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https://www.readbyqxmd.com/read/30509297/molecular-characterisation-of-equid-alphaherpesvirus-1-strains-isolated-from-aborted-fetuses-in-poland
#1
Anna Karolina Matczuk, Małgorzata Skarbek, Natalia Anna Jackulak, Barbara Anna Bażanów
BACKGROUND: Equid alphaherpesvirus 1 (EHV-1) is one of the main infectious causative agents of abortion in mares and can also be associated with stillbirth, neonatal foal death, rhinopneumonitis in young horses and a neurological disorder called equine herpesvirus myeloencephalopathy (EHM). The neuropathogenicity of the virus was shown to be significantly higher in EHV-1 strains that carry a single nucleotide point (SNP) mutation in the ORF30, which encodes a catalytic subunit of viral DNA polymerase (ORF30 D752 )...
December 3, 2018: Virology Journal
https://www.readbyqxmd.com/read/30507091/a-pathogenic-homozygous-mutation-in-the-pleckstrin-homology-domain-of-rasa1-is-responsible-for-familial-tricuspid-atresia-in-an-iranian-consanguineous-family
#2
Ahoura Nozari, Ehsan Aghaei-Moghadam, Aliakbar Zeinaloo, Afagh Alavi, Saghar Ghasemi Firouzabdi, Shohre Minaee, Marzieh Eskandari Hesari, Farkhondeh Behjati
Objective: Tricuspid atresia (TA) is a rare life-threatening form of congenital heart defect (CHD). The genetic mechanisms underlying TA are not clearly understood. According to previous studies, the endocardial cushioning event, as the primary sign of cardiac valvulogenesis, is governed by several overlapping signaling pathways including Ras/ ERK pathway. RASA1, a regulator of cardiovascular development, is involved in this pathway and its haploinsufficiency (due to heterozygous mutations) has been identified as the underlying etiology of the autosomal dominant capillary malformation/arteriovenous malformation (CM/AVM)...
April 2019: Cell Journal
https://www.readbyqxmd.com/read/30503343/natural-killer-natural-killer-t-helper-and-cytotoxic-t-cells-in-the-decidua-from-recurrent-spontaneous-abortion-with-normal-and-abnormal-chromosome-karyotypes
#3
Jia Liu, Peng Dong, Shijun Wang, Jian Li
PROBLEM: Recurrent spontaneous abortion (RSA) is associated with immune imbalance at the maternal-fetal interface. Decidual immune cells and cytokines expressed at this interface regulate the response of the maternal immune system to the fetus. However, the populations and cytokine expression levels of these lymphocytes in miscarriage with normal and abnormal chromosome karyotypes remain unclear. METHODS: We assessed the populations and cytokine expression levels of Natural Killer (NK), Natural Killer T (NKT), Helper T (Th) and Cytotoxic T (Tc) cells in the decidua of RSA by flow cytometry and simultaneously analyzed the fetal chromosome karyotypes of these miscarriages...
November 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30489187/fatal-ruptured-ectopic-pregnancy-a-case-report
#4
S H Jayanth, Girish Chandra, S Praveen
A 26-year-old unmarried female with a history of acute abdominal pain and bleeding per vagina was brought unresponsive to the hospital. She was in shock on arrival and could not be resuscitated. Death was registered as a medico-legal case. Further investigation by the police revealed that she had amenorrhoea for eight weeks and had tested positive for pregnancy. She had consumed abortion pills purchased from a local pharmacist without consulting a doctor and had developed acute abdominal pain after 48 h. Autopsy revealed a ruptured ectopic pregnancy (tubal type)...
November 29, 2018: Medico-legal Journal
https://www.readbyqxmd.com/read/30487178/the-male-gamete-membrane-protein-dmp9-dau2-is-required-for-double-fertilization-in-flowering-plants
#5
Taro Takahashi, Toshiyuki Mori, Kenji Ueda, Lixy Yamada, Shiori Nagahara, Tetsuya Higashiyama, Hitoshi Sawada, Tomoko Igawa
All flowering plants exhibit a unique type of sexual reproduction called 'double fertilization' in which each pollen tube-delivered sperm cell fuses with an egg and a central cell. Proteins that localize to the plasma membrane of gametes regulate one-to-one gamete pairing and fusion between male and female gametes for successful double fertilization. Here, we have identified a membrane protein from Lilium longiflorum generative cells using proteomic analysis and have found that the protein is an ortholog of Arabidopsis DUF679 DOMAIN MEMBRANE PROTEIN 9 (DMP9)/DUO1-ACTIVATED UNKNOWN 2 (DAU2)...
