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https://www.readbyqxmd.com/read/30315916/the-impact-of-nursing-homes-staff-education-on-end-of-life-care-in-residents-with-advanced-dementia-a-quality-improvement-study
#1
Paola Di Giulio, Silvia Finetti, Fabrizio Giunco, Ines Basso, Debora Rosa, Francesca Pettenati, Alessandro Bussotti, Daniele Villani, Simona Gentile, Lorenzo Boncinelli, Massimo Monti, Sandro Spinsanti, Massimo Piazza, Lorena Charrier, Franco Toscani
CONTEXT: End-of-life care in nursing homes (NH) needs improvement. We carried out a study in 29 NHs in the Lombardy Region (Italy). OBJECTIVES: To compare End-of-Life care in NH residents with advanced dementia before and after an educational intervention aimed to improving palliative care. METHODS: The intervention consisted of a 7-hour lecture, followed by two 3-hour meetings consisting of case discussions. The intervention was held in each NH and well attended by NH staff...
October 10, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/30315757/additional-molecular-and-clinical-evidence-open-the-way-to-definitive-iarc-classification-of-the-brca1-c-5332g-a-p-asp1778asn-variant
#2
Angelo Minucci, Maurizio Lalle, Rossella De Leo, Giorgia Mazzuccato, Giovanni Scambia, Andrea Urbani, Anna Fagotti, Paola Concolino, Ettore Capoluongo
OBJECTIVES: In silico splicing analysis, a mini-gene assay and splicing data, obtained using RNA from blood samples, have shown that the BRCA1 c.5332G > A variant induces exon 21 skipping. However, despite these evidences, up to date, this variant is unclassified. The aim of this study is to provide further molecular and clinical evidence for the BRCA1 c.5332G > A variant in a patient with high grade serous ovarian carcinoma (HGSOC) to allow a definitive classification of this variant...
October 10, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/30315651/italian-acacia-honey-exhibits-lytic-effects-against-the-crayfish-pathogens-aphanomyces-astaci-and-fusarium-avenaceum
#3
Daniela Sateriale, Elisa Scioscia, Roberta Colicchio, Chiara Pagliuca, Paola Salvatore, Ettore Varricchio, Maria Grazia Volpe, Marina Paolucci, Caterina Pagliarulo
This study purpose was to evaluate the in vitro inhibitory properties of Italian acacia honey extracts against pathogenic aquatic oomycete/fungal isolates that cause different diseases in crayfish, resulting in an elevated mortality rate. The antimycotic activity of acacia honey aqueous extracts were evaluated against the strain UEF88662 of Aphanomyces astaci (oomycete) and the strain SMM2 of Fusarium avenaceum (fungus). The extracts preparation was carried out with water by a cheap, not complex and organic solvent-free procedure, with low environmental impact and the higher possibility of large-scale reproducibility...
October 13, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/30314777/potential-associations-between-the-mite-varroa-destructor-and-other-stressors-in-honeybee-colonies-apis-mellifera-l-in-temperate-and-subtropical-climate-from-argentina
#4
Agostina Giacobino, Adriana Pacini, Ana Molineri, Graciela Rodríguez, Paola Crisanti, Natalia Bulacio Cagnolo, Julieta Merke, Emanuel Orellano, Ezequiel Bertozzi, Hernán Pietronave, Marcelo Signorini
The presence of Varroa destructor in colonies of Apis mellifera is explained by the interaction among a number of factors including beekeeping practices and surrounding environment features. The aim of this study was to evaluate the relative impact of environment geographical region and beekeeping management on Varroa infestation levels throughout a year. A monitoring study was carried out during 2015 in north-central regions from Argentina, consisting of three sampling dates: 1) autumn survey before autumn acaricide treatment; 2) autumn survey after autumn acaricide treatment and 3) spring survey...
