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Platelet cell indices

Saad Bakrim, Youssef Motiaa, Ali Ouarour, Azlarab Masrar
Introduction: Numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature...
2018: Pan African Medical Journal
Vybhav Venkatesh, Rakesh Kumar, Dinesh Kumar Varma, Prateek Bhatia, Jaivinder Yadav, Devi Dayal
BACKGROUND: There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM. METHODS: We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 healthy controls, in a tertiary care pediatric hospital. Platelet indices including Platelet count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-Large cell ratio (P-LCR), Plateletcrit (PCT) were measured, and their means were compared between cases and controls and various subgroups among the cases...
September 2018: Journal of Diabetes and its Complications
Mengju Liu, Jian Peng, Ningwen Tai, James A Pearson, Changyun Hu, Junhua Guo, Lin Hou, Hongyu Zhao, F Susan Wong, Li Wen
AIMS/HYPOTHESIS: Innate immune effectors interact with the environment to contribute to the pathogenesis of the autoimmune disease, type 1 diabetes. Although recent studies have suggested that innate immune Toll-like receptors (TLRs) are involved in tissue development, little is known about the role of TLRs in tissue development, compared with autoimmunity. We aimed to fill the knowledge gap by investigating the role of TLR9 in the development and function of islet beta cells in type 1 diabetes, using NOD mice...
August 9, 2018: Diabetologia
Izabela Grzegorczyk-Karolak, Bogdan Kontek, Renata Kontek, Halina Wysokińska, Beata Olas
BACKGROUND: It is widely known that reactive oxygen species (ROS) can cause oxidative damage in cells and have been linked to the pathogenesis of oxidative diseases, such as atherosclerosis, ischemia, neurodegenerative disease, diabetes, or cancer. Recently, much attention has been focused on preventive strategies for oxidative stress and related diseases. Plants represent a source of bioactive compounds whose antioxidant activity may be useful in protecting against pro-oxidative reactions...
August 7, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Sidan Li, Runhui Wu, Bin Wang, Lingling Fu, Guanghua Zhu, Xuan Zhou, Jie Ma, Liqiang Zhang, Maoquan Qin
The delay in platelet recovery after hematopoietic stem cell transplantation (HSCT) is closely related to the overall survival rate of transplanted children. The use of platelet-producing agents such as eltrombopag and romiplostim has made great progress in treating diseases such as immune thrombocytopenia and aplastic anemia. However, the use of such drugs in patients with thrombocytopenia after transplantation, especially in children, is rare. This study aimed to report eltrombopag treatment for 3 children with primary platelet engraftment failure and secondary thrombocytopenia after allogeneic HSCT...
August 4, 2018: Journal of Pediatric Hematology/oncology
Devi Subbarayan, Chidambharam Choccalingam, Chittode Kodumudi Anantha Lakshmi
Background: Automation helps improve laboratory operational efficiency and reduce the turnaround time. Pneumatic tube systems (PTS) automate specimen transport between the lab and other areas of the hospital. Its effect on complete blood count (CBC) and coagulation is still controversial. Aim: To study the effects of pneumatic tube system sample transport on complete blood count and coagulation parameters to compare them with hand delivered samples. Methods: 75 paired samples for complete blood count and 25 paired samples for coagulation analysis were compared between samples sent via pneumatic tube system and hand delivered system...
2018: Advances in Hematology
Alicja Iwaszko, Hieronim Borowicz, Stanislaw Graczyk, Malwina Slowikowska, Aleksandra Pliszczak-Krol, Artur Niedzwiedz
Recurrent airway obstruction (RAO), also known as heaves, is an allergic respiratory condition that develops in horses following an exposure to aeroallergens in hay and straw. This is manifested by airway hyperreactivity, inflammation, bronchoconstriction, as well as a leukocyte and platelet infiltration into the airways. Platelet activation and an increase in circulating platelet-leukocyte aggregates may lead to airway remodeling. The aim of this study was to explore the effect of seven-day antigen challenge on dynamics of platelet indices and CD41/61 and CD62 P expression on platelets in horses with RAO...
August 2018: Veterinary Immunology and Immunopathology
Lydia Hopp, Henry Loeffler-Wirth, Lilit Nersisyan, Arsen Arakelyan, Hans Binder
We analyzed the blood transcriptome of sepsis framed within community-acquired pneumonia (CAP) and characterized its molecular and cellular heterogeneity in terms of functional modules of co-regulated genes with impact for the underlying pathophysiological mechanisms. Our results showed that CAP severity is associated with immune suppression owing to T-cell exhaustion and HLA and chemokine receptor deactivation, endotoxin tolerance, macrophage polarization, and metabolic conversion from oxidative phosphorylation to glycolysis...
