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https://www.readbyqxmd.com/read/30533265/fine-structure-of-the-aggregate-silk-nodules-in-the-orb-web-spider-nephila-clavata
#1
Myung-Jin Moon
Among the triad spinning units for capture thread producing system in the orb-web spiders, aqueous gluey substances are produced from two pairs of aggregate silk glands (ASG). Although biochemical analysis of glue substance is produced by way of their passage through the ASG, its structural modifications in the nodular area have been nearly neglected till now. This paper focused on identifying the fine structural characteristics of the aggregate nodules in the golden orb-web spider Nephila clavata using both of light and transmission electron microscopes...
2018: Animal Cells and Systems
https://www.readbyqxmd.com/read/30530249/full-energy-peak-efficiency-calibration-for-the-assay-of-large-volume-radioactive-waste-drums-in-a-segmented-gamma-scanner
#2
Sabyasachi Patra, Chhavi Agarwal, Sanhita Chaudhury
Large volume radioactive waste drums with low/intermediate level of alpha activity, generated in radiochemical laboratories, are in general screened for special nuclear materials (SNM) in a segmented gamma scanner (SGS) before disposal. The assay methodology traditionally requires a standard drum of identical geometry and thereby making the procedure relying on the availability of a true standard, which is often difficult to organize. Here, we report a non-conventional absolute segmented gamma scanning (ASGS) methodology for the assay of 200 L waste drums, avoiding the use of a standard drum...
November 27, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/30509940/combination-of-aspirin-plus-macrolides-in-patients-with-severe-community-acquired-pneumonia-a-hypothesis-generating-study
#3
Marco Falcone, Alessandro Russo, Yuichiro Shindo, Alessio Farcomeni, Filippo Pieralli, Roberto Cangemi, Jinliang Liu, Jingyan Xia, Junya Okumura, Masahiro Sano, Christopher Jones, Vieri Vannucchi, Massimo Mancone, Scott Micek, Feng Xu, Francesco Violi, Marin Kollef
Objectives. While the inflammatory response to severe pneumonia is paramount in reining in and resolving the infection, the excessive inflammation can lead to deleterious effects. We theorized that patients with severe community-acquired pneumonia (CAP), treated with macrolides and aspirin, would receive benefit beyond conventional antibiotic therapy. Methods. An observational study was conducted on patients with severe CAP. All patients were admitted to 5 teaching hospitals (in Italy, USA, Japan, and China), and data were gathered from their electronic medical records...
December 3, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/30505666/the-enzymatic-biosynthesis-of-acylated-steroidal-glycosides-and-their-cytotoxic-activity
#4
Ming Liu, Jian-Qiang Kong
Herein we describe the discovery and functional characterization of a steroidal glycosyltransferase (SGT) from Ornithogalum saundersiae and a steroidal glycoside acyltransferase (SGA) from Escherichia coli and their application in the biosynthesis of acylated steroidal glycosides (ASGs). Initially, an SGT gene, designated as OsSGT1, was isolated from O. saundersiae . OsSGT1-containing cell free extract was then used as the biocatalyst to react with 49 structurally diverse drug-like compounds. The recombinant OsSGT1 was shown to be active against both 3 β - and 17 β -hydroxyl steroids...
October 2018: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/30426298/survey-study-on-the-practice-patterns-of-the-evaluation-and-management-of-incidental-pancreatic-cysts
#5
Donevan Westerveld, April Goddard, Nieka Harris, Vikas Khullar, Justin Forde, Peter V Draganov, Chris E Forsmark, Dennis Yang
BACKGROUND AND AIMS: Various gastrointestinal societies have released guidelines on the evaluation of asymptomatic pancreatic cysts (PCs). These guidelines differ on several aspects, which create a conundrum for clinicians. The aim of this study was to evaluate preferences and practice patterns in the management of incidental PCs in light of these societal recommendations. METHODS: An electronic survey distributed to members of the American Society for Gastrointestinal Endoscopy (ASGE)...
