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Physical therapy and als

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https://www.readbyqxmd.com/read/29204783/the-impact-of-rehabilitative-interventions-on-quality-of-life-a-qualitative-evidence-synthesis-of-personal-experiences-of-individuals-with-amyotrophic-lateral-sclerosis
#1
REVIEW
Ammarah Y Soofi, Vanina Dal Bello-Haas, Michelle E Kho, Lori Letts
BACKGROUND: The nature of amyotrophic lateral sclerosis (ALS) is progressive and degenerative, thus influencing individuals physically, emotionally, and socially. A broad review of qualitative studies that describe the personal experiences of people with ALS with physiotherapy, occupational therapy and speech and language pathology interventions, and how those affect QoL is warranted. PURPOSE: This study synthesizes qualitative research regarding the potential that rehabilitation interventions have to maintain and/or improve QoL from the perspective of people with ALS...
December 4, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28835399/a-case-control-study-of-hormonal-exposures-as-etiologic-factors-for-als-in-women-euro-motor
#2
James P K Rooney, Anne E Visser, Fabrizio D'Ovidio, Roel Vermeulen, Ettore Beghi, Adriano Chio, Jan H Veldink, Giancarlo Logroscino, Leonard H van den Berg, Orla Hardiman
OBJECTIVE: To investigate the role of hormonal risk factors for amyotrophic lateral sclerosis (ALS) among women from 3 European countries. METHODS: ALS cases and matched controls were recruited over 4 years in Ireland, Italy, and the Netherlands. Hormonal exposures, including reproductive history, breastfeeding, contraceptive use, hormonal replacement therapy, and gynecologic surgical history, were recorded with a validated questionnaire. Logistic regression models adjusted for age, education, study site, smoking, alcohol, and physical activity were used to determine the association between female hormones and ALS risk...
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28694091/combined-intranasal-nerve-growth-factor-and-ventricle-neural-stem-cell-grafts-prolong-survival-and-improve-disease-outcome-in-amyotrophic-lateral-sclerosis-transgenic-mice
#3
Shi-Jiang Zhong, Yan-Hua Gong, Yan-Chen Lin
Amyotrophic lateral sclerosis (ALS) is a fatal disease that selectively involves motor neurons. Neurotrophic factor supplementation and neural stem cell (NSC) alternative therapy have been used to treat ALS. The two approaches can affect each other in their pathways of action, and there is a possibility for synergism. However, to date, there have been no studies demonstrating the effects of combined therapy in the treatment of ALS. In this study, for the first time, we adopted a method involving the intranasal administration of nerve growth factor combined with lateral ventricle NSC transplantation using G93A-SOD1 transgenic mice as experimental subjects to explore the treatment effect of this combined therapy in ALS...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28527504/telehealth-in-physical-medicine-and-rehabilitation-a-narrative-review
#4
REVIEW
Adam S Tenforde, Jaye E Hefner, Jodi E Kodish-Wachs, Mary A Iaccarino, Sabrina Paganoni
Telehealth refers to health care interactions that leverage telecommunication devices to provide medical care outside the traditional face-to-face, in-person medical encounter. Technology advances and research have expanded use of telehealth in health care delivery. Physical medicine and rehabilitation providers may use telehealth to deliver care to populations with neurologic and musculoskeletal conditions, commonly treated in both acute care and outpatient settings. Patients with impaired mobility and those living in locations with reduced access to care may particularly benefit...
May 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28387447/withdrawn-interventions-for-fatigue-and-weight-loss-in-adults-with-advanced-progressive-illness
#5
REVIEW
Cathy Payne, Philip J Wiffen, Suzanne Martin
BACKGROUND: Fatigue and unintentional weight loss are two of the commonest symptoms experienced by people with advanced progressive illness. Appropriate interventions may bring considerable improvements in function and quality of life to seriously ill people and their families, reducing physical, psychological and spiritual distress. OBJECTIVES: To conduct an overview of the evidence available on the efficacy of interventions used in the management of fatigue and/or unintentional weight loss in adults with advanced progressive illness by reviewing the evidence contained within Cochrane reviews...
April 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27964824/pain-in-amyotrophic-lateral-sclerosis
#6
REVIEW
Adriano Chiò, Gabriele Mora, Giuseppe Lauria
Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS) although it is reported by most of these patients. It occurs at all stages of the disease and can be an onset symptom preceding motor dysfunction. Pain is correlated with a deterioration in patients' quality of life and increased prevalence of depression. In the later stages of ALS, pain can be severe enough to require increased use of sedative and analgesic drugs, and is among the events that predict clinical deterioration and death...
