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T David Luo, Alejandro Marquez-Lara, Zachary K Zabarsky, Jeremy B Vines, Katie C Mowry, Alexander H Jinnah, Xue Ma, Benjamin W Berwick, Jeffrey S Willey, Zhongyu Li, Thomas L Smith, Tadhg J O'Gara
PURPOSE: Various animal models have been proposed to mimic the pathophysiologic process of intervertebral disc degeneration, a leading cause of back pain. The purpose of this study is to describe a minimally invasive technique via percutaneous needle puncture of the annulus fibrosus in New Zealand white rabbits. METHODS: Under fluoroscopic guidance, an 18-gauge spinal needle was inserted 2 cm lateral to the midline spinous process. The needle was slowly advanced at approximately 45° angle until it was adjacent to the L5/L6 disc space...
May 2018: Journal of Orthopaedic Surgery
Guoxin Fan, Chaobo Feng, Wangcheng Xie, Dongdong Wang, Fei Liu, Chun Yuan, Zhi Zhou, Shisheng He
Background: Percutaneous endoscopic transforaminal discectomy (PETD) is usually chosen for lumbar disc herniation due to its obvious advantages such as small incision and absence of nerve or muscular traction. However, learning PETD is a great challenge for inexperienced surgeons. Objective: The study aimed to investigate whether isocentric navigation would be beneficial in PETD training. Methods: A total of 117 inexperienced surgeons were trained with PETD at L2/3, L3/4, L4/5, and L5/S1 on the cadavers without (Group A n=58) or with (Group B n=59) isocentric navigation...
2018: BioMed Research International
Haydn Hoffman, Shelley S Bennett, Charles H Li, Piia Haakana, Daniel C Lu
Background Lumbar spinal stenosis (LSS) is the most common indication for spine surgery among the geriatric population. Although decompressive surgery is effective, older patients do not benefit as much as younger patients, and they are frequently excluded from studies assessing postoperative physiotherapy. We sought to evaluate the long-term outcomes after surgery when a novel postoperative physiotherapy regimen was included. Methods We performed a retrospective review of patients with LSS greater than 70 years old who underwent lumbar decompressive surgery by the senior author over the past five years...
June 11, 2018: Curēus
Chenglong Liu, Fei Zhang, Haihua Liu, Fang Wei
PURPOSE: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. METHODS: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested at relevant time points during an observation period of 28 days. Expression of CX3CL1 and NF-κBin the dorsal root ganglion (DRG) were performed by using Western blotting and RT-PCR...
July 2018: Acta Cirúrgica Brasileira
Phani Krishna Karthik Yelamarthy, Tarush Rustagi, Rajat Mahajan, Vishwajeet Singh, Kalidutta Das, Murari Lal Bansal, Bibhudendu Mohapatra, Harvinder Singh Chhabra
Background: Charcot spinal arthropathy (CSA), a destructive spinal pathology, is seen in patients with impaired sensation. Superimposed infection in the affected spinal segments can lead to a challenge in the diagnosis and management. Spinal cord injury (SCI) is the leading cause of CSA as persons with SCI have significantly impaired sensation. Though infection of the CSA is rare, SCI persons are prone to superimposed infection of the Charcot spine. We report atypical presentations of three cases of CSA with superimposed infection...
2018: Spinal Cord Series and Cases
Miral V Lunagariya, Khyati P Thakor, Reena R Varma, Bhargav N Waghela, Chandramani Pathak, Mohan N Patel
Square planar mononuclear platinum(ii) complexes were synthesized in the presence of neutral bidentate heterocyclic (5-quinoline 1,3,5-tri-substituted pyrazole scaffold) ligands and K2 PtCl4 salt. The synthesized compounds were characterized by micro-elemental analysis, FT-IR, UV-vis, 1 H NMR, 13 C NMR, TGA, mass spectrometry and molar conductivity. Their biological activities were investigated by in vitro brine shrimp lethality bioassay, in vitro antimicrobial study against five different pathogens, in vivo cellular level cytotoxicity against Schizosaccharomyces pombe cells, and in vitro anti-proliferation assay...
February 1, 2018: MedChemComm
A B Spejo, G B Chiarotto, A D F Ferreira, D A Gomes, R S Ferreira, B Barraviera, A L R Oliveira
BACKGROUND: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a promising tool that can reduce glial reaction and provide trophic factors to lesioned neurons. METHODS: Lewis adult female rats were submitted to a unilateral ventral funiculus cut at the spinal levels L4, L5, and L6. The animals were divided into the following groups: IA (intramedullary axotomy), IA + DMEM (Dulbecco's modified Eagle's medium), IA + FS (fibrin sealant), IA + MSC (106 cells), and IA + FS + MSC (106 cells)...
