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https://www.readbyqxmd.com/read/30116398/peripheral-blood-mitochondrial-dna-copy-number-as-a-novel-potential-biomarker-for-diabetic-nephropathy-in-type-2-diabetes-patients
#1
Ghada Al-Kafaji, Abdulah Aljadaan, Amer Kamal, Moiz Bakhiet
The mitochondrial DNA copy number (mtDNA-CN) is a surrogate measure of mitochondrial function and altered mtDNA-CN reflects the oxidant-induced cell damage. A previous study by our group demonstrated that a reduction in the renal mtDNA-CN is implicated in the pathogenesis of diabetic nephropathy (DN), a leading cause of end-stage renal disease in diabetic patients. In the present study, it was investigated whether the mtDNA-CN in the peripheral blood may be utilized as a biomarker for DN in type 2 diabetes (T2D) patients...
August 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30114929/annals-express-relationship-between-serum-thyrotropin-and-urine-albumin-excretion-in-euthyroid-subjects-with-diabetes
#2
Gautam Das, P N Taylor, Hussam Abusahmin, Amer Ali, Brian P Tennant, John Geen, Onyebuchi Okosieme
BACKGROUND: Microalbuminuria represents vascular and endothelial dysfunction. Thyroid hormones can influence urine albumin excretion (UAE) as it exerts crucial effects on the kidney and on the vascular system. This study explores the relationship between serum thyrotropin (TSH) and UAE in euthyroid patients with diabetes. METHODS: 433 patients with Type 1 or 2 diabetes were included in this retrospective cross-sectional study. Data included anthropometric measurements and biochemical parameters from diabetes clinic...
August 16, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/30114500/endovascular-repair-of-iliac-vein-laceration-associated-to-complex-pelvic-fracture
#3
Vicente Mosquera, Carlota Fernández, Amer Zanabili, Jose A Del Castro, Mónica G Pandavenes, Manuel Alonso
BACKGROUND: Iliac vein injury associated with pelvic fracture due to blunt trauma is an uncommon and difficult diagnosis but a life-threatening condition which often requires an emergent management. Although open repair has been traditionally used as the treatment of choice in unstable patients, it is controversial, given the difficulty injured vessel exposure in patients with significant retroperitoneal hematoma as well as tamponade effect loss associated to laparotomy. We present a challenging case of iliac vein laceration successfully treated by placement of a self-expanding covered stent...
August 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30113759/development-of-field-cancerization-in-the-clinically-normal-oral-mucosa-of-shisha-smokers
#4
Hatem W Amer, Hend M Waguih, Dalia H El-Rouby
OBJECTIVES: This study aimed to investigate the changes that occur in the oral mucosa of shisha smokers and compare them to cigarette smokers, non-smokers and smokers of both shisha and cigarettes and to detect whether these changes could be detected biochemically in saliva. METHODS: Four groups of subjects were included in our study (16 in each group); cigarette smokers, shisha smokers, non-smokers and smokers of both. A salivary sample and a mucosal biopsy were obtained from each subject...
August 16, 2018: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/30109425/be-careful-of-the-masquerades-differentiating-secondary-myelodysplasia-from-myelodysplastic-syndromes-in-clinical-practice
#5
Rory M Shallis, Mina L Xu, Nikolai A Podoltsev, Susanna A Curtis, Bryden T Considine, Suchin R Khanna, Alexa J Siddon, Amer M Zeidan
In patients suspected to have myelodysplastic syndrome (MDS), especially in those patients without cytogenetic abnormalities or blast excess, accurate morphologic review by an expert hematopathologist and meticulous exclusion of other secondary causes of myelodysplasia are vital to establish the diagnosis. Errors in diagnosis can lead to dangerous consequences such as the administration of hypomethylating agents, lenalidomide, or even the use of intensive chemotherapy or allogeneic hematopoietic cell transplantation in patients who do not have an underlying MDS or even a malignant hematopoietic process...
August 14, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30109162/malignant-pleural-mesothelioma-biphasic-type-an-unusual-and-insidious-case-of-rapidly-progressive-small-blue-cell-tumor
#6
Carlos Salazar, Nelson Kanter Md, Amer Abboud
Malignant pleural mesothelioma (MPM) is a rare neoplasm. It predominantly affects elderly individuals aged over 70 years presenting with a unilateral pleural tumor usually associated with previous asbestos exposure. The respiratory symptoms are associated with ipsilateral pleural involvement with concomitant pleural effusions. The diagnosis of MPM is established by the morphologic and immunohistochemical features of a cytologic specimen. MPM can present as three histologic subtypes: epithelioid, sarcomatoid, or biphasic...
