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https://www.readbyqxmd.com/read/30099654/added-value-of-non-criteria-antiphospholipid-antibodies-for-antiphospholipid-syndrome-lessons-learned-from-year-long-routine-measurements
#1
Polona Žigon, Anuška Podovšovnik, Aleš Ambrožič, Matija Tomšič, Alojzija Hočevar, Nataša Gašperšič, Žiga Rotar, Sonja Praprotnik, Snežna Sodin Šemrl, Saša Čučnik
The international classification criteria for definite antiphospholipid syndrome (APS) include three laboratory measurements: lupus anticoagulant (LA), IgG and IgM isotypes of anti-cardiolipin (aCL) and anti-β2glycoprotein I antibodies (anti-β2GPI). When persistently elevated, they are specific for APS; however, many patients that fulfil clinical criteria may exhibit negative serological results. These "seronegative" APS (SN-APS) are exposed to an increased thrombotic risk. The aims of our cross-sectional, retrospective study of consecutive autoimmune patients' samples were to evaluate the association of non-criteria antiphospholipid antibodies (aPL) with thrombosis and obstetric events, to calculate the risk score for adverse events and to assess the specific contribution of single aPL positivity in SN-APS...
August 11, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30058959/rationale-design-and-baseline-participant-characteristics-in-the-mri-and-cognitive-substudy-of-the-cardiovascular-outcomes-for-people-using-anticoagulation-strategies-trial
#2
Mukul Sharma, Robert G Hart, Eric E Smith, Jackie Bosch, Fei Yuan, Amparo Casanova, John W Eikelboom, Stuart J Connolly, Gloria Wong, Rafael Diaz, Patricio Lopez-Jaramillo, Georg Ertl, Stefan Störk, Gilles R Dagenais, Eva M Lonn, Lars Ryden, Andrew M Tonkin, John D Varigos, Deepak L Bhatt, Kelley Rh Branch, Jeffrey L Probstfield, Jae-Hyung Kim, Jong-Won Ha, Martin O'Donnell, Dragos Vinereanu, Keith Aa Fox, Yan Liang, Lisheng Liu, Jun Zhu, Nana Pogosova, Aldo P Maggioni, Alvaro Avezum, Leopoldo S Piegas, Katalin Keltai, Matyas Keltai, Nancy Cook Bruns, Scott Berkowitz, Salim Yusuf
Background Covert vascular disease of the brain manifests as infarcts, white matter hyperintensities, and microbleeds on MRI. Their cumulative effect is often a decline in cognition, motor impairment, and psychiatric disorders. Preventive therapies for covert brain ischemia have not been established but represent a huge unmet clinical need. Aims The MRI substudy examines the effects of the antithrombotic regimens in COMPASS on incident covert brain infarcts (the primary outcome), white matter hyperintensities, and cognitive and functional status in a sample of consenting COMPASS participants without contraindications to MRI...
July 30, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30056785/case-report-and-systematic-review-of-pulmonary-embolism-mimicking-st-elevation-myocardial-infarction
#3
Pedro A Villablanca, Peter P Vlismas, Tatsiana Aleksandrovich, Arthur Omondi, Tanush Gupta, David F Briceno, Mario J Garcia, Jose Wiley
Background To study trends in the clinical presentation, electrocardiograms, and diagnostic imaging in patients with pulmonary embolism presenting as ST segment elevation. Methods We performed a systematic literature search for all reported cases of pulmonary embolism mimicking ST-elevation myocardial infarction. Pre-specified data such as clinical presentation, electrocardiogram changes, transthoracic echocardiographic findings, cardiac biomarkers, diagnostic imaging, therapy, and outcomes were collected. Results We identified a total of 34 case reports...
July 30, 2018: Vascular
https://www.readbyqxmd.com/read/30053822/unusual-case-of-chronic-recurrent-multifocal-osteomyelitis
#4
Ausra Snipaitiene, Rima Sileikiene, Justina Klimaite, Edita Jasinskiene, Rimantas Uktveris, Lina Jankauskaite
BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory bone disorder that primarily affects young girls, with a mean age of 10 years at onset. Generally, it is a self-limited disease. However, recent data indicate that more than 50% of patients have a chronic persistent disease and about 20% a recurring course of this condition. Also, there are more cases reported with associated auto-inflammatory and autoimmune diseases. In this case report, we present a rare case of sporadic CRMO in which the patient eventually developed C-ANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies)-associated renal vasculitis and hyperparathyroidism...