November 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/30314733/integration-of-diffusion-magnetic-resonance-tractography-into-tomotherapy-radiation-treatment-planning-for-high-grade-gliomas
#5
Luisa Altabella, Sara Broggi, Paola Mangili, Gian Marco Conte, Valentina Pieri, Antonella Iadanza, Antonella Del Vecchio, Nicoletta Anzalone, Nadia di Muzio, Riccardo Calandrino, Andrea Falini, Antonella Castellano
INTRODUCTION: Fractionated radiotherapy in brain tumors is commonly associated with several detrimental effects, largely related to the higher radiosensitivity of the white matter (WM) with respect to gray matter. However, no dose constraints are applied to preserve WM structures at present. Magnetic Resonance (MR) Tractography is the only technique that allows to visualize in vivo the course of WM eloquent tracts in the brain. In this study, the feasibility of integrating MR Tractography in tomotherapy treatment planning has been investigated, with the aim to spare eloquent WM regions from the dose delivered during treatment...
October 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/30314612/a-home-based-prism-adaptation-training-for-neglect-patients
#6
Paola Fortis, Roberta Ronchi, Valeria Velardo, Elena Calzolari, Elisabetta Banco, Lorella Algeri, Maria Simonetta Spada, Giuseppe Vallar
Spatial neglect is a debilitating disorder frequently observed after damage to the right cerebral hemisphere. Previous investigations have revealed that prism adaptation (PA) therapy can lead to improvements in neglect-related symptoms. In the typical PA protocol patients repeatedly point toward a visual target while wearing prism goggles. A few years ago, a novel PA procedure, involving a variety of more "ecological" visuo-motor activities during adaptation, less repetitive than a sequence of pointings, was introduced by our research group, and shown to be able to improve neglect-related symptoms to the same extent as the standard pointing task...
September 18, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/30314603/molecular-imaging-of-neuroinflammation-in-idiopathic-parkinson-s-disease
#7
Andreas-Antonios Roussakis, Paola Piccini
Neuroinflammation is an important aspect of Parkinson's disease. The study of Parkinson's disease neuroinflammation is quite challenging and is accompanied by controversy. To date, molecular imaging studies have been targeting microglia and more recently astrocytes. In this review article, we discuss the findings from key PET studies with tracers specific for the translocator protein (microglia-specific) and novel evidence from the development of astrocyte-specific PET tracers. We also discuss evidence from pathology studies and in the animal model of Parkinson's disease that form the biological background of current and newer PET neuroinflammation tracers...
2018: International Review of Neurobiology
https://www.readbyqxmd.com/read/30314390/3d-printing-of-pla-clay-nanocomposites-influence-of-printing-temperature-on-printed-samples-properties
#8
Bartolomeo Coppola, Nicola Cappetti, Luciano Di Maio, Paola Scarfato, Loredana Incarnato
In this study, the possibility of using a layered silicate-reinforced polylactic acid (PLA) in additive manufacturing applications was investigated. In particular, the aim of this work was to study the influence of printing temperature in the 3D printing process of PLA/clay nanocomposites. For this reason, two PLA grades (4032D and 2003D, D-isomer content 1.5 and 4, respectively) were melt-compounded by a twin screw extruder with a layered silicate (Cloisite 30B) at 4 wt %. Then, PLA and PLA/clay feedstock filaments (diameter 1...
October 11, 2018: Materials
https://www.readbyqxmd.com/read/30314343/overview-of-the-maturation-machinery-of-the-h-cluster-of-fefe-hydrogenases-with-a-focus-on-hydf
#9
REVIEW
Marco Bortolus, Paola Costantini, Davide Doni, Donatella Carbonera
Hydrogen production in nature is performed by hydrogenases. Among them, [FeFe]-hydrogenases have a peculiar active site, named H-cluster, that is made of two parts, synthesized in different pathways. The cubane sub-cluster requires the normal iron-sulfur cluster maturation machinery. The [2Fe] sub-cluster instead requires a dedicated set of maturase proteins, HydE, HydF, and HydG that work to assemble the cluster and deliver it to the apo-hydrogenase. In particular, the delivery is performed by HydF. In this review, we will perform an overview of the latest knowledge on the maturation machinery of the H-cluster, focusing in particular on HydF...
