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https://www.readbyqxmd.com/read/30112605/minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-an-international-expert-consensus-initiative-for-improvement-of-animal-modeling-in-sepsis
#1
REVIEW
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
BACKGROUND: Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. OBJECTIVE: To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May 2017. The goal of the conference was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models...
August 14, 2018: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/30106875/minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-an-international-expert-consensus-initiative-for-improvement-of-animal-modeling-in-sepsis
#2
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
Pre-clinical animal studies precede the majority of clinical trials. While the clinical definitions of sepsis and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The goal of the conference was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models...
August 14, 2018: Shock
https://www.readbyqxmd.com/read/30105433/minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-an-international-expert-consensus-initiative-for-improvement-of-animal-modeling-in-sepsis
#3
REVIEW
Marcin F Osuchowski, Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H Chaudry, Craig M Coopersmith, Clifford Deutschman, Susanne Drechsler, Philip Efron, Claes Frostell, Gerhard Fritsch, Waldemar Gozdzik, Judith Hellman, Markus Huber-Lang, Shigeaki Inoue, Sylvia Knapp, Andrey V Kozlov, Claude Libert, John C Marshall, Lyle L Moldawer, Peter Radermacher, Heinz Redl, Daniel G Remick, Mervyn Singer, Christoph Thiemermann, Ping Wang, W Joost Wiersinga, Xianzhong Xiao, Basilia Zingarelli
PURPOSE: Pre-clinical animal studies precede the majority of clinical trials. While the clinical sepsis definitions and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The conference goal was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the "Minimum Quality Threshold in Pre-Clinical Sepsis Studies" (MQTiPSS), to enhance translational value of these models...
August 14, 2018: Infection
https://www.readbyqxmd.com/read/30062727/lipid-profile-and-long-term-outcome-in-premature-myocardial-infarction
#4
Max-Paul Winter, Franz Wiesbauer, Hermann Blessberger, Noemi Pavo, Patrick Sulzgruber, Kurt Huber, Johann Wojta, Klaus Distelmaier, Irene M Lang, Georg Goliasch
BACKGROUND: Premature myocardial infarction (≤40 years) represents a rare disease with a distinct risk factor profile and a lipid phenotype that is characterized by a predominance of elevated triglyceride-rich lipoproteins. So far high-density and low-density lipoproteins remain the primary targets for risk stratification and treatment evaluation in coronary artery disease, but this strategy might be insensitive in patients with premature myocardial infarction. AIM: Aim of this study was to investigate the predictive value of different lipid fractions on long-term cardiovascular outcome in patients with premature myocardial infarction...
July 30, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30053222/effect-of-reducing-the-ratio-of-omega-6-to-omega-3-fatty-acids-in-diets-of-low-protein-quality-on-nursery-pig-growth-performance-and-immune-response
#5
Lee-Anne Huber, Seema Hooda, Rebecca E Fisher-Heffernan, Niel A Karrow, Cornelis F M de Lange
A total of 240 newly weaned pigs (5.25 ± 0.15 kg BW) were used to determine the dietary omega-6-to-omega-3 (ω-6:ω-3) fatty acid ratio that optimized growth performance and immune responses when fed corn and soybean meal-based diets with low protein quality. Pigs were randomly assigned to 1 of 5 dietary treatments (n=6 pens/treatment; d 0 of study): [1] positive control (High; included animal proteins and 5% corn oil), [2] negative control (Low0; corn and soybean meal-based and 5% corn oil), or 1 of 3 Low diets with increasing supplementation of fish oil to replace corn oil: [3] 1...
July 21, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30051799/multicenter-assessment-of-the-rapid-unyvero-blood-culture-molecular-assay
#6
Sandra Christina Burrack-Lange, Yoann Personne, Monika Huber, Elisabeth Winkler, Jan Weile, Cornelius Knabbe, Julia Görig, Holger Rohde
PURPOSE: Bloodstream infections remain an important cause of morbidity and mortality. Rapid diagnosis can reduce the time from empiric antimicrobial therapy to targeted therapy and improve patient outcomes. METHODOLOGY: The fully automated Unyvero Blood Culture (BCU) Application (Curetis GmbH) can identify a broad panel of pathogens (36 analytes covering over 50 pathogens) and 16 antibiotic resistance gene markers simultaneously in about 5 h. The assay was evaluated in three clinical laboratories in comparison to routine microbiological procedures...
