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https://www.readbyqxmd.com/read/30458921/the-controversies-challenges-and-complexities-of-lyme-disease-a-narrative-review
#1
Marie Claire Van Hout
PURPOSE: Lyme disease has become an increasingly important global public health concern. METHOD: A narrative review was conducted and designed to present a broad perspective on Lyme disease, and describe its history and development in terms of clinical care and public health implications. A structured literature search was conducted based on the question; what is currently known about Lyme disease? RESULTS: The narrative review is presented in chronological order in terms of a summary of the history of Lyme disease, the complexities of clinical diagnosis, the problematic interpretation of serologic testing, the conflicting guidelines for diagnosis, treatment and management of chronic Lyme, and benefits of antibiotic treatment...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30429707/acrodermatitis-chronica-atrophicans-various-faces-of-the-late-form-of-lyme-borreliosis
#2
Anna Moniuszko-Malinowska, Piotr Czupryna, Justyna Dunaj, Sławomir Pancewicz, Adam Garkowski, Maciej Kondrusik, Sambor Grygorczuk, Joanna Zajkowska
Introduction: Acrodermatitis chronica atrophicans (ACA) is probably the most common late and chronic manifestation of the Lyme borreliosis seen in European patients. Aim: To analyze epidemiological data, and to investigate the effects of treatment of patients with ACA. Material and methods: Nine patients were included in the study. All patients had serological examinations (ELISA and Western blot) and histopathological examination of the skin lesions performed...
October 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/30400667/precision-medicine-the-role-of-the-msids-model-in-defining-diagnosing-and-treating-chronic-lyme-disease-post-treatment-lyme-disease-syndrome-and-other-chronic-illness-part-2
#3
Richard I Horowitz, Phyllis R Freeman
We present a precision medical perspective to assist in the definition, diagnosis, and management of Post Treatment Lyme Disease Syndrome (PTLDS)/chronic Lyme disease. PTLDS represents a small subset of patients treated for an erythema migrans (EM) rash with persistent or recurrent symptoms and functional decline. The larger population with chronic Lyme disease is less understood and well defined. Multiple Systemic Infectious Disease Syndrome (MSIDS) is a multifactorial model for treating chronic disease(s), which identifies up to 16 overlapping sources of inflammation and their downstream effects...
November 5, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/30380925/dermatology-related-uses-of-medical-cannabis-promoted-by-dispensaries-in-canada-europe-and-the-united-states
#4
Megan Lim, Mark G Kirchhof
There is a growing interest in the use of medical cannabis for a variety of dermatologic conditions. Despite the lack of evidence to validate the effectiveness and safety of marijuana, it is approved to treat a variety of dermatologic conditions in the United States. Furthermore, medical cannabis dispensaries have been making unsubstantiated claims about medical cannabis. It is important for dermatologists to know about the purported use of medical cannabis to help patients navigate this new treatment option, particularly as cannabis becomes legal in Canada in October 2018...
October 31, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/30322049/removing-the-mask-of-average-treatment-effects-in-chronic-lyme-disease-research-using-big-data-and-subgroup-analysis
#5
Lorraine Johnson, Mira Shapiro, Jennifer Mankoff
Lyme disease is caused by the bacteria borrelia burgdorferi and is spread primarily through the bite of a tick. There is considerable uncertainty in the medical community regarding the best approach to treating patients with Lyme disease who do not respond fully to short-term antibiotic therapy. These patients have persistent Lyme disease symptoms resulting from lack of treatment, under-treatment, or lack of response to their antibiotic treatment protocol. In the past, treatment trials have used small restrictive samples and relied on average treatment effects as their measure of success and produced conflicting results...
October 12, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/30273247/neuroborreliosis-and-neurosyphilis
#6
John J Halperin
PURPOSE OF REVIEW: This article presents an overview of the current diagnosis and management of two spirochetal infections of the nervous system, neuroborreliosis (Lyme disease) and neurosyphilis, focusing on similarities and differences. Although neuroborreliosis was first identified almost a century ago, much confusion remains about how to accurately diagnose this quite treatable nervous system infection. Well-established diagnostic tools and therapeutic regimens exist for neurosyphilis, which has been well-known for centuries...