November 13, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30410949/adr-evaluation-of-screening-colonoscopies-during-2016-2017-in-a-private-health-clinic-in-peru
#6
Julio F León Moreno
Background and study aims  High-quality colonoscopy is fundamental for preventing colorectal cancer (CRC). The adenoma detection rate (ADR) is a key colonoscopy quality measure. The aim of this study was to establish the screening colonoscopy ADR of a tertiary referral center in Peru, identify the relationship between the ADR and patient age, sex and the colonoscopist, and determine the endoscopic and histopathological characteristics of the lesions found. Patients and methods  A retrospective observational longitudinal study was undertaken between January 2016 and June 2017...
November 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/30402576/biliary-and-pancreatic-lithotripsy-devices
#7
Rabindra R Watson, Mansour A Parsi, Harry R Aslanian, Adam J Goodman, David R Lichtenstein, Joshua Melson, Udayakumar Navaneethan, Rahul Pannala, Amrita Sethi, Shelby A Sullivan, Nirav C Thosani, Guru Trikudanathan, Arvind J Trindade, John T Maple
Background and Aims: Lithotripsy is a procedure for fragmentation or destruction of stones to facilitate their removal or passage from the biliary or pancreatic ducts. Although most stones may be removed endoscopically using conventional techniques such as endoscopic sphincterotomy in combination with balloon or basket extraction, lithotripsy may be required for clearance of large, impacted, or irregularly shaped stones. Several modalities have been described, including intracorporeal techniques such as mechanical lithotripsy (ML), electrohydraulic lithotripsy (EHL), and laser lithotripsy, as well as extracorporeal shock-wave lithotripsy (ESWL)...
November 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30366810/asge-high-risk-criteria-for-choledocholithiasis-are-they-applicable-in-cholecystectomized-patients
#8
Mafalda Sousa, Rolando Pinho, Luísa Proença, Jaime Rodrigues, João Silva, Catarina Gomes, João Carvalho
BACKGROUND AND AIMS: The guidelines by the American Society for Gastrointestinal Endoscopy (ASGE) suggest that in patients with gallbladder in situ, endoscopic retrograde cholangiopancreatography (ERCP) should be performed in the presence of high-risk criteria for choledocholithiasis, after biochemical tests and abdominal ultrasound. There are no specific recommendations for cholecystectomized patients. The aim of this study was to evaluate the applicability of ASGE criteria for ERCP in cholecystectomized patients with suspected choledocholithiasis...
October 6, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/30352260/tissue-specific-transcription-of-proteases-and-nucleases-across-the-accessory-salivary-gland-principal-salivary-gland-and-gut-of-nezara-viridula
#9
Sijun Liu, Purushottam R Lomate, Bryony C Bonning
The phytophagous stink bug, Nezara viridula (L.) infests multiple plant species and impacts agricultural production worldwide. We analyzed the transcriptomes of N. viridula accessory salivary gland (ASG), principal salivary gland (PSG) and gut, with a focus on putative digestive proteases and nucleases that present a primary obstacle for the stability of protein- or nucleic acid-based stink bug control approaches. We performed high throughput Illumina sequencing followed by de novo transcriptome assemblies...
October 21, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/30345149/determination-of-asenapine-in-presence-of-its-inactive-metabolites-in-human-plasma-by-lc-ms-ms
#10
Nirav P Patel, Mallika Sanyal, Naveen Sharma, Dinesh S Patel, Pranav S Shrivastav, Bhavin N Patel
A highly selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been described for the determination of asenapine (ASE) in presence of its inactive metabolites N -desmethyl asenapine (DMA) and asenapine- N -glucuronide (ASG). ASE, and ASE 13C-d3, used as internal standard (IS), were extracted from 300 µL human plasma by a simple and precise liquid-liquid extraction procedure using methyl tert -butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP8e (100 mm × 4...
October 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/30292612/aortoiliac-calcification-correlates-with-5-year-survival-after-abdominal-aortic-aneurysm-repair
#11
Matthew J TerBush, Khurram Rasheed, Zane Z Young, Jennifer L Ellis, Roan J Glocker, Adam J Doyle, Kathleen G Raman, Michael C Stoner
BACKGROUND: An anatomic severity grade (ASG) score to categorize and to define anatomic factors for abdominal aortic aneurysm (AAA) repair was proposed. Other studies have previously reported that aortic anatomic complexity is a marker of survival and resource utilization after repair, although it remains unclear whether individual components of the ASG score independently contribute to survival. This study analyzed and validated an aortic and iliac artery calcium scoring system that can potentially predict survival after AAA repair...
