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Ali A Asadi-Pooya, Raidah AlBaradie, Tyson Sawchuk, Zahra Bahrami, Abeer Al Amer, Jeffrey Buchhalter
PURPOSE: We compared various clinical characteristics of psychogenic nonepileptic seizures (PNES) between young patients from Iran, Saudi Arabia, and Canada, three nations with significantly different socioeconomic and demographic characteristics. This international cross-cultural comparative study may advance our knowledge and understanding of PNES in children and adolescents across the cultures and borders. METHODS: In this retrospective study, we investigated all patients 16 years of age or younger, with PNES admitted to the epilepsy monitoring units at one center in Iran, one center in Saudi Arabia, and one center in Canada...
December 2, 2018: Epilepsy & Behavior: E&B
Mostafa M Amer, Ana C Carrasco, Daniel J Leonard, John W Ward, Jonathan Clayden
Imidazolidinone derivatives of a range of aromatic α-amino acids, on treatment with phosgene and potassium iodide, undergo a mild Bischler-Napieralski-style cyclocarbonylation reaction that generates a tricyclic lactam by insertion of a C═O group between amino acid nitrogen and the ortho position of the aryl substituent. Regio- and diastereoselective functionalization of the lactam generates a library of substituted dihydroisoquinolinones and their congeners in enantioenriched form.
December 5, 2018: Organic Letters
Mona Mostafa Korany, Marwa Ahmed Amer, Laila Ahmed Rashed, Marwah Adly Saleh
Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Perilesional skin biopsies were taken from 24 BP patients and 13 controls. The biopsies were stained by direct immunofluorescence using rabbit anti-human AQP 3 FITC antibody. The expression of AQP 3 was weak in 5 patients (20.8%), moderate in 18 patients (75%), strong in 1 patient (4.2%) in the suprabasal layers...
December 4, 2018: Archives of Dermatological Research
Vito Colella, Adnan Hodžić, Roberta Iatta, Gad Baneth, Amer Alić, Domenico Otranto
Leishmania infantum causes potentially life-threatening disease in humans. To determine the extent of the animal reservoir for this pathogen in Bosnia and Herzegovina, we tested dogs and cats. We found that a large proportion of dogs were exposed to or infected with L. infantum, indicating endemicity in dogs and zoonotic risk for humans.
February 17, 2019: Emerging Infectious Diseases
Patrick R Varley, Mazen S Zenati, Andrew Klobuka, Juliana Tobler, Ahmad Hamad, Melissa E Hogg, Herbert J Zeh, Amir A Borhani, Amer H Zureikat
BACKGROUND: We sought to investigate whether robotic pancreatoduodenectomy (RPD) mitigates adverse outcomes in patients with high-risk morphometric features compared to the open approach (OPD). METHODS: Morphometric parameters for RPD and OPDs were measured by two blinded radiologists. The morphometric parameter best correlating with adverse outcomes was identified and used in multivariable models to evaluate the impact of surgical approach (open vs. robotic) on outcomes of patients with high-risk morphometric features...
November 30, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Sarah Ahmed Mohamed Mahmoud, Hatem Wael Amer, Sally Ibrahim Mohamed
Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumour arising from odontogenic epithelium. It was classified into primary type and secondary type. A previous study revealed that primary ameloblastic carcinoma cases were associated with more favourable prognosis than secondary cases. The aim of the present work was: to report the clinical, histopathological, immunohistochemical, and ploidy status, and therapeutic details of four cases of primary AC, and to review the literature with regard to clinical, follow-up, prognosis, histopathological, and immunohistochemical information of primary AC...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Vestine Uwiringiyimana, Marga C Ocké, Sherif Amer, Antonie Veldkamp
OBJECTIVES: The aim of this study was to review the factors associated with stunting in the northern province of Rwanda by assessing anthropometric status, dietary intake, and overall complementary feeding practices. METHODS: This was a cross-sectional study with 138 children 5 to 30 mo of age. A structured questionnaire was used to collect information on sociodemographic characteristics of each mother and child and breastfeeding and complementary feeding practices...
