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Physical therapy and multiple sclerosis

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https://www.readbyqxmd.com/read/28331298/psychosocial-predictors-of-patient-adherence-to-disease-modifying-therapies-for-multiple-sclerosis
#1
Fahad D Alosaimi, Alaa AlMulhem, Hanan AlShalan, Mohammad Alqazlan, Abdulgader Aldaif, Matthew Kowgier, Janooshsheya Balasundaram, Sanjeev Sockalingam
OBJECTIVES: Our aim was to identify the impact of psychosocial predictors, specifically relationship style, depressive symptoms, anxiety symptoms, cognitive impairment, and culture-specific disease beliefs, on treatment adherence for multiple sclerosis (MS) patients. METHODS: In this cross-sectional observational study, patients from two MS clinics in Saudi Arabia completed self-reported questionnaires focused on MS treatment adherence, physical symptom burden, relationship style, cultural beliefs, depressive symptoms, anxiety, and cognitive impairment...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28283110/access-delivery-and-perceived-efficacy-of-physiotherapy-and-use-of-complementary-and-alternative-therapies-by-people-with-progressive-multiple-sclerosis-in-the-united-kingdom-an-online-survey
#2
Evan Campbell, Elaine Coulter, Paul Mattison, Angus McFadyen, Linda Miller, Lorna Paul
INTRODUCTION: All people with progressive MS in the United Kingdom should have access to physiotherapy through the National Health Service (NHS). However levels of access and delivery are unknown. Furthermore there is no research on perceived efficacy of physiotherapy or the use of complementary and alternative medicine in people with progressive MS in the United Kingdom. METHODS: An online survey was carried out via the UK MS Register. Inclusion criteria were diagnosis of progressive MS, a member of UK MS Register and 18 years or older...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28273780/risk-factors-for-non-adherence-to-disease-modifying-therapy-in-pediatric-multiple-sclerosis
#3
Carolyn E Schwartz, Stephanie A Grover, Victoria E Powell, Austin Noguera, Jean K Mah, Soe Mar, Lauren Mednick, Brenda L Banwell, Gulay Alper, Mary Rensel, Mark Gorman, Amy Waldman, Teri Schreiner, Emmanuelle Waubant, E Ann Yeh
BACKGROUND: Adherence to disease-modifying therapies (DMTs) in pediatric multiple sclerosis (MS) is not well understood. We examined the prevalence and risk factors for poor adherence in pediatric MS. METHODS: This cross-sectional study recruited youth with MS from 12 North American pediatric MS clinics. In addition to pharmacy-refill data, patients and parents completed self-report measures of adherence and quality of life. Additionally, patients completed measures of self-efficacy and well-being...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28271325/nebulization-of-rns60-a-physically-modified-saline-attenuates-the-adoptive-transfer-of-experimental-allergic-encephalomyelitis-in-mice-implications-for-multiple-sclerosis-therapy
#4
Susanta Mondal, Suresh B Rangasamy, Supurna Ghosh, Richard L Watson, Kalipada Pahan
Developing a new and effective therapeutic approach against multiple sclerosis (MS) is always an important area of research. RNS60 is a bioactive aqueous solution generated by subjecting normal saline to Taylor-Couette-Poiseuille flow under elevated oxygen pressure. Recently we have demonstrated that RNS60, administered through intraperitoneal injection, ameliorated clinical symptoms and disease progression of experimental allergic encephalomyelitis (EAE), an animal model of MS. Since the intravenous route is not preferred for treating a chronic condition, we tested if nebulization of RNS60 could attenuate the disease process of adoptively-transferred EAE in mice...
March 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28267811/patient-education-for-people-with-multiple-sclerosis-associated-fatigue-a-systematic-review
#5
Maria Janina Wendebourg, Christoph Heesen, Marcia Finlayson, Björn Meyer, Jana Pöttgen, Sascha Köpke
BACKGROUND: Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease often causing decreased quality of life, social withdrawal and unemployment. Studies examining the effect of pharmacological interventions demonstrated only minor effects, whereas non-pharmacological interventions as e.g. patient education programs have shown promising results. OBJECTIVE: We aim to systematically review the literature to determine the effect of patient education programs on fatigue in MS...
2017: PloS One
https://www.readbyqxmd.com/read/28243183/multidisciplinary-management-of-sexual-dysfunction-perineal-pain-and-elimination-dysfunction-in-a-woman-with-multiple-sclerosis
#6
Michela Miletta, Fabrizio Bogliatto, Leonardo Bacchio
BACKGROUND: Multiple sclerosis (MS) is a chronic disease that commonly affects young women and is associated with sexual dysfunction (SD) and lower anourogenital dysfunction, which affect quality of life. We evaluated the importance of an integrated multidisciplinary approach in the Lower Female Ano-Uro-Genital Network (LFAUGN) to manage a variety of complex symptoms. METHODS: A 40-year-old woman with MS and primary concerns about perineal pain and SD was treated by a trained midwife from the LFAUGN and a physical therapist after a multidisciplinary diagnostic process that included gynecologic evaluation for perineal pain and SD, physiatric assessment, urologic assessment for bladder retention (BR), and surgical examination for obstructed defecation syndrome (ODS)...
