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Aging muscle

Daniël H van Raalte, Eva van der Palen, Pauline Idema, Liza Wong, Sander W M Keet, Mariska Vlot, Raymond Tukkie, Bob van Vlies, Erik H Serné, Reinier W Ten Kate
BACKGROUND: Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients. METHODS: Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Thirty-six participants were studied in the fasted state (22 ND subjects and 14 T2D patients termed NDF and T2DF) and 34 participants 1-h following a glucose challenge (18 ND subjects and 16 T2D patients indicated as NDG and T2DG)...
December 17, 2018: Experimental and Clinical Endocrinology & Diabetes
Francesco Campa, Gabriele Semprini, Pedro B Júdice, Gianluca Messina, Stefania Toselli
This study aimed to evaluate the associations of anthropometry, functional movement patterns (FMP) and physical performance characteristics with repeated-sprint ability (RSA) in male youth soccer players. Thirty six athletes (ages 16.6±0.5 years, BMI 22.0±1.3 kg/m2 ) completed the RSA test and other physical tests including countermovement jump with (CMJA) and without the help of arms (CMJ), 10-m and 20-m straight-line sprints, Yo-Yo Intermittent Recovery Test Level 1 (Yo-Yo), and functional movement screen (FMS)...
December 17, 2018: International Journal of Sports Medicine
Stephan Nowak, Henry W S Schroeder, Steffen Fleck
OBJECTIVES: We analyzed our results using Hemopatch® as a new dural sealant after durotomy in cranial and spinal neurosurgical procedures. PATIENTS AND METHODS: In our prospective single center study, we analyzed all patients who received Hemopatch® used as a dural sealant between October 2016 and May 2017. 34 patients received Hemopatch® used as a dural sealant in the study period. We included 23 (67.6%) female and 11 (32.3%) male patients. The mean age was 56 years (4-83 years)...
December 11, 2018: Clinical Neurology and Neurosurgery
Byung Kook Lee, In Soo Cho, Joo Suk Oh, Wook Jin Choi, Jung Hee Wee, Chang Sun Kim, Won Young Kim, Chun Song Youn
INTRODUCTION: The aim of this trial was to investigate the effect of a continuous infusion of a neuromuscular blockade (NMB) in comatose out-of-hospital cardiac arrest (OHCA) subjects who underwent targeted temperature management (TTM). METHODS: In this open-label, multicenter trial, subjects resuscitated from OHCA were randomly assigned to receive either NMB (38 subjects) or placebo (43 subjects) for 24 hours. Sedatives and analgesics were given according to the protocol of each hospital during TTM...
2018: PloS One
Ryan C Ward, Kathleen F Janz, Elena M Letuchy, Clayton Peterson, Steven M Levy
INTRODUCTION: Nearly 8 million American adolescents participate in sports. Participation declines in young adulthood. PURPOSE: This study assessed longitudinal effects of high school sport participation and muscle power on young adult bone strength. METHODS: 228 young adults from the Iowa Bone Development Study completed an interscholastic sport participation questionnaire. Current physical activity (PA) behaviors were assessed via questionnaire...
December 14, 2018: Medicine and Science in Sports and Exercise
Karlo J Lizarraga, Philip D Thompson, Henry P Moore, Gabriel Mizraji, Oscar S Gershanik, Carlos Singer, Anthony E Lang
Importance: Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias. Objective: To introduce and characterize the dancing dorsal quadrilaterals, a novel peripherally induced movement disorder that predominantly affects dorsal quadrilateral muscles (trapezius and rhomboids) after upper spine instrumentation. Design, Setting, and Participants: Between 1990 and 2015, a total of 4 patients who developed abnormal movements of the dorsal quadrilateral muscles after upper spine instrumentation were referred to movement disorders clinics at 3 academic medical centers in the United States, Canada, and Argentina...
December 17, 2018: JAMA Neurology
M Norring, A Valros, J Valaja, H-K Sihvo, K Immonen, E Puolanne
Wooden breast myopathy, a condition where broiler breast muscles show a hardened consistency post-mortem, has been described recently. However, it is not known how wooden breast myopathy affects the bird activity or welfare. Altogether, over 340 birds of five commonly used commercial hybrids were housed in 25 pens, and sample birds killed at ages of 22, 32, 36, 39 and 43 days. Their breast muscle condition was assessed post-mortem by palpation. The birds were gait scored and their latency to lie was measured before killing...
