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Leonardo Iaccarino, Arianna Sala, Silvia Paola Caminiti, Roberto Santangelo, Sandro Iannaccone, Giuseppe Magnani, Daniela Perani
Visual hallucinations (VH) are a core clinical feature of dementia with Lewy bodies (DLB), but their specific neural substrate remains elusive. We used 18 F-FDG-PET to study the neural dysfunctional signature of VH in a group of 38 DLB patients (mean age±SD 72.9 ± 7.5) with available anamnestic records, cognitive and neurological examination and NeuroPsychiatric Inventory assessing VH. We tested the voxel-wise correlation between 18 F-FDG-PET hypometabolism and VH NPI scores at the whole-group level, then adopting inter-regional correlation analysis to explore the resting-state networks (RSNs) metabolic connectivity in DLB patients with and without visual hallucinations, as compared to N = 38 age-matched healthy controls (HCs) (mean age±SD 71...
July 4, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Elisabetta Panza, Giuseppe Ercolano, Paola De Cicco, Chiara Armogida, Giosuè Scognamiglio, Gerardo Botti, Giuseppe Cirino, Angela Ianaro
Malignant melanoma is one of the most leading form of skin cancer associated with a low patient survival rate. Increasing evidence revealed that microRNAs (miRNAs) play a crucial role in the occurrence and development of several form of cancer including melanoma. In this study, we aimed at investigating the expression and role of miR-143-3p in human malignant melanoma. Our results showed that the expression of miR-143-3p was lower in human melanoma cells, as well as human biopsy specimens, when compared to normal human melanocytes...
August 8, 2018: Biochemical Pharmacology
Pasquale Giorio, Gianpiero Guida, Carmela Mistretta, Mohamed Houssemeddine Sellami, Marco Oliva, Paola Punzo, Paolo Iovieno, Carmen Arena, Anna De Maio, Stefania Grillo, Rossella Albrizio
Mediterranean tomato landraces adapted to arid environments represent an option to counteract drought, and to address the complexity of responses to water deficit and recovery, which is a crucial component of plant adaptation mechanisms. We investigated physiological, biochemical and molecular responses of two Mediterranean tomato landraces, "Locale di Salina" (Lc) and "Pizzutello di Sciacca" (Pz) under two dehydration periods and intermediate rehydration in greenhouse pot-experiments. Relationship between CO2 assimilation and stomatal conductance under severe water stress (gs < 0...
August 11, 2018: Plant Biology
Alexander J Stratigos, Maria Concetta Fargnoli, Arcangela De Nicolo, Ketty Peris, Susana Puig, Efthymia Soura, Chiara Menin, Donato Calista, Paola Ghiorzo, Mario Mandala, Daniella Massi, Monica Rodolfo, Laura Del Regno, Irene Stefanaki, Helen Gogas, Veronique Bataille, Margaret A Tucker, David Whiteman, Eduardo Nagore, Maria Teresa Landi
BACKGROUND: Many melanoma observational studies have been carried out across different countries and geographic areas using heterogeneous assessments of epidemiologic risk factors and clinical variables. AIM: To develop a consensus questionnaire to standardize epidemiologic and clinical data collection for melanoma risk assessment. METHODS: We used a stepwise strategy that included: compilation of variables from case-control datasets collected at various centers of the MelaNostrum Consortium; integration of variables from published case-control studies; consensus discussion of the collected items by MelaNostrum members; revision by independent experts; addition of online tools and image-based charts; questionnaire testing across centers, and generation of a final draft...
August 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Tien Canh Le, Mircea Alexandru Mateescu, Samaneh Ahmadifar, Lucia Marcocci, Paola Pietrangeli
Zymography on peroxidase-entrapped gels enables the determination of the intrinsic specific activity (ISA) of H2 O2 -producing oxidases in the presence of interfering enzymes including catalase (decomposing hydrogen peroxide). To reveal the searched oxidase, the zymography gel is incubated first in the developing solution containing the appropriate substrate of the oxidase and an oxidizable chromogen such as o-phenylenediamine (o-PDA) peroxidase substrate. The zymographic gel, after image analysis, can be restained by Coomassie Blue for molecular weights, for the whole electrophoretic pattern and for the protein concentration, thus allowing for the determination of oxidase ISA...