June 6, 2018: Curēus
https://www.readbyqxmd.com/read/30107056/magnetization-blocking-in-fe2iiidy2iii-molecular-magnets-ab-initio-calculations-and-epr
#7
Veacheslav Vieru, Liviu Ungur, Valeriu Cemortan, Andrey Sukhanov, Amer Baniodeh, Christopher E Anson, Annie K Powell, Violeta Voronkova, Liviu Chibotaru
We investigate the magnetism and the magnetization blocking of a series of [Fe2Dy2(OH)2(teaH)2(RC6H4COO)6] complexes, where teaH3 = triethanolamine and R = meta-CN (1), para-CN (2), meta-CH3 (3), para-NO2 (4) and para-CH3 (5), by combining ab initio calculations and EPR measurements. BS-DFT calculations show that in all compounds the Fe-Fe exchange interaction is antiferromagnetic and by far stronger than Fe-Dy and Dy-Dy ones. As a result, the lowest two exchange doublets probed by EPR mostly originate from the Ising interaction of Dy ions in all compounds...
August 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/30105752/speckle-tracking-carotid-artery-circumferential-strain-is-a-marker-of-arterial-sclerosis-but-not-coronary-atherosis
#8
Daniel M Patton, Terry Li, Marie-France Hétu, Andrew G Day, Erika Preece, Murray F Matangi, Amer M Johri
PURPOSE: Circumferential speckle tracking carotid artery strain is a novel method of quantifying vessel wall stiffness. We hypothesized that carotid wall stiffness would be associated with carotid intimal medial thickening (a medial process associated with risk factors), but not coronary artery disease (an intimal process). METHODS: Bilateral carotid artery ultrasound was conducted on outpatients who had previously undergone elective coronary angiography. Mean carotid artery far wall circumferential strain (FWCS) was assessed for correlations with coronary angiographic stenosis, cardiac risk factors, carotid intima-media thickness (CIMT), and carotid plaque...
August 13, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/30102586/what-are-the-challenges-and-facilitators-for-implementing-a-24-hour-telephone-cancer-service-in-qatar-a-literature-review
#9
Amer Zawahreh, Janet Rankin, Ahmed Abu Jaber, Abdulqadir Nashwan
OBJECTIVE: To identify the challenges and facilitators for implementing a 24-h telephone cancer service. DATA SOURCES: English language articles were retrieved from Medline, Cumulative Index of Nursing and Allied Health Literature, and Ovid Nursing electronic databases published from 2000 to 2015. STUDY DESIGN: The authors performed an integrative literature review. The qualitative and quantitative articles were evaluated using the Critical Appraisal Skills Program...
August 13, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/30101279/consensus-on-shared-measures-of-mobility-and-cognition-from-the-canadian-consortium-on-neurodegeneration-in-aging-ccna
#10
Manuel Montero-Odasso, Quincy J Almeida, Louis Bherer, Amer M Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Susan Muir-Hunter, Karen Z H Li, Teresa Liu-Ambrose, William McIlroy, Laura Middleton, José A Morais, Ryota Sakurai, Mark Speechley, Akshya Vasudev, Olivier Beauchet, Jeffrey M Hausdorff, Caterina Rosano, Stephanie Studenski, Joe Verghese
Background: A new paradigm is emerging in which mobility and cognitive impairments, previously studied, diagnosed, and managed separately in older adults, are in fact regulated by shared brain resources. Deterioration in these shared brain mechanisms by normal aging and neurodegeneration increases the risk of developing dementia, falls, and fractures. This new paradigm requires an integrated approach to measuring both domains. We aim to identify a complementary battery of existing tests of mobility and cognition in community-dwelling older adults that enable assessment of motor-cognitive interactions...
June 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/30100012/cumulus-cells-of-camel-camelus-dromedarius-antral-follicles-are-multipotent-stem-cells
#11
Islam M Saadeldin, Ayman Abdel-Aziz Swelum, Mona Elsafadi, Amer Mahmood, Musaad Alfayez, Abdullah N Alowaimer
The mammalian ovary is a highly dynamic organ, in which proliferation and differentiation occur constantly during the entire life span, particularly in camels that are characterized by a follicular wave pattern and induced ovulation. Granulosa cells are the main cells of mature follicles. Two distinct cell types, namely, the mural and cumulus granulosa cells are distinguished on the basis of antral fluid increase. The multipotency of follicular fluid and the luteinizing cell were recently demonstrated. However, reports regarding the plasticity of cumulus cells are lacking...
September 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/30095789/letter-to-editor-analysis-of-explanted-magnetically-controled-growing-rods-from-seven-uk-spinal-centers
#12
Amit Nemade, Suken Shah, Amer Samdani
No abstract text is available yet for this article.
August 7, 2018: Spine
https://www.readbyqxmd.com/read/30088044/conviction-in-the-face-of-affliction-a-case-series-of-jehovah-s-witnesses-with-myeloid-malignancies
#13
Rory M Shallis, Mina L Xu, Susanna A Curtis, Erin Medoff, Rose Mixon, Anna Folkers, Amer M Zeidan
No abstract text is available yet for this article.
August 7, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/30085261/pifa-pluss-p4-assay-for-screening-of-heparin-induced-thrombocytopenia
#14
Frances B Compton, Reem Alrabeh, Lisa Q Nguyen, Elena Nedelcu, Amer Wahed, Nghia D Nguyen
Background: The PIFA PLUSS PF4 Rapid Assay (PIFA) is a rapid screening test used for the diagnosis of heparin-induced thrombocytopenia (HIT). Objective: To determine the usefulness of this assay as a screening method in our institution. Methods: A total of 159 specimens from patients with suspected HIT were included in our study. We simultaneously performed PIFA assay and confirmatory polyspecific enzyme-linked immunosorbent assay (ELISA)...