July 27, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29982364/parvalbumin-interneurons-shape-neuronal-vulnerability-in-blunt-tbi
#7
Akila Chandrasekar, Florian Olde Heuvel, Lilla Tar, Anna M Hagenston, Annette Palmer, Birgit Linkus, Albert C Ludolph, Markus Huber-Lang, Tobias Boeckers, Hilmar Bading, Francesco Roselli
Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been detected. Parvalbumin (PV) interneurons are major regulators of perisomatic inhibition, principal neurons firing, and overall cortical excitability. However, their role in acute TBI pathogenic cascades is unclear. We exploited the chemogenetic Pharmacologically Selective Activation Module and Pharmacologically Selective Effector Module control of PV-Cre+ neurons and the Designer Receptors Exclusively Activated by Designer Drug (DREADD) control of principal neurons in a blunt model of TBI to explore the role of inhibition in shaping neuronal vulnerability to TBI...
June 30, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29922174/diet-induced-obesity-affects-muscle-regeneration-after-murine-blunt-muscle-trauma-a-broad-spectrum-analysis
#8
Pengfei Xu, Jens-Uwe Werner, Sebastian Milerski, Carmen M Hamp, Tatjana Kuzenko, Markus Jähnert, Pascal Gottmann, Luisa de Roy, Daniela Warnecke, Alireza Abaei, Annette Palmer, Markus Huber-Lang, Lutz Dürselen, Volker Rasche, Annette Schürmann, Martin Wabitsch, Uwe Knippschild
Injury to skeletal muscle affects millions of people worldwide. The underlying regenerative process however, is a very complex mechanism, time-wise highly coordinated, and subdivided in an initial inflammatory, a regenerative and a remodeling phase. Muscle regeneration can be impaired by several factors, among them diet-induced obesity (DIO). In order to evaluate if obesity negatively affects healing processes after trauma, we utilized a blunt injury approach to damage the extensor iliotibialis anticus muscle on the left hind limb of obese and normal weight C57BL/6J without showing any significant differences in force input between normal weight and obese mice...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29869085/structured-assessment-of-laparoscopic-camera-navigation-skills-the-salas-score
#9
T Huber, M Paschold, F Schneble, A Poplawski, F Huettl, F Watzka, H Lang, W Kneist
BACKGROUND: Tools are needed to assess laparoscopic camera navigation (LCN) in the operating room. Here, we aimed to develop an objective rating scale for LCN. STUDY DESIGN: We defined the following key aspects of LCN: operational field centering, correct angle of the horizon, correct instrument visualization, verbal commands from the operating surgeon, and manual corrections from the operating surgeon. We then developed a score based on intraoperative error evaluation from intraoperative recordings of 80 procedures...
June 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29850639/neutrophils-in-tissue-trauma-of-the-skin-bone-and-lung-two-sides-of-the-same-coin
#10
REVIEW
A Kovtun, D A C Messerer, K Scharffetter-Kochanek, M Huber-Lang, A Ignatius
Following severe tissue injury, patients are exposed to various danger- and microbe-associated molecular patterns, which provoke a strong activation of the neutrophil defense system. Neutrophils trigger and modulate the initial posttraumatic inflammatory response and contribute critically to subsequent repair processes. However, severe trauma can affect central neutrophil functions, including circulation half-life, chemokinesis, phagocytosis, cytokine release, and respiratory burst. Alterations in neutrophil biology may contribute to trauma-associated complications, including immune suppression, sepsis, multiorgan dysfunction, and disturbed tissue regeneration...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29713320/a-conformational-change-in-c-reactive-protein-enhances-leukocyte-recruitment-and-reactive-oxygen-species-generation-in-ischemia-reperfusion-injury
#11
Jan R Thiele, Johannes Zeller, Jurij Kiefer, David Braig, Sheena Kreuzaler, Yvonne Lenz, Lawrence A Potempa, Florian Grahammer, Tobias B Huber, M Huber-Lang, Holger Bannasch, G Björn Stark, Karlheinz Peter, Steffen U Eisenhardt
Introduction: C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isoforms expressing pro-inflammatory neo-epitopes [pCRP* and monomeric C-reactive protein (mCRP)]. Here, we investigate the role of CRP isoforms in renal ischemia/reperfusion injury (IRI)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29706429/heart-failure-subtypes-and-thromboembolic-risk-in-patients-with-atrial-fibrillation-the-prefer-in-af-hf-substudy