July 27, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/30039233/management-of-venous-thromboembolism-in-pregnancy
#5
REVIEW
Annemarie E Fogerty
PURPOSE OF REVIEW: This manuscript addresses the risks for venous thromboembolism (VTE) during pregnancy and the associated challenges of both diagnosis and treatment. RECENT FINDINGS: The obstacles to diagnosis given lack of specificity of typical biomarkers to predict VTE in pregnancy, as well as the unique fetal and bleeding risks introduced by managing massive pulmonary embolism (PE) with thrombolytics or thrombectomy are highlighted. VTE during pregnancy and the postpartum window occurs at a 6-10-fold higher rate compared with age-matched peers and is a major cause of morbidity and mortality...
July 23, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29967898/-serratia-marcescens-sepsis-in-a-child-with-deep-venous-thrombosis-a-case-report
#6
Iulia Armean, Carmen Duicu, Cornel Aldea, Lorena Melit
Introduction: Venous thromboembolism is a rare condition in paediatrics that included both deep venous thrombosis and pulmonary embolism. Serratia marcescens is a gram-negative bacterium that belongs to the Enterobacteriaceae family and tends to affect immunocompromised hosts. Case report: We report the case of an 11-year-old boy, admitted in the Pediatric Clinic I from Emergency County Hospital Tîrgu Mureş, Romania with intense pain, swelling, cyanosis and claudication of the left foot...
January 2018: Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29964323/discovery-of-novel-plasma-biomarkers-for-future-incident-venous-thromboembolism-by-untargeted-synchronous-precursor-selection-mass-spectrometry-proteomics
#7
S B Jensen, K Hindberg, T Solomon, E N Smith, J D Lapek, D J Gonzalez, N Latysheva, K A Frazer, S K Braekkan, J-B Hansen
BACKGROUND: Prophylactic anticoagulant treatment may substantially reduce the incidence of venous thromboembolism (VTE) but entails considerable risk of severe bleeding. Identification of individuals at high risk of VTE through the use of predictive biomarkers is desirable in order to achieve a favorable benefit-to-harm ratio. OBJECTIVE: We aimed to identify predictive protein biomarker candidates of VTE. METHODS: We performed a case-control study of 200 individuals that participated in the Tromsø Study, a population-based cohort, where blood samples were collected before the VTE events occurred...
July 2, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29956554/left-atrial-thrombus-resolution-in-non-valvular-atrial-fibrillation-or-flutter-biomarker-substudy-results-from-a-prospective-study-with-rivaroxaban-x-tra
#8
Kazuo Miyazawa, Daniele Pastori, Christoph Hammerstingl, Riccardo Cappato, Isabelle Ling Meng, Frank Kramer, Ariel Cohen, Anke Schulz, Martin van Eickels, Gregory Y H Lip, Francisco Marin
BACKGROUND: Non-vitamin K antagonist oral anticoagulants including rivaroxaban are widely used for stroke prevention in patients with atrial fibrillation (AF). We investigated the relationship between plasma biomarkers (indicative of thrombogenesis, fibrinolysis and inflammation) and left atrial thrombus resolution after rivaroxaban treatment. METHODS: This was an ancillary analysis of the X-TRA study, which was a prospective interventional study evaluating the use of rivaroxaban for left atrial/left atrial appendage (LA/LAA) thrombus resolution in AF patients...
June 29, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29951959/the-role-of-serum-calcium-level-in-intracerebral-hemorrhage-hematoma-expansion-is-there-any
#9
REVIEW
Mostafa Jafari, Mario Di Napoli, Yvonne H Datta, Eric M Bershad, Afshin A Divani
Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke, with a high rate of mortality and morbidity. Even with the best current medical or surgical interventions, outcomes remain poor. The location and initial hematoma volume are strong predictors of mortality. Hematoma expansion (HE) is a further marker of poor prognosis that may be at least partly preventable. Several risk factors for HE have been identified, including baseline ICH volume, anticoagulation, and computed tomography angiography spot signs...
June 27, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29890520/overcoming-heparin-associated-rt-qpcr-inhibition-and-normalization-issues-for-microrna-quantification-in-patients-with-acute-myocardial-infarction
#10
Jose Coelho-Lima, Ashfaq Mohammed, Suzanne Cormack, Samuel Jones, Rajiv Das, Mohaned Egred, Pedram Panahi, Simi Ali, Ioakim Spyridopoulos
BACKGROUND:  Cardiac-enriched micro ribonucleic acids (miRNAs) are released into the circulation following ST-elevation myocardial infarction (STEMI). Lack of standardized approaches for reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) data normalization and presence of RT-qPCR inhibitors (e.g. heparin) in patient blood samples have prevented reproducible miRNA quantification in this cohort and subsequent translation of these biomarkers to clinical practice...
