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Cancer prevent

Jinling Wang, Xiuju Sun
Kidney cancer is one of the deadly cancers and is the cause of significant number of deaths worldwide. The treatments used for the treatment of kidney cancer are limited and associated with number of side effects. Therefore, there is need for the development of new drug options or to identify novel therapeutic targets for the treatment of kidney cancer. In this study we investigated the potential of miR-375 as the therapeutic target for the treatment of Kidney cancer. The results revealed that miR-375 is significantly downregulated in the Kidney cancer cells...
August 2, 2018: Environmental Toxicology and Pharmacology
Alexey Koval, Constant A Pieme, Emerson Ferreira Queiroz, Simone Ragusa, Kamal Ahmed, Artem Blagodatski, Jean-Luc Wolfender, Tatiana V Petrova, Vladimir L Katanaev
Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natural products, especially plants, have been used for the treatment of various diseases from ancient times. We examined extracts from several indigenous Cameroonian herbs and tested their effects on proliferation and Wnt signaling in TNBC and CC cells...
August 8, 2018: Cancer Letters
Aisha Siddiqi, Bano Saidullah, Sarwat Sultana
The present study was designed to evaluate the protective effects of hesperidin, a flavonoid on DEN initiated and Fe-NTA promoted renal carcinogenesis in Wistar rats. Renal cancer was initiated by a single i.p. injection of DEN (200 mg/kg b.wt.) and promoted with Fe-NTA (9 mg Fe/kg b.wt. i.p.) twice a week for 16 weeks. Rats were simultaneously administered with hesperidin (100 and 200 mg/kg b.wt.) for 16 consecutive weeks. The chemopreventive effect of hesperidin was assessed in terms of antioxidant activities, renal function, PGE2 level, and the expressions of COX-2 and VEGF...
August 11, 2018: Environmental Toxicology
Cristina Aguirre-Portolés, Jaime Feliu, Guillermo Reglero, Ana Ramírez de Molina
At the time of diagnosis, 20% of patients with colorectal cancer (CRC) present with metastasis. Among individuals with primary lesions, 50% of them will develop distant tumors with time. Therefore, early diagnosis and prediction of aggressiveness is crucial for therapy design and disease prognosis. Tumoral cells must undergo significant changes in energy metabolism to meet increased structural and energetic demands for cell proliferation, and metabolic alterations are considered to be a hallmark of cancer. Here, we present ABCA1, a regulator of cholesterol transport, as a new marker for invasion and colorectal cancer survival...
August 11, 2018: Molecular Oncology
A Leeman, M Del Pino, L Marimon, A Torné, J Ordi, B Ter Harmsel, C J L M Meijer, D Jenkins, F J Van Kemenade, W G V Quint
Cervical screening aims to identify women with high-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia 2-3 (HSIL/CIN2-3) or invasive cervical cancer (ICC). Identification of women with severe premalignant lesions or ICC (CIN3+) could ensure their rapid treatment and prevent overtreatment. We investigated high-risk human papillomavirus (hrHPV) detection with genotyping and methylation of FAM19A4/miR124-2 for detection of CIN3+ in 538 women attending colposcopy for abnormal cytology. All women had an additional cytology with hrHPV testing (GP5+/6+-PCR-EIA+), genotyping (HPV16/18, HPV16/18/31/45), and methylation analysis (FAM19A4/miR124-2) and at least one biopsy...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
Remila Rezhake, Xiao-Qian Xu, Sandrine Montigny, Anouk Berger, Shang-Ying Hu, Zhi-Hua Liu, Rengaswamy Sankaranarayanan, You-Lin Qiao, Partha Basu, Fang-Hui Zhao
Cancer care professionals are pivotal in translating the knowledge into action in the continuum of cancer control process. Unfortunately, in China and the Association of South-east Asian Nations (ASEAN), limited training opportunities are available for health professionals in the area of cancer prevention and control. Therefore, the Cancer Hospital, Chinese Academy of Medical Sciences (CICAMS), and the International Agency for Research on Cancer (IARC) collaboratively designed and held the China-ASEAN Cancer Control and Prevention Training Program to provide continuing education opportunities for cancer professionals from China and ASEAN countries...
