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Daniel Martin-Collado, Timothy J Byrne, Clara Diaz, Peter R Amer
The last decades of developments in animal breeding, genetics, genomics and data recording technologies have allowed the evaluation of larger numbers of animal and animal traits than ever before. This should help make animal breeding choices more informed, but it also makes them far more complex. This complexity may be overwhelming farmers, thus compromising realization of potential genetic gain in livestock industries. However, the effect of complexity of animal breeding choices on farmers' selection of animals has received very little theoretical consideration to date...
October 17, 2018: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
Nikolai A Podoltsev, Mengxin Zhu, Amer M Zeidan, Rong Wang, Xiaoyi Wang, Amy J Davidoff, Scott F Huntington, Smith Giri, Steven D Gore, Xiaomei Ma
Current guidelines recommend therapeutic phlebotomy for all polycythemia vera (PV) patients and additional cytoreductive therapy (eg, hydroxyurea [HU]) for high-risk PV patients. Little is known about the impact of these therapies in the real-world setting. We conducted a retrospective cohort study of older adults diagnosed with PV from 2007 to 2013 using the linked Surveillance, Epidemiology, and End Results-Medicare database. Multivariable Cox proportional hazards models were used to assess the effect of phlebotomy and HU on overall survival (OS) and the occurrence of thrombotic events...
October 23, 2018: Blood Advances
Zohar Habot-Wilner, Liran Tiosano, Juan M Sanchez, Shiri Shulman, Dana Barequet, Ori Rahat, Gil Amarilyo, Radgonde Amer
PURPOSE: To report the epidemiology, etiology, ocular characteristics, treatment and visual outcome of pediatric uveitis in Israel. METHODS: Retrospective study from two tertiary uveitis centers. RESULTS: Included were 107 patients (182 eyes), 55% females. Mean age at diagnosis 8.8 years. Uveitis was predominantly anterior, idiopathic, bilateral, and chronic. Systemic associations were seen in 36% of patients of which the most common disease was juvenile idiopathic arthritis...
October 17, 2018: Ocular Immunology and Inflammation
William E Fisher, Zobeida Cruz-Monserrate, Amy L McElhany, Gregory B Lesinski, Phil A Hart, Ria Ghosh, George Van Buren, Douglas S Fishman, Jo Ann S Rinaudo, Jose Serrano, Sudhir Srivastava, Thomas Mace, Mark Topazian, Ziding Feng, Dhiraj Yadav, Stephen J Pandol, Steven J Hughes, Robert Y Liu, Emily Lu, Robert Orr, David C Whitcomb, Amer S Abouhamze, Hanno Steen, Zachary M Sellers, David M Troendle, Aliye Uc, Mark E Lowe, Darwin L Conwell
High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults...
November 2018: Pancreas
Mohamed A Amer, Mohamed O Tomoum
INTRODUCTION: Rhinoscleroma (RS) is a chronic, progressive, granulomatous infectious disease endemic in Egypt and the Middle East, affecting the nose in 95-100% of cases, and resulting in functional and esthetic sequelae. The aim of the study was to investigate the feasibility of performing reconstructive procedures to improve external deformities in RS patients, with long-term follow up. PATIENTS & METHODS: This prospective, controlled cohort study included 25 patients who were seeking rhinoplasty to improve their esthetic appearance, with evident clinical and histopathological history of RS...
September 26, 2018: Journal of Cranio-maxillo-facial Surgery
Samir A El-Shazly, Mohamed M Ahmed, Mohammad S Al-Harbi, Mohamed E Alkafafy, Hanan B El-Sawy, Sayed A M Amer
The present study was performed to assess anti-obesity effects of raw pineapple juice in high fat diet (HFD)-induced fatness. Based on food type, rats were divided into normal diet and HFD groups. When animals of HFD group become obese, they were given pineapple juice along with either HFD or normal diet. Blood biochemistry, liver and muscle gene expressions were analyzed. HFD induced significant elevations in body weight, body mass index (BMI), body fat accumulation, liver fat deposition and blood lipids while juice restored these parameters near to their normal values...