#12
Jolanta M Siller-Matula, Ladislav Pecen, Giuseppe Patti, Markus Lucerna, Paulus Kirchhof, Maciej Lesiak, Kurt Huber, Freek W A Verheugt, Irene M Lang, Giulia Renda, Renate B Schnabel, Rolf Wachter, Dipak Kotecha, Jean-Marc Sellal, Miklos Rohla, Fabrizio Ricci, Raffaele De Caterina
BACKGROUND AND OBJECTIVES: To assess thromboembolic and bleeding risks in patients with heart failure (HF) and atrial fibrillation (AF) according to HF type. METHODS: We analyzed 6170 AF patients from the Prevention of thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF), and categorized patients into: HF with reduced left-ventricular ejection fraction (HFrEF; LVEF < 40%); mid-range EF (HFmrEF; LVEF: 40-49%); lower preserved EF (HFLpEF; LVEF: 50-60%), higher preserved EF (HFHpEF; LVEF > 60%), and no HF...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29598897/feasibility-and-safety-of-treating-non-unions-in-tibia-femur-and-humerus-with-autologous-expanded-bone-marrow-derived-mesenchymal-stromal-cells-associated-with-biphasic-calcium-phosphate-biomaterials-in-a-multicentric-non-comparative-trial
#13
Enrique Gómez-Barrena, Philippe Rosset, Florian Gebhard, Philippe Hernigou, Nicola Baldini, Helène Rouard, Luc Sensebé, Rosa M Gonzalo-Daganzo, Rosaria Giordano, Norma Padilla-Eguiluz, Eduardo García-Rey, José Cordero-Ampuero, Juan Carlos Rubio-Suárez, Julien Stanovici, Christian Ehrnthaller, Markus Huber-Lang, Charles Henri Flouzat-Lachaniette, Nathalie Chevallier, Davide Maria Donati, Gabriela Ciapetti, Sandrine Fleury, Manuel-Nicolás Fernandez, José-Rafael Cabrera, Cristina Avendaño-Solá, Tiziana Montemurro, Carmen Panaitescu, Elena Veronesi, Markus Thomas Rojewski, Ramin Lotfi, Massimo Dominici, Hubert Schrezenmeier, Pierre Layrolle
BACKGROUND: ORTHO-1 is a European, multicentric, first in human clinical trial to prove safety and feasibility after surgical implantation of commercially available biphasic calcium phosphate bioceramic granules associated during surgery with autologous mesenchymal stromal cells expanded from bone marrow (BM-hMSC) under good manufacturing practices, in patients with long bone pseudarthrosis. METHODS: Twenty-eight patients with femur, tibia or humerus diaphyseal or metaphyso-diaphyseal non-unions were recruited and surgically treated in France, Germany, Italy and Spain with 100 or 200 million BM-hMSC/mL associated with 5-10 cc of bioceramic granules...
March 19, 2018: Biomaterials
https://www.readbyqxmd.com/read/29471322/whole-body-nitrogen-utilization-and-tissue-protein-and-casein-synthesis-in-lactating-primiparous-sows-fed-low-and-high-protein-diets
#14
Lee-Anne Huber, Marko Rudar, Nathalie L Trottier, John P Cant, Cornelis F M de Lange
Twenty-eight lactating Yorkshire and Yorkshire × Landrace primiparous sows were used to test the hypothesis that feeding a diet with reduced CP concentration and supplemented with crystalline AA (CAA) does not decrease milk protein yield and litter growth but improves apparent N utilization for milk protein production. Sows were assigned to 1 of 2 dietary treatments: 1) control (CON; 16.2% CP; analyzed content) or 2) low CP with CAA to meet estimated requirements of limiting AA (LCP; 12.7% CP) over a 17-d lactation period...
June 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29454576/janus-face-of-complement-driven-neutrophil-activation-during-sepsis
#15
REVIEW
R Halbgebauer, C Q Schmidt, C M Karsten, A Ignatius, M Huber-Lang
During local and systemic inflammation, the complement system and neutrophil granulocytes are activated not only by pathogens, but also by released endogenous danger signals. It is recognized increasingly that complement-mediated neutrophil activation plays an ambivalent role in sepsis pathophysiology. According to the current definition, the onset of organ dysfunction is a hallmark of sepsis. The preceding organ damage can be caused by excessive complement activation and neutrophil actions against the host, resulting in bystander injury of healthy tissue...
June 2018: Seminars in Immunology
https://www.readbyqxmd.com/read/29381150/expression-of-the-ctla-4-ligand-cd86-on-plasmacytoid-dendritic-cells-pdc-predicts-risk-of-disease-recurrence-after-treatment-discontinuation-in-cml
#16
C Schütz, S Inselmann, S Saussele, C T Dietz, M C Müller, E Eigendorff, C A Brendel, S K Metzelder, T H Brümmendorf, C Waller, J Dengler, M E Goebeler, R Herbst, G Freunek, S Hanzel, T Illmer, Y Wang, T Lange, F Finkernagel, R Hehlmann, M Huber, A Neubauer, A Hochhaus, J Guilhot, F X Mahon, M Pfirrmann, A Burchert
This corrects the article DOI: 10.1038/leu.2017.9.