July 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29876337/the-role-of-inflammation-in-venous-thromboembolism
#11
REVIEW
Brian R Branchford, Shannon L Carpenter
Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT), and pulmonary embolism (PE), is becoming increasingly recognized as a cause of morbidity and mortality in pediatrics, particularly among hospitalized children. Furthermore, evidence is accumulating that suggests the inflammatory response may be a cause, as well as consequence, of VTE, but current anticoagulation treatment regimens are not designed to inhibit inflammation. In fact, many established clinical VTE risk factors such as surgery, obesity, cystic fibrosis, sepsis, systemic infection, cancer, inflammatory bowel disease, and lupus likely modulate thrombosis through inflammatory mediators...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29871978/the-use-of-biomarkers-to-predict-specific-causes-of-death-in-patients-with-atrial-fibrillation-insights-from-the-aristotle-trial
#12
Abhinav Sharma, Ziad Hijazi, Ulrika Andersson, Sana M Al-Khatib, Renato D Lopes, John H Alexander, Claes Held, Elaine M Hylek, Sergio Leonardi, Michael Hanna, Justin A Ezekowitz, Agneta Siegbahn, Christopher B Granger, Lars Wallentin
Background -Atrial fibrillation (AF) is associated with an increased risk of death. High-sensitivity troponin-T, growth differentiation factor-15 (GDF-15), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and interleukin-6 levels are predictive of cardiovascular (CV) events and total and CV death in anticoagulated AF patients. The prognostic utility of these biomarkers for cause-specific death is unknown. Methods -The ARISTOTLE trial randomized 18,201 patients with AF to apixaban or warfarin. Biomarkers were measured at randomization in 14,798 patients (1...
June 5, 2018: Circulation
https://www.readbyqxmd.com/read/29778365/cerebral-microbleeds-and-intracranial-haemorrhage-risk-in-patients-anticoagulated-for-atrial-fibrillation-after-acute-ischaemic-stroke-or-transient-ischaemic-attack-cromis-2-a-multicentre-observational-cohort-study
#13
Duncan Wilson, Gareth Ambler, Clare Shakeshaft, Martin M Brown, Andreas Charidimou, Rustam Al-Shahi Salman, Gregory Y H Lip, Hannah Cohen, Gargi Banerjee, Henry Houlden, Mark J White, Tarek A Yousry, Kirsty Harkness, Enrico Flossmann, Nigel Smyth, Louise J Shaw, Elizabeth Warburton, Keith W Muir, Hans Rolf Jäger, David J Werring
BACKGROUND: Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that are prone to intracranial bleeding. We aimed to determine whether presence of cerebral microbleeds can identify patients at high risk of symptomatic intracranial haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient ischaemic attack. METHODS: Our observational, multicentre, prospective inception cohort study recruited adults aged 18 years or older from 79 hospitals in the UK and one in the Netherlands with atrial fibrillation and recent acute ischaemic stroke or transient ischaemic attack, treated with a vitamin K antagonist or direct oral anticoagulant, and followed up for 24 months using general practitioner and patient postal questionnaires, telephone interviews, hospital visits, and National Health Service digital data on hospital admissions or death...
June 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29773500/an-analysis-on-distribution-and-inter-relationships-of-biomarkers-under-rivaroxaban-in-japanese-patients-with-non-valvular-atrial-fibrillation-cvi-aro-1
#14
Shinya Suzuki, Takeshi Yamashita, Hidefumi Kasai, Takayuki Otsuka, Koichi Sagara
Prothrombin time (PT) has been widely used for measuring anticoagulation intensity under rivaroxaban therapy, but precise information has not been well established yet. Consecutive 96 non-valvular atrial fibrillation (NVAF) under rivaroxaban between Jan/June, 2015 were recruited. Serum concentration (SC) and PT with 5 representative reagents available in Japan (Neoplastin Plus®, Thromborel S®, Thrombocheck PT®, Thrombocheck PT Plus®, and Recombiplastin®) at 2-4 hours after (peak) and before intake of rivaroxaban (trough) were measured at outpatient clinic in the cardiovascular institute (CVI ARO study 1)...
March 15, 2018: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29739912/early-cerebral-vein-after-endovascular-ischemic-stroke-treatment-predicts-symptomatic-reperfusion-hemorrhage
#15
Samuel C D Cartmell, Robyn L Ball, Rajani Kaimal, Nicholas A Telischak, Michael P Marks, Huy M Do, Robert L Dodd, Gregory W Albers, Maarten G Lansberg, Jeremy J Heit
BACKGROUND AND PURPOSE: Parenchymal hemorrhage (PH) after endovascular mechanical thrombectomy in acute ischemic stroke leads to worse outcomes. Better clinical and imaging biomarkers of symptomatic reperfusion PH are needed to identify patients at risk. We identified clinical and imaging predictors of reperfusion PH after endovascular mechanical thrombectomy with attention to early cerebral veins (ECVs) on postreperfusion digital subtraction angiography. METHODS: We performed a retrospective cohort study of consecutive acute ischemic stroke patients undergoing endovascular mechanical thrombectomy at our neurovascular referral center...
