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https://www.readbyqxmd.com/read/30106985/noninvasive-scoring-systems-predict-hepatic-and-extra-hepatic-cancers-in-patients-with-nonalcoholic-fatty-liver-disease
#1
Noam Peleg, Orly Sneh Arbib, Assaf Issachar, Michal Cohen-Naftaly, Marius Braun, Amir Shlomai
BACKGROUND: Liver fibrosis predicts liver-related morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD). Non-invasive scores correlate with the degree of liver fibrosis in these patients. AIMS AND METHODS: To investigate the accuracy of noninvasive scoring systems in predicting long-term outcomes and cancer incidence of patients with NAFLD, we performed a single-center retrospective study of patients with biopsy proven NAFLD. Mean follow up period was 100 months...
2018: PloS One
https://www.readbyqxmd.com/read/30105919/surgical-management-of-normocalcemic-primary-hyperparathyroidism-and-the-impact-of-intraoperative-parathyroid-hormone-testing-on-outcome
#2
Gina Trinh, Eleni Rettig, Salem I Noureldine, Jonathon O Russell, Nishant Agrawal, Aarti Mathur, Jason D Prescott, Martha A Zeiger, Ralph P Tufano
Objective To review our surgical experience and the impact of intraoperative parathyroid hormone (IOPTH) testing among patients with normocalcemic primary hyperparathyroidism. Study Design Case series with chart review. Setting Academic referral hospital. Subject and Methods Normocalcemic hyperparathyroidism (NCHPT) patients were identified with normal-range blood ionized calcium and serum elevated parathyroid hormone. Patient demographics, intraoperative findings, IOPTH dynamics, and biochemical outcomes were compared with those of classic primary hyperparathyroidism (PHPT) patients...
August 14, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/30105471/fatal-poisonings-associated-with-new-psychoactive-substances
#3
Robert Kronstrand, Davide Guerrieri, Svante Vikingsson, Ariane Wohlfarth, Henrik Gréen
This chapter describes how new psychoactive substances (NPS) have been involved in fatal intoxications from 2010 and onwards. It summarizes the circumstances, antemortem symptoms, and adverse effects that have led to death after ingestion of one or more NPS and tabulates concentrations, and postmortem findings from these intoxications.Consumption of NPS exerts health problems and unknown risks for the users. Data on toxicity of many NPS are scarce or nonexistent and long-term toxicity and risks are still largely unknown...
August 14, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/30104872/management-of-severe-copd-exacerbations-focus-on-beclomethasone-dipropionate-formoterol-glycopyrronium-bromide
#4
REVIEW
Marco Mantero, Dejan Radovanovic, Pierachille Santus, Francesco Blasi
The major determinant of the decline in lung function, quality of life, and the increased mortality risk in patients with COPD is represented by severe acute exacerbations of the disease, that is, those requiring patients' hospitalization, constituting a substantial social and health care burden in terms of morbidity and medical resource utilization. Different long-term therapeutic strategies have been proposed so far in order to prevent and/or reduce the clinical and social impact of these events, the majority of which were extrapolated from trials initially focused on the effect of long-acting muscarinic antagonist and subsequently on the efficacy of long-acting β2-agonists in combination or not with inhaled corticosteroids...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/30104296/glycemic-control-and-risk-of-infections-among-people-with-type-1-or-type-2-diabetes-in-a-large-primary-care-cohort-study
#5
Julia A Critchley, Iain M Carey, Tess Harris, Stephen DeWilde, Fay J Hosking, Derek G Cook
OBJECTIVE: Diabetes mellitus (DM) increases the risk of infections, but the effect of better control has not been thoroughly investigated. RESEARCH DESIGN AND METHODS: With the use of English primary care data, average glycated hemoglobin (HbA1c ) during 2008-2009 was estimated for 85,312 patients with DM ages 40-89 years. Infection rates during 2010-2015 compiled from primary care, linked hospital, and mortality records were estimated across 18 infection categories and further summarized as any requiring a prescription or hospitalization or as cause of death...
