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Neonatal candidemia

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https://www.readbyqxmd.com/read/30314389/advances-in-the-treatment-of-mycoses-in-pediatric-patients
#1
REVIEW
Elias Iosifidis, Savvas Papachristou, Emmanuel Roilides
The main indications for antifungal drug administration in pediatrics are reviewed as well as an update of the data of antifungal agents and antifungal policies performed. Specifically, antifungal therapy in three main areas is updated as follows: a) Prophylaxis of premature neonates against invasive candidiasis; b) management of candidemia and meningoencephalitis in neonates; and c) prophylaxis, empiric therapy, and targeted antifungal therapy in children with primary or secondary immunodeficiencies. Fluconazole remains the most frequent antifungal prophylactic agent given to high-risk neonates and children...
October 11, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/30281546/pediatric-candidemia-epidemiology-and-morbidities-a-nationwide-cohort
#2
Karen Rokkedal Lausch, Kia Hee Schultz Dungu, Michael Thude Callesen, Henrik Schrøder, Steen Rosthøj, Anja Poulsen, Lars Østergaard, Klaus Leth Mortensen, Merete Storgaard, Henrik C Schønheyder, Mette Søgaard, Maiken C Arendrup
INTRODUCTION: Candidemia is the most frequent pediatric fungal infection, but incompletely elucidated in population-based settings. We performed a nationwide cohort study including all pediatric patients with candidemia in Denmark from 2004-2014 to determine age, incidence, species distribution, underlying diseases, patient management and outcomes. METHODS: All candidemia episodes were identified through the active nationwide fungemia surveillance program. Susceptibility testing followed the EUCAST E...
September 29, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/30193562/pathology-of-neonatal-non-albicans-candidiasis-autopsy-study-and-literature-review
#3
Claire Hemedez, Elizabeth Trail-Burns, Quanfu Mao, Sharon Chu, Sunil K Shaw, Joseph M Bliss, Monique E De Paepe
Introduction/Objectives Non- albicans Candida species such as Candida parapsilosis and Candida glabrata have emerged as prevalent pathogens in premature infants. The aim of this study was to systematically delineate the histopathologic findings in neonatal non- albicans candidiasis. Methods We performed a retrospective clinicopathologic analysis of extremely premature (23-28 weeks' gestation) infants diagnosed with invasive candidiasis. Archival autopsy tissues were subjected to periodic acid-Schiff, methenamine-silver and anti- Candida (immuno)histochemical stains, as well as dual anti- Candida and anti-cytokeratin or anti-CD31 immunofluorescence assays...
September 7, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/30078958/spectrum-of-candidal-species-isolated-from-neonates-admitted-in-an-intensive-care-unit-of-teaching-hospital-of-kashmir-north-india
#4
Asifa Nazir, Talat Masoodi
BACKGROUND: Candidal infections are an important cause of morbidity and mortality in Neonatal Intensive Care Unit. Neonatal candidiasis is increasing in frequency, mainly because of increase in the survival of babies with low-birth weight, preterm births, advancement in medical field, life support systems, relative immunodeficiency, and extensive use of broad-spectrum antibiotics. Over the past few decades, there has been a progressive shift from the predominance of Candida albicans to nonalbicans Candida species...