August 14, 2018: Journal of Neuroinflammation
Anders Joelson, Barbro I Danielson, Rune Hedlund, Per Wretenberg, Karin Frennered
BACKGROUND: This case series of consecutive patients evaluated sagittal balance and health-related quality of life (HRQoL) 3 decades after in situ arthrodesis for high-grade isthmic spondylolisthesis. METHODS: Global sagittal balance, pelvic parameters, and compensatory mechanisms were evaluated on standing lateral radiographs of the spine and pelvis for 28 of 39 consecutive patients, 28 to 41 years after in situ arthrodesis for high-grade L5 to S1 spondylolisthesis...
August 15, 2018: Journal of Bone and Joint Surgery. American Volume
Wendy Saltzman, David H Abbott, Neil Binkley, Ricki J Colman
Estrogen depletion leads to bone loss in almost all mammals with frequent regular ovarian cycles. However, subordinate adult female common marmosets (Callithrix jacchus) undergo socially induced anovulation and hypoestrogenism without clinically apparent adverse skeletal consequences. Thus, we speculated that this non human primate might have evolved a mechanism to avoid estrogen-depletion bone loss. To test this possibility, we performed three experiments in which lumbar-spine (L5-L6) bone mineral content (BMC) and density (BMD) were assessed using dual-energy X-ray absorptiometry: (i) cross-sectionally in 13 long-term ovariectomized animals and 12 age- and weight-matched controls undergoing ovulatory cycles; (ii) longitudinally in 12 animals prior to, 3-4 and 6-7 months following ovariectomy (ovx), and six controls; and (iii) cross-sectionally in nine anovulatory subordinate and nine dominant females...
August 14, 2018: American Journal of Primatology
Luke J Norbury, Katarzyna Basałaj, Anna Zawistowska-Deniziak, Alicja Sielicka, Przemysław Wilkowski, Agnieszka Wesołowska, Peter M Smooker, Halina Wędrychowicz
Fasciola hepatica infection continues to be a major problem in the agriculture sector, particularly in sheep and cattle. Cathepsin L and B proteases are major components of the excretory/secretory material of the parasite, and their roles in several important aspects of parasite invasion and survival has led to their use as targets in rational vaccine design. Previous studies in rats demonstrated that the use of stage-specific antigens, cathepsin B2 and cathepsin L5, as part of a multivalent vaccine, was able to confer significant protection against challenge...
July 15, 2018: Veterinary Parasitology
Tina W Wong, Daniel G Gridley, Iman Feiz-Erfan
Background: Epidural venous plexus congestion at L5-S1 due to inferior vena cava (IVC) thrombosis led to an acute cauda equina syndrome (CES). Laminectomy to rule out an epidural abscess, allowing for resection of the dilated veins, led to immediate symptom resolution. Case Description: A 47-year-old male presented with acute urinary retention and left greater than right lower extremity paresis of 2 weeks duration. Magnetic resonance imaging (MRI) revealed a contrast-enhancing space-occupying anterior epidural L5-S1 level lesion resulting in cauda equina compression...
2018: Surgical Neurology International
Navneh Samagh, Raghavendra K Pai, Thomas K Mathews, Kiran Jangra, Ravi G Varma
Background and Aims: Pre-emptive analgesia using caudal epidural technique is an underutilized technique in lumbosacral spine surgery patients. We intend to study if pre-emptive analgesia with a single caudal epidural injection of ropivacaine is an effective method of postoperative analgesia by assessing the quality and duration of pain relief and intraoperative opioid requirement. Material and Methods: Eighty patients undergoing lumbosacral spine surgeries by the posterior approach were randomized to ropivacaine (R) group ( n = 40) and saline (S) group ( n = 40)...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Angelika Więckowska, Olga Gajewska-Woźniak, Anna Głowacka, Benjun Ji, Kamil Grycz, Julita Czarkowska-Bauch, Małgorzata Skup
Complete thoracic spinal cord transection (SCT) impairs excitatory cholinergic inputs to ankle extensor (Soleus; Sol) but not to flexor (Tibialis Anterior; TA) α-motoneurons (MNs) modifiable by locomotor training applied post-transection. The purpose of this study was to investigate whether Sol and TA MNs adapt to changes in cholinergic environment by differential regulation of their muscarinic receptors M2 (M2R). We examined Chrm2 (M2R gene) transcript level, high-affinity [3 H]QNB ligand binding, distribution and density of M2R immunolabeling in lumbar (L) segments in intact and SCT rats, with or without inclusion of 5-week treadmill locomotor training...