August 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30104063/long-term-results-of-the-modified-konno-procedure-in-high-risk-children-with-obstructive-hypertrophic-cardiomyopathy
#6
Mikael Laredo, Diala Khraiche, Olivier Raisky, Régis Gaudin, Fanny Bajolle, Alice Maltret, Sylvie Chevret, Damien Bonnet, Pascal R Vouhé
OBJECTIVE: Transaortic septal myectomy is the gold standard surgery in obstructive hypertrophic cardiomyopathy, but it is not optimal for children aged less than 5 years and with right ventricular outflow tract obstruction. We evaluated outcomes with the modified Konno procedure in children with severe forms of obstructive hypertrophic cardiomyopathy. METHODS: A total of 79 consecutive children who underwent the modified Konno procedure in our center between 1991 and 2016 were included...
July 18, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30103088/gestational-weight-gain-recommendations-for-chilean-women-a-mathematical-optimization-approach
#7
M L Garmendia, O Matus, S Mondschein, J P Kusanovic
OBJECTIVES: We examined if the guidelines for gestational weight gain (GWG) proposed by the Institute of Medicine (IOM) are the most suitable for Chilean women. STUDY DESIGN: Secondary analysis of records of single full-term births at the Dr. Sótero del Río Hospital, Santiago, Chile, during 2003-2012 (n = 62,579). METHODS: From clinical records, we obtained data regarding maternal age, height, prepregnancy and at delivery weights, pathologies during pregnancy such as gestational diabetes (GDM) and pre-eclampsia, gestational age at delivery, and number of infants born small for gestational age (SGA) and large for gestational age (LGA)...
August 10, 2018: Public Health
https://www.readbyqxmd.com/read/30103022/parvovirus-b19-in-endomyocardial-biopsy-of-patients-with-idiopathic-dilated-cardiomyopathy-foe-or-bystander
#8
C Hjalmarsson, J-A Liljeqvist, M Lindh, K Karason, E Bollano, A Oldfors, B Andersson
BACKGROUND: Parvovirus B19 (PVB19) has emerged as one of the viruses possibly inducing chronic myocarditis and subsequent IDCM. AIM: to investigate the presence and the long-term consequences of PVB19-DNA within myocardial biopsies in patients with IDCM and to compare the findings with those of donor hearts (control group). METHODS AND RESULTS: 40 hospitalized IDCM patients (age 47 ±12y) with LVEF 27 ±12% were included. The presence of PVB19-DNA in myocardial biopsies, and of IgG and IgM antibodies in patient sera was analysed...
August 10, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/30102825/donor-dopamine-does-not-affect-liver-graft-survival-evidence-of-safety-from-a-randomized-controlled-trial
#9
Urs Benck, Matthias Jung, Bernd Krüger, Anja Grimm, Christel Weiss, Benito A Yard, Frank Lehner, Anja Kiessling, Lutz Fischer, Anja Gallinat, Axel Kleespies, Thomas Lorf, Robert Sucher, Christian Mönch, Marcus N Scherer, Axel Rahmel, Peter Schemmer, Bernhard K Krämer, Peter Schnuelle
Treatment of the brain-dead donor (DBD) with low-dose dopamine improves the outcomes after kidney and heart transplantation. This study investigates the course of liver allografts from multi-organ donors enrolled in the randomized dopamine trial between 2004 and 2007 (clinicalTrials. gov Identifier: NCT00115115). Twohundred sixty-four hemodynamically stable DBDs were randomly assigned to receive low-dose dopamine. Dopamine was infused at 4 μg/kg/min for a median duration of 6.0 hours (IQR 4.4-7.5 hours). We assessed the outcomes of 212 liver transplants performed at 32 European centers...
August 13, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30102498/impact-of-socio-demographic-characteristics-and-long-term-complications-on-quality-of-life-in-patients-with-diabetes-mellitus
#10
Miodrag Stojanović, Goran Cvetanović, Marija Anđelković-Apostolović, Dijana Stojanović, Nataša Rančić
OBJECTIVE: Diabetes mellitus (DM) has been one of the leading chronic diseases worldwide over past decades. The objective of the study was to identify predictors associated with health-related quality of life (HRQOL) in diabetic patients. METHODS: A cross-sectional questionnaire-based study was conducted at the General Hospital of the city of Leskovac, between June and November 2015. The Short Form-36 (SF-36) questionnaire, EuroQol-5D (EQ-5D) and EuroQol-VAS (EQ-VAS) questionnaires were used...