2018: Methods in Molecular Biology
Hari-Mandir K Khalsa, Ross J Baldessarini, Mauricio Tohen, Paola Salvatore
BACKGROUND: Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk. METHODS: In a study sample of 216 initially hospitalized, first-psychotic episode subjects diagnosed with DSM-IV-TR BD-I, we identified recent (within 1 month before hospitalization) aggression by ratings on the Brief Psychiatric Rating Scale-Expanded and review of detailed clinical research records...
August 11, 2018: International Journal of Bipolar Disorders
Kathrin Reetz, Imis Dogan, Christian Hohenfeld, Claire Didszun, Paola Giunti, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Ilaria Giordano, Katrin Bürk, Massimo Pandolfo, Jörg B Schulz
OBJECTIVE: To provide a systematic evaluation of the broad clinical variability in Friedreich ataxia (FRDA), a multisystem disorder presenting mainly with afferent ataxia but also a complex phenotype of nonataxia symptoms. METHODS: From the large database of the European Friedreich's Ataxia Consortium for Translational Studies, 650 patients with genetically confirmed FRDA were included. Detailed data of medical history documentation, questionnaires, and reports on clinical features were analyzed to provide in-depth description of the clinical profile and frequency rates of phenotypical features with a focus on differences between typical-onset and late-onset FRDA...
August 10, 2018: Neurology
Beth Hands, Paola Chivers, Tegan Grace, Fleur McIntyre
BACKGROUND: There are few exercise interventions focused on adolescents with low motor competence and most interventions are short with little follow up and engagement over time. METHODS AND PROCEDURES: Fifty-eight adolescents with low motor competence (39 males, Mean Age  = 13.6, SD = 1.4 years) attended an exercise clinic twice a week for each 13 week program. Two programs ran each year, and participants attended for as long as they felt progress was made or they turned 18 years of age...
August 7, 2018: Research in Developmental Disabilities
Matteo Canale, Paola Ulivi, Francesco Giuseppe Foschi, Emanuela Scarpi, Serena De Matteis, Gabriele Donati, Giorgio Ercolani, Mario Scartozzi, Luca Faloppi, Alessandro Passardi, Emiliano Tamburini, Martina Valgiusti, Giorgia Marisi, Giovanni Luca Frassineti, Andrea Casadei Gardini
Radiofrequency ablation (RFA) is an effective local treatment for curative intent in patients with cirrhosis of the liver and hepatocellular carcinoma (HCC) with diameter <3 cm. Several meta-analyses have shown that RFA and surgical resection are comparable in terms of their impact on overall survival. The only clinical data available on markers that are predictive of recurrence and survival after RFA treatment are based on retrospective observational studies. Prospective randomized trials are thus needed to further research in this area...
September 2018: Critical Reviews in Oncology/hematology
Greta Chiara Cermisoni, Alessandra Alteri, Laura Corti, Elisa Rabellotti, Enrico Papaleo, Paola Viganò, Ana Maria Sanchez
Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase...
August 8, 2018: International Journal of Molecular Sciences
Fernando J Meijide, Rodrigo H Da Cuña, José P Prieto, Luciana S Dorelle, Paola A Babay, Fabiana L Lo Nostro
Chemical pollution from pharmaceuticals is increasingly recognized as a major hazard to the aquatic biota. Among the wide variety of pharmaceuticals, fluoxetine (FLX) is one of the most widely prescribed antidepressants, and therefore, it is frequently identified in the aquatic environment. As FLX is designed to alter human behaviour and many physiological pathways are conserved across vertebrates, this drug may affect the behaviour of fish living in FLX-polluted environments. Here, we exposed groups of female mosquitofish Gambusia holbrooki to waterborne FLX for 14 days, under semi-static conditions with daily renewal of test solutions...