December 17, 2018: Animal: An International Journal of Animal Bioscience
Robinson Ramírez-Vélez, Antonio Garcia-Hermoso, Daniel Humberto Prieto-Benavides, Jorge Enrique Correa-Bautista, Aura Cristina Quino-Ávila, Claudia Maritza Rubio-Barreto, Katherine González-Ruíz, Hugo Alejandro Carrillo, María Correa-Rodríguez, Emilio González-Jiménez, Jacqueline Schmidt Rio-Valle
This study aimed to evaluate the associations between the muscle mass to visceral fat (MVF) ratio and cardiometabolic risk factors in a large population of college students in Colombia and to propose cut-off points of this index for the metabolic syndrome (MetS). A total of 1464 young adults recruited from the FUPRECOL (Asociación de la Fuerza Prensil con Manifestaciones Tempranas de Riesgo Cardiovascular en Jóvenes y Adultos Colombianos) study were categorised into four groups based on their MVF ratio. Muscle mass and visceral fat level of the participants were measured using a bioelectrical impedance analysis...
December 17, 2018: British Journal of Nutrition
Akira Saito, Masahiko Wakasa, Minoru Kimoto, Takashi Ishikawa, Megumi Tsugaruya, Yu Kume, Kyoji Okada
AIM: To clarify the age-related changes in muscle elasticity or thickness of the lower extremities in older women, and to analyze their relationship with physical functions. METHODS: The muscle elasticity and thickness of the rectus femoris and medial head of the gastrocnemius of 102 young women (young group) and 221 elderly women (elderly group) were measured using ultrasonography. In the elderly group, physical functions, including knee extension strength, Timed Up and Go test, single-leg standing, maximum gait speed and Four Square Step Test were also measured...
December 16, 2018: Geriatrics & Gerontology International
Michael D Tarpey, Ana P Valencia, Kathryn C Jackson, Adam J Amorese, Nicholas P Balestrieri, Randall H Renegar, Stephen J P Pratt, Terence E Ryan, Joseph M McClung, Richard M Lovering, Espen E Spangenburg
KEY POINTS: Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is expressed in skeletal muscle. Skeletal muscle specific knockout of Brca1 in mice caused a loss of muscle quality, identifiable by reductions in muscle force production and mitochondrial respiratory capacity...
November 22, 2018: Journal of Physiology
Abdolreza Medghalchi, Mitra Akbari, Yousef Alizadeh, Reza Soltani Moghadam
Purpose: This study was conducted to determine the demographics, clinical features, severity, and activity of thyroid eye disease (TED) in patients of a referral center in the north of Iran. Methods: Patients with TED who were referred to Amir-Almomenin Hospital, Rasht, Iran from March 2012 to March 2014 were enrolled in this cross-sectional study. The measurements of proptosis, lid width, lagophthalmos, extraocular muscle function, and visual acuity were recorded...
December 2018: Journal of Current Ophthalmology
Alexandre Henrique Nowotny, Mariene Guizeline Calderon, Pablo Albuquerque de Souza, Andreo Fernando Aguiar, Guillaume Léonard, Bruno Mazziotti Oliveira Alves, Cesar Ferreira Amorim, Rubens Alexandre da Silva
Background: Chronic low back pain (CLBP) is an important disorder in athletes that may negatively affect their performance in competitions. The literature usually recommends physiotherapy based on exercises for back pain management in athletes. Recent evidence suggests that interventions based on lumbar muscle stabilisation exercises (LMSE) and back endurance-resistance exercises (BERE) may improve back pain and function performance. However, it is still unclear which type of exercise is more effective for the treatment of CLBP in athletes...
2018: BMJ Open Sport & Exercise Medicine
Charlotte Rosso, Jean-Charles Lamy
Background: Resting Motor threshold (rMT) is one of the measurement obtained by Transcranial Magnetic Stimulation (TMS) that reflects corticospinal excitability. As a functional marker of the corticospinal pathway, the question arises whether rMT is a suitable biomarker for predicting post-stroke upper limb function. To that aim, we conducted a systematic review of relevant studies that investigated the clinical significance of rMT in stroke survivors by using correlations between upper limb motor scores and rMT...
2018: Frontiers in Neurology
Davide Mondin, Julian A Owen, Massimo Negro, Giuseppe D'Antona
Modifiable risk factors for hamstring injury include lack of strength, fatigue and muscle strength asymmetry. Assessing lower body strength in the field is problematic as "gold standard assessment" are expensive, non-portable and assessment is time-consuming. Therefore, the objective of this study was to examine the validity and reliability of an adapted aneroid sphygmomanometer test of hamstring and quadricep strength. In 14 active males (age 23.1 ± 2.5 years; height 180.9 ± 8.2 cm; weight 88.4 ± 8...
2018: Frontiers in Physiology
Catarina Falcão de Campos, Pedro Viana, Isabel de Castro, José Castro, Mamede de Carvalho, Isabel Conceição
OBJECTIVES: Myasthenia gravis (MG) is an autoimmune disease associated with antibodies against the nicotinic muscle acetylcholine receptor (AChR) at the neuromuscular junction. Dysautonomia has been previously described in MG. Electrochemical skin conductance (ESC), assessed by Sudoscan® , is a non-invasive method that allows evaluation of sudomotor function. Since sweat glands are innervated by sudomotor, postganglionic, cholinergic sympathetic C-fibers, we hypothesized that ESC could be a reliable method for assessing autonomic dysfunction in MG...
December 13, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
Sidney Grosprêtre, Philippe Gimenez, Laurent Mourot, Giuseppe Coratella
This study investigated the neuromuscular fatigue following an elastic band exercise (EB) of the plantar flexors, compared to an intermittent phasic isometric exercise (ISO). Eleven young healthy males (age: 24.2 ± 3.7) took part in the study, consisting of one experimental session involving two 5-min fatiguing protocols separated by 20 min rest and performed randomly. Both exercises were performed at maximal motor output of the plantar flexor muscles, EMG being used as a feedback signal. Neuromuscular fatigue was assessed through changes in maximal voluntary contraction (MVC) and in evoked responses of soleus and gastrocnemii muscles to posterior tibial nerve stimulation (H-reflex, M-wave, V-wave)...
December 11, 2018: Journal of Electromyography and Kinesiology
Anthony Tickner, Seiha Thorng, Mary Martin, Valerie Marmolejo
Rupture of the tibialis anterior tendon is a rare condition reported to occur most often spontaneously in patients >45 years of age. Diagnosis is often delayed due to transient pain at the time of rupture and the ability of the long extensors to compensate for the lost action of the tibialis anterior. Treatment has been proposed to be based on the activity level of the individual; however, no consensus has been reached on the optimal treatment modality for this rare condition. A systematic review and meta-analysis were performed to determine outcomes obtained with conservative and surgical management...
December 13, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Nilo Riva, Gabriele Mora, Gianni Sorarù, Christian Lunetta, Ottavia E Ferraro, Yuri Falzone, Letizia Leocani, Raffaella Fazio, Mauro Comola, Giancarlo Comi
BACKGROUND: Spasticity is a major determinant of disability and decline in quality of life in patients with motor neuron disease. Cannabinoids have been approved for symptomatic treatment of spasticity in multiple sclerosis. We investigated whether cannabinoids might also reduce spasticity in patients with motor neuron disease. METHODS: We did an investigator-initiated, randomised, double-blind, placebo-controlled, phase 2 clinical trial at four tertiary motor neuron disease centres in Italy...
December 13, 2018: Lancet Neurology
Seok Woo Hong, Jeong Keun Lee, Jeong-Hyun Kang
OBJECTIVES: The aim of the study was to verify associations among degenerative changes in the cervical spine, head and neck postures, and myofascial pain in the craniocervical musculature in elderly with myofascial temporomandibular disorders (TMDs). METHODS: A total of 120 participants (mean age, 68.3 ± 7.5 years) were included: 45 participants had no signs of orofacial or cervical pain, 26 participants had myofascial TMD only (mTMD), and 49 participants had both myofascial TMD and cervical pain (cerTMD)...
December 7, 2018: Archives of Gerontology and Geriatrics
Danny M Pincivero, Rachael R Polen, Brittany N Byrd
INTRODUCTION: Agonist muscle contraction mode and intensity effects on antagonist co-activation was examined between men and women. METHODS: Fifteen healthy young men (mean ± standard deviation age = 24.9 ± 4.2 years, body mass index = 23.17 ± 2.34) and 15 women (mean ± standard deviation age = 21.8 ± 2.3 years, body mass index = 24.16 ± 2.91) performed five isokinetic concentric and eccentric maximal-effort elbow flexor/extensor contractions to establish their peak torque...
December 8, 2018: Journal of Electromyography and Kinesiology
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