August 13, 2018: Journal of Neurochemistry
Koji Ishikawa, Tomoaki Toyone, Toshiyuki Shirahata, Yoshifumi Kudo, Akira Matsuoka, Hiroshi Maruyama, Chikara Hayakawa, Soji Tani, Masaya Sekimizu, Koki Tsuchiya, Takeshi Eguro, Yusuke Oshita, Tomoyuki Ozawa, Yusuke Nakao, Shigeo Sano, Takashi Nagai, Koji Kanzaki, Katsunori Inagaki
STUDY DESIGN: Prospective feasibility study on consecutive patients. OBJECTIVE: The aim of this study was to investigate the ability of regional BMD around the pedicle screw to predict the screw fixation. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is the gold standard technique for spinal fusion. Despite the advantage of biomechanical stability, screw loosening is a common complication. In previous studies, pullout strength and screw insertional torque were correlated, and most importantly, affected by bone mineral density (BMD)...
August 10, 2018: Clinical Spine Surgery
Lenka Pešáková, Jana Hlávková, Marie Nakládalová, Pavel Urban, Petr Gaďourek, Tomáš Tichý, Alena Boriková, Andrea Laštovková, Daniela Pelclová
OBJECTIVE: As a part of regular revision of the List of Occupational Diseases in the Czech Republic, efforts have been made to add a new item so that lumbar spine disease caused by overload may be recognized as occupational one, with adherence to the valid national rules, that is, clinical criteria are met and objective assessment confirms working conditions under which, according to recent scientific knowledge, such an occupational disease develops. The aim is to provide information on the use of a proposed method for working condition assessment in a real setting, based on the initial experiences gained from a pilot study carried out to validate the method...
June 2018: Central European Journal of Public Health
Yuma Saito, Yu Kume, Ayuto Kodama, Kotaro Sato, Megumi Yasuba
BACKGROUND: Limited information is available on the relationship between sleep disturbances during nighttime and the behavioral and psychological symptoms of dementia in older nursing-home residents. However, a few reports on the association between the circadian rest-activity rhythm and the behavioral and psychological symptoms of dementia in older residents have been published. The main objective of the present study was to examine the association among the circadian rest-activity rhythm, behavioral and psychological symptoms, and the cognitive function status among older individuals living in facilities...
August 13, 2018: Chronobiology International
Clay M Elswick, Hazem M Ahmed
BACKGROUND: Treatment failures of artificial disc implantation are well-described, but posterior herniation of the arthroplasty core is rare. We present a case of posterior herniation of the arthroplasty core resulting in cauda equina syndrome in a 36-yr-old woman. Preoperative imaging studies including computed tomography (CT), magnetic resonance imaging (MRI), and CT Myelogram were performed; only the CT Myelogram demonstrated the severe compression well. This report highlights the radiographic findings on multiple imaging modalities, clinical implications, and management considerations of posterior arthroplasty failures...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
Aiden Morrison, Nadezda Sokolova, James Curran
This paper investigates the challenges of developing a multi-frequency radio frequency interference (RFI) monitoring and characterization system that is optimized for ease of deployment and operation as well as low per unit cost. To achieve this, we explore the design and development of a multiband global navigation satellite system (GNSS) front-end which is intrinsically capable of synchronizing side channel information from non-RF sensors, such as inertial measurement units and integrated power meters, to allow the simultaneous production of substantial amounts of sampled spectrum while also allowing low-cost, real-time monitoring and logging of detected RFI events...
August 8, 2018: Sensors
Alexandre Rasouli, Jason M Cuellar, Lea Kanim, Rick Delamarter
BACKGROUND: Recent studies demonstrate the efficacy of lumbar arthroplasty using the ProDisc-L. Patients frequently present with multilevel pathology and may be candidates for multilevel disk replacement. PURPOSE: To evaluate clinical outcomes and sagittal range of motion of operated levels and adjacent lumbar motion segments in multiple-level ProDisc-L constructs after 2-6 years follow-up. PATIENT SAMPLE: A total of 159 patients underwent adjacent 2-level (n=114), 3-level (n=41), or 4-level (n=4) lumbar total disk replacement (TDR)...
August 7, 2018: Clinical Spine Surgery
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