October 2018: Food Science and Biotechnology
Tahira Zubair, Amanullah Abbasi, Osama Ahsan Khan, Erum Amer
OBJECTIVE: To determine the association between passive smoking and chronic obstructive pulmonary disease. METHODS: The cross-sectional study was conducted from October 2015 to March 2016 at the Ojha campus of Dow University Hospital, Karachi, and comprised individuals who denied past or current active smoking and exposure to bio-mass fuel. The subjects were attendants coming with patients, hospital staff, faculty and medical students aged 15-64 years. Each subject undertook pulmonary function tests via spirometer after filling a proforma based on assessment and quantification of the exposure to second- hand smoke and common symptoms of chronic obstructive pulmonary disease...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Muhammad Imtiaz Hasan, Wasim Amer, Nabeea Junaid
OBJECTIVE: To ascertain the effectiveness of implementing the American Diabetes Association/European Association for the Study of Diabetes 2009 consensus algorithm in achieving glycaemic control in patients with type 2 diabetes. METHODS: The prospective, observational, open label, product registry was conducted at 38 sites across 7 cities in Pakistan between July 2011 and February 2014. Uncontrolled type 2 diabetes patients were either initiated on or switched to insulin glargine from other basal insulin...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Markus Ameres, Michael Melter, Robert Zant, Stefan Schilling, Tobias Geis
pLT is a highly standardized therapy for children with end-stage liver disease and liver-based metabolic diseases. However, NCs after transplantation occur and especially younger children are considered as more vulnerable and susceptible to NCs. Up to now, detailed data particularly for the very young age group do not exist. We therefore retrospectively studied NCs in children after pLT under age of 24 months. Forty children aged between 19 days and 22 months were evaluated according to type of NC and potential risk factors...
October 12, 2018: Pediatric Transplantation
Amer M Zeidan, Rory M Shallis, Rong Wang, Amy Davidoff, Xiaomei Ma
Myelodysplastic syndromes (MDS) consist of a heterogeneous group of myeloid neoplasms characterized by inefficient hematopoiesis, variable cytopenias and a considerable risk of progression to acute myeloid leukemia. Epidemiological assessment of MDS has been hampered by evolving diagnostic criteria and delayed classification of MDS as cancers until 2001. The poorly-understood nature of these neoplasms combined with the lack of effective therapies for decades contributed to suboptimal case ascertainment and underreporting...
September 21, 2018: Blood Reviews
Elizabeth A Rapp van Roden, Robert Tyler Richardson, Stephanie A Russo, William C Rose, Kristen F Nicholson, Ross S Chafetz, Peter G Gabos, Suken A Shah, Amer F Samdani, James G Richards
BACKGROUND: Nonsurgically treated patients with AIS demonstrate altered scapular kinematics and decreased patient-reported shoulder function compared with typically developing adolescents. It is unknown whether surgical correction of the spine deformity has beneficial or detrimental effects on scapulothoracic joint function, as previous assessments of shoulder function following surgery have only focused on humerothoracic motion. The objective of this study was to perform a comprehensive analysis of scapular kinematics before and after PSF and compare postoperative scapular kinematics in AIS to those of a typically developing cohort...
October 11, 2018: Journal of Pediatric Orthopedics
Ron Neumann, Dana Barequet, Amir Rosenblatt, Radgonde Amer, Yael Ben-Arie-Weintrob, Tamar Hareuveni-Blum, Vicktoria Vishnevskia-Dai, Eyal Raskin, Oren Blumenfeld, Shiri Shulman, Juan M Sanchez, Victor Flores, Zohar Habot-Wilner
PURPOSE: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. METHODS: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). RESULTS: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis...
October 12, 2018: Ocular Immunology and Inflammation
Asmaa Amer, Hussein Taha, Nagwa Ammar, Maha Salama, Taha El-Alfy
BACKGROUND AND OBJECTIVE: The DNA fingerprinting is used to determine the relationship between species in the same genus or between genera related to the same family. The aim of this study was to determine the relationships between two samples related to the same family Convolvulaceae, representing two genera, Cressa Linn. and Cuscuta Yunck. by RAPD, ISSR and SCoT molecular techniques (PCR based DNA fingerprint). MATERIALS AND METHODS: The RAPD, ISSR and SCoT based DNA fingerprinting techniques were implemented to identify the fingerprint diversity between two genera, Cressa Linn...
January 2018: Pakistan Journal of Biological Sciences: PJBS
Medhat Kamel Amer, Ahmed Ragab Ahmed, Asmaa Ahmed Abdel Hamid, Sameh Fayek GamalEl Din
We aimed in this retrospective study to evaluate non-surgical preoperative parameters and testicular histopathology in determining the sperm retrieval rate (SRR) in non-obstructive azoospermic (NOA) patients. We evaluated the data of 1,395 consecutive patients who underwent 1st time micro-dissection testicular sperm extraction (micro-TESE) that was done by fifteen different senior andrologists and a consequent undefined number of biologists assisting them in the operative rooms from January 2010 to May 2013 in a specialised IVF centre...
