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Device therapy

Susanne Jung, Christian Ott, Marina V Karg, Agnes Bosch, Michael Schmid, Christian Schlundt, Stephan Achenbach, Roland E Schmieder
OBJECTIVE: In patients with resistant hypertension, percutaneous placement of an iliac arteriovenous coupler device leads to a reduction of blood pressure (BP) via decreased total vascular resistance and improved arterial compliance. However, long-term efficacy and safety need to be further explored. We report on the first case of 3.5-year follow-up in a patient who underwent implantation of an iliac arteriovenous coupler device. RESULTS: A patient with resistant hypertension was admitted to hospital...
August 14, 2018: Journal of Hypertension
Ahmit Gupta, Steven R Bailey
PURPOSE OF REVIEW: This article provides an update on percutaneous devices to treat diastolic dysfunction, current clinical experience, and actively enrolling trials. We also discuss potential complications and limitations of devices. RECENT FINDINGS: Exertional symptoms including exertional dyspnea and exercise intolerance are common features of heart failure that are driven by left ventricular and left atrial non-compliance that results in pulmonary vascular congestion...
August 15, 2018: Current Cardiology Reports
William King, Krista Toler, Jennifer Woodell-May
There has been significant debate over the role of white blood cells (WBCs) in autologous therapies, with several groups suggesting that WBCs are purely inflammatory. Misconceptions in the practice of biologic orthopedics result in the simplified principle that platelets deliver growth factors, WBCs cause inflammation, and the singular value of bone marrow is the stem cells. The aim of this review is to address these common misconceptions which will enable better development of future orthopedic medical devices...
2018: BioMed Research International
Yu Kumagai, Takanori Arimoto, So Yamauchi, Daisuke Kutsuzawa, Hayato Tsuchiya, Masafumi Watanabe
No abstract text is available yet for this article.
August 2018: HeartRhythm Case Reports
Robert Jay Rowen
The world is facing crisis in management of infectious diseases. The mainstay of treatment has been chemical anti-infectives. These drugs are failing, as superbugs emerge and medicine becomes more sophisticated with treatments such as prosthetic devices, which can harbor bacteria protected by biofilm. This case report describes a 68-year-old woman who received bilateral artificial hips on October 27, 2015. The right hip prosthesis subsequently became septic by June 2016. Three orthopedic surgeons offered her a several month program, which included removal of the prosthesis, implantation of an antibiotic impregnated "spacer" and months of intravenous antibiotics...
April 2018: Medical Gas Research
N LeVasseur, C Stober, M Ibrahim, S Gertler, J Hilton, A Robinson, S McDiarmid, D Fergusson, S Mazzarello, B Hutton, A A Joy, M McInnes, M Clemons
Background: The choice of vascular access for systemic therapy administration in breast cancer remains an area of clinical equipoise, and patient preference is not consistently acknowledged. Using a patient survey, we evaluated the patient experience with vascular access during treatment for early-stage breast cancer and explored perceived risk factors for lymphedema. Methods: Patients who had received systemic therapy for early-stage breast cancer were surveyed at 2 Canadian cancer centres...
August 2018: Current Oncology
N LeVasseur, C Stober, K Daigle, A Robinson, S McDiarmid, S Mazzarello, B Hutton, A Joy, D Fergusson, J Hilton, M McInnes, M Clemons
Background: Despite advances in systemic therapy choices for patients with early-stage breast cancer, optimal practices for intravenous (IV) access remain unknown. That lack of knowledge holds particularly true for the use of central venous access devices (cvads) such as peripherally inserted central catheters (piccs) and implanted vascular access devices (ports). Methods: Using a survey of Canadian oncologists and oncology nurses responsible for the care of breast cancer patients, we evaluated current access practices, perceptions of complications, and perceptions of risk, and we estimated complication rates and evaluated perceived risk factors for lymphedema...
August 2018: Current Oncology
Vidhi Jain, Chinmoy Sahu, Nayani Amrin Fatema Afzal Hussain, Malay Ghar, Kashi Nath Prasad
Background: Chryseobacterium indologenes is a hospital environment contaminant and can cause healthcare-associated infections. Methods: Patients with C. indologenes infections in a tertiary care center in North India for 6 months were evaluated for susceptibility patterns, comorbidities, mechanical devices, risk factors, and treatment outcomes. The organism was provisionally identified phenotypically, and identification was confirmed by the BD Phoenix automated microbiology system...