August 7, 2018: Ecotoxicology and Environmental Safety
Antonietta Cerulli, Milena Masullo, Paola Montoro, Jan Hošek, Cosimo Pizza, Sonia Piacente
Corylus avellana L. (Betulaceae) leaves, consumed as infusion, are used in traditional medicine, for the treatment of hemorrhoids, varicose veins, phlebitis, and edema due to their astringent, vasoprotective, and antiedema properties. In previous works we reported from the leaves of Corylus avellana cv. "Tonda di Giffoni" diarylheptanoid derivatives, a class of plant secondary metabolites with a wide variety of bioactivities. With the aim to give an interesting and economically feasible opportunity to C...
July 26, 2018: Journal of Pharmaceutical and Biomedical Analysis
Tej Azad, Daniel Vail, Jason Bentley, Summer Han, Paola Suarez, Kunal Varshneya, Vaishali Mittal, Anand Veeravagu, Manisha Desai, Jay Bhattacharya, John Ratliff
STUDY DESIGN: Retrospective longitudinal cohort analysis of patients diagnosed in 2010, with continuous enrollment six months prior to and 12 months following the initial visit. OBJECTIVE: To determine whether provider specialty influences patterns of opiate utilization long after initial diagnosis. SUMMARY OF BACKGROUND DATA: Patients with low back pain present to a variety of providers and receive a spectrum of treatments, including opiate medications...
August 7, 2018: Spine
Antonino Chillura, Antonino Naro, Fabrizio Ciappina, Alessia Bramanti, Paola Lauria, Placido Bramanti, Rocco Salvatore Calabrò
INTRODUCTION: The approach of an external stimulus to the peripersonal space (PPS) modifies some physiological measures, including the cerebral blood flow (CBF) in the supplementary motor area and premotor cortex. CBF measurement may be useful to assess brain activations when producing specific motor responses, likely mediated by cortical and subcortical neural circuits. METHODS: This study investigated PPS in 15 healthy humans by characterizing the hemodynamic responses (pulsatility index, PI; and heart rate, HR) related to different directions of movements of individual's hand toward and backward his/her own face, so to perturb PPS)...
August 9, 2018: Brain and Behavior
Andrew Evans, Rubina M Trimboli, Alexandra Athanasiou, Corinne Balleyguier, Pascal A Baltzer, Ulrich Bick, Julia Camps Herrero, Paola Clauser, Catherine Colin, Eleanor Cornford, Eva M Fallenberg, Michael H Fuchsjaeger, Fiona J Gilbert, Thomas H Helbich, Karen Kinkel, Sylvia H Heywang-Köbrunner, Christiane K Kuhl, Ritse M Mann, Laura Martincich, Pietro Panizza, Federica Pediconi, Ruud M Pijnappel, Katja Pinker, Sophia Zackrisson, Gabor Forrai, Francesco Sardanelli
This article summarises the information that should be provided to women and referring physicians about breast ultrasound (US). After explaining the physical principles, technical procedure and safety of US, information is given about its ability to make a correct diagnosis, depending on the setting in which it is applied. The following definite indications for breast US in female subjects are proposed: palpable lump; axillary adenopathy; first diagnostic approach for clinical abnormalities under 40 and in pregnant or lactating women; suspicious abnormalities at mammography or magnetic resonance imaging (MRI); suspicious nipple discharge; recent nipple inversion; skin retraction; breast inflammation; abnormalities in the area of the surgical scar after breast conserving surgery or mastectomy; abnormalities in the presence of breast implants; screening high-risk women, especially when MRI is not performed; loco-regional staging of a known breast cancer, when MRI is not performed; guidance for percutaneous interventions (needle biopsy, pre-surgical localisation, fluid collection drainage); monitoring patients with breast cancer receiving neo-adjuvant therapy, when MRI is not performed...