September 6, 2018: Nutrition
Rachel M Holden, Marie-France Hétu, Terry Y Li, Emilie Ward, Laura E Couture, Julia E Herr, Erin Christilaw, Michael A Adams, Amer M Johri
OBJECTIVE: Pre-clinical studies suggest that growth arrest-specific protein 6 (Gas6), a member of the vitamin K dependent family of proteins, is implicated in atherosclerosis. A role for Gas6 in stabilizing atherosclerotic plaque has been suggested. Our aim was to determine the association between Gas6 and measures of carotid artery atherosclerosis in humans undergoing elective coronary angiography. Secondary aims were to determine the association between Gas6 and sex, diabetes, and obesity...
November 30, 2018: Clinical Biochemistry
Ciaran Grafton-Clarke, Laura Grace, Neil Roberts, Amer Harky
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was, 'In patients undergoing cardiac surgery, is postoperative massage therapy effective in reducing pain, anxiety and physiological parameters?'. Altogether, 287 papers were found using the reported search, of which 7 papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and the results of these papers are tabulated...
December 1, 2018: Interactive Cardiovascular and Thoracic Surgery
Ciaran Grafton-Clarke, Laura Grace, Amer Harky
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: In patients undergoing cardiac surgery, is postoperative music therapy effective in reducing pain and anxiety? Altogether, 153 papers were found using the reported search method, of which 7 represented the best evidence to answer the clinical question. Six of the included studies were randomized trials, with 1 further non-randomized trial. The specific music protocols utilized widely varied, ranging from 1 short session on day 1 postoperatively to multiple sessions per day over a 72-h period...
December 1, 2018: Interactive Cardiovascular and Thoracic Surgery
Marwa Ali A Fathi, Amer Ali Abd El-Hafeez, Dalia Abdelhamid, Samar H Abbas, Monica M Montano, Mohamed Abdel-Aziz
A new series of 1,3,4-oxadiazole/chalcone hybrids was designed, synthesized, identified with different spectroscopic techniques and biologically evaluated as inhibitors of EGFR, Src, and IL-6. The synthesized compounds showed promising anticancer activity, particularly against leukemia, with 8v being the most potent. The synthesized compounds exhibited strong to moderate cytotoxic activities against K-562, KG-1a, and Jurkat leukemia cell lines in MTT assays. Compound 8v showed the strongest cytotoxic activity with IC50 of 1...
November 22, 2018: Bioorganic Chemistry
Jae P Jung, Mazen S Zenati, Ahmad Hamad, Melissa E Hogg, Richard L Simmons, Amer H Zureikat, Herbert J Zeh, Brian A Boone
BACKGROUND: Achieving margin negative resection is a significant determinant of outcome in pancreatic adenocarcinoma (PDA). However, because of the fibrotic nature of PDA, it can be difficult to discriminate fibrosis from active disease intra-operatively. We sought to determine if post-hoc video review of robotic pancreatico-duodenectomy (RPD) could predict the portal/superior mesenteric vein (PV/SMV) margin status on final pathology. METHODS: Experienced pancreatic surgeons, blinded to patient and operative variables, reviewed the PV/SMV margin for available RPD videos of consecutive PDA patients from 9/2012 through 6/2017...
November 27, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Yusra Habib Khan, Tauqeer Hussain Mallhi, Azmi Sarriff, Amer Hayat Khan, Nida Tanveer
Chronic kidney disease (CKD) is an asymptomatic disease associated with high morbidity and life-threatening complications that lead to decreased life expectancy. Worldwide prevalence of CKD is escalating at an alarming rate. Large population-based representative surveys have been reported in Western countries to estimate the prevalence of the disease. However, there is paucity of data as far as developing nations are concerned. Asia is the world's largest continent accommodating maximum number of under-developed and developing countries with an unclear picture of prevalence of CKD...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Farzana Hakim, Amir Rashid, Amer Fakhr, Saleem Ahmed Khan
OBJECTIVE: To evaluate matrix metalloproteinase-9 gene expression in rheumatoid arthritis patients on disease modifying anti-rheumatic agents with the objective to further modify the current treatment regimen if indicated in order to prevent progression to deforming rheumatoid arthritis. STUDY DESIGN: Cross-sectional comparative study. PLACE AND DURATION OF STUDY: CREAM Lab (Centre for Research in Experimental and Applied Medicine) and Department of Biochemistry and Molecular Biology, Army Medical College, in collaboration with Rheumatology Department at Military Hospital Rawalpindi from November 2015 to November 2016...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Amer Melhem, Vincent Rogé, T T Dai Huynh, Arnaud Stolz, Abderazek Talbi, Cyril Tchiffo-Tameko, Thomas Lecas, Chantal Boulmer-Leborgne, Eric Millon, Nadjib Semmar
In this paper, an original homemade system is presented in detail for the electrical and thermoelectrical characterizations of several types of materials from bulk to thin films. This setup was built using a modulated CO2 laser beam to probe the thermoelectric properties at different depths below the surface. It allows a simultaneous measurement of the electrical conductivity ( σ ) and the Seebeck coefficient ( S ), from room temperature up to 250 °C. A commercial sample of Bi2 Te3 was first used to validate the Seebeck coefficient measurement...