July 2018: Indian Journal of Critical Care Medicine
Nicholas Duncan Furness, Alistair Phillips, Sian Gallacher, James Charles Sherard Beazley, Jonathan Peter Evans, Andrew David Toms, William Thomas, Christopher David Smith
AIM: To determine whether a mechanical, high-frequency vibration device (Tenease™ ) can improve pain and function for the treatment of tennis elbow (TE), compared with standard treatment. METHODS: Adults presenting to an elbow clinic with a clinical diagnosis of TE were randomized to standard treatment with physiotherapy, activity modification and analgesia or standard treatment plus Tenease therapy. Tenease therapy consisted of a 6-week period of treatment using the Tenease device with three 10-min episodes each day...
May 2018: Journal of Orthopaedic Surgery
Michael C Burger, Marlies Wagner, Kea Franz, Patrick N Harter, Oliver Bähr, Joachim P Steinbach, Christian Senft
Ventriculoperitoneal shunts equipped with a reservoir and a valve to manually switch off the shunt function can be used for intraventricular injections of therapeutics in patients suffering from a communicating hydrocephalus caused by leptomeningeal metastases. These shunt devices avoid the risk of injecting therapeutics through the distal leg of the shunt system into the intraperitoneal space, which may cause toxicity. Furthermore, regular intraventricular injections of chemotherapeutics help to maintain sufficient concentrations in the ventricular space...
August 14, 2018: Journal of Clinical Medicine
Meng-Lu Zhu, Xiao-Ling Xu, Xiao-Juan Wang, Nan-Nan Zhang, Kong-Jun Lu, Jing Qi, Fei-Yang Jin, Di Liu, Yong-Zhong Du
Targeted Drug Delivery Systems (TDDS) have attracted wide attention with reduced drug side effects and improved anti-tumor efficacy in comparison with traditional preparations. While targeting moiety in existing TDDS principally focused on recognition of receptors on the surface of tumor cells, accumulation into tumor tissue only could be performed by enhanced permeability and retention effect and active transportation into tumor cells. Doxorubicin (DOX)-loaded sialic acid-dextran (Dex)-octadecanoic acid (OA) micelles (SA-Dex-OA/DOX) were designed for targeting hepatocellular carcinoma effectively...
August 15, 2018: Molecular Pharmaceutics
Kei Ichiji, Yusuke Yoshida, Noriyasu Homma, Xiaoyong Zhang, Ivo Bukovsky, Yoshihiro Takai, Makoto Yoshizawa
In radiation therapy, for accurate radiation dose delivery to a target tumor and reduction of the extra exposure of normal tissues, real-time tumor tracking is an important technique typically for a lung cancer treatment since the lung tumor moves with patient's respiration. To observe the tumor motion in real time, X-ray fluoroscopic devices can be employed, and various tracking techniques have been proposed to track the tumor. However, development of an accurate and fast-tracking method for clinical use is still a challenging task since the obscureness can cause the decreased tracking accuracy and additional processing time for improving the accuracy...
August 15, 2018: Physics in Medicine and Biology
Elaissa T Hardy, Yannan J Wang, Sanathan Iyer, Robert G Mannino, Yumiko Sakurai, Thomas H Barker, Taiyun Chi, Yeojoon Youn, Hua Wang, Ashley C Brown, Wilbur A Lam
Hemorrhage or uncontrolled bleeding can arise either due to a medical condition or from a traumatic injury and are typically controlled with the application of a hemostatic agent. Hemostatic agents are currently derived from animal or human products, which carry risks of blood borne infections and immune dysregulation. Therefore, the need exists for novel biomedical therapies not derived from animal or human products to achieve hemostasis. Accordingly, we created an interdigitated microelectronic bandage that applies low voltage electrical stimulation to an injury site, resulting in faster clot formation without excessive heating, accelerated fibrin formation, and hemostasis overall...