January 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/28218343/immediate-affective-responses-of-gait-training-in-neurological-rehabilitation-a-randomized-crossover-trial
#7
Martin Niedermeier, Larissa Ledochowski, Andreas Mayr, Leopold Saltuari, Martin Kopp
OBJECTIVE: To examine the immediate effects of physical therapy and robotic-assisted gait training on affective responses of gait training in neurological rehabilitation. DESIGN: Randomized crossover trial with blinded observers. PATIENTS: Sixteen patients with neurological disorders (stroke, traumatic brain injury, spinal cord injury, multiple sclerosis). METHODS: All patients underwent 2 single treatment sessions: physical therapy and robotic-assisted gait training...
February 16, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28161400/memory-b-cells-are-major-targets-for-effective-immunotherapy-in-relapsing-multiple-sclerosis
#8
REVIEW
David Baker, Monica Marta, Gareth Pryce, Gavin Giovannoni, Klaus Schmierer
Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune disease, supportive evidence is perhaps circumstantial, often based on animal studies, and is questioned by the perceived failure of CD4-depleting antibodies to control relapsing MS. Therefore, it was interestingly to find that current MS-treatments, believed to act via T cell inhibition, including: beta-interferons, glatiramer acetate, cytostatic agents, dimethyl fumarate, fingolimod, cladribine, daclizumab, rituximab/ocrelizumab physically, or functionally in the case of natalizumab, also depleted CD19+, CD27+ memory B cells...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28159850/protocol-for-a-prospective-observational-study-of-cortical-lower-urinary-tract-control-changes-following-intradetrusor-injection-of-botulinum-toxin-a-in-patients-with-multiple-sclerosis
#9
Rodolfo A Elizondo, Christof Karmonik, Timothy B Boone, Rose Khavari
INTRODUCTION: Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A (OnaBotA; Botox Allergan, Dublin, Ireland) is a highly effective option for these patients...
February 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/27965510/the-effect-of-high-dose-steroid-treatment-used-for-the-treatment-of-acute-demyelinating-diseases-on-endothelial-and-cardiac-functions
#10
Mehmet Vedat Çaldır, Güner Koyuncu Çelik, Özgür Çiftçi, İbrahim Haldun Müderrisoğlu
OBJECTIVE: The cardiovascular effects of short-term high-dose steroid treatment (pulse steroid treatment) have not yet been clarified. We examined the short- and long-term effects of pulse steroid treatment in demyelinating diseases on endothelial and cardiac functions. METHODS: In this prospective study, we included 35 patients (20 females and 15 males; mean age, 32.8±9.3 years) who were not treated with steroids and who were previously diagnosed with multiple sclerosis or neuromyelitis optica...
December 1, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27919499/quality-of-life-and-its-correlates-in-adolescent-multiple-sclerosis-patients
#11
Slavica Ostojic, Dejan Stevanovic, Jasna Jancic
INTRODUCTION: Measures of health-related quality of life (HRQOL) are considered to be more comprehensive in health outcome assessments than scales assessing only the degree of neurological deficit. OBJECTIVE: The aim of the study was to evaluate HRQOL and its correlates among adolescents with multiple sclerosis (MS) in Serbia. METHODS: Demographic, clinical, and patient-reported outcome data were collected for 21 adolescents with MS, aged 14-18 years...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27904656/the-berlin-treatment-algorithm-recommendations-for-tailored-innovative-therapeutic-strategies-for-multiple-sclerosis-related-fatigue
#12
REVIEW
Christian Veauthier, Helge Hasselmann, Stefan M Gold, Friedemann Paul
More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome symptom of their disease. The mechanisms underlying MS-related fatigue are poorly understood, and objective criteria for distinguishing and evaluating levels of fatigue and tiredness have not yet been developed...
2016: EPMA Journal
https://www.readbyqxmd.com/read/27885061/alemtuzumab-improves-quality-of-life-outcomes-compared-with-subcutaneous-interferon-beta-1a-in-patients-with-active-relapsing-remitting-multiple-sclerosis
#13
Rafael Arroyo González, Mariko Kita, Heidi Crayton, Eva Havrdova, David H Margolin, Stephen L Lake, Gavin Giovannoni
BACKGROUND: Alemtuzumab was superior on clinical and magnetic resonance imaging (MRI) outcomes versus subcutaneous interferon beta-1a in phase 3 trials in patients with relapsing-remitting multiple sclerosis. OBJECTIVE: To examine quality-of-life (QoL) outcomes in the alemtuzumab phase 3 trials. METHODS: Patients who were treatment naive (Comparison of Alemtuzumab and Rebif(®) Efficacy in Multiple Sclerosis I [CARE-MS I]) or had an inadequate response to prior therapy (CARE-MS II) received annual courses of alemtuzumab 12 mg/day at baseline (5 days) and Month 12 (3 days) or subcutaneous interferon beta-1a 44 µg three times/week...
