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Water splitting hypoxia

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https://www.readbyqxmd.com/read/29207953/genomic-signature-of-highland-adaptation-in-fish-a-case-study-in-tibetan-schizothoracinae-species
#1
Chao Tong, Fei Tian, Kai Zhao
BACKGROUND: Genome-wide studies on highland adaptation mechanism in terrestrial animal have been widely reported with few available for aquatic animals. Tibetan Schizothoracinae species are ideal model systems to study speciation and adaptation of fish. The Schizothoracine fish, Gymnocypris przewalskii ganzihonensis had underwent the ecological niche shift from salt water to freshwater, and also experienced a recent split from Gymnocypris przewalskii przewalskii. In addition, G. p. ganzihonensis inhabited harsh aquatic environment including low temperature and hypoxia as well as other Schizothoracinae species, its genetic mechanism of highland adaptation have yet to be determined...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/27532320/carbon-dot-decorated-carbon-nitride-nanoparticles-for-enhanced-photodynamic-therapy-against-hypoxic-tumor-via-water-splitting
#2
Di-Wei Zheng, Bin Li, Chu-Xin Li, Jin-Xuan Fan, Qi Lei, Cao Li, Zushun Xu, Xian-Zheng Zhang
Hypoxia, a typical feature of solid tumors, remarkably restricts the efficiency of photodynamic therapy (PDT). Here, a carbon nitride (C3N4)-based multifunctional nanocomposite (PCCN) for light-driven water splitting was used to solve this problem. Carbon dots were first doped with C3N4 to enhance its red region absorption because red light could be used to trigger the in vivo water splitting process. Then, a polymer containing a protoporphyrin photosensitizer, a polyethylene glycol segment, and a targeting Arg-Gly-Asp motif was synthesized and introduced to carbon-dot-doped C3N4 nanoparticles...
September 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/22412864/effects-of-long-term-space-flight-on-erythrocytes-and-oxidative-stress-of-rodents
#3
Angela Maria Rizzo, Paola Antonia Corsetto, Gigliola Montorfano, Simona Milani, Stefania Zava, Sara Tavella, Ranieri Cancedda, Bruno Berra
Erythrocyte and hemoglobin losses have been frequently observed in humans during space missions; these observations have been designated as "space anemia". Erythrocytes exposed to microgravity have a modified rheology and undergo hemolysis to a greater extent. Cell membrane composition plays an important role in determining erythrocyte resistance to mechanical stress and it is well known that membrane composition might be influenced by external events, such as hypothermia, hypoxia or gravitational strength variations...
2012: PloS One
https://www.readbyqxmd.com/read/20089769/glycolysis-and-the-tricarboxylic-acid-cycle-are-linked-by-alanine-aminotransferase-during-hypoxia-induced-by-waterlogging-of-lotus-japonicus
#4
Marcio Rocha, Francesco Licausi, Wagner L Ara├║jo, Adriano Nunes-Nesi, Ladaslav Sodek, Alisdair R Fernie, Joost T van Dongen
The role of nitrogen metabolism in the survival of prolonged periods of waterlogging was investigated in highly flood-tolerant, nodulated Lotus japonicus plants. Alanine production revealed to be a critical hypoxic pathway. Alanine is the only amino acid whose biosynthesis is not inhibited by nitrogen deficiency resulting from RNA interference silencing of nodular leghemoglobin. The metabolic changes that were induced following waterlogging can be best explained by the activation of alanine metabolism in combination with the modular operation of a split tricarboxylic acid pathway...
March 2010: Plant Physiology
https://www.readbyqxmd.com/read/19793859/body-composition-at-high-altitude-a-randomized-placebo-controlled-trial-of-dietary-carbohydrate-supplementation
#5
RANDOMIZED CONTROLLED TRIAL
Jamie H Macdonald, Samuel J Oliver, Kelly Hillyer, Stephan Sanders, Zoe Smith, Catherine Williams, Danny Yates, Hazel Ginnever, Edward Scanlon, Edward Roberts, Dave Murphy, Justin Lawley, Eleanor Chichester
BACKGROUND: Body mass loss is inevitable with chronic hypoxic exposure. However, the exact body-composition changes, their causes, and possible treatments remain unknown. OBJECTIVE: The objective was to investigate body composition during a high-altitude expedition by using non-empirically derived methods, experimentally manipulating energy intake, and investigating the influence of initial body composition. DESIGN: Forty-one participants completed a 21-d expedition in the Himalayas...
November 2009: American Journal of Clinical Nutrition
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