August 15, 2018: Lab on a Chip
Kleiton G R Yamaçake, Felipe Carneiro, Jose Cury, Rodolfo Lourenço, Peter C Françolin, Affonso C Piovesan, Miguel Srougi, Willian C Nahas, Ioannis M Antonopoulos
OBJECTIVES: To study the efficacy of Low intensity Extracorporeal Shockwave Therapy (Li- ESWT) for the treatment of erectile dysfunction (ED) in kidney transplanted men. METHODS: Twenty men (mean age = 53.7 years) were selected. This was a double-blinded, prospective, randomized, sham-controlled trial. The ESWT protocol was based in a 2 treatment sessions per week for 3 weeks. The sham treatment was performed using the same device replacing the effective probe for one that emits zero energy...
August 14, 2018: International Journal of Impotence Research
Eva Pericolini, Bruna Colombari, Gianmarco Ferretti, Ramona Iseppi, Andrea Ardizzoni, Massimo Girardis, Arianna Sala, Samuele Peppoloni, Elisabetta Blasi
BACKGROUND: Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for both acute and chronic infections in humans. In particular, its ability to form biofilm, on biotic and abiotic surfaces, makes it particularly resistant to host's immune defenses and current antibiotic therapies as well. Innovative antimicrobial materials, like hydrogel, silver salts or nanoparticles have been used to cover new generation catheters with promising results. Nevertheless, biofilm remains a major health problem...
August 14, 2018: BMC Microbiology
Berry Fairchild, Warren Ellsworth, Jesse C Selber, David Bogue, Dmitry Zavlin, Stephanie Nemir, Christina Checka, Mark W Clemens
Background: Traditional two-stage breast reconstruction involves placement of a textured surface tissue expander (TTE). Recent studies have demonstrated textured surface devices have higher propensity for bacterial contamination and biofilm formation. Objectives: The purpose of this study was to evaluate the safety and efficacy of smooth surface tissue expanders (STE) in immediate breast reconstruction. Methods: We retrospectively reviewed consecutive women undergoing STE breast reconstruction from 2016 to 2017 at three institutions...
August 10, 2018: Aesthetic Surgery Journal
Lina Zhang, Feng Dai, Alexandria Brackett, Yuhang Ai, Lingzhong Meng
PURPOSE: The association between conflicts of interest (COI) and study results or article conclusions in goal-directed hemodynamic therapy (GDHT) research is unknown. METHODS: Randomized controlled trials comparing GDHT with usual care were identified. COI were classified as industry sponsorship, author conflict, device loaner, none, or not reported. The association between COI and study results (complications and mortality) was assessed using both stratified meta-analysis and mixed effects meta-regression...
August 13, 2018: Intensive Care Medicine
Fleur V Y Tjong, Niek E G Beurskens, Petr Neuzil, Pascal Defaye, Peter-Paul Delnoy, John Ip, Juan Jose Garcia Guerrero, Mayer Rashtian, Rajesh Banker, Vivek Reddy, Derek Exner, Johannes Sperzel, Reinoud E Knops
PURPOSE: Use of novel medical technologies, such as leadless pacemaker (LP) therapy, may be subjected to a learning curve effect. The objective of the current study was to assess the impact of operators' experience on the occurrence of serious adverse device effects (SADE) and procedural efficiency. METHODS: Patients implanted with a Nanostim LP (Abbott, USA) within two prospective studies (i.e., LEADLESS ll IDE and Leadless Observational Study) were assessed. Patients were categorized into quartiles based on operator experience...
August 13, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Besma Sidia, Christian Saleh, Meidi El Issa, Marie-Luise Mono
Background: Recent randomized controlled trial (RCTs) comparing percutaneous closure with antithrombotic treatment in patients with patent foramen ovale (PFO) and cryptogenic stroke revealed inconsistent results. Indeed, there is still no consensus on the management of these patients, namely closure or medical therapy treatment. Methods: To take stock of the PFO management after cryptogenic stroke, we conducted a literature review that included 16 articles dealing with different therapeutic strategies and long-term outcomes of these results...
2018: Surgical Neurology International
Ryan Chang Tseng, Ching-Chuen Chen, Sheng-Min Hsu, Han-Sheng Chuang
Rapid diagnosis and screening of diseases have become increasingly important in predictive and preventive medicine as they improve patient treatment strategies and reduce cost as well as burden on our healthcare system. In this regard, wearable devices are emerging as effective and reliable point-of-care diagnostics that can allow users to monitor their health at home. These wrist-worn, head-mounted, smart-textile, or smart-patches devices can offer valuable information on the conditions of patients as a non-invasive form of monitoring...
August 13, 2018: Sensors
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