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https://www.readbyqxmd.com/read/27894674/emergence-of-plasmid-mediated-colistin-resistance-and-new-delhi-metallo-%C3%AE-lactamase-genes-in-extensively-drug-resistant-escherichia-coli-isolated-from-a-patient-in-thailand
#1
Wantana Paveenkittiporn, Anusak Kerdsin, Sukanya Chokngam, Charatdao Bunthi, Somchai Sangkitporn, Christopher J Gregory
We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
November 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27825605/antimicrobial-resistance-in-enterobacteriaceae-in-brazil-focus-on-%C3%AE-lactams-and-polymyxins
#2
REVIEW
Jorge Luiz Mello Sampaio, Ana Cristina Gales
During the last 30 years there has been a dissemination of plasmid-mediated β-lactamases in Enterobacteriaceae in Brazil. Extended spectrum β-lactamases (ESBL) are widely disseminated in the hospital setting and are detected in a lower frequency in the community setting. Cefotaximases are the most frequently detected ESBL type and Klebsiella pneumoniae is the predominant species among ESBL producers. Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae became widely disseminated in Brazil during the last decade and KPC production is currently the most frequent resistance mechanism (96...
October 25, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27807154/detection-of-an-escherichia-coli-st167-strain-with-two-tandem-copies-of-blandm-1-encoded-in-the-chromosome
#3
Ping Shen, Maoli Yi, Ying Fu, Zhi Ruan, Xiaoxing Du, Yunsong Yu, Xinyou Xie
The emergence and spread of New Delhi metallo-β-lactamase-1 (NDM-1)-producing Enterobacteriaceae have disseminated rapidly throughout the world, posing an urgent threat to public health. Previous studies confirmed that the blaNDM-1 gene is typically encoded in plasmids, but rarely in chromosome. Here, we discovered a multi-drug resistant Escherichia coli strain Y5, originating from a urine sample and containing the blaNDM-1 gene, which were unable to transfer by either conjugation or electrotransformation...
November 2, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27754764/combination-of-tigecycline-and-levofloxacin-for-successful-treatment-of-nosocomial-pneumonia-caused-by-new-delhi-metallo-%C3%AE-lactamase-1-producing-raoultella-planticola
#4
Zhijie Pan, Rong Liu, Pei Zhang, Hua Zhou, Yiqi Fu, Jianying Zhou
Raoultella planticola is a gram-negative bacterium that rarely causes diseases in humans. Here, we present a case of hospital-acquired pneumonia caused by R. planticola that likely originated in the gastrointestinal tract. To the best of our knowledge, this is the second report describing the detection of the gene New Delhi Metallo-β-lactamase-1 (blaNDM-1) in multidrug-resistant R. planticola. Clinical samples were collected for bacterial culture and antimicrobial susceptibility testing from a patient during hospitalization...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27737785/detection-of-carbapenemase-activity-in-enterobacteriaceae-using-lc-ms-ms-in-comparison-with-the-neo-rapid-carb-kit-using-direct-visual-assessment-and-colorimetry
#5
Charlotte A Huber, Hanna E Sidjabat, Hosam M Zowawi, David Kvaskoff, Sarah Reed, John F McNamara, Kate L McCarthy, Patrick Harris, Benjamin Toh, Alexander M Wailan, David L Paterson
It has been described that the sensitivity of the Carba NP test may be low in the case of OXA-48-like carbapenamases and mass spectrometry based methods as well as a colorimetry based method have been described as alternatives. We evaluated 84 Enterobacteriaceae isolates including 31 OXA-48-like producing isolates and 13 isolates that produced either an imipenemase (IMP; n=8), New Delhi metallo-β-lactamase (NDM; n=3), or Klebsiella pneumoniae carbapenemase (KPC; n=2), as well as 40 carbapenemase negative Enterobacteriaceae isolates...
October 11, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27714593/emergence-of-new-delhi-metallo-beta-lactamase-1-and-other-carbapenemase-producing-acinetobacter-calcoaceticus-baumannii-complex-among-patients-in-hospitals-in-ha-noi-viet-nam
#6
D N Tran, H H Tran, M Matsui, M Suzuki, S Suzuki, K Shibayama, T D Pham, T T Van Phuong, D A Dang, H S Trinh, C T Loan, L T V Nga, H R van Doorn, H F L Wertheim
Acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant A. baumannii isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems...
