Muwei Li, Kurt G Schilling, Fei Gao, Lyuan Xu, Soyoung Choi, Yurui Gao, Zhongliang Zu, Adam W Anderson, Zhaohua Ding, Bennett A Landman, John C Gore
Cognitive decline with aging involves multifactorial processes, including changes in brain structure and function. This study focuses on the role of white matter functional characteristics, as reflected in blood oxygenation level-dependent signals, in age-related cognitive deterioration. Building on previous research confirming the reproducibility and age-dependence of blood oxygenation level-dependent signals acquired via functional magnetic resonance imaging, we here employ mediation analysis to test if aging affects cognition through white matter blood oxygenation level-dependent signal changes, impacting various cognitive domains and specific white matter regions...
March 1, 2024: Cerebral Cortex