August 9, 2018: Insights Into Imaging
Paola Bonetti, Montserrat Climent, Fabiana Panebianco, Chiara Tordonato, Angela Santoro, Matteo Jacopo Marzi, Pier Giuseppe Pelicci, Andrea Ventura, Francesco Nicassio
The role of the tumour-suppressor miR-34 family in breast physiology and in mammary stem cells (MaSCs) is largely unknown. Here, we revealed that miR-34 family, and miR-34a in particular, is implicated in mammary epithelium homoeostasis. Expression of miR-34a occurs upon luminal commitment and differentiation and serves to inhibit the expansion of the pool of MaSCs and early progenitor cells, likely in a p53-independent fashion. Mutant mice (miR34-KO) and loss-of-function approaches revealed two separate functions of miR-34a, controlling both proliferation and fate commitment in mammary progenitors by modulating several pathways involved in epithelial cell plasticity and luminal-to-basal conversion...
August 9, 2018: Oncogene
Tiago Lemos Cerqueira, Armando Fartolino Guerrero, Clara Krystal Pérez Fermin, Ricardo Wang, Evelin Elfriede Balbino, Janis L Breeze, Paola Gonzalez Mego, Daniele Argentina Silva, Walid Ezzeldin Omer, Nathalie Monique Vandevelde
BACKGROUND: End-stage renal disease (ESRD) is the last stage of chronic kidney disease, mainly caused by type 2 diabetes mellitus and characterized by an increased mortality risk related to cardiovascular disease. Low-dose aspirin (acetylsalicylic acid or ASA) seems to effectively prevent cardiovascular events in patients with ESRD. However, the number of interventional studies in this population remains limited and the mechanisms of aspirin-related bleeding remain poorly understood. Aspirin's efficacy and safety may be modified by the presence of type 2 diabetes mellitus or platelet hyperreactivity...
August 9, 2018: JMIR Research Protocols
Caterina Di Bella, Luca Lacitignola, Salvatore Grasso, Paola Centonze, Antonella Greco, Rossella Ostuni, Antonio Crovace, Francesco Staffieri
OBJECTIVE: To evaluate the effects of an alveolar recruitment maneuver (ARM) followed by 5 cmH2 O positive end-expiratory pressure (PEEP) in dogs undergoing laparoscopy. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: A group of 20 dogs undergoing laparoscopic ovariectomy. METHODS: Dogs were sedated with acepromazine and methadone intramuscularly; anesthesia was induced with propofol intravenously and maintained with inhaled isoflurane...
April 16, 2018: Veterinary Anaesthesia and Analgesia
Paola Camiscia, Enrique D V Giordano, M Emilia Brassesco, Pablo Fuciños, Lorenzo Pastrana, M F Cerqueira, Guillermo A Picó, Nadia Woitovich Valetti
The cellulose from soybean hull, a waste without value from the argentine agriculture, was successfully obtained by using two different treatments: the traditional alkaline-bleaching pathway and from a simple pre-alkaline treatment at low temperatures. The comparison of both methods yielded similar results regarding its ability to open the lignin cellulosic structure of the hull and the total elimination of the lignin content. Fourier Transform Infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning electron microscopy (SEM), 13 C nuclear magnetic resonance (13 C-RMN) and Raman spectroscopy were used to characterize the structures and the properties of cellulose...
October 15, 2018: Carbohydrate Polymers
Donella Puliti, Marco Zappa, Paolo Giorgi Rossi, Elena Pierpaoli, Gianfranco Manneschi, Daniela Ambrogetti, Leonardo Ventura, Paola Mantellini
BACKGROUND: We evaluated the association between volumetric breast density (BD) and risk of advanced cancers after a negative screening episode. METHODS: A cohort of 16,752 women aged 49-54 years at their first screening mammography in the Florence screening programme was followed for breast cancer (BC) incidence until the second screening round. Volumetric BD was measured using fully automated software. The cumulative incidence of advanced cancer after a negative screening episode (including stage II or more severe cancer during the screening interval - on average 28 months - and at the subsequent round) was calculated separately for Volpara density grade (VDG) categories...
August 9, 2018: Breast Cancer Research: BCR
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