October 6, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27685673/emerging-new-delhi-metallo-%C3%AE-lactamase-1-type-producing-gram-negative-bacteria-isolated-from-cairo-university-pediatric-hospital-cairo-egypt
#7
Mona Wassef, Mona Abdelhaleim, Doaa Ghaith, Yasmin El-Mahdy
New Delhi metallo-β-lactamase (NDM) compromises the efficacy of almost all β-lactam antibiotics, including carbapenems. This study aimed to screen for the blaNDM-1-type gene and NDM-1-type carbapenemase production among Gram-negative bacteria in Cairo University Pediatric Hospital (Cairo, Egypt). Among 382 Gram-negative clinical isolates collected over the period October 2013 to May 2014, 100 clinical isolates showing reduced carbapenem (imipenem and meropenem) susceptibility were included in this study. Initial phenotypic screening for NDM enzyme production was performed by Etest for metallo-β-lactamases (EMBL)...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27668722/effect-of-single-dose-carbapenem-exposure-on-transcriptional-expression-of-blandm-1-and-mexa-in-pseudomonas-aeruginosa
#8
Debarati Choudhury, Deepjyoti Paul, Anindya Sundar Ghosh, Anupam Das Talukdar, Manabendra Dutta Choudhury, Anand Prakash Maurya, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee
The therapeutic option of a carbapenem antibiotic is compromised in Pseudomonas aeruginosa owing both to acquired and intrinsic resistance mechanisms. In recent years, New Delhi metallo-β-lactamase has been the focus as a predominant carbapenem resistance determinant. However, it is unclear which of the mechanisms might be adopted by a P. aeruginosa strain possessing both blaNDM-1 and an overexpressed MexAB-OprM system during carbapenem therapy. This study investigated the interplay of both mechanisms in clinical isolates of P...
December 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27649032/carbapenem-resistance-in-clonally-distinct-clinical-strains-of-vibrio-fluvialis-isolated-from-diarrheal-samples
#9
Goutam Chowdhury, Gururaja Perumal Pazhani, Anirban Sarkar, Krishnan Rajendran, Asish K Mukhopadhyay, Mihir K Bhattacharya, Amit Ghosh, Thandavarayan Ramamurthy
Carbapenems have been used for many years to treat severe nosocomial Enterobacteriaceae infections. The spread of resistance to these drugs among other bacterial families is an emerging problem worldwide, mostly caused by New Delhi metallo-β-lactamase (NDM-1). We screened for the prevalence of NDM-1-expressing enteric pathogens from hospitalized patients with acute diarrhea in Kolkata, India, and identified 27 Vibrio fluvialis-harboring blaNDM-1 (NDM-VF) strains. These isolates were also resistant to all the tested antimicrobial drugs except doxycycline...
October 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27624962/aryl-alkyl-lysines-membrane-active-small-molecules-active-against-murine-model-of-burn-infection
#10
Chandradhish Ghosh, Goutham B Manjunath, Mohini M Konai, Divakara S S M Uppu, Krishnamoorthy Paramanandham, Bibek R Shome, Raju Ravikumar, Jayanta Haldar
Infections caused by drug-resistant Gram-negative pathogens continue to be significant contributors to human morbidity. The recent advent of New Delhi metallo-β-lactamase-1 (blaNDM-1) producing pathogens, against which few drugs remain active, has aggravated the problem even further. This paper shows that aryl-alkyl-lysines, membrane-active small molecules, are effective in treating infections caused by Gram-negative pathogens. One of the compounds of the study was effective in killing planktonic cells as well as dispersing biofilms of Gram-negative pathogens...
February 12, 2016: ACS Infectious Diseases
https://www.readbyqxmd.com/read/27624807/an-irish-outbreak-of-new-delhi-metallo-%C3%AE-lactamase-ndm-1-carbapenemase-producing-enterobacteriaceae-increasing-but-unrecognized-prevalence
#11
C O'Connor, M Cormican, T W Boo, E McGrath, B Slevin, A O'Gorman, M Commane, S Mahony, E O'Donovan, J Powell, R Monahan, C Finnegan, M G Kiernan, J C Coffey, L Power, N H O'Connell, C P Dunne
BACKGROUND: Carbapenemase-producing Enterobacteriaceae (CPE) may cause healthcare-associated infections with high mortality rates. New Delhi metallo-β-lactamase-1 (NDM-1) is among the most recently discovered carbapenemases. AIM: To report the first outbreak of NDM-1 CPE in Ireland, including microbiological and epidemiological characteristics, and assessing the impact of infection prevention and control measures. METHODS: This was a retrospective microbiological and epidemiological review...