July 2018: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/29912684/large-outbreaks-of-fungal-and-bacterial-bloodstream-infections-in-a-neonatal-unit-south-africa-2012-2016
#5
Erika van Schalkwyk, Samantha Iyaloo, Serisha D Naicker, Tsidiso G Maphanga, Ruth S Mpembe, Thokozile G Zulu, Mabatho Mhlanga, Sibongile Mahlangu, Motlatji B Maloba, Grace Ntlemo, Kgomotso Sanyane, Dini Mawela, Nelesh P Govender
Candidemia is a major cause of healthcare-associated infections. We describe a large outbreak of Candida krusei bloodstream infections among infants in Gauteng Province, South Africa, during a 4-month period; a series of candidemia and bacteremia outbreaks in the neonatal unit followed. We detected cases by using enhanced laboratory surveillance and audited hospital wards by environmental sampling and epidemiologic studies. During July-October 2014, among 589 patients, 48 unique cases of C. krusei candidemia occurred (8...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29762868/candidemia-in-children-epidemiology-prevention-and-management
#6
REVIEW
Elpis Mantadakis, Zoe Dorothea Pana, Theoklis Zaoutis
Candidemia is the leading cause of invasive fungal infections in hospitalised children. The highest rates of candidemia have been recorded in neonates and infants <1 year of age. Candidemia is more frequent in neonates and young infants than in adults, and is associated with better clinical outcomes, but higher inpatient costs. Over the last 10 years, a declining trend has been noted in the incidence of paediatric candidemia in the US and elsewhere due to the hospital-wide implementation of central-line insertion and maintenance bundles that emphasise full sterile barrier precautions, chlorhexidine skin preparation during line insertion, meticulous site and tubing care, and daily discussion of catheter necessity...
May 15, 2018: Mycoses
https://www.readbyqxmd.com/read/29522195/neonatal-and-pediatric-candidemia-results-from-population-based-active-laboratory-surveillance-in-four-us-locations-2009-2015
#7
Kaitlin Benedict, Monika Roy, Sarah Kabbani, Evan J Anderson, Monica M Farley, Sasha Harb, Lee H Harrison, Lindsay Bonner, Vijitha Lahanda Wadu, Kaytlyn Marceaux, Rosemary Hollick, Zintar G Beldavs, Alexia Y Zhang, William Schaffner, Caroline R Graber, Gordana Derado, Tom M Chiller, Shawn R Lockhart, Snigdha Vallabhaneni
Introduction: Candida is a leading cause of healthcare-associated bloodstream infections in the United States. Infants and children have unique risk factors for candidemia, and the Candida species distribution in this group is different that among adults; however, candidemia epidemiology in this population has not been described recently. Methods: We conducted active population-based candidemia surveillance in 4 US metropolitan areas between 2009 and 2015. We calculated incidences among neonates (0-30 days old), infants (0-364 days old), and noninfant children (1-19 years old), documented their clinical features and antifungal drug resistance...
August 17, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29488584/-epidemiology-species-antifungal-resistance-and-outcome-of-candidemia-in-a-university-hospital-in-buenos-aires-argentina-for-16-years
#8
Iris Nora Tiraboschi, Natalia Cintia Pozzi, Luciana Farías, Susana García, Norma Beatriz Fernández
BACKGROUND: The epidemiology of candidemia vary by region. AIM: To determine the epidemiology of candidemia in a hospital for 16 years. MATERIAL AND METHODS: Episodes of candidemia occurred in the Hospital de Clinicas of Buenos Aires were reviewed, from 01/01/98 to 31/12/13. RESULTS: 374 episodes of candidemia were identified. The incidence was 2.21/1,000 discharges and increased from 1.96 (1998-2005) to 2.25 (2006-2013) (p = 0...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29371558/strategies-to-reduce-mortality-in-adult-and-neonatal-candidemia-in-developing-countries
#9
REVIEW
Harsimran Kaur, Arunaloke Chakrabarti
Candidemia, the commonest invasive fungal infection, is associated with high morbidity and mortality in developing countries, though the exact prevalence is not known due to lack of systematic epidemiological data from those countries. The limited studies report a very high incidence of candidemia and unique epidemiology with a different spectrum of Candida species. The recent global emergence of multi-drug resistant Candida auris is looming large as an important threat in hospitalized patients of developing countries...
July 19, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29348997/diagnosis-and-management-of-a-fatal-case-of-sepsis-caused-by-candida-parapsilosis-sensu-stricto-in-a-neonate-with-omphalocele
#10
Simone Santana, Tania Salci, Patricia Andriato, Patricia Bonfim-Mendonça, Silvana Caparroz-Assef, Melyssa Negri, Terezinha Svidzinski
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate.