November 28, 2018: Development
https://www.readbyqxmd.com/read/30483261/regulation-of-placental-extravillous-trophoblasts-by-the-maternal-uterine-environment
#6
REVIEW
Jürgen Pollheimer, Sigrid Vondra, Jennet Baltayeva, Alexander Guillermo Beristain, Martin Knöfler
During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is critical for adapting blood flow and nutrient transport to the developing fetus. Failures in this process have been noticed in different pregnancy complications such as preeclampsia, intrauterine growth restriction, stillbirth, or recurrent abortion. Upon invasion into the decidua, the endometrium of pregnancy, EVTs encounter different maternal cell types such as decidual macrophages, uterine NK (uNK) cells and stromal cells expressing a plethora of growth factors and cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30479343/clearance-of-maternal-barriers-by-paternal-mir159-to-initiate-endosperm-nuclear-division-in-arabidopsis
#7
Youshang Zhao, Songyun Wang, Wenye Wu, Lei Li, Ting Jiang, Binglian Zheng
Sperm entry triggers central cell division during seed development, but what factors besides the genome are inherited from sperm, and the mechanism by which paternal factors regulate early division events, are not understood. Here we show that sperm-transmitted miR159 promotes endosperm nuclear division by repressing central cell-transmitted miR159 targets. Disruption of paternal miR159 causes approximately half of the seeds to abort as a result of defective endosperm nuclear divisions. In wild-type plants, MYB33 and MYB65, two miR159 targets, are highly expressed in the central cell before fertilization, but both are rapidly abolished after fertilization...
November 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/30473897/vesicouterine-fistula-vuf-as-a-rare-urogenital-complication-managed-with-delayed-surgical-repair-a-case-report-and-review-of-the-literature
#8
Evangelos N Symeonidis, Elias Sdralis, Asterios Symeonidis, Christos Georgiadis, Vasileios Kalyvas, Apostolos Malioris, Michail Papathanasiou
Vesicouterine fistula (VUF) represents a rare urogenital complication. It is considered to be the least common type of urogenital fistulas. Iatrogenic reasons have been shown to be the most prominent cause, with lower segment caesarean section accounting for approximately two-thirds of the cases. The highest incidence concerns young females of reproductive age. VUF can present with clinical symptoms varying from cyclic hematuria, amenorrhea, and vaginal leakage of urine to secondary infertility and first-trimester abortion...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30442200/a-new-case-report-of-severe-mucopolysaccharidosis-type-vii-diagnosis-treatment-with-haematopoietic-cell-transplantation-and-prenatal-diagnosis-in-a-second-pregnancy
#9
Francesca Furlan, Attilio Rovelli, Miriam Rigoldi, Mirella Filocamo, Barbara Tappino, Douglas Friday, Serena Gasperini, Silvana Mariani, Claudia Izzi, Maria Pia Bondioni, Cinzia Gellera, Anna Venerando, Nicoletta Villa, Maria Del Carmen Rodriguez Perez, Fabio Pavan, Andrea Biondi, Rossella Parini
A new patient with severe mucopolysaccharidosis (MPS) type VII is reported. Non-immune hydrops fetalis (NIHF) was diagnosed during pregnancy. At birth, he showed generalized hydrops and dysmorphic features typical of MPS. Many diagnoses were excluded before reaching the diagnosis of MPS VII at 8 months of life. During the first year of life he had frequent respiratory infections associated with restrictive and obstructive bronchopneumopathy and underwent three surgical interventions: decompression of the spinal cord at the craniocervical junction, bilateral inguinal hernia, and bilateral clubfoot...
November 16, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/30425429/adenine-type-and-diphenyl-urea-derived-cytokinins-improve-the-postharvest-performance-of-iris-germanica-l-cut-scapes
#10
Syed Sabhi Ahmad, Inayatullah Tahir, Arif Shafi Wani, Riyaz Ahmad Dar, Shaziya Nisar
An experiment was designed to evaluate the effect of various adenine derived cytokinins (kinetin and 6-benzylaminopurine) and diphenyl urea cytokinin (thidiazuron) on the postharvest performance of cut scapes of Iris germanica . Flower scapes were harvested with the oldest bud at '1 day before anthesis stage', brought to laboratory under water, cut to a uniform length of 35 cm, divided into three sets viz., kinetin (KIN), 6-benzyl aminopurine (BAP) and thidiazuron (TDZ). Each set of scapes was treated with a particular cytokinin alone or in combination with 0...