October 11, 2018: Andrologia
Pipat Piewngam, Yue Zheng, Thuan H Nguyen, Seth W Dickey, Hwang-Soo Joo, Amer E Villaruz, Kyle A Glose, Emilie L Fisher, Rachelle L Hunt, Barry Li, Janice Chiou, Sujiraphong Pharkjaksu, Sunisa Khongthong, Gordon Y C Cheung, Pattarachai Kiratisin, Michael Otto
Probiotic nutrition is frequently claimed to improve human health. In particular, live probiotic bacteria obtained with food are thought to reduce intestinal colonization by pathogens, and thus to reduce susceptibility to infection. However, the mechanisms that underlie these effects remain poorly understood. Here we report that the consumption of probiotic Bacillus bacteria comprehensively abolished colonization by the dangerous pathogen Staphylococcus aureus in a rural Thai population. We show that a widespread class of Bacillus lipopeptides, the fengycins, eliminates S...
October 10, 2018: Nature
Amer Sebaaly, Pomme Jouffroy, Pierre Emmanuel Moreau, Camille Rodaix, Guillaume Riouallon
OBJECTIVES: To evaluate the accuracy of reduction of the acetabular articular surface using an intraoperative CT scanner (O-Arm) and screw navigation compared to a classical open technique. DESIGN: Prospective matched Cohort study SETTING:: Tertiary referral center PATIENTS/PARTICIPANTS:: Adult patients with acute acetabular fractures. All patients were treated by two senior surgeons using intraoperative imaging and screw navigation. MAIN OUTCOME MEASUREMENTS: The primary outcome measure was articular reduction...
September 25, 2018: Journal of Orthopaedic Trauma
Mashaal Dhir, Amer H Zureikat
No abstract text is available yet for this article.
October 8, 2018: Annals of Surgical Oncology
Khaoula Bouazizi, Amer Rahhal, Slawomir Kusmia, Morgane Evin, Carine Defrance, Philippe Cluzel, Myriam Berthet, Fabrice Atassi, Pascal Leprince, Guillaume Lebreton, Nadjia Kachenoura, Stéphane N Hatem, Alban Redheuil
BACKGROUND: Atrial fibrillation is associated with an atrial cardiomyopathy composed mainly of fibrosis and adipose tissue accumulation. We hypothesized that MRI, when used in an optimal ex vivo setting allowing high spatial resolution without motion artifacts, can help characterizing the complex 3D left atrial (LA) wall composition in human myocardial samples, as compared to histology. METHODS: This prospective case-control study was approved by the institutional review board...
2018: PloS One
Maxim Norkin, Bronwen E Shaw, Ruta Brazauskas, Heather R Tecca, Helen L Leather, Juan Gea-Banacloche, Rammurti Kamble, Zachariah DeFilipp, David A Jacobsohn, Olle Ringden, Yoshihiro Inamoto, Kimberly Kasow, David Buchbinder, Peter Shaw, Peiman Hematti, Raquel Schears, Sherif M Badawy, Hillard M Lazarus, Neel Bhatt, Biljana Horn, Saurabh Chhabra, Kristin Page, Betty Hamilton, Gerhard C Hildebrandt, Jean A Yared, Vaibhav Agrawal, Amer Beitinjaneh, Navneet Majhail, Tamila Kindwall-Keller, Richard F Olsson, Helene Schoemans, Robert Peter Gale, Siddhartha Ganguly, Ibrahim Ahmed, Harry C Schouten, Jane Liesveld, Nandita Khera, Amir Steinberg, Ami J Shah, Melhem Solh, David I Marks, Witold Rybka, Mahmoud Aljurf, Andrew C Dietz, Usama Gergis, Biju George, Sachiko Seo, Mary E D Flowers, Minoo Battiwalla, Bipin N Savani, Marcie L Riches, John R Wingard
BACKGROUND: We analyzed late fatal infections (LFI) in allogeneic stem cell transplant (HCT) recipients reported to the Center for International Blood and Marrow Transplant Research. METHODS: We analyzed the incidence, infection types and risk factors contributing to LFI in 10336 adult and 5088 pediatric subjects surviving ≥2 years after first HCT without relapse. RESULTS: Among 2245 adult and 377 pediatric subjects who died, infections were a primary or contributory cause of death in 687(31%) and 110(29%) subjects, respectively...
October 1, 2018: Biology of Blood and Marrow Transplantation
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