December 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27600040/molecular-epidemiology-and-genome-dynamics-of-new-delhi-metallo-beta-lactamase-ndm-producing-extraintestinal-pathogenic-e-coli-expec-strains-from-india
#12
Amit Ranjan, Sabiha Shaik, Agnismita Mondal, Nishant Nandanwar, Arif Hussain, Torsten Semmler, Narender Kumar, Sumeet Tiwari, Savita Jadhav, Lothar H Wieler, Niyaz Ahmed
The global dissemination amidst increasing incidence of carbapenem-resistant, Gram-negative organisms has resulted in acute public health concerns. Here, we present a retrospective multicenter study on molecular characterization of metallo-beta-lactamase (MBL) producing clinical E. coli isolates recovered from extraintestinal infections in two hospitals in Pune, India. We screened a large sample size of 510 E. coli isolates for MBL production wherein we profiled their molecular determinants, antimicrobial resistance phenotypes, functional virulence properties, genomic features and transmission dynamics...
September 6, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27593176/the-global-epidemiology-of-carbapenemase-producing-enterobacteriaceae
#13
David van Duin, Yohei Doi
Carbapenemase-producing Enterobacteriaceae (CPE) are an important and increasing threat to global health. Both clonal spread and plasmid-mediated transmission contribute to the ongoing rise in incidence of these bacteria. Among the 4 classes of β-lactamases defined by the Ambler classification system, the carbapenemases that confer carbapenem resistance in Enterobacteriaceae belong to 3 of them: Class A (K. pneumoniae carbapenemases, KPC), Class B (metallo-β-lactamases, MBL including New Delhi metallo-β-lactamases, NDM) and Class D (OXA-48-like carbapenemases)...
August 11, 2016: Virulence
https://www.readbyqxmd.com/read/27584588/reducing-the-impact-of-carbapenem-resistant-enterobacteriaceae-on-vulnerable-patient-groups-what-can-be-done
#14
Gökhan Metan, Murat Akova
PURPOSE OF REVIEW: Carbapenem-resistant Enterobacteriaceae (CRE) is a worldwide challenge and associated with a high mortality rate in critically ill patients. This review focused on rapid diagnosis, optimization of antimicrobial therapy, and implication of effective infection control precautions to reduce impact of CRE on vulnerable patients. RECENT FINDINGS: Several new diagnostic assays have recently been described for the early diagnosis of CRE. Retrospective studies are supportive for colistin plus meropenem combination for the treatment of CRE infections; however, solid evidence is still lacking...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27575913/emergence-of-multidrug-resistant-new-delhi-metallo-%C3%AE-lactamase-1-producing-klebsiella-pneumoniae-in-egypt
#15
Mahmoud A F Khalil, Abdelaziz Elgaml, Mohammed El-Mowafy
Despite expansion of the New Delhi metallo-β-lactamase-1 (NDM-1) worldwide, the incident of outbreaks regarding Egypt is still uncommon. In this survey, we denounce the emanation of multidrug-resistant NDM-1-producing Klebsiella pneumoniae in Egypt. We have reclaimed 46 unrepeatable carbapenem-resistant K. pneumoniae isolates at El-demerdash hospital, Ain Shams University, Cairo, Egypt. All the isolates showed a decreased sensitivity to imipenem and meropenem via the disc diffusion method. Among the isolates, 10 were proven as NDM-1 producers by utilizing the phenotypic methods (modified Hodge test and EDTA synergistic test) and specific PCR detection of NDM-1 encoding gene, blaNDM-1...