November 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/30397472/the-abortion-and-mental-health-controversy-a-comprehensive-literature-review-of-common-ground-agreements-disagreements-actionable-recommendations-and-research-opportunities
#11
REVIEW
David C Reardon
The abortion and mental health controversy is driven by two different perspectives regarding how best to interpret accepted facts. When interpreting the data, abortion and mental health proponents are inclined to emphasize risks associated with abortion, whereas abortion and mental health minimalists emphasize pre-existing risk factors as the primary explanation for the correlations with more negative outcomes. Still, both sides agree that (a) abortion is consistently associated with elevated rates of mental illness compared to women without a history of abortion; (b) the abortion experience directly contributes to mental health problems for at least some women; (c) there are risk factors, such as pre-existing mental illness, that identify women at greatest risk of mental health problems after an abortion; and (d) it is impossible to conduct research in this field in a manner that can definitively identify the extent to which any mental illnesses following abortion can be reliably attributed to abortion in and of itself...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/30388961/comparing-women-s-financial-costs-of-induced-abortion-at-a-facility-vs-seeking-treatment-for-complications-from-unsafe-abortion-in-zambia
#12
Ann M Moore, Mardieh Dennis, Ragnar Anderson, Akinrinola Bankole, Anna Abelson, Giulia Greco, Bellington Vwalika
Although abortion is legal in Zambia under a variety of broad conditions, unsafe abortion remains common. The purpose of this project was to compare the financial costs for women when they have an induced abortion at a facility, with costs for an induced abortion outside a facility, followed by care for abortion-related complications. We gathered household wealth data at one point in time (T1) and longitudinal qualitative data at two points in time (T1 and T2, three-four months later), in Lusaka and Kafue districts, between 2014 and 2015...
December 2018: Reproductive Health Matters
https://www.readbyqxmd.com/read/30385414/cytological-and-itraq-based-quantitative-proteomic-analyses-of-hau-cms-in-brassica-napus-l
#13
Shuangping Heng, Fengyi Chen, Chao Wei, Xianwen Li, Bin Yi, Chaozhi Ma, Jinxing Tu, Jinxiong Shen, Tingdong Fu, Jing Wen
Hau cytoplasmic male sterility (CMS) is a new type of CMS that was originally identified in Brassica juncea and subsequently transferred to B. napus and B. rapa. To further elucidate the molecular mechanism underlying hau CMS in B. napus, semithin section analysis and iTRAQ-based differential proteomic analysis were performed to compare the hau CMS and its maintainer line. Cytological analysis revealed that abnormal anther development in the hau CMS line was arrested during the differentiation of stamen archesporial cells...
October 29, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/30382313/mapping-of-the-male-sterile-mutant-gene-ftms-in-brassica-rapa-l-ssp-pekinensis-via-bsr-seq-combined-with-whole-genome-resequencing
#14
Chong Tan, Zhiyong Liu, Shengnan Huang, Hui Feng
A male sterile mutant was created by 60 Co γ-rays of microspores isolated from Chinese cabbage DH line 'FT'. A candidate gene for the male sterile trait was identified as Bra010198. Male sterility is used for hybrid seed production in Chinese cabbage. In this study, we derived a male sterile mutant (ftms) from Chinese cabbage DH line 'FT' by irradiating microspores with 60 Co γ-rays and realized the rapid trait transformation from male fertility to sterility for creating valuable breeding materials. Genetic analysis indicated that the male sterile trait is controlled by a single recessive nuclear gene, ftms...
October 31, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/30382070/-a-case-report-of-laparoscopy-assisted-distal-gastrectomy-for-early-gastric-cancer-with-abortive-beh%C3%A3-et-disease
#15
Yukari Ono, Toru Aoyama, Yukio Maezawa, Tsutomu Sato, Kentaro Hara, Masahiro Asari, Junya Morita, Shinya Amano, Sho Sawazaki, Masakatsu Numata, Takashi Ohshima, Norio Yukawa, Munetaka Masuda, Yasushi Rino
A 32-year-old woman with a history of undergoing upper gastrointestinal surgery was administered prednisolone for abortive Behçet's disease since 2015. In March 2017, upper gastrointestinal endoscopy revealed a 0-IIc type early stage gastric carcinoma at the posterior wall of the gastric antrum. The pathological diagnosis was signet-ring cell carcinoma. This gastric carcinoma was classified as cT1aN0M0; therefore, endoscopic submucosal dissection(ESD)was performed for the expanded indication lesion in April 2017...