November 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27813441/primary-progressive-multiple-sclerosis-current-therapeutic-strategies-and-future-perspectives
#14
Alberto Gajofatto, Marco Turatti, Maria Donata Benedetti
Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with heterogeneous features. Primary progressive (PP) MS is a rare disease subtype characterized by continuous disability worsening from onset. No disease-modifying therapy is currently approved for PP MS due to the negative or inconsistent results of clinical trials conducted on a wide range of interventions, which are reviewed in the present paper. Areas covered: The features and results of randomized trials of disease-modifying treatments for PP MS are discussed, including immunosuppressants, immunomodulators, monoclonal antibodies, and putative neuroprotective agents...
November 15, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27778158/neurorehabilitation-applied-neuroplasticity
#15
Fary Khan, Bhasker Amatya, Mary P Galea, Roman Gonzenbach, Jürg Kesselring
The prevalence of disability due to neurological conditions is escalating worldwide. Neurological disorders have significant disability-burden with long-term functional and psychosocial issues, requiring specialized rehabilitation services for comprehensive management, especially treatments tapping into brain recovery 'neuroplastic' processes. Neurorehabilitation is interdisciplinary and cross-sectorial, requiring coordinated effort of diverse sectors, professions, patients and community to manage complex condition-related disability...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27676919/efficacity-of-exercise-training-on-multiple-sclerosis-patients-with-cognitive-impairments
#16
Amandine Chenet, Alexandra Gosseaume, Sandrine Wiertlewski, Brigitte Perrouin-Verbe
OBJECTIVE: Cognitive impairment in multiple sclerosis (MS) is common, present in 40 to 60% of patients, and is under diagnosis. Currently, there is no effective drug and non-pharmacological treatments that are developed. We propose to evaluate the effectiveness of exercise training (ET) on cognitive impairment. MATERIALS/PATIENTS AND METHODS: The study included patients from University Hospital of Nantes with an EDSS of between 3 and 4.5. They followed an exercise therapy program during 8 weeks, in groups, including aerobic physical activity (Nordic walking, gymnastics and exercise of balance) and recreational activities (billiards and boccia)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27673100/poster-347-physical-therapy-utilization-in-the-management-of-multiple-sclerosis-in-the-united-states
#17
Lin Mu
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27648171/a-combined-exercise-model-for-improving-muscle-strength-balance-walking-distance-and-motor-agility-in-multiple-sclerosis-patients-a-randomized-clinical-trial
#18
Bahram Sangelaji, Mohammadreza Kordi, Farzaneh Banihashemi, Seyed Massood Nabavi, Sara Khodadadeh, Maryam Dastoorpoor
BACKGROUND: Multiple sclerosis (MS) is a neurological disease with a variety of signs and symptoms. Exercise therapy has been shown to improve physical functions in MS. However, questions about an optimal exercise therapy remain. In this regard, we suggest a combined exercise therapy including aerobic and resistance exercises for MS patients. The study is designed to observe, test and compare the effects of proposed combined exercises on strength, balance, agility, fatigue, speed, and walking distance in people with mild to moderate MS [0 < expanded disability status scale (EDSS) < 5]...
July 6, 2016: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/27640924/brain-health-time-matters-in-multiple-sclerosis
#19
REVIEW
Gavin Giovannoni, Helmut Butzkueven, Suhayl Dhib-Jalbut, Jeremy Hobart, Gisela Kobelt, George Pepper, Maria Pia Sormani, Christoph Thalheim, Anthony Traboulsee, Timothy Vollmer
INTRODUCTION: We present international consensus recommendations for improving diagnosis, management and treatment access in multiple sclerosis (MS). Our vision is that these will be used widely among those committed to creating a better future for people with MS and their families. METHODS: Structured discussions and literature searches conducted in 2015 examined the personal and economic impact of MS, current practice in diagnosis, treatment and management, definitions of disease activity and barriers to accessing disease-modifying therapies (DMTs)...
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27616882/self-reported-quality-of-life-in-multiple-sclerosis-patients-preliminary-results-based-on-the-polish-ms-registry
#20
Waldemar Brola, Piotr Sobolewski, Małgorzata Fudala, Stanisław Flaga, Konrad Jantarski, Danuta Ryglewicz, Andrzej Potemkowski
BACKGROUND: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry. METHODS: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale...
2016: Patient Preference and Adherence
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