2018: Frontiers in Immunology
Xudong Zhang, Jinqiang Wang, Zhaowei Chen, Quanyin Hu, Chao Wang, Junjie Yan, Gianpietro Dotti, Peng Huang, Zhen Gu
Radical surgery still represents the treatment choice for several malignancies. However, local and distant tumor relapses remain the major causes of treatment failure, indicating that a postsurgery consolidation treatment is necessary. Immunotherapy with checkpoint inhibitors has elicited impressive clinical responses in several types of human malignancies and may represent the ideal consolidation treatment after surgery. Here, we genetically engineered platelets from megakaryocyte (MK) progenitor cells to express the programmed cell death protein 1 (PD-1)...
July 31, 2018: Nano Letters
Linming Fang, Huaying Sheng, Danying Wan, Chihong Zhu, Ruibin Jiang, Xiaojiang Sun, Jianguo Feng
The overall survival rate of patients with non-small cell lung cancer (NSCLC) following resection remains poor due to the high rates of recurrence and metastasis. The investigation of novel biomarkers is clinically necessary to improve treatment strategies. Multidrug resistance-associated protein 1 (MRP1) and platelet count are linked to a poor prognosis in various types of cancer. However, it is unknown whether MRP1 or platelet count is a suitable prognostic indicator of NSCLC. In the present study, 427 patients with operable NSCLC were enlisted...
July 2018: Oncology Letters
Mari Kono, Shiori Matsuhiroya, Fumie Nakazawa, Masako Kaido, Atsushi Wada, Yoshiaki Tomiyama
Ultrastructure analysis of immature platelets is difficult because of the lack of a suitable marker and their relatively low concentration in total platelets. We investigated the morphological and optical properties of human immature platelets produced and enriched in immunodeficient mice via human CD34-positive cell administration. Immunodeficient mice were injected with human CD34-positive cells and administered eltrombopag orally for 14 days (eltro-mice). Some of these mice were maintained for 2-3 months (steady-state-mice)...
July 30, 2018: Platelets
Gilda Varricchi, Antonio Pecoraro, Giancarlo Marone, Gjada Criscuolo, Giuseppe Spadaro, Arturo Genovese, Gianni Marone
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7Rα. TSLP is primarily expressed by activated lung and intestinal epithelial cells, keratinocytes, and fibroblasts. However, dendritic cells (DCs), mast cells, and presumably other immune cells can also produce TSLP. Different groups of investigators have demonstrated the existence of two variants for TSLP in human tissues: the main isoform expressed in steady state is the short form (sf TSLP), which plays a homeostatic role, whereas the long form (lfTSLP) is upregulated in inflammatory conditions...
2018: Frontiers in Immunology
Xianhao Dong, Xingyu Yuan, Lina Wang, Jinlong Liu, Adam C Midgley, Zhihong Wang, Kai Wang, Jianfeng Liu, Meifeng Zhu, Deling Kong
Formation of a continuous endothelial cell (EC) monolayer inside the luminal surface with enhanced hemocompatibility, is a promising solution for improving performance and overall patency of small-diameter vascular grafts. There has been much debate regarding the ideal substrate surface topography to achieve this. Here, we investigated different polycaprolactone (PCL)-derived substrate surfaces fabricated from nanofibers, microfibers, or with smooth surfaces, and evaluated their effect on hemocompatibility and EC behavior...
July 20, 2018: Biomaterials
Catherine M Stefaniuk, Hong Hong, Clifford V Harding, Robert W Maitta
OBJECTIVES: In platelets, α-synuclein is important in calcium-dependent granule release. Notably, cells release α-synuclein in setting of cell damage or death. Therefore, we investigated α-synuclein levels in plasma of single donor platelet (SDP) units during storage. METHODS: Aliquots were obtained from same SDP units for 7 days from day of donation. Additionally, randomly sampled SDP units at same storage time points were also assayed by enzyme-linked immunosorbent assay...