February 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27676908/mobile-team-rehabilitation-rehabilitation-an-activity-outside-results-of-3-years-of-functioning-to-the-p%C3%A3-le-saint-helier
#7
Aurélie Duruflé, Claire Le-Meur, Marie-Pierre Reillon, Claire Lozach, Benoit Nicolas
Many mobile teams were created over the past decade in various medical specialties including physical medicine and rehabilitation (MPR). The Pôle Saint-Helier has created a mobile team of rehabilitation-reintegration (EM2R) in December 2012 with support from the Regional Health Agency of Brittany. It operates on the health territory No. 5 of Brittany near people experiencing neurological disability. Its main mission is to implement the necessary devices to facilitate the home return of people hospitalized after a neurological event or maintaining to home people with neurological disorders...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27459462/epidemiology-of-major-neurodegenerative-diseases-in-women-contribution-of-the-nurses-health-study
#8
REVIEW
Kaitlin A Hagan, Kassandra L Munger, Alberto Ascherio, Francine Grodstein
OBJECTIVES: To review the contribution of the Nurses' Health Study (NHS) to identifying the role of lifestyle, diet, and genetic or biological factors in several neurodegenerative diseases, including cognitive decline, multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. METHODS: We completed a narrative review of the publications of the NHS and NHS II between 1976 and 2016. RESULTS: In primary findings for cognitive function, higher intake of nuts, moderate alcohol consumption, and higher physical activity levels were associated with better cognitive function...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27437724/active-music-therapy-approach-in-amyotrophic-lateral-sclerosis-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Alfredo Raglio, Elena Giovanazzi, Debora Pain, Paola Baiardi, Chiara Imbriani, Marcello Imbriani, Gabriele Mora
This randomized controlled study assessed the efficacy of active music therapy (AMT) on anxiety, depression, and quality of life in amyotrophic lateral sclerosis (ALS). Communication and relationship during AMT treatment were also evaluated. Thirty patients were assigned randomly to experimental [AMT plus standard of care (SC)] or control (SC) groups. AMT consisted of 12 sessions (three times a week), whereas the SC treatment was based on physical and speech rehabilitation sessions, occupational therapy, and psychological support...
December 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27164308/pulmonary-physical-therapy-techniques-to-enhance-survival-in-amyotrophic-lateral-sclerosis-a-systematic-review
#10
REVIEW
Chelsea E Macpherson, Clare C Bassile
BACKGROUND AND PURPOSE: Respiratory insufficiency is the primary cause of morbidity and mortality in individuals with amyotrophic lateral sclerosis (ALS). Although mechanical interventions are effective in prolonging survival through respiratory support, pulmonary physical therapy interventions are being investigated. The purpose of this systematic review was to examine the effectiveness of pulmonary physical therapy interventions across the progressive stages of ALS. METHODS: Six databases were searched for articles from inception to December 2014 investigating pulmonary physical therapy interventions in the ALS population...
July 2016: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/27112034/clinical-and-laboratory-signs-associated-to-serious-dengue-disease-in-hospitalized-children
#11
Sheila Moura Pone, Yara Hahr Marques Hökerberg, Raquel de Vasconcellos Carvalhaes de Oliveira, Regina Paiva Daumas, Tamiris Moura Pone, Marcos Vinicius da Silva Pone, Patricia Brasil
OBJECTIVE: To evaluate the validity of clinical and laboratory signs to serious dengue disease in hospitalized children. METHODS: Retrospective cohort of children (<18 years) hospitalized with dengue diagnosis (2007-2008). Serious dengue disease was defined as death or use of advanced life support therapy. Accuracy measures and area under the receiver operating characteristic curve were calculated. RESULTS: Of the total (n=145), 53.1% were female, 69% aged 2-11 years, and 15...
September 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/26927092/roles-of-rna-binding-proteins-in-dna-damage-response
#12
REVIEW
Mihoko Kai
Living cells experience DNA damage as a result of replication errors and oxidative metabolism, exposure to environmental agents (e.g., ultraviolet light, ionizing radiation (IR)), and radiation therapies and chemotherapies for cancer treatments. Accumulation of DNA damage can lead to multiple diseases such as neurodegenerative disorders, cancers, immune deficiencies, infertility, and also aging. Cells have evolved elaborate mechanisms to deal with DNA damage. Networks of DNA damage response (DDR) pathways are coordinated to detect and repair DNA damage, regulate cell cycle and transcription, and determine the cell fate...
February 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26854610/identification-of-possible-sirna-molecules-for-tdp43-mutants-causing-amyotrophic-lateral-sclerosis-in-silico-design-and-molecular-dynamics-study
#13
Vishwambhar Vishnu Bhandare, Amutha Ramaswamy
The DNA binding protein, TDP43 is a major protein involved in amyotrophic lateral sclerosis and other neurological disorders such as frontotemporal dementia, Alzheimer disease, etc. In the present study, we have designed possible siRNAs for the glycine rich region of tardbp mutants causing ALS disorder based on a systematic theoretical approach including (i) identification of respective codons for all mutants (reported at the protein level) based on both minimum free energy and probabilistic approaches, (ii) rational design of siRNA, (iii) secondary structure analysis for the target accessibility of siRNA, (iii) determination of the ability of siRNA to interact with mRNA and the formation/stability of duplex via molecular dynamics study for a period of 15ns and (iv) characterization of mRNA-siRNA duplex stability based on thermo-physical analysis...