October 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30239603/holistic-approach-in-patients-with-presumed-lyme-borreliosis-leads-to-less-than-10-of-confirmation-and-more-than-80-of-antibiotics-failure
#7
Elie Haddad, Kahina Chabane, Stéphane Jaureguiberry, Gentiane Monsel, Valérie Pourcher, Eric Caumes
Background: There is no precise idea whether patients with chronic symptoms attributed to Lyme borreliosis (LB) have LB or another disease. Methods: We evaluated patients consulting for a presumed LB with a holistic approach including presumptive treatment. We included symptomatic patients who consulted with a presumed LB. They were classified as confirmed LB when they had four criteria, and possible LB if three with a positive clinical response to presumptive treatment...
September 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30210529/impact-of-fmr1-premutation-on-neurobehavior-and-bioenergetics-in-young-monozygotic-twins
#8
Eleonora Napoli, Andrea Schneider, Randi Hagerman, Gyu Song, Sarah Wong, Flora Tassone, Cecilia Giulivi
Mitochondrial dysfunction (MD) has been identified in lymphocytes, fibroblasts and brain samples from adults carrying a 55-200 CGG expansion in the fragile X mental retardation 1 ( FMR1 ) gene (premutation; PM); however, limited data are available on the bioenergetics of pediatric carriers. Here we discuss a case report of three PM carriers: two monozygotic twins (aged 8 years) harboring an FMR1 allele with 150-180 CGG repeats, with no cognitive or intellectual issues but diagnosed with depression, mood instability and ADHD, and their mother (asymptomatic carrier with 78 CGG repeats)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/30166820/the-persistent-lyme-disease-true-chronic-lyme-disease-rather-than-post-treatment-lyme-disease-syndrome
#9
Alexis Lacout, Mostafa El Hajjam, Pierre-Yves Marcy, Christian Perronne
No abstract text is available yet for this article.
July 2018: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/30115716/adult-onset-still-s-disease-with-haemorrhagic-pericarditis-and-tamponade-preceded-by-acute-lyme-disease
#10
Anthony J Ocon, Alysia V Kwiatkowski, Ruben Peredo-Wende, Richard Blinkhorn
A 61-year-old Caucasian man presented with a fever of unknown origin, a transient erythematous rash on his right upper extremity and chest pressure after being treated for erythema migrans (Lyme disease). Echocardiogram demonstrated a large pericardial effusion with tamponade. He underwent pericardiostomy with tube placement. Workup for infectious and malignant etiologies was negative. Histology of the pericardium showed acute on chronic fibrinous haemorrhagic pericarditis. The patient met criteria for adult-onset Still's disease...
August 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30106352/a-next-generation-sequencing-based-molecular-approach-to-characterize-a-tick-vector-in-lyme-disease
#11
Anil K Madugundu, Babylakshmi Muthusamy, Sreelakshmi K Sreenivasamurthy, Chandra Bhavani, Jyoti Sharma, Bankatesh Kumar, Krishna R Murthy, Raju Ravikumar, Akhilesh Pandey
Next-generation sequencing approaches have revolutionized genomic medicine and enabled rapid diagnosis for several diseases. These approaches are widely used for pathogen detection in several infectious diseases. Lyme disease is a tick-borne infectious disease, which affects multiple organs. The causative organism is a spirochete, Borrelia burgdorferi, which is transmitted by ticks. Lyme disease can be treated easily if detected early, but its diagnosis is often delayed or is incorrect leading to a chronic debilitating condition...
August 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/30028768/recognizing-and-treating-lyme-disease
#12
Scott J Saccomano, Debra A Hrelic
Lyme disease is the most commonly reported vector-borne disease in the United States. After initial antibiotic treatment for patients with Lyme disease, ongoing symptoms that may persist have considerable long-term impact on healthcare costs. Posttreatment Lyme disease syndrome is characterized by a host of chronic symptoms that can leave patients physically and mentally disabled.
August 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29943705/mosquito-and-tick-borne-illnesses-in-the-united-states-guidelines-for-the-recognition-and-empiric-treatment-of-zoonotic-diseases-in-the-wilderness
#13
Suresh Antony
In the United States, tick-borne illnesses account for a significant number of patients that have been seen and treated by health care facilities. This in turn, has resulted in a significant morbidity and mortality and economic costs to the country. The distribution of these illnesses is geographically variable and is related to the climate as well. Many of these illnesses can be diagnosed and treated successfully, if recognized and started on appropriate antimicrobial therapy early in the disease process. Patient with illnesses such as Lyme disease, Wet Nile illness can result in chronic debilitating diseases if not recognized early and treated...