November 2018: Review of Scientific Instruments
Dilan J Albarawi, Amer A Balatay, Nasir Al-Allawi
PURPOSE: Hemoglobin (Hb) F% is increased in up to half of beta-thalassemia (β-thal) carriers. Several polymorphisms have been linked to such variability in different populations, including HBG2 - 158(C>T) ( Xmn I polymorphism) on chromosome 11. To determine the role of this polymorphism in such variability among Iraqi Kurds, the current study was initiated. MATERIALS AND METHODS: A total of 102 consecutive patients diagnosed as β-thal minor were enrolled. The enrollees had their diagnosis based on peripheral blood counts and high-performance liquid chromatography to determine HbA2 and HbF...
October 2018: Journal of Laboratory Physicians
Amer M Najjar, Jason M Johnson, Dawid Schellingerhout
Imaging plays a critical role in the management of the highly complex and widely diverse central nervous system (CNS) malignancies in providing an accurate diagnosis, treatment planning, response assessment, prognosis, and surveillance. Contrast-enhanced magnetic resonance imaging (MRI) is the primary modality for CNS disease management due to its high contrast resolution, reasonable spatial resolution, and relatively low cost and risk. However, defining tumor response to radiation treatment and chemotherapy by contrast-enhanced MRI is often difficult due to various factors that can influence contrast agent distribution and perfusion, such as edema, necrosis, vascular alterations, and inflammation, leading to pseudoprogression and pseudoresponse assessments...
November 28, 2018: Bioengineering
Amer Takkem, Charif Barakat, Safa Zakaraia, Khaled Zaid, Johnny Najmeh, Mahdi Ayoub, Mohammad Yaman Seirawan
Introduction: Abnormal cell proliferation appears to be a possible predictor of tumorigenesis, Ki-67 protein expression is closely related to the cell proliferation and could be used as a biomarker for the growth in the most of human tumors. The aim of the study: Investigating of Ki-67 expression in the pathological grades of oral epithelial dysplasia and oral squamous cell carcinomas. Materials and Methods: The sample consisted of 30 formalin-fixed, paraffin-embedded specimens of oral epithelial dysplasia (OED), 30 other of oral squamous cell carcinomas (OSCC), and 10 normal oral epithelium (NOE) were conventionally stained with hematoxylin and eosin and immunohistochemically stained with Ki-67 monoclonal antibody...
November 29, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Rehab A Karam, Haidy E Zidan, Tamer M Abd Elrahman, Samir A Badr, Samar A Amer
Many tumor-suppressor genes contain CpG islands in their promoter regions which raised the necessity of investigating the role of methylation in silencing these genes. We examined p16 methylation as a potential biomarker in the peripheral blood of colorectal cancer (CRC) patients. Using methylation-specific polymerase chain reaction method, the methylation status of p16 was investigated in the tumor tissue and blood of 65 CRC patients and blood samples from 70 healthy control individuals. Also, the relationship between p16 methylation level and the clinical-pathological findings in CRC was evaluated...
November 28, 2018: Journal of Cellular Biochemistry
Emily Ionson, Jayneel Limbachia, Soham Rej, Klajdi Puka, Ronnie I Newman, Stephen Wetmore, Amer M Burhan, Akshya Vasudev
BACKGROUND: Late-life depression (LLD) is a disabling disorder and antidepressants are ineffective in as many as 60% of cases. Converging evidence shows a strong correlation between LLD and subsequent risk of cardiovascular disease. There is a need for new, well-tolerated, non-pharmacological augmentation interventions that can treat depressive symptoms as well as improve heart rate variability (HRV), an important prognostic marker for development of subsequent cardiovascular disease...
November 28, 2018: British Journal of Psychiatry: the Journal of Mental Science
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