October 3, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30283604/randomised-controlled-trial-comparing-modified-sano-s-and-narrow-band-imaging-international-colorectal-endoscopic-classifications-for-colorectal-lesions
#12
Leonardo Zorrón Cheng Tao Pu, Kuan Loong Cheong, Doreen Siew Ching Koay, Sze Pheh Yeap, Amanda Ovenden, Mahima Raju, Andrew Ruszkiewicz, Philip W Chiu, James Y Lau, Rajvinder Singh
AIM: To assess the utility of modified Sano's (MS) vs the narrow band imaging international colorectal endoscopic (NICE) classification in differentiating colorectal polyps. METHODS: Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial. Based on the MS or the NICE classifications, patients were randomised for real-time endoscopic diagnosis. This was followed by biopsies, endoscopic or surgical resection. The endoscopic diagnosis was then compared to the final (blinded) histopathology...
September 16, 2018: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/30251847/generic-hapten-synthesis-broad-specificity-monoclonal-antibodies-preparation-and-ultrasensitive-elisa-for-five-antibacterial-synergists-in-chicken-and-milk
#13
Hongfang Li, Shaoqin Ma, Xiya Zhang, Chenglong Li, Baolei Dong, Mari Ghulam Mujtaba, Yujie Wei, Xiao Liang, Xuezhi Yu, Kai Wen, Wenbo Yu, Jianzhong Shen, Zhanhui Wang
An antibody with broad specificity and principally depending on hapten structure and size is a key reagent for developing a class-selective immunoassay. In the present study, three new generic haptens of antibacterial synergists (ASGs) were proposed using trimethoprim as the starting molecule. These haptens contained carboxyl groups on the meta position of trimethoxybenzene for conjugating to protein, while, the common moiety of ASGs, i.e., diaminopyrimidine, was intentionally and maximally exposed to the immune system in animals in order to induce antibodies with broad specificity against ASGs...
October 24, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30210415/the-australian-sheep-goat-scale-an-evaluation-of-factor-structure-and-convergent-validity
#14
Kenneth Drinkwater, Andrew Denovan, Neil Dagnall, Andrew Parker
The Australian Sheep-Goat Scale (ASGS) is a commonly used measure of belief in the paranormal. The scale contains items that index extrasensory perception (ESP), psychokinesis (PK), and life after death (LAD). Although, research employs the ASGS as both a general (unidimensional) and factorial (multidimensional) measure, few studies have examined the appropriateness of these solutions. Accordingly, the present paper tested the psychometric integrity of the ASGS via two studies. Study 1 assessed ASGS factorial structure using confirmatory factor analysis...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30196719/-the-role-of-endoscopy-registries-in-quality-health-care-the-first-data-from-the-hungarian-endoscopic-retrograde-cholangiopancreatography-ercp-registry
#15
Dániel Pécsi, Péter Hegyi, Andrea Szentesi, Szilárd Gódi, Ferenc Pakodi, Áron Vincze
INTRODUCTION: The continuous monitoring of quality indicators in gastrointestinal endoscopy has become an essential requirement nowadays. Most of these data cannot be extracted from the currently used free text reports, therefore a structured web-based data-collecting system was developed to record the indicators of pancreatobiliary endoscopy. AIM: A structured data-collecting system, the ERCP Registry, was initiated to monitor endoscopic retrograde cholangiopancreatography (ERCP) examinations prospectively, and to verify its usability...
September 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/30187668/arthritis-in-sarcoidosis-a-multicentric-study-from-india
#16
Vikas Agarwal, Vinita Agrawal, Amita Aggarwal, Parshant Aggarwal, Abhra C Chowdhury, Parasar Ghosh, Avinash Jain, Able Lawrence, Durga P Misra, Ramnath Misra, Madhusmita M Mohapatra, Alok Nath, Vir S Negi, Sapan Pandya, Vishnu V Reddy, Shiva Prasad, Aman Sharma, Vineeta Shobha, Yogesh P Singh, Saumya R Tripathy, Anupam Wakhlu
INTRODUCTION: Ten to 15% of patients with sarcoidosis have associated arthritis. Chronic arthritis is fairly uncommon. There is a paucity of data on articular manifestations of the disease from India. METHODS: Case records of adult patients with sarcoidosis presenting to 11 rheumatology centers from 2005 to 2017 were retrospectively reviewed. Joint involvement was assessed clinically, classified as acute or chronic depending on duration of symptoms less or greater than 6 months, respectively...