July 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29716435/micromolar-zinc-in-annexin-a5-anticoagulation-as-a-potential-remedy-for-rprgl3-associated-recurrent-pregnancy-loss
#16
Hayrünnisa Danisik, Nadia Bogdanova, Arseni Markoff
Deficient expression of the placental anticoagulant annexin A5 (ANXA5) has been associated with thrombophilia-related pregnancy complications and ultimately with recurrent pregnancy loss (RPL). Carrier status of M2/ANXA5 ( RPRGL3), common ANXA5 promoter variant, has been identified as genetic cause of reduced ANXA5 levels and proposed as biomarker for successful anticoagulant treatment of RPL women. A murine model of AnxA5 loss of function displayed characteristic placental pathology and fetal loss that was alleviated through anticoagulant intervention...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29590221/andexanet-alfa-effectively-reverses-edoxaban-anticoagulation-effects-and-associated-bleeding-in-a-rabbit-acute-hemorrhage-model
#17
Genmin Lu, Polly Pine, Janet M Leeds, Francis DeGuzman, Pratikhya Pratikhya, Joyce Lin, John Malinowski, Stanley J Hollenbach, John T Curnutte, Pamela B Conley
INTRODUCTION: Increasing use of factor Xa (FXa) inhibitors necessitates effective reversal agents to manage bleeding. Andexanet alfa, a novel modified recombinant human FXa, rapidly reverses the anticoagulation effects of direct and indirect FXa inhibitors. OBJECTIVE: To evaluate the ability of andexanet to reverse anticoagulation in vitro and reduce bleeding in rabbits administered edoxaban. MATERIALS AND METHODS: In vitro studies characterized the interaction of andexanet with edoxaban and its ability to reverse edoxaban-mediated anti-FXa activity...
2018: PloS One
https://www.readbyqxmd.com/read/29569024/soluble-fibrin-monomer-complex-and-prediction-of-cardiovascular-events-in-atrial-fibrillation-the-observational-murcia-atrial-fibrillation-project
#18
José Miguel Rivera-Caravaca, Vanessa Roldán, Marta Romera, María Asunción Esteve-Pastor, Mariano Valdés, Gregory Y H Lip, Vicente Vicente, Francisco Marín
BACKGROUND: Soluble fibrin monomer complex (SFMC) is a biomarker of fibrin formation abnormally elevated in clinical situations of hypercoagulability. OBJECTIVE: We investigated the association and predictive performance of SFMC for stroke, adverse cardiovascular events, cardiovascular mortality and all-cause mortality in a cohort of patients with atrial fibrillation (AF) receiving vitamin K antagonist (VKA) anticoagulant therapy. DESIGN: During the second semester of 2007, we included 1226 AF outpatients stable on VKAs (INR 2...
June 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29563835/optimized-multiparametric-flow-cytometric-analysis-of-circulating-endothelial-cells-and-their-subpopulations-in-peripheral-blood-of-patients-with-solid-tumors-a-technical-analysis
#19
Fangbin Zhou, Yaying Zhou, Ming Yang, Jinli Wen, Jun Dong, Wenyong Tan
Background: Circulating endothelial cells (CECs) and their subpopulations could be potential novel biomarkers for various malignancies. However, reliable enumerable methods are warranted to further improve their clinical utility. This study aimed to optimize a flow cytometric method (FCM) assay for CECs and subpopulations in peripheral blood for patients with solid cancers. Patients and methods: An FCM assay was used to detect and identify CECs. A panel of 60 blood samples, including 44 metastatic cancer patients and 16 healthy controls, were used in this study...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29549537/enoxaparin-pretreatment-effect-on-local-and-systemic-inflammation-biomarkers-in-the-animal-burn-model
#20
Hember Vicci, Antonio Eblen-Zajjur, Mercedes López, Gustavo Crespo, Maria Navarro
Low-molecular weight heparins (LMWH) are anticoagulants that have shown anti-inflammatory activity in several experimental models. Hot water burn inflammatory model accurately simulates human clinical situations allowing its use for nociception test and evaluation of anti-inflammatory drugs. The present study aims to evaluate the enoxaparin pretreatment on local and systemic inflammation biomarkers in the animal burn model. Inflammation was induced by submersing the rat left hind paw in water at 60o  C for 60 s...
March 16, 2018: Inflammopharmacology
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