keyword
https://read.qxmd.com/read/38486648/ophthalmic-manifestations-of-migraine-in-a-nigerian-tertiary-health-facility
#1
JOURNAL ARTICLE
Eiman Bashir, Lawan Abdu, Mohammed Isyaku, Zahraddeen Garba Habib, Saudat Garba Habib, Musbahu Sani Kurawa, Sadiq Hassan
BACKGROUND: Migraine is a group of headache syndromes, with a prevalence of 5%-25%. Migraine is a complex recurrent headache disorder, often unilateral, throbbing or pulsating in nature aggravated by physical activity, bright light, and loud noises. Symptoms associated with migraine without aura are nausea, anorexia, and varying degrees of ophthalmic problems ranging from visual aura, ocular symptoms, and ophthalmoplegia. OBJECTIVES: The study determined the pattern and ophthalmic manifestations of migraine in Aminu Kano Teaching Hospital, Kano, Nigeria...
2024: Journal of the West African College of Surgeons
https://read.qxmd.com/read/38422705/somatosensory-and-psychosocial-profile-of-migraine-patients-a-cross-sectional-study
#2
JOURNAL ARTICLE
Mauro Barone, Fernando Imaz, Giancarlo De la Torre Canales, Maximiliano Venosta, Julian Dri, Leonardo Intelangelo
BACKGROUND: Migraine is a chronic neurological disorder that involves the brain, characterized by a series of abnormal neuronal networks interacting at different levels of the central and peripheral nervous system. Furthermore, it is known that psychosocial features contribute to the exacerbation and chronicity of symptoms. OBJECTIVE: To compare the somatosensory and psychosocial profiles of migraine patients with a control group. METHODS: We conducted a cross-sectional study comparing the somatosensory and psychosocial profiