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Physical therapy and multiple sclerosis

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https://www.readbyqxmd.com/read/29784250/update-on-pediatric-onset-multiple-sclerosis
#1
REVIEW
A Ruet
Pediatric-onset multiple sclerosis (POMS) has distinctive features compared with adult-onset multiple sclerosis (AOMS), and warrants caution despite being a rare form of MS. POMS diagnostic criteria are somewhat different from those used in AOMS, with acute disseminated encephalomyelitis being a key differential diagnosis of MS in children. Other differential diagnoses that have to be ruled out before diagnosing MS include demyelinating syndromes, autoimmune and systemic pathologies, and infectious, genetic, metabolic and neoplastic diseases...
May 18, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29772185/therapies-for-mobility-disability-in-persons-with-multiple-sclerosis
#2
Jessica F Baird, Brian M Sandroff, Robert W Motl
Mobility disability is one of the most widespread and impactful consequences of multiple sclerosis (MS). Disease modifying drugs (DMDs) may delay the progression of disability over time; however, there is minimal evidence supporting the efficacy of DMDs for reversing mobility disability or restoring ambulatory function in persons with MS. Areas covered: This review outlines symptomatic pharmacologic and non-pharmacologic therapeutic approaches that target mobility disability with the goal of restoring and improving walking function...
May 17, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29771386/immunotherapy-in-cns-cancers-the-role-of-immune-cell-trafficking
#3
Nivedita M Ratnam, Mark R Gilbert, Amber J Giles
Glioblastoma (GBM) is a highly malignant CNS tumor with very poor survival despite intervention with conventional therapeutic strategies. Although the CNS is separated from the immune system by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), emerging evidence of immune surveillance and the selective infiltration of GBMs by immune suppressive cells indicates that there is breakdown or compromise of these physical barriers. This in turn offers hope that immunotherapy can be applied to specifically target and reduce tumor burden...
May 15, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29680460/effects-of-hippotherapy-in-multiple-sclerosis-pilot-study-on-quality-of-life-spasticity-gait-pelvic-floor-depression-and-fatigue
#4
Susana Muñoz-Lasa, Carlos López de Silanes, M Ángeles Atín-Arratibel, Carmen Bravo-Llatas, Salvador Pastor-Jimeno, Nuria Máximo-Bocanegra
INTRODUCTION AND OBJECTIVE: Hippotherapy is being used as a promising method in the physical treatment of multiple sclerosis (MS). MATERIAL AND METHOD: Comparative open clinical pre-post study into hippotherapy intervention during a 6-month period in patients with MS (n=6). Not randomised and with control group (n=4). The study was performed by MHG Foundation. RESULTS: A statistically significant improvement was observed in the therapy group in: spasticity pre-post measured by the modified Ashworth scale (P=...
April 18, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29678888/bovine-spastic-syndrome-a-review
#5
REVIEW
Victoria Goeckmann, Sophie Rothammer, Ivica Medugorac
Bovine spastic syndrome (BSS) was described for the first time in 1941. The disease occurs in various-maybe even all-cattle breeds and is a chronic-progressive neuromuscular disorder that commonly affects cattle of at least three years of age. Typical clinical signs of the disease are clonic-tonic cramps of the hindlimbs that occur in attacks. Since BSS does not recover, affected animals can only be treated symptomatically by improving welfare conditions and management factors, or with physical therapy or drugs...
April 20, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29668401/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-2-effect-on-white-matter-integrity
#6
Ameen Barghi, Jane B Allendorfer, Edward Taub, Brent Womble, Jarrod M Hicks, Gitendra Uswatte, Jerzy P Szaflarski, Victor W Mark
BACKGROUND: Constraint-induced movement therapy (CIMT) is a method of physical rehabilitation that has demonstrated clinical efficacy in patients with chronic stroke, cerebral palsy, and multiple sclerosis (MS). OBJECTIVE: This pilot randomized controlled trial tested whether CIMT can also induce increases in white matter integrity in patients with MS. METHODS: Twenty adults with chronic hemiparetic MS were randomized to receive either CIMT or complementary and alternative medicine (CAM) treatment (reported in the first article of this pair)...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29668399/phase-ii-randomized-controlled-trial-of-constraint-induced-movement-therapy-in-multiple-sclerosis-part-1-effects-on-real-world-function
#7
Victor W Mark, Edward Taub, Gitendra Uswatte, David M Morris, Gary R Cutter, Terrie L Adams, Mary H Bowman, Staci McKay
BACKGROUND: Constraint-Induced Movement therapy (CIMT) has controlled evidence of efficacy for improving real-world paretic limb use in non-progressive physically disabling disorders (stroke, cerebral palsy). OBJECTIVE: This study sought to determine whether this therapy can produce comparable results with a progressive disorder such as multiple sclerosis (MS). We conducted a preliminary phase II randomized controlled trial of CIMT versus a program of complementary and alternative medicine (CAM) treatments for persons with MS, to evaluate their effect on real-world disability...
March 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29611013/correction-to-nebulization-of-rns60-a-physically-modified-saline-attenuates-the-adoptive-transfer-of-experimental-allergic-encephalomyelitis-in-mice-implications-for-multiple-sclerosis-therapy
#8
Susanta Mondal, Suresh B Rangasamy, Supurna Ghosh, Richard L Watson, Kalipada Pahan
The original version of this article unfortunately contained a mistake. The Figure 3, 4, 5 legends have been misplaced. The updated legends along with the figures are corrected with this erratum.
April 2, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29609859/cognitive-behavioral-therapies-and-multiple-sclerosis-fatigue-a-review-of-literature
#9
REVIEW
Moussa A Chalah, Samar S Ayache
BACKGROUND: Patients with multiple sclerosis (MS) commonly suffer from fatigue, a multidimensional symptom with physical, cognitive and psychosocial components that can drastically alter the quality of life. Despite its debilitating nature, the current treatment options are limited by their modest efficacy and numerous side effects. Cognitive behavioral therapies (CBT) have been applied in MS patients and might be of help in relieving fatigue. This constitutes the main objective of the current review...
March 30, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29583054/sequencing-of-disease-modifying-therapies-for-relapsing-remitting-multiple-sclerosis-a-theoretical-approach-to-optimizing-treatment
#10
Francois Grand'Maison, Michael Yeung, Sarah A Morrow, Liesly Lee, Francois Emond, Brian J Ward, Pierre Laneuville, Robyn Schecter
Multiple sclerosis (MS) is a chronic disease which usually begins in young adulthood and is a lifelong condition. Individuals with MS experience physical and cognitive disability resulting from inflammation and demyelination in the central nervous system. Over the past decade, several disease-modifying therapies (DMTs) have been approved for the management of relapsing-remitting MS (RRMS), which is the most prevalent phenotype. The chronic nature of the disease and the multiple treatment options make benefit-risk-based sequencing of therapy essential to ensure optimal care...
March 27, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29579644/physiotherapeutic-interventions-in-multiple-sclerosis-across-europe-regions-and-other-factors-that-matter
#11
Patrícia Martinková, Jenny Freeman, Adéla Drabinová, Elena Erosheva, Davide Cattaneo, Johanna Jonsdottir, Ilse Baert, Tori Smedal, Anders Romberg, Peter Feys, Jose Alves-Guerreiro, Mario Habek, Thomas Henze, Carme Santoyo Medina, Antonie Beiske, Paul Van Asch, Daphne Bakalidou, Yeliz Salcı, Erieta Nikolikj Dimitrova, Markéta Pavlíková, Kamila Řasová
BACKGROUND: A wide variety of interventions exists in physical therapy (PT), but knowledge about their use across different geographical regions is limited. This study investigated the use of PT interventions in people with multiple sclerosis (MS) across Europe. It aimed to determine whether regions differ in applying interventions, and explore whether factors other than regions play a role in their use. METHODS: In an online cross-sectional survey, 212 respondents from 115 European workplaces providing PT services to people with MS representing 26 countries (four European regions) participated...
March 14, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29523642/psychiatric-comorbidity-is-associated-with-disability-progression-in-multiple-sclerosis
#12
Kyla A McKay, Helen Tremlett, John D Fisk, Tingting Zhang, Scott B Patten, Lorne Kastrukoff, Trudy Campbell, Ruth Ann Marrie
OBJECTIVE: Emerging evidence suggests that comorbidity may influence disability outcomes in multiple sclerosis (MS); we investigated the association between psychiatric comorbidity and MS disability progression in a large multiclinic population. METHODS: This retrospective cohort study accessed prospectively collected information from linked clinical and population-based health administrative databases in the Canadian provinces of British Columbia and Nova Scotia...
April 10, 2018: Neurology
https://www.readbyqxmd.com/read/29518781/efficacy-of-psychosocial-interventions-for-people-with-multiple-sclerosis-a-meta-analysis-of-specific-treatment-effects
#13
Amy-Lee Sesel, Louise Sharpe, Sharon L Naismith
BACKGROUND: Psychosocial interventions are often used as an adjunct to the medical management of multiple sclerosis (MS). However, the efficacy of such approaches for a range of psychosocial indications remains unclear. OBJECTIVE: To determine the efficacy of psychosocial therapies for people with MS (PwMS). METHODS: We searched 6 electronic databases (Medline, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, and Clinicaltrials...
2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29455894/cognitive-behavioural-therapy-for-ms-related-fatigue-explained-a-longitudinal-mediation-analysis
#14
L E van den Akker, H Beckerman, E H Collette, H Knoop, G Bleijenberg, J W Twisk, J Dekker, V de Groot
BACKGROUND: Cognitive behavioural therapy (CBT) effectively reduces fatigue directly following treatment in patients with Multiple Sclerosis (MS), but little is known about the process of change during and after CBT. DESIGN: Additional analysis of a randomized clinical trial. OBJECTIVE: To investigate which psychological factors mediate change in fatigue during and after CBT. METHODS: TREFAMS-CBT studied the effectiveness of a 16-week CBT treatment for MS-related fatigue...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29405761/guided-imagery-improves-mood-fatigue-and-quality-of-life-in-individuals-with-multiple-sclerosis-an-exploratory-efficacy-trial-of-healing-light-guided-imagery
#15
Laura K Case, Paula Jackson, Revere Kinkel, Paul J Mills
Multiple sclerosis is a disabling and progressive neurological disease that has significant negative effects on health-related quality of life. This exploratory efficacy study examined the effects of Healing Light Guided Imagery (HLGI), a novel variant of guided imagery, compared with a wait-list control in patients with relapsing-remitting multiple sclerosis. Changes in the Beck Depression Inventory, Fatigue Severity Scale, and Multiple Sclerosis Quality of Life instrument (physical and mental components) were compared between groups...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29384828/evaluation-of-vitamin-b12-deficiency-and-associated-factors-in-patients-with-systemic-sclerosis
#16
Diler Tas Kilic, Ali Akdogan, Levent Kilic, Alper Sari, Abdulsamet Erden, Berkan Armagan, Muhammed Kilickaya, Umut Kalyoncu, Turan Turhan, Sedat Kiraz, Selma Karaahmetoglu
BACKGROUND/OBJECTIVE: In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed to determine the frequency and the potential causes of Vit B12 deficiency in SSc patients. METHODS: We conducted a cross-sectional analysis of 62 SSc patients in a single center in 1 year period. Medical history and physical examination of patients were reevaluated. Data about organ involvements were obtained from hospital file records...
January 30, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29374527/autologous-hematopoietic-stem-cell-transplantation-for-systemic-sclerosis-a-systematic-review-and-meta-analysis
#17
Roni Shouval, Nadav Furie, Pia Raanani, Arnon Nagler, Anat Gafter-Gvili
Autologous hematopoietic stem cell transplantation (AHSCT) has been proposed as a therapeutic modality for severe systemic sclerosis (SSc). We set out to systematically review and meta-analyze the efficacy and safety of AHSCT in SSc. Randomized controlled trials (RCTs) and retrospective studies comparing AHSCT with standard immunosuppressive therapy were included. Of 363 titles screened from multiple databases, 15 were extracted for further investigation, and 4 met inclusion criteria (3 RCTs and 1 retrospective analysis)...
January 31, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29323240/engineered-3d-printed-artificial-axons
#18
Daniela Espinosa-Hoyos, Anna Jagielska, Kimberly A Homan, Huifeng Du, Travis Busbee, Daniel G Anderson, Nicholas X Fang, Jennifer A Lewis, Krystyn J Van Vliet
Myelination is critical for transduction of neuronal signals, neuron survival and normal function of the nervous system. Myelin disorders account for many debilitating neurological diseases such as multiple sclerosis and leukodystrophies. The lack of experimental models and tools to observe and manipulate this process in vitro has constrained progress in understanding and promoting myelination, and ultimately developing effective remyelination therapies. To address this problem, we developed synthetic mimics of neuronal axons, representing key geometric, mechanical, and surface chemistry components of biological axons...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29307293/the-role-of-testosterone-in-ms-risk-and-course
#19
Tanuja Chitnis
There is significant animal model data demonstrating a benefit of testosterone on both inflammatory and neuroprotective mechanisms relevant to multiple sclerosis (MS). Several studies have demonstrated lowered testosterone levels in up to 40% of men with MS. Lower testosterone levels were correlated with worsened scores of physical and cognitive disability. There is increasing data suggesting a role of testosterone in MS risk. A pilot study has demonstrated significant benefits of testosterone replacement therapy on cognitive, radiological, and immunological outcome measures in men with MS...
January 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29202154/changing-student-attitudes-toward-interprofessional-learning-and-collaboration-evidence-for-the-effectiveness-of-partnering-with-healthcare-mentors-in-the-academic-setting
#20
Robert Wellmon, Mary Baumberger-Henry, Normajean Colby, Linda Knauss, Patricia Fletcher
PURPOSE: Individuals living with chronic health conditions serving as healthcare mentors (HCM) allow the creation of high impact, authentic learning experiences. The purpose of this study was to examine the effectiveness of a 6-hour curricular experience involving HCM in changing student attitudes toward interprofessional learning (IPL) and collaboration (IPC). METHODS: Thirty-eight students from clinical psychology, nursing, physical therapy, and social work programs participated in either the learning intervention (n=19) or the control group (n=19)...
2017: Journal of Allied Health
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