October 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/30359373/revisiting-human-t-cell-lymphotropic-virus-types-1-and-2-infections-among-rural-population-in-gabon-central-africa-thirty-years-after-the-first-analysis
#16
Melanie Caron, Guillaume Besson, Cindy Padilla, Maria Makuwa, Dieudonne Nkoghe, Eric Leroy, Mirdad Kazanji
HTLV-1 infection is considered as highly endemic in central Africa. Thirty years ago, a first epidemiological study was performed in Gabon, central Africa, and revealed that the prevalence varied from 5.0 to 10.5%. To evaluate current distribution of HTLVs in Gabon, 4.381 samples were collected from rural population living in 220 villages distributed within the 9 provinces of country. HTLVs prevalence was determined using two ELISA tests and positive results were confirmed by Western Blot. The overall HTLV-1 seroprevalence was of 7...
October 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30357496/matsubara-yano-suture-a-simple-uterine-compression-suture-for-postpartum-hemorrhage-during-cesarean-section
#17
Hironori Takahashi, Yosuke Baba, Rie Usui, Hirotada Suzuki, Kenji Horie, Hitoshi Yano, Akihide Ohkuchi, Shigeki Matsubara
AIMS: The aims of this study were to clarify: (i) the effectiveness of Matsubara-Yano uterine compression suture (MY) to achieve hemostasis in the presence of postpartum hemorrhage (PPH) during cesarean section, (ii) the type of PPH for which MY is effective, (iii) post-operative complications of MY, and (iv) outcomes of pregnancy after MY. METHODS: This retrospective observational study was performed using medical records of patients for whom MY had been performed between January 1, 2009 and December 31, 2017...
October 24, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/30341574/the-arabidopsis-nucleoporin-nup1-is-essential-for-megasporogenesis-and-early-stages-of-pollen-development
#18
Shuguang Bao, Guangshuang Shen, Guichen Li, Zhikang Liu, Muhammad Arif, Qingqing Wei, Shuzhen Men
Loss-of-function of nucleoporin NUP1 in Arabidopsis causes defect in both male and female gametogenesis. Its ovules are arrested during meiosis, and its pollen grains are aborted at mitosis I. Nuclear pore complex (NPC) plays crucial roles in nucleocytoplasmic trafficking of proteins and RNAs. The NPC contains approximately 30 different proteins termed nucleoporins (NUPs). So far, only a few of plant NUPs have been characterized. The Arabidopsis NUP1 was identified as an ortholog of the yeast NUP1 and animal NUP153...
October 19, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/30336534/the-link-between-selenium-oxidative-stress-and-pregnancy-induced-hypertensive-disorders
#19
REVIEW
Teofana O Bizerea, Stefana G Dezsi, Otilia Marginean, Ramona Stroescu, Alexandru Rogobete, Otilia Bizerea-Spiridon, Constantin Ilie
BACKGROUND: The first line of defence against oxidative stress (OS) are the endogenous antioxidants, such as the Se containing compounds. During pregnancy, OS is caused by the intense growth activity of the fetus; therefore, the placenta is a key place for the activity of many seleno-compounds such as glutathione-peroxidase and thioredoxinreductase. METHODS: This review aims to establish the link between the type of selenium compounds, their concentration, their metabolic pathways, and their role in both physiologic and pathologic processes during pregnancy...
October 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/30322529/abortion-storm-induced-by-the-live-c-abortus-vaccine-1b-strain-in-a-vaccinated-sheep-flock-mimicking-a-natural-wild-type-infection
#20
K Laroucau, R Aaziz, F Vorimore, M F Menard, D Longbottom, G Denis
Chlamydia abortus is responsible for enzootic abortion (known as ovine enzootic abortion (OEA) and enzootic abortion of ewes (EAE)) in both sheep and goats and has major economic implications for the farming industry worldwide. A virulence-attenuated mutant strain of C. abortus (strain 1B) is currently commercially available as a live attenuated vaccine for immunization of sheep and goats in several European countries. Following an abortion storm in a French flock of 200 ewes that occurred two years after vaccination of 36 replacement ewes with the commercial 1B vaccine strain, the vaginal swabs of 3 vaccinated and 7 unvaccinated aborted ewes and 12 of the 13 dead fetuses were found to be positive for C...
November 2018: Veterinary Microbiology
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