April 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29341770/search-for-neutrinoless-quadruple-%C3%AE-decay-of-150-nd-with-the-nemo-3-detector
#17
R Arnold, C Augier, A S Barabash, A Basharina-Freshville, S Blondel, S Blot, M Bongrand, D Boursette, V Brudanin, J Busto, A J Caffrey, S Calvez, M Cascella, C Cerna, J P Cesar, A Chapon, E Chauveau, A Chopra, L Dawson, D Duchesneau, D Durand, V Egorov, G Eurin, J J Evans, L Fajt, D Filosofov, R Flack, X Garrido, H Gómez, B Guillon, P Guzowski, R Hodák, A Huber, P Hubert, C Hugon, S Jullian, A Klimenko, O Kochetov, S I Konovalov, V Kovalenko, D Lalanne, K Lang, Y Lemière, T Le Noblet, Z Liptak, X R Liu, P Loaiza, G Lutter, M Macko, C Macolino, F Mamedov, C Marquet, F Mauger, B Morgan, J Mott, I Nemchenok, M Nomachi, F Nova, F Nowacki, H Ohsumi, C Patrick, R B Pahlka, F Perrot, F Piquemal, P Povinec, P Přidal, Y A Ramachers, A Remoto, J L Reyss, C L Riddle, E Rukhadze, R Saakyan, R Salazar, X Sarazin, Yu Shitov, L Simard, F Šimkovic, A Smetana, K Smolek, A Smolnikov, S Söldner-Rembold, B Soulé, D Štefánik, I Štekl, J Suhonen, C S Sutton, G Szklarz, J Thomas, V Timkin, S Torre, Vl I Tretyak, V I Tretyak, V I Umatov, I Vanushin, C Vilela, V Vorobel, D Waters, F Xie, A Žukauskas
We report the results of a first experimental search for lepton number violation by four units in the neutrinoless quadruple-β decay of ^{150}Nd using a total exposure of 0.19 kg yr recorded with the NEMO-3 detector at the Modane Underground Laboratory. We find no evidence of this decay and set lower limits on the half-life in the range T_{1/2}>(1.1-3.2)×10^{21}  yr at the 90% C.L., depending on the model used for the kinematic distributions of the emitted electrons.
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29259232/cardiac-depression-in-pigs-after-multiple-trauma-characterization-of-posttraumatic-structural-and-functional-alterations
#18
M Kalbitz, S Schwarz, B Weber, B Bosch, J Pressmar, F M Hoenes, C K Braun, K Horst, T P Simon, R Pfeifer, P Störmann, H Hummler, F Gebhard, H C Pape, M Huber-Lang, F Hildebrand
The purpose of this study was to define the relationship between cardiac depression and morphological and immunological alterations in cardiac tissue after multiple trauma. However, the mechanistic basis of depressed cardiac function after trauma is still elusive. In a porcine polytrauma model including blunt chest trauma, liver laceration, femur fracture and haemorrhage serial trans-thoracic echocardiography was performed and correlated with cellular cardiac injury as well as with the occurrence of extracellular histones in serum...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215403/suv-as-a-possible-predictor-of-disease-extent-and-therapy-duration-in-complex-tuberculosis
#19
David Lang, Helmut Huber, Bernhard Kaiser, Irene Virgolini, Bernd Lamprecht, Michael Gabriel
OBJECTIVE: F-FDG PET/CT provides information on disease extension and activity in neoplastic and inflammatory conditions. So far, little is known about whether SUVmax of a reference lesion can allow a prognosis to be given regarding patient-specific outcome parameters in complex cases of tuberculosis (TB). METHODS: We retrospectively identified 37 patients (21 men, 16 women; mean age, 50.4 years) who underwent F-FDG PET/CT for the evaluation of active TB before treatment initiation...
February 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28986662/mesenchymal-stem-cells-in-peripheral-blood-of-severely-injured-patients
#20
R Wiegner, N-E Rudhart, E Barth, F Gebhard, L Lampl, M S Huber-Lang, R E Brenner
PURPOSE: Mesenchymal stem cells (MSCs) are primarily stromal cells present in bone marrow and other tissues that are crucial for tissue regeneration and can be mobilized into peripheral blood after different types of organ damage. However, little is known about MSC appearance in blood in the setting of polytrauma. METHODS: We conducted a monocentered and longitudinal observational clinical study in 11 polytraumatized patients with an injury severity score (ISS) ≥ 24 to determine the numbers of MSCs in peripheral blood...
October 6, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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