October 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30313437/a-new-cave-dwelling-species-of-plakina-porifera-homoscleromorpha-from-crete-greece-south-aegean-sea
#10
AnaÍra Lage, Hannah Paola Mota Araujo, Vasilis Gerovasileiou, Guilherme Muricy
Recent studies showed a high diversity of the class Homoscleromorpha (Porifera) in the North Aegean Sea. In the South Aegean Sea, however, only one species of the homoscleromorph genus Plakina, P. weinbergi, was reported so far. Here we describe a new species of Plakina from a marine cave in the South Aegean Sea (Crete Island, Greece), viz., Plakina strongylata sp. nov. The new species is white, fragile, with a highly folded surface, and its spicules are diods, triods and calthrops with rounded extremities plus mono- and dilophose diods, mono-, di- and trilophose triods, and mono-, di, tri- and tetralophose calthrops...
August 31, 2018: Zootaxa
https://www.readbyqxmd.com/read/30312790/levodopa-may-affect-cortical-excitability-in-parkinson-s-disease-patients-with-cognitive-deficits-as-revealed-by-reduced-activity-of-cortical-sources-of-resting-state-electroencephalographic-rhythms
#11
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Valentina Catania, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Laura Bonanni, Raffaella Franciotti, Marco Onofrj, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Lucia Fraioli, Lucilla Parnetti, Lucia Farotti, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Giovanni B Frisoni, Maria Francesca De Pandis
We hypothesized that dopamine neuromodulation might affect cortical excitability in Parkinson's disease (PD) patients set in quiet wakefulness, as revealed by resting state eyes-closed electroencephalographic (rsEEG) rhythms at alpha frequencies (8-12 Hz). Clinical and rsEEG rhythms in PD with dementia (N = 35), PD with mild cognitive impairment (N = 50), PD with normal cognition (N = 35), and normal (N = 50) older adults were available from an international archive. Cortical rsEEG sources were estimated by exact low-resolution brain electromagnetic tomography...
August 30, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/30312760/up-regulation-of-cox-2-and-mpges-1-by-27-hydroxycholesterol-and-4-hydroxynonenal-a-crucial-role-in-atherosclerotic-plaque-instability
#12
Simona Gargiulo, Daniela Rossin, Gabriella Testa, Paola Gamba, Erica Staurenghi, Fiorella Biasi, Giuseppe Poli, Gabriella Leonarduzzi
Atherosclerosis is currently understood to be mainly the consequence of a complicated inflammatory process at the different stages of plaque development. Among the several inflammatory molecules involved, up-regulation of the functional cyclooxygenase 2/membrane-bound prostaglandin E synthase 1 (COX-2/mPGES-1) axis plays a key role in plaque development. Excessive production of oxidized lipids, following low-density lipoprotein (LDL) oxidation, is a characteristic feature of atherosclerosis. Among LDLs, the oxysterol 27-hydroxycholesterol (27-OH) and the aldehyde 4-hydroxynonenal (HNE) substantially accumulate in the atherosclerotic plaque, contributing to its progression and instability through a variety of processes...
October 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30312724/core-shell-arginine-containing-chitosan-microparticles-for-enhanced-transcorneal-permeation-of-drugs
#13
Nicolò Mauro, Giulia Di Prima, Paola Varvarà, Mariano Licciardi, Gennara Cavallaro, Gaetano Giammona
Chitosan oligosaccharide (C) was functionalized with L-arginine (A) and short hydrocarbon chains (C8 ) to design an amphiphilic copolymer, henceforth CAC8 , leading to microparticles consisting of an arginine-decorated hydrophilic shell and inner hydrophobic domains allowing the encapsulation of high amount hydrophobic drugs such as sorafenib tosylate (> 10 % w/w). L-arginine side chains were selected in order to impart the final microparticles enhanced transcorneal penetration properties, thus overcoming the typical biological barriers which hamper the absorption of drugs upon topical ocular administration...