September 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/30142252/molecular-species-determination-of-oligosaccharides-and-glycoconjugates-in-soybean-lecithin-powders
#17
Jingjing Kang, Ru Yin, Dong Cao
BACKGROUND: Oligosaccharides and glycoconjugates in soybean lecithin powder are very important for the properties and functions of the materials that contain it. Oligosaccharides can trigger infusion reactions and color changes in soybean lecithin during medical injections; glycoconjugates in the form of glycolipids can also change the physical behavior of lecithin. The molecular components of oligosaccharides and glycoconjugates in soybean lecithin powder were studied in this paper. RESULTS: Three oligosaccharides and 21 glycoconjugates were verified in soybean lecithin powders for the first time...
August 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/30113564/reducing-radiation-dose-for-high-resolution-flat-panel-ct-imaging-of-superior-semicircular-canal-dehiscence
#18
Amgad El Mekabaty, Seth E Pross, Mesha Martinez, John P Carey, Monica S Pearl
OBJECTIVE: High-resolution flat panel computed tomography (FPCT) is useful for the evaluation of temporal bone pathologies. While radiation exposure remains a concern, efforts have been devoted to reduce dose, while maintaining image quality. We hypothesize that removing the antiscatter grid (ASG) results in decreased radiation exposure, while maintaining diagnostic image quality for the evaluation of superior semicircular canal dehiscence (SSCD). METHODS: Ten patients with clinical suspicion for SSCD participated in this prospective study...
September 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30112436/antibody-drug-conjugates-in-bladder-cancer
#19
REVIEW
Panagiotis J Vlachostergios, Christopher D Jakubowski, Muhammad J Niaz, Aileen Lee, Charlene Thomas, Amy L Hackett, Priyanka Patel, Naureen Rashid, Scott T Tagawa
Urothelial carcinoma (UC) is characterized by expression of a plethora of cell surface antigens, thus offering opportunities for specific therapeutic targeting with use of antibody-drug conjugates (ADCs). ADCs are structured from two major constituents, a monoclonal antibody (mAb) against a specific target and a cytotoxic drug connected via a linker molecule. Several ADCs are developed against different UC surface markers, but the ones at most advanced stages of development include sacituzumab govitecan (IMMU-132), enfortumab vedotin (ASG-22CE/ASG-22ME), ASG-15ME for advanced UC, and oportuzumab monatox (VB4-845) for early UC...
July 30, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/30105290/peroral-endoscopic-myotomy-is-effective-and-safe-in-non-achalasia-esophageal-motility-disorders-an-international-multicenter-study
#20
Mouen A Khashab, Pietro Familiari, Peter V Draganov, Hanaa Dakour Aridi, Joo Young Cho, Michael Ujiki, Ricardo Rio Tinto, Hubert Louis, Pankaj N Desai, Vic Velanovich, Eduardo Albéniz, Amyn Haji, Jeffrey Marks, Guido Costamagna, Jacques Devière, Yaseen Perbtani, Mason Hedberg, Fermin Estremera, Luis A Martin Del Campo, Dennis Yang, Majidah Bukhari, Olaya Brewer, Omid Sanaei, Lea Fayad, Amol Agarwal, Vivek Kumbhari, Yen-I Chen
Background and study aims : The efficacy of per oral endoscopic myotomy (POEM) in non-achalasia esophageal motility disorders such as esophagogastric junction outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and jackhammer esophagus (JE) has not been well demonstrated. The aim of this international multicenter study was to assess clinical outcomes of POEM in patients with non-achalasia disorders, namely DES, JE, and EGJOO, in a large cohort of patients. Patients and methods : This was a retrospective study at 11 centers...
August 2018: Endoscopy International Open
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