difference in the association between normal-weight and obese Korean individuals. METHODS AND RESULTS: Data collected from the Korean National Health and Nutrition Examination Survey (KNHANES) 2015, conducted from January to December 2015, were analyzed. Overall, 4620 subjects were examined and divided into two subgroups: 2987 and 1633 subjects in the normal-weight and obese groups, respectively...
November 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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