June 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/30102418/long-term-outcome-of-primary-immune-mediated-thrombocytopenia-in-dogs
#11
K Simpson, P Chapman, A Klag
OBJECTIVES: To determine the incidence of relapse after discharge from the hospital in dogs with a diagnosis of presumed primary immune-mediated thrombocytopenia, risk factors associated with relapse and whether or not indefinite use of immunosuppressive medication influences risk of relapse. MATERIALS AND METHODS: Medical records from August 2007 through July 2016 were reviewed to identify dogs with a diagnosis of presumed primary immune-mediated thrombocytopenia...
August 13, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/30102186/intensity-modulated-radiation-therapy-versus-conventional-radiation-for-anal-cancer-in-the-veterans-affairs-system
#12
Alex K Bryant, Minh-Phuong Huynh-Le, Daniel R Simpson, Loren K Mell, Samir Gupta, James D Murphy
PURPOSE: Compared with conventional radiation therapy, intensity modulated radiation therapy (IMRT) may reduce acute toxicity from anal cancer treatment, potentially leading to improved long-term outcomes. We analyze the effect of IMRT on short- and long-term outcomes among a large sample of US veterans. METHODS AND MATERIALS: From a national Veterans Affairs database, we identified 779 patients (n = 403 conventional radiation therapy, n = 376 IMRT) with locally advanced anal squamous cell carcinoma diagnosed between 2000 and 2015 and treated with concurrent chemoradiation therapy...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/30101847/relationship-between-serum-sodium-level-within-the-low-normal-range-on-admission-and-long-term-clinical-outcomes-in-patients-with-acute-decompensated-heart-failure
#13
Masaru Hiki, Takatoshi Kasai, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Takao Kato, Shoko Suda, Tetsuro Miyazaki, Atsutoshi Takagi, Hiroyuki Daida
Although hyponatremia during hospitalization for acute decompensated heart failure (ADHF) is reportedly related with poor prognosis, the available data regarding the impact of serum sodium level within the low-normal range at admission on clinical events in patients with ADHF is limited.We studied eligible patients admitted to our institution in 2007-2011. All the patients were categorized into 3 groups according to the admission serum sodium levels of < 135 mmol/L (hyponatremia), ≥ 135 and < 140 mmol/L (low-normal range), or ≥ 140 mmol/L (normal range)...
August 11, 2018: International Heart Journal
https://www.readbyqxmd.com/read/30101362/clinical-and-radiological-outcome-at-mean-follow-up-of-11-years-after-hip-arthroscopy
#14
Martin Olach, Pascal Gerhard, Karlmeinrad Giesinger, Christoph Lampert, Johannes B Erhardt
INTRODUCTION: The use of hip arthroscopy (HA) has substantially increased over the last decade. However, while the benefits of HA after 1 year in patients with femoroacetabular impingement (FAI) are well documented, long-term data on the progression of osteoarthritis (OA) or patient-reported outcomes (PROMs) are lacking. OBJECTIVES: To evaluate long-term clinical and radiological outcomes after HA. MATERIALS AND METHODS: Preoperative clinical records, operative notes, and radiographs from all patients who underwent HA at our hospital between 1998 and 2006 were reviewed...
August 13, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/30101313/heart-team-decision-making-and-long-term-outcomes-for-1000-consecutive-cases-of-coronary-artery-disease
#15
Carina T Domingues, Milan Milojevic, Daniel J F M Thuijs, Nicolas M van Mieghem, Joost Daemen, Ron T van Domburg, A Pieter Kappetein, Stuart J Head
OBJECTIVES: The Heart Team has been recommended as standard care for patients with coronary artery disease (CAD). However, little is known about the real benefits, potential treatment delays and late outcomes of this approach. Our goal was to determine the safety and feasibility of multidisciplinary Heart Team decision making for patients with CAD. METHODS: We retrospectively assessed 1000 consecutive cases discussed by the Heart Team between November 2010 and January 2012...