August 11, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Heide Götze, Sabine Taubenheim, Andreas Dietz, Florian Lordick, Anja Mehnert
PURPOSE: Our study provides a detailed overview of comorbid conditions and health-related quality of life of long-term cancer survivors and analyses the impact of demographic, disease- and treatment-related characteristics. METHODS: We present data obtained from 1000 survivors across mixed tumour entities 5 and 10 years after cancer diagnosis in a cross-sectional study. We analyse the prevalence of physical symptoms and health conditions via self-report and health-related quality of life using the EORTC QLQ-C30 in comparison to gender- and age-matched reference values of the general population...
August 10, 2018: Journal of Cancer Survivorship: Research and Practice
Brendan T Finicle, Vaishali Jayashankar, Aimee L Edinger
While cancer cell proliferation depends on access to extracellular nutrients, inadequate tumour perfusion means that glucose, amino acids and lipids are often in short supply. To overcome this obstacle to growth, cancer cells utilize multiple scavenging strategies, obtaining macromolecules from the microenvironment and breaking them down in the lysosome to produce substrates for ATP generation and anabolism. Recent studies have revealed four scavenging pathways that support cancer cell proliferation in low-nutrient environments: scavenging of extracellular matrix proteins via integrins, receptor-mediated albumin uptake and catabolism, macropinocytic consumption of multiple components of the tumour microenvironment and the engulfment and degradation of entire live cells via entosis...
August 10, 2018: Nature Reviews. Cancer
Belal A Muhammad, Sheema Almozyan, Roya Babaei-Jadidi, Emenike K Onyido, Anas Saadeddin, Seyed Hossein Kashfi, Bradley Spencer-Dene, Mohammad Ilyas, Anbarasu Lourdusamy, Axel Behrens, Abdolrahman Shams Nateri
Wnt/β-catenin signaling plays a critical role during development of both normal and malignant colorectal cancer (CRC) tissues. Phosphorylation of β-catenin protein alters its trafficking and function. Such conventional allosteric regulation usually involves a highly specialized set of molecular interactions, which may specifically turn on a particular cell phenotype. This study identifies a novel transcription modulator with an FLYWCH/Zn-finger DNA-binding domain, called "FLYWCH1". Using a modified yeast-2-hybrid based Ras-Recruitment system, it is demonstrated that FLYWCH1 directly binds to unphosphorylated (nuclear) β-catenin efficiently suppressing the transcriptional activity of Wnt/β-catenin signaling that cannot be rescued by TCF4...
August 10, 2018: Molecular Cancer Research: MCR
Steven Ramondt, A Susana Ramírez
OBJECTIVE: A growing body of research suggests that exposure to too much information - particularly contradictory information that characterizes much health-related information - can lead to feeling overwhelmed. This construct has been conflated with fatalistic beliefs that are negatively associated with preventive behaviors. The objective of this study was to adapt the 8-item Cancer Information Overload (CIO) scale to assess overload of healthy diet information. METHODS: Confirmatory factor analyses with a community sample of rural California adults (n = 290; 75% female; 58% Latino; 46% ≤ H...
July 26, 2018: Patient Education and Counseling
Grégory Ninot, Philippe Debourdeau, Françoise Blanc-Legier, Françoise De Crozals, Gaétan De Rauglaudre, Samy Khouri, Sylvie Kirscher, Laurent Mineur, Isabelle Piollet, Isabelle Sant, Pierre Schillinger, Daniel Serin
Advances in early detection and treatment have pushed in a few decades the management of cancers from a management model of the end of life to the management of a chronic disease. This evolution has accelerated the development of supportive care in two directions, firstly towards the best possible support to the end of life in advanced cancer patients (palliative care) and secondly to the limitation of treatment toxicities, the prevention of relapse and the return to life as "normal" as possible (care for after cancer)...
August 7, 2018: Bulletin du Cancer
Hoang Quy Nguyen, Nhu Hanh To, Patricia Zadigue, Stéphane Kerbrat, Alexandre De La Taille, Sabine Le Gouvello, Yazid Belkacemi
Ionizing radiation-exposure induces a variety of cellular reactions, such as senescence and apoptosis. Senescence is a permanent arrest state of the cell division, which can be beneficial or detrimental for normal tissue via an inflammatory response and senescence-associated secretion phenotype. Damage to healthy cells and their microenvironment is considered as an important source of early and late complications with an increased risk of morbidity in patients after radiotherapy (RT). In addition, the benefit/risk ratio may depend on the radiation technique/dose used for cancer eradication and the irradiated volume of healthy tissues...