July 28, 2018: European Journal of Haematology
Yueh-Chien Lin, Chien-Chin Chen, Wei-Min Chen, Kuan-Ying Lu, Tang-Long Shen, Yeong-Chin Jou, Cheng-Huang Shen, Norihiko Ohbayashi, Yasunori Kanaho, Yuan-Li Huang, Hsinyu Lee
Lysophosphatidic acid (LPA) is a bioactive lipid growth factor which is present in high levels in serum and platelets. LPA binds to its specific G-protein-coupled receptors, including LPA1 to LPA6 , thereby regulating various physiological functions, including cancer growth, angiogenesis, and lymphangiogenesis. Our previous study showed that LPA promotes the expression of the lymphangiogenic factor vascular endothelial growth factor (VEGF)-C in prostate cancer (PCa) cells. Interestingly, LPA has been shown to regulate the expression of calreticulin (CRT), a multifunctional chaperone protein, but the roles of CRT in PCa progression remain unclear...
July 24, 2018: Biochimica et Biophysica Acta
Uiju Cho, Hong Sik Park, So Young Im, Chang Young Yoo, Ji Han Jung, Young Jin Suh, Hyun Joo Choi
Systemic inflammatory markers derived from peripheral blood cell, such as the neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (dNLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR), have been demonstrated as prognostic markers in several types of malignancy. Here, we investigated and compared the association between systemic inflammatory markers and survival and developed a prognostic nomogram in breast cancer patients. We reviewed the clinical and pathological records of 661 patients diagnosed with invasive breast carcinoma between 1993 and 2011...
2018: PloS One
Yoshikazu Matsuoka, Fumiaki Nakamura, Kazuo Hatanaka, Tatsuya Fujioka, Satoshi Otani, Takafumi Kimura, Yoshihiro Fujimura, Hiroaki Asano, Yoshiaki Sonoda
Umbilical cord blood transplantation (UCBT) is often associated with delayed neutrophil and platelet recovery. Engraftment failure is another major obstacle. Several factors influence these serious complications, including the numbers of total nucleated cells (TNCs) and CD34+ cells which have been used as reliable factors for selecting UCB units for transplantation. However, whether both factors are reliable indices of the hematopoietic stem cell (HSC) activity of UCB units remains unknown. To evaluate the quality of UCB units, we quantified the actual number of transplantable CD34+ CD133+ HSCs (tHSCs) residing in UCB units...
July 25, 2018: International Journal of Hematology
Norma Maugeri, Annalisa Capobianco, Patrizia Rovere-Querini, Giuseppe A Ramirez, Enrico Tombetti, Patrizia Della Valle, Antonella Monno, Valentina D'Alberti, Anna Maria Gasparri, Stefano Franchini, Armando D'Angelo, Marco E Bianchi, Angelo A Manfredi
Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma. Microparticles released from activated platelets in the blood of SSc patients (SSc-microparticles) are abundant and express the damage-associated molecular pattern (DAMP) HMGB1. SSc-microparticles interacted with neutrophils in vitro and in immunocompromised mice and promoted neutrophil autophagy, which was characterized by mobilization of their granule content, enhanced proteolytic activity, prolonged survival, and generation of neutrophil extracellular traps (NETs)...
July 25, 2018: Science Translational Medicine
Yian Zhang, Zheng Wei, Jing Li, Rupan Gao, Peng Liu
Monoclonal gammopathy (MG), a positive result of serum immunofixation electrophoresis (SIFE), has been reported in cases of diffuse large B-cell lymphoma (DLBCL). We performed this study to further investigate the prognostic value of MG in DLBCL.We retrospectively reviewed patients diagnosed with DLBCL between January 2007 and December 2014, and identified 37 patients with MG. The clinical characteristics of these patients were then reviewed. A 1:2 case-control analysis was conducted on 74 matched controls, who were patients with DLBCL and without MG...
July 2018: Medicine (Baltimore)
Şule Gökçe, Zafer Kurugöl, Aslı Suner
INTRODUCTION AND OBJECTIVE: Acute bronchiolitis might be associated with morbidity and mortality in infants. The aim of this study was to evaluate the role of mean platelet volume (MPV) in the prediction of acute bronchiolitis. METHOD: One hundred and eighty four of these infants were diagnosed with acute bronchiolitis and 100 were healthy children. The ability of MPV, C-reactive protein (CRP), white blood cell (WBC) count and lymphocyte values to predict all bronchiolitis group and the control group were examined by receiver operating characteristic (ROC) curve and their respective areas under the curves (AUC) with 95% confidence intervals...
July 25, 2018: Clinical Respiratory Journal
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