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29147867/population-structure-of-candida-parapsilosis-no-genetic-difference-between-french-and-uruguayan-isolates-using-microsatellite-length-polymorphism
#11
COMPARATIVE STUDY
Marie Desnos-Ollivier, Victoria Bórmida, Philippe Poirier, Céline Nourrisson, Dinorah Pan, Stéphane Bretagne, Andrès Puime, Françoise Dromer
Candida parapsilosis is a human commensal yeast, frequently involved in infection worldwide and especially in neonates. It is the second species responsible for bloodstream infections in Uruguay and the third species in France. We were interested in knowing whether the population structure of isolates responsible for candidemia in France and in Uruguay was different. Genotyping methods based on microsatellite length polymorphism (MLP) have been described and are especially used for investigation of local outbreaks...
April 2018: Mycopathologia
https://www.readbyqxmd.com/read/28884129/candidemia-in-the-neonatal-intensive-care-unit-a-retrospective-observational-survey-and-analysis-of-literature-data
#12
Giuseppina Caggiano, Grazia Lovero, Osvalda De Giglio, Giovanna Barbuti, Osvaldo Montagna, Nicola Laforgia, Maria Teresa Montagna
We evaluated the epidemiology of Candida bloodstream infections in the neonatal intensive care unit (NICU) of an Italian university hospital during a 9-year period as a means of quantifying the burden of infection and identifying emerging trends. Clinical data were searched for in the microbiological laboratory database. For comparative purposes, we performed a review of NICU candidemia. Forty-one candidemia cases were reviewed (overall incidence, 3.0 per 100 admissions). Candida parapsilosis sensu stricto (58...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28872714/microbial-epidemiology-of-candidaemia-in-neonatal-and-paediatric-intensive-care-units-at-the-children-s-medical-center-tehran
#13
Arezu Charsizadeh, Hossein Mirhendi, Bahram Nikmanesh, Hamid Eshaghi, Koichi Makimura
Invasive candidiasis is a major cause of morbidity and mortality in children. However, limited data are available on the epidemiology of this infection in paediatric settings in Iran. The aim of this study was to determine the prevalence, microbial epidemiology, risk factors and clinical outcomes associated with candidaemia in intensive care units at the Children's Medical Center, Tehran, Iran. All blood and other normally sterile specimen cultures positive for Candida species were included. Isolates were identified by morphological and molecular methods...
January 2018: Mycoses
https://www.readbyqxmd.com/read/28734712/-candidemia-in-pediatrics-species-distribution-and-antifungal-susceptibility
#14
Luciana B Guzzetti, Cecilia M Vescina, M Florencia Gil, Blanca M Gatti
Serious infections caused by Candida yeasts are frequent in the hospital population. Due to differences in species distribution and antifungal susceptibility testing depending on the geographic area and the type of patient, it is important to study the epidemiology of each institution. For this purpose, we conducted a retrospective, descriptive study on the occurrence of candidemia in the Children's Hospital "Superiora Sor María Ludovica" of the city of La Plata. In a 6-year period (2010-2015), 177 candidemia episodes were recorded...
July 19, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28699797/candidemia-and-invasive-candidiasis-among-hospitalized-neonates-and-pediatric-patients
#15
Rachel Harrington, Sylvia L Kindermann, Qingjiang Hou, Robert J Taylor, Nkechi Azie, David L Horn
OBJECTIVE: To investigate the epidemiology, treatment, length of stay (LOS) and costs for neonatal and pediatric inpatients with invasive candidiasis (IC). METHODS: The Cerner Health Facts Database was used to assess inpatients (2005-2014) identified by positive blood or cerebrospinal fluid (CSF) Candida cultures. Log-transformed LOS and cost were examined in candidemia-only patients (n = 191) using multivariable linear regression. RESULTS: A total of 202 patients had a positive culture (blood: n = 192; CSF: n = 10; both: n = 2)...