June 26, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29741589/c-reactive-protein-response-in-patients-with-post-treatment-lyme-disease-symptoms-versus-those-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#14
Melanie Uhde, Alyssa Indart, Brian A Fallon, Gary P Wormser, Adriana R Marques, Suzanne D Vernon, Armin Alaedini
No abstract text is available yet for this article.
September 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29706237/-pathway-to-diagnosis-and-real-life-experience-of-patients-believing-they-are-affected-by-chronic-lyme-disease
#15
E Forestier, F Gonnet, A Revil-Signorat, A C Zipper
OBJECTIVES: Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience. METHOD: A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Interviews were analyzed by 2 general medical practice interns, supervised by a general practitioner with a diploma in socio-anthropology and an infectious diseases specialist...
April 26, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29513260/otolaryngological-symptoms-in-patients-treated-for-tick-borne-diseases
#16
Klaudia Sowula, Jacek Składzień, Joanna Szaleniec, Jolanta Gawlik
infections are borreliosis (Lyme disease) and tick-borne encephalitis (TBE). Lately there is growing incidence of Bartonella, Babesia, Anaplasma and Brucella co-infections. The similarity between the symptoms of tick-borne diseases and other pathologies causes serious diagnostic issues. MATERIAL AND METHODS: 216 patients aged 18-55, who presented to the outpatient clinic for tick-borne diseases in the years 2014-2016, were enrolled in the study. The patients had been diagnosed with Lyme disease and co-infections...
February 28, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29438352/the-financial-implications-of-a-well-hidden-and-ignored-chronic-lyme-disease-pandemic
#17
Marcus Davidsson
1 million people are predicted to get infected with Lyme disease in the USA in 2018. Given the same incidence rate of Lyme disease in Europe as in the USA, then 2.4 million people will get infected with Lyme disease in Europe in 2018. In the USA by 2050, 55.7 million people (12% of the population) will have been infected with Lyme disease. In Europe by 2050, 134.9 million people (17% of the population) will have been infected with Lyme disease. Most of these infections will, unfortunately, become chronic. The estimated treatment cost for acute and chronic Lyme disease for 2018 for the USA is somewhere between 4...
February 13, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29416466/exacerbation-of-chronic-pain-after-dental-extractions-in-a-patient-with-post-treatment-lyme-disease-syndrome
#18
Stephanie Lim, Sakura Kinjo
A subset of patients who had Lyme disease experience postinfectious signs or symptoms called post-treatment Lyme disease syndrome (PTLDS). PTLDS is a chronic condition including pain in joints and muscles, neurological symptoms including demyelinating diseases, peripheral neuropathy, headaches, sleep disturbances, fatigue, and cardiac conditions. We report a case of difficult acute pain management in a patient with PTLDS who underwent dental extractions and required admission to an intensive care unit for pain control...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29402399/tick-borne-illness-lyme-disease
#19
REVIEW
Larry M Bush, Maria T Vazquez-Pertejo
Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species. Over 90% of US cases occur in northeasternstates from Maine to Virginia, and in Wisconsin, Minnesota, and Michigan. Infection also takes place in northern California and Oregon. Lyme borreliosis is also diagnosed in parts of Europe, China, and Japan. The white-footed mouse is the primary animal reservoir for B. burgdorferi in the U...
May 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29359181/development-and-validation-of-a-serologic-test-panel-for-detection-of-powassan-virus-infection-in-u-s-patients-residing-in-regions-where-lyme-disease-is-endemic
#20
Angela M Thomm, Anna M Schotthoefer, Alan P Dupuis, Laura D Kramer, Holly M Frost, Thomas R Fritsche, Yvette A Harrington, Konstance K Knox, Sue C Kehl
Powassan virus (POWV) is an emerging tick-borne arbovirus presenting a public health threat in North America. POWV lineage II, also known as deer tick virus, is the strain of the virus most frequently found in Ixodes scapularis ticks and is implicated in most cases of POWV encephalitis in the United States. Currently, no commercial tests are available to detect POWV exposure in tick-borne disease (TBD) patients. We describe here the development and analytical validation of a serologic test panel to detect POWV infections...
January 2018: MSphere
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