October 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30312335/the-added-value-of-whole-body-magnetic-resonance-imaging-in-the-management-of-patients-with-advanced-breast-cancer
#14
Fabio Zugni, Francesca Ruju, Paola Pricolo, Sarah Alessi, Monica Iorfida, Marco Angelo Colleoni, Massimo Bellomi, Giuseppe Petralia
This study investigates the impact of whole-body MRI (WB-MRI) in addition to CT of chest-abdomen-pelvis (CT-CAP) and 18F-FDG PET/CT (PET/CT) on systemic treatment decisions in standard clinical practice for patients with advanced breast cancer (ABC). WB-MRI examinations in ABC patients were extracted from our WB-MRI registry (2009-2017). Patients under systemic treatment who underwent WB-MRI and a control examination (CT-CAP or PET/CT) were included. Data regarding progressive disease (PD) reported either on WB-MRI or on the control examinations were collected...
2018: PloS One
https://www.readbyqxmd.com/read/30311070/polycystic-ovary-syndrome-implication-for-drug-metabolism-on-assisted-reproductive-techniques-a-literature-review
#15
REVIEW
Enrique Reyes-Muñoz, Thozhukat Sathyapalan, Paola Rossetti, Mohsin Shah, Min Long, Massimo Buscema, Gaetano Valenti, Valentina Lucia La Rosa, Stefano Cianci, Salvatore Giovanni Vitale
Polycystic ovary syndrome (PCOS) affects 6-10% of women and could be considered one of the most common endocrine alterations in women of reproductive age. The syndrome is characterized by several hormonal and metabolic alterations, including insulin resistance and hyperandrogenism, which play a severe detrimental role in the patient's fertility. We aimed to offer an overview about drug metabolism in the PCOS population. Nevertheless, we did not find any study that directly compared drug metabolism between PCOS and healthy women...
October 11, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/30311053/the-role-of-clinical-and-neuroimaging-features-in-the-diagnosis-of-cadasil
#16
Anna Bersano, Gloria Bedini, Hugh Stephen Markus, Paolo Vitali, Enrico Colli-Tibaldi, Franco Taroni, Cinzia Gellera, Silvia Baratta, Lorena Mosca, Paola Carrera, Maurizio Ferrari, Cristina Cereda, Gaetano Grieco, Silvia Lanfranconi, Franca Mazucchelli, Davide Zarcone, Maria Luisa De Lodovici, Giorgio Bono, Giorgio Battista Boncoraglio, Eugenio Agostino Parati, Maria Vittoria Calloni, Patrizia Perrone, Bianca Maria Bordo, Cristina Motto, Elio Agostoni, Alessandro Pezzini, Alessandro Padovani, Giuseppe Micieli, Anna Cavallini, Graziella Molini, Francesco Sasanelli, Maria Sessa, Giancarlo Comi, Nicoletta Checcarelli, Massimo Carmerlingo, Manuel Corato, Simona Marcheselli, Laura Fusi, Giampiero Grampa, Davide Uccellini, Simone Beretta, Carlo Ferrarese, Barbara Incorvaia, Carlo Sebastiano Tadeo, Laura Adobbati, Vincenzo Silani, Giuseppe Faragò, Nadia Trobia, Caspar Grond-Ginsbach, Livia Candelise
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL. METHODS: Patients with lacunar stroke or TIA were included in the present study...