October 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28477628/epidemiology-of-candida-albicans-and-non-c-albicans-of-neonatal-candidemia-at-a-tertiary-care-hospital-in-western-china
#16
Jinjian Fu, Yanling Ding, Ba Wei, Lin Wang, Shaolin Xu, Peixu Qin, Liuhua Wei, Lijun Jiang
BACKGROUND: Although the majority of Candida infections occur in the developing world, candidemia epidemiology is poorly understood in these countries. The aim of this study was to investigate the epidemiology of non-Candida albicans (non-C. albicans) candidemia among neonates at Liuzhou Maternity and Child Healthcare Hospital in China. METHODS: A retrospective review of all positive blood culture about Candida species in neonatal intensive care unit was conducted between January 2012 and November 2015...
May 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28444360/role-of-early-onset-neutropenia-in-development-of-candidemia-in-premature-infants
#17
Nermin Ramy, Mohamed Hashim, Heba Abou Hussein, Happy Sawires, Maha Gaafar, Ayat El Maghraby
Background: The aim of the study was to assess the effect of early-onset neutropenia (EON) on the development of candidemia in premature infants and evaluate other risk factors. Materials and Methods: This prospective study was carried out in a neonatal intensive care unit of Cairo University Hospital. Fifty neutropenic premature infants were matched to 50 non-neutropenics. Subjects were then regrouped into candidemics and non-candidemics to study other risk factors such as central venous catheters, mechanical ventilation, parenteral nutrition, drugs as corticosteroids and others...
February 1, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28289498/intracardiac-fungal-mass-in-a-term-neonate
#18
Magdy M El-Sayed Ahmed, Mustafa Kurkluoglu, Conor F Hynes, Darren Klugman, Elena Puscasiu, Dilip S Nath
Systemic fungal infections pose insidious challenges in neonatal intensive care settings. We present the case of a 9-day-old male term neonate admitted for polymicrobial sepsis and hepatic dysfunction who later developed candidemia superinfection. Despite broad antifungal therapy, the fungemia was complicated by progressive growth of a fungus ball in the right ventricular outflow tract that threatened cardiac function. Surgical excision of the mass was undertaken by right atriotomy and histologic examination confirmed Candida albicans...
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28195093/molecular-identification-of-candida-species-isolated-from-cases-of-neonatal-candidemia-using-polymerase-chain-reaction-restriction-fragment-length-polymorphism-in-a-tertiary-care-hospital
#19
COMPARATIVE STUDY
Akeela Fatima, Gulnaz Bashir, Tehmeena Wani, Abiroo Jan, Amrish Kohli, Mosin S Khan
CONTEXT: Candida spp. is an emerging cause of bloodstream infections worldwide. Delay in speciation of Candida isolates by conventional methods and resistance to antifungal drugs in various Candida species are responsible for the increase in morbidity and mortality due to candidemia. Hence, the rapid identification of Candida isolates is very important for the proper management of patients with candidemia. AIMS: The aim was to re-evaluate the identification of various Candida spp...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28159945/simultaneous-two-site-blood-culture-for-diagnosis-of-neonatal-sepsis
#20
Priya Tomar, Amit Garg, Rashee Gupta, Abhishek Singh, Navratan Kumar Gupta, Amit Upadhyay
OBJECTIVE: To evaluate efficacy of two blood cultures taken simultaneously from two different sites as compared to standard practice of single blood culture in diagnosis of neonatal sepsis. STUDY DESIGN: Prospective cohort study. Setting: A tertiary-care center at a public hospital. PARTICIPANTS: 475 neonates admitted to intensive care unit with suspected sepsis, from August 2014-July 2015. INTERVENTION: Two blood cultures drawn from two different peripheral veins in patients with suspected neonatal sepsis...
March 15, 2017: Indian Pediatrics
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