August 7, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/30100676/is-single-stage-implant-based-breast-reconstruction-ssbr-with-an-acellular-matrix-safe-strattice%C3%A2-or-meso-biomatrix%C3%A2-in-ssbr
#16
Nadine S Hillberg, Patrick I Ferdinandus, Rieky E G Dikmans, Bjorn Winkens, Juliette Hommes, René R W J van der Hulst
Background: Acellular matrices (AM) might enable a direct single-stage breast reconstruction procedure resulting in an improved efficacy of the reconstruction phase for patients. Safety concerns are an important issue due to a recent study which shows that single-stage breast reconstruction with Strattice™ resulted in more complications versus a two-stage reconstruction. Therefore, the goal of this study is to compare the short- and long-term complications of a single-stage breast reconstruction with the use of two types of AM (Strattice™ and Meso Biomatrix®) versus two-stage breast reconstruction without the use of an AM...
2018: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/30100383/midfacial-growth-and-dental-arch-relationships-in-bilateral-cleft-palate-following-secondary-alveolar-bone-grafting-and-orthodontic-intervention-factors-predicting-a-le-fort-i-osteotomy-at-age-18
#17
Gerhard K P Bittermann, Adrianus P de Ruiter, Arnold Jn Bittermann, Aebele B Mink van de Molen, Robert Jj van Es, Ron Koole, Antoine Jwp Rosenberg
OBJECTIVE: To evaluate midfacial growth and dental arch relationships in patients treated for bilateral cleft lip and palate (BCLP). MATERIALS AND METHODS: Data were collected from all patients with BCLP treated at our hospital between 2004 and 2014, with or without premaxillary osteotomy (PO). Dental casts for pre-secondary alveolar bone grafting with PO (SABG + PO) and end-point dental casts were analyzed using the BAURU yardstick scoring system. Pre-SABG + PO, post-SABG + PO, and end-point SABG + PO lateral cephalograms were analyzed...
July 26, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/30100023/socioeconomic-deprivation-is-not-associated-with-reduced-survival-of-lung-transplant-recipients
#18
Andrei M Beliaev, Peter M Alison, Denise Reddy, Mark O'Carroll, Christopher Lewis, Tanya J McWilliams
BACKGROUND: Important risk factors for long-term survival of lung transplant (LT) recipients are infection, acute graft rejection (AR) and chronic lung allograft dysfunction (CLAD). Socioeconomic deprivation (SED) is associated with increased graft failure rate after heart and kidney transplantation, but has not been investigated in LT recipients. The aim of this study was to evaluate an association between LT recipients' SED status and development of AR, CLAD, and long-term survival...
October 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/30099419/-the-influence-of-type-2-diabetes-mellitus-on-early-and-late-results-of-percutaneous-coronary-intervention-for-non-st-segment-elevation-myocardial-infarction
#19
Katarzyna Birkner, Bartosz Hudzik, Piotr Desperak, Mariusz Gąsior
OBJECTIVE: The aim: We aimed at assessing the prognostic significance of diabetes mellitus in patients with NSTEMI treated with PCI as well as determining the independent predictors of worse prognosis. PATIENTS AND METHODS: Materials and methods: We performed a retrospective analysis of 830 patients hospitalized between January 2006 and December 2012 with diagnoses of NSTEMI and undergoing angiography and percutaneous coronary interventions. Patients were divided into two groups: with diabetes mellitus (246 patients) and without diabetes mellitus (584 patients)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/30099168/effectiveness-and-safety-of-rivaroxaban-compared-to-acenocumarol-after-infra-inguinal-surgical-revascularization
#20
Vítor Ferreira, Cristiana Freixo, João Gonçalves, Gabriela Teixeira, Inês Antunes, Carlos Veiga, Daniel Mendes, Joana Martins, Rui Almeida
BACKGROUND: Optimal antithrombotic therapy after lower limb infra-inguinal revascularization remains a controversial topic. The use of anticoagulants, alone or in combination with antiplatelet drugs, can potentially improve patency rate and limb salvage, particularly in patients with risk factors for early thrombosis. Bleeding is the main complication of long term anticoagulant use. New oral anticoagulants can represent an attractive alternative to the standard vitamin K-antagonists. OBJECTIVE: evaluate the effectovemess (bypass occlusion and major amputation) and safety (major bleeding and all-cause mortality) of rivaroxaban compared to acenocoumarol after infra-inguinal lower limb surgical revascularization...
August 9, 2018: Annals of Vascular Surgery
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