September 2018: Critical Reviews in Oncology/hematology
Anna C Beck, Paolo Goffredo, Imran Hassan, Sonia L Sugg, Geeta Lal, James R Howe, Ronald J Weigel
BACKGROUND: Readmissions represent a substantial burden to the health care system. Risk factors for 30-day readmission after adrenalectomy were examined. METHODS: Patients who underwent adrenalectomy were selected from the American College of Surgeons National Surgical Quality Improvement Program database from 2011 to 2015. RESULTS: Among 4,221 patients who underwent adrenalectomy, 216 (5.1%) were readmitted. On multivariate analysis, pre-operative predictive factors associated with readmission were American Society of Anesthesiologists classification (odds ratio [OR] 1...
August 7, 2018: Surgery
Marcello Monti, Viviana De Rosa, Francesca Iommelli, Maria Vincenza Carriero, Cristina Terlizzi, Rosa Camerlingo, Stefania Belli, Rosa Fonti, Giovanni Di Minno, Silvana Del Vecchio
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis...
August 9, 2018: International Journal of Molecular Sciences
Jariya Umka Welbat, Pornthip Chaisawang, Wanassanun Pannangrong, Peter Wigmore
5-fluorouracil or 5-FU (a chemotherapeutic medication) has been revealed to induce memory deficits in many cancer patients. Asiatic acid (AA) is a triterpenoid extract from Centella asiatica. This compound can ameliorate intracellular oxidative stress caused by chemotherapy drugs. Recent studies have shown that AA is capable of inhibiting neuronal generation and memory deficit produced by 5-FU chemotherapy. This study aimed to assess the molecular mechanisms of AA related to hippocampal neurogenesis and memory in rats receiving 5-FU...
August 9, 2018: Nutrients
Altaf Mohammed, Nagendra Sastry Yarla, Venkateshwar Madka, Chinthalapally V Rao
Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin, naproxen, sulindac, celecoxib, and licofelone), statins and other natural agents-both individually, and in combinations. Most preclinical trials although were efficacious, only few agents entered clinical trials and have been proven to be potential chemopreventive agents for colon cancer...
August 8, 2018: International Journal of Molecular Sciences
Hannah E Walters, Lynne S Cox
Chronological age represents the greatest risk factor for many life-threatening diseases, including neurodegeneration, cancer, and cardiovascular disease; ageing also increases susceptibility to infectious disease. Current efforts to tackle individual diseases may have little impact on the overall healthspan of older individuals, who would still be vulnerable to other age-related pathologies. However, recent progress in ageing research has highlighted the accumulation of senescent cells with chronological age as a probable underlying cause of pathological ageing...
August 8, 2018: International Journal of Molecular Sciences
Eleni Pavlidou, Maria Mantzorou, Aristeidis Fasoulas, Christina Tryfonos, Dimitris Petridis, Constantinos Giaginis
INTRODUCTION: Moderate wine consumption is a characteristic of the Mediterranean diet. Studies around the world have shown a beneficial effect of moderate alcohol intake, especially wine, on health. This review aims to critically summarise the most recent studies that investigate the beneficial effects of moderate wine intake on human health. METHODS: The PubMed database was comprehensively searched to identify trials published from 2013 to 2018 that investigated the association between moderate wine consumption and health...
August 8, 2018: Diseases (Basel)
M Janaki Ramaiah, S Vaishnave
BMI-1 (B-lymphoma Mo-MLV insertion region 1) is a key protein partner in polycomb repressive complex 1 (PRC1) that helps in maintaining the integrity of the complex. It is also a key player in ubiquitination of histone H2A which affects gene expression pattern involved in various cellular processes such as cell proliferation, growth, DNA repair, apoptosis and senescence. In many cancers, Overexpression of BMI1correlates with advanced stages of disease, aggressive clinicopathological behavior, poor prognosis resistance to radiation and chemotherapy...
August 7, 2018: Gene
Sholeh Kiani, Haleh Akhavan-Niaki, Sadegh Fattahi, Saeid Kavoosian, Nadali Babaian Jelodar, Nadali Bagheri, Hamid Najafi Zarrini
BACKGROUND: Genetic alterations and epigenetic modifications are two main factors involved in gastric carcinogenesis, progression, and metastasis. Several miRNAs such as miRNA-9 and miRNA-326 may play important role in gastric cancer by targeting the 3'UTR of the caudal type homeobox (CDX) 1 and 2 mRNA respectively. The use of herbal medicines has been widely considered in the treatment of cancers such as gastric cancer. Sulforaphane extracted from broccoli may indirectly prevent cancer through affecting different signaling pathways...
August 7, 2018: Gene
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