August 30, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27570310/molecular-characterization-and-computational-modelling-of-new-delhi-metallo-%C3%AE-lactamase-5-from-an-escherichia-coli-isolate-koec3-of-bovine-origin
#16
D Purkait, A Ahuja, U Bhattacharjee, A Singha, K Rhetso, T K Dey, S Das, R K Sanjukta, K Puro, I Shakuntala, A Sen, A Banerjee, I Sharma, R S Bhatta, M Mawlong, C Guha, N R Pradhan, S Ghatak
Emergence of antimicrobial resistance mediated through New Delhi metallo-β-lactamases (NDMs) is a serious therapeutic challenge. Till date, 16 different NDMs have been described. In this study, we report the molecular and structural characteristics of NDM-5 isolated from an Escherichia coli isolate (KOEC3) of bovine origin. Using PCR amplification, cloning and sequencing of full blaNDM gene, we identified the NDM type as NDM-5. Cloning of full gene in E. coli DH5α and subsequent assessment of antibiotic susceptibility of the transformed cells indicated possible role of native promoter in expression blaNDM-5...
June 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27565452/detection-of-new-delhi-metallo-beta-lactamase-encoded-by-blandm-1-in-enterobacter-aerogenes-in-china
#17
Yong Shen, Wei-Qiang Xiao, Jiao-Mei Gong, Jun Pan, Qing-Xia Xu
BACKGROUND: The increase in blaNDM -1 in Enterobacteriaceae has become a major concern worldwide. In previous study, we investigated clonal dissemination and mechanisms of resistance to carbapenem in China. METHODS: We carried out retrospective surveillance for blaNDM -1 among carbapenem-resistant enterobacter strains, which were isolated from patients at our hospital by bacterial strains selection, antimicrobial susceptibility testing, species identification, and molecular detection of resistance gene...
August 27, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27553951/molecular-characterization-of-invasive-carbapenem-resistant-acinetobacter-baumannii-from-a-tertiary-care-hospital-in-south-india
#18
Saranya Vijayakumar, Radha Gopi, Priya Gunasekaran, Manjurekar Bharathy, Kamini Walia, Shalini Anandan, Balaji Veeraraghavan
INTRODUCTION: Acinetobacter baumannii is an important opportunistic pathogen responsible for causing nosocomial infections. Carbapenems are considered to be the drug of choice to treat infections caused by multidrug-resistant A. baumannii. The prevalent mechanism of carbapenem resistance in A. baumannii is enzymatic degradation by β-lactamases. Therefore, the aim of the study is to determine the prevalence and distribution of molecular determinants among the clinical isolates of carbapenem-resistant A...
September 2016: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/27551277/carbapenem-resistance-in-acinetobacter-baumannii-and-other-acinetobacter-spp-causing-neonatal-sepsis-focus-on-ndm-1-and-its-linkage-to-isaba125
#19
Somdatta Chatterjee, Saswati Datta, Subhasree Roy, Lavanya Ramanan, Anindya Saha, Rajlakshmi Viswanathan, Tapas Som, Sulagna Basu
Carbapenem-resistant determinants and their surrounding genetic structure were studied in Acinetobacter spp. from neonatal sepsis cases collected over 7 years at a tertiary care hospital. Acinetobacter spp. (n = 68) were identified by ARDRA followed by susceptibility tests. Oxacillinases, metallo-β-lactamases (MBLs), extended-spectrum β-lactamases and AmpCs, were detected phenotypically and/or by PCR followed by DNA sequencing. Transconjugants possessing the bla NDM-1(New Delhi metallo-β-lactamase) underwent further analysis for plasmids, integrons and associated genes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27534373/the-role-of-doxycycline-in-the-therapy-of-multidrug-resistant-e-coli-an-in-vitro-study
#20
Chih-Cheng Lai, Chi-Chung Chen, Hui-Ling Huang, Yin-Ching Chuang, Hung-Jen Tang
This study assessed the in vitro antibacterial activity of combinations of amikacin and doxycycline or tigecycline against multidrug-resistant E. coli isolates. Twenty-four different pulsotypes, including 10 extended-spectrum β-lactamase (ESBL)-, 10 carbapenem-resistant, 2 New Delhi Metallo-beta-lactamase (NDM)- and 2 Klebsiella pneumoniae carbapenemase (KPC)-E. coli isolates were collected. All 24 isolates were susceptible to amikacin and tigecycline. Only 30% of ESBL and 50% of carbapenem-resistant E. coli were susceptible to doxycycline...
August 18, 2016: Scientific Reports
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