October 11, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30311027/soluble-ctla-4-as-a-favorable-predictive-biomarker-in-metastatic-melanoma-patients-treated-with-ipilimumab-an-italian-melanoma-intergroup-study
#17
Maria Pia Pistillo, Vincenzo Fontana, Anna Morabito, Beatrice Dozin, Stefania Laurent, Roberta Carosio, Barbara Banelli, Francesca Ferrero, Laura Spano, Enrica Tanda, Pier Francesco Ferrucci, Chiara Martinoli, Emilia Cocorocchio, Michele Guida, Stefania Tommasi, Federica De Galitiis, Elena Pagani, Gian Carlo Antonini Cappellini, Paolo Marchetti, Pietro Quaglino, Paolo Fava, Simona Osella-Abate, Paolo Antonio Ascierto, Mariaelena Capone, Ester Simeone, Massimo Romani, Francesco Spagnolo, Paola Queirolo
CTLA-4 blockade by means of ipilimumab (IPI) potentiates the immune response and improves overall survival (OS) in a minority of metastatic melanoma (MM) patients. We investigated the role of soluble CTLA-4 (sCTLA-4) as a possible biomarker for identifying this subset of patients. sCTLA-4 levels were analyzed at baseline in sera from 113 IPI-treated MM patients by ELISA, and the median value (200 pg/ml) was used to create two equally sized subgroups. Associations of sCTLA-4 with best overall response (BOR) to IPI and immune-related adverse events (irAEs) were evaluated through logistic regression...
October 11, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30310143/the-umbrella-siop-rtsg-2016-wilms-tumour-pathology-and-molecular-biology-protocol
#18
REVIEW
Gordan M Vujanić, Manfred Gessler, Ariadne H A G Ooms, Paola Collini, Aurore Coulomb-l'Hermine, Ellen D'Hooghe, Ronald R de Krijger, Daniela Perotti, Kathy Pritchard-Jones, Christian Vokuhl, Marry M van den Heuvel-Eibrink, Norbert Graf
On the basis of the results of previous national and international trials and studies, the Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new study protocol for paediatric renal tumours: the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). Currently, the overall outcomes of patients with Wilms tumour are excellent, but subgroups with poor prognosis and increased relapse rates still exist. The identification of these subgroups is of utmost importance to improve treatment stratification, which might lead to reduction of the direct and late effects of chemotherapy...
October 11, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/30309975/triple-therapy-versus-single-and-dual-long-acting-bronchodilator-therapy-in-chronic-obstructive-pulmonary-disease-a-systematic-review-and-meta-analysis
#19
REVIEW
Mario Cazzola, Paola Rogliani, Luigino Calzetta, Maria Gabriella Matera
We performed a meta-analysis to compare the impact of triple combination therapy with inhaled corticosteroids (ICSs), long-acting β2 -agonists (LABAs), and long-acting muscarinic receptor antagonists (LAMAs) versus LABA/LAMA combination or single long-acting bronchodilator therapy in chronic obstructive pulmonary disease. ICS/LABA/LAMA combination reduced the risk of exacerbation (relative risk: 0.70, 95%CI 0.53-0.94) and improved trough FEV1 (mean difference, mL: +37.94, 95%CI 18.83-53.89) versus LABA/LAMA combination...
October 11, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30309905/in-vivo-modeling-of-human-neuron-dynamics-and-down-syndrome
#20
Raquel Real, Manuel Peter, Antonio Trabalza, Shabana Khan, Mark A Smith, Joana Dopp, Samuel J Barnes, Ayiba Momoh, Alessio Strano, Emanuela Volpi, Graham Knott, Frederick J Livesey, Vincenzo De Paola
Harnessing the potential of human stem cells for modelling the physiology and diseases of cortical circuitry requires monitoring cellular dynamics in vivo. Here, we show that human iPSC-derived cortical neurons transplanted in the adult mouse cortex consistently organized in large (up to ~100 mm3 ) vascularized neuron-glia territories with complex cytoarchitecture. Longitudinal imaging of >4000 grafted developing human neurons revealed that neuronal arbors refined via branch-specific retraction; human synaptic networks substantially restructured over 4 months, with balanced rates of synapse formation and elimination; and oscillatory population activity mirrored the patterns of fetal neural networks...
October 11, 2018: Science
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