April 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/25982050/interaction-of-physical-function-quality-of-life-and-depression-in-amyotrophic-lateral-sclerosis-characterization-of-a-large-patient-cohort
#14
Sonja Körner, Katja Kollewe, Susanne Abdulla, Antonia Zapf, Reinhard Dengler, Susanne Petri
BACKGROUND: Due to lack of any curative therapy for ALS, symptomatic treatment and maintenance of quality of life (QoL) is very important. We aimed to characterize the affected domains of QoL in ALS patients and to identify factors which are associated with reduced QoL and increased depression. METHODS: 159 ALS patients answered standardized questionnaires (Beck Depression Inventory-II, SF-36 Health Survey questionnaire, revised ALS functional rating scale). Multiple regression analysis was used to identify correlations between clinical features of ALS patients and depression/QoL scores...
2015: BMC Neurology
https://www.readbyqxmd.com/read/25238733/treatment-of-frontotemporal-dementia
#15
Richard M Tsai, Adam L Boxer
Frontotemporal dementia (FTD) encompasses a spectrum of neurodegenerative diseases with heterogeneous clinical presentations and two predominant types of underlying neuropathology. FTD typically comprises three distinct clinical syndromes: behavioral variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), and nonfluent variant primary progressive aphasia (nfvPPA). FTD also frequently overlaps both clinically and neuropathologically with three other neurodegenerative syndromes: corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)...
November 2014: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/25036750/accelerated-neuronal-differentiation-toward-motor-neuron-lineage-from-human-embryonic-stem-cell-line-h9
#16
David Lu, Eric Y T Chen, Philip Lee, Yung-Chen Wang, Wendy Ching, Christopher Markey, Chase Gulstrom, Li-Ching Chen, Thien Nguyen, Wei-Chun Chin
Motor neurons loss plays a pivotal role in the pathoetiology of various debilitating diseases such as, but not limited to, amyotrophic lateral sclerosis, primary lateral sclerosis, progressive muscular atrophy, progressive bulbar palsy, pseudobulbar palsy, and spinal muscular atrophy. However, advancement in motor neuron replacement therapy has been significantly constrained by the difficulties in large-scale production at a cost-effective manner. Current methods to derive motor neuron heavily rely on biochemical stimulation, chemical biological screening, and complex physical cues...
March 2015: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/25033844/clinical-relevance-of-stem-cell-therapies-in-amyotrophic-lateral-sclerosis
#17
REVIEW
Amit K Srivastava
Amyotrophic lateral sclerosis (ALS), characterized by the progressive loss of both upper and lower motor neurons, is a fatal neurodegenerative disorder. This disease is often accompanied by a tremendous physical and emotional burden not only for the patients, but also for their families and friends as well. There is no clinically relevant treatment available for ALS. To date, only one Food and Drug Administration (FDA)-approved drug, Riluzole, licensed 18 years ago, has been proven to marginally prolong patients' survival without improving the quality of their lives...
May 2014: Neurology India
https://www.readbyqxmd.com/read/24315469/systematic-review-of-non-invasive-positive-pressure-ventilation-for-chronic-respiratory-failure
#18
REVIEW
Liam M Hannan, Giulio S Dominelli, Yi-Wen Chen, W Darlene Reid, Jeremy Road
BACKGROUND: This systematic review examined the effect of non-invasive positive pressure ventilation (NIPPV) on patient reported outcomes (PROs) and survival for individuals with or at risk of chronic respiratory failure (CRF). METHODS: Randomised controlled trials (RCTs) and prospective non-randomised studies in those treated with NIPPV for CRF were identified from electronic databases, reference lists and grey literature. Diagnostic groups included in the review were amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), Duchenne muscular dystrophy (DMD), restrictive thoracic disease (RTD) and obesity hypoventilation syndrome (OHS)...
February 2014: Respiratory Medicine
https://www.readbyqxmd.com/read/24286340/iyengar-yoga-therapy-as-an-intervention-for-cramp-management-in-individuals-with-amyotrophic-lateral-sclerosis-three-case-reports
#19
Subbappa Ribeiro
OBJECTIVES: Patients with amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of motor neurons, experience cramps at all stages of the illness. There is, at present, no effective medication to control the cramps and no agreement on how to treat the symptom in ALS patients. SUBJECTS: Three individuals who were diagnosed with ALS and reported suffering cramps in various parts of the body, which limited their activities or affected their sleep were invited to try Iyengar yoga...
April 2014: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/24220224/effect-of-treadmill-training-on-fatigue-in-multiple-sclerosis-a-pilot-study
#20
RANDOMIZED CONTROLLED TRIAL
Elisa Gervasoni, Davide Cattaneo, Johanna Jonsdottir
People with multiple sclerosis (PwMS) tend to be less physically active than the general population. Limited physical activity increases fatigue, possibly affecting other functions such as balance. Treadmill training is a promising method to ameliorate these symptoms. The aim of this study was to assess the effect of treadmill training on fatigue and balance. Thirty PwMS were recruited; the mean age was 47.6 (SD 9.2). The median EDSS score was 5.5 (range 3-6.5). Individuals were randomized into a control group receiving 12 sessions of conventional therapy and an experimental group receiving conventional therapy including 15 min of treadmill training...
March 2014: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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