August 6, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/30082477/a-visually-apparent-and-quantifiable-ct-imaging-feature-identifies-biophysical-subtypes-of-pancreatic-ductal-adenocarcinoma
#15
Eugene J Koay, Yeonju Lee, Vittorio Cristini, John S Lowengrub, Ya'an Kang, F Anthony San Lucas, Brian P Hobbs, Rong Ye, Dalia Elganainy, Muayad Almahariq, Ahmed M Amer, Shun Yu, Deyali Chatterjee, Huaming Yan, Peter C Park, Mayrim V Rios Perez, Dali Li, Naveen Garg, Kim Reiss, Anil Chauhan, Mohamed M Zaid, Newsha Nikzad, Robert A Wolff, Milind Javle, Gauri R Varadhachary, Rachna T Shroff, Prajnan Das, Jeffrey E Lee, Mauro Ferrari, Anirban Maitra, Cullen M Taniguchi, Michael P Kim, Christopher H Crane, Matthew H G Katz, Huamin Wang, Priya Bhosale, Eric P Tamm, Jason B Fleming
BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology. METHODS: We developed a quantitative method to categorize the PDAC morphology on pre-therapy CT scans from multiple datasets of patients with resectable and metastatic disease, and correlated these patterns with clinical/pathologic measurements...
August 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30081163/open-vs-endovascular-repair-of-descending-thoracic-aortic-aneurysm-disease-a-systematic-review-and-meta-analysis
#16
REVIEW
Amer Harky, Jeffrey Shi Kai Chan, Chris Ho Ming Wong, Rafal Al Nasiri, Mohamad Bashir
OBJECTIVE: The purpose of this study was to determine whether thoracic endovascular aortic repair reduces death and morbidity compared with open surgical repair for descending thoracic aortic disease. METHODS: A comprehensive search was undertaken among the four major databases (PubMed, Embase, Scopus and Ovid) to identify all randomized and nonrandomized controlled trials comparing open versus endovascular repair in thoracic aortic aneurysm. Databases where evaluated and assessed to July 2017...
August 3, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30078055/a-comprehensive-review-of-the-diagnosis-and-management-of-congenital-scoliosis
#17
REVIEW
Charles E Mackel, Ajit Jada, Amer F Samdani, James H Stephen, James T Bennett, Ali A Baaj, Steven W Hwang
PURPOSE: To provide the reader with a comprehensive but concise understanding of congenital scoliosis METHODS: We have undertaken to summarize available literature on the pathophysiology, epidemiology, and management of congenital scoliosis. RESULTS: Congenital scoliosis represents 10% of pediatric spine deformity and is a developmental error in segmentation, formation, or a combination of both leading to curvature of the spine. Treatment options are complicated by balancing growth potential with curve severity...
August 4, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/30074223/biomechanical-evaluation-of-nano-zirconia-coatings-on-ti-6al-7nb-implant-screws-in-rabbit-tibias
#18
Thekra I Hamad, Abdalbseet A Fatalla, Amer Subhi Waheed, Zena G M Azzawi, Ying-Guang Cao, Ke Song
The clinical success of dental implants can be improved by achieving optimum implant properties, such as their biomechanical and surface characteristics. Nano-structured coatings can play an important role in improving the implant surface. The purpose of the present study was to determine the most appropriate conditions for electrophoretic deposition (EPD) of nano-zirconia coatings on Ti-6Al-7Nb substrates and to evaluate the structural and biomechanical characteristics of these deposited coatings on the dental implants...
June 2018: Current medical science
https://www.readbyqxmd.com/read/30073601/evolution-of-a-novel-robotic-training-curriculum-in-a-complex-general-surgical-oncology-fellowship
#19
L Mark Knab, Mazen S Zenati, Anton Khodakov, Maryjoe Rice, Amr Al-Abbas, David L Bartlett, Amer H Zureikat, Herbert J Zeh, Melissa E Hogg
BACKGROUND: Robotic surgery is increasingly being used for complex oncologic operations, although currently there is no standardized curriculum in place for surgical oncologists. We describe the evolution of a proficiency-based robotic training program implemented for surgical oncology fellows, and demonstrate the outcomes of the program. METHODS: A 5-step robotic curriculum began integration in July 2013. Fellows from July 2013 to August 2017 were included. An education portfolio was created for each fellow, including pre-fellowship experience, fellowship experience with data from robotic curriculum and operative experience, and post-fellowship practice information...
August 2, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30073161/synthesis-antiviral-and-antimicrobial-evaluation-of-benzyl-protected-diversified-c-nucleosides
#20
Ahmed Bari, Syed S Ali, Amer M Alanazi, Muhammad A Mashwani, Abdulrahman M Al-Obaid
Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utilizing same strategy, we propose the synthesis of diversified C -nucleosides ( 3 - 14 ) by reaction with N , N dinucleophiles. These nucleoside analogs were than tested against viral, bacterial and fungal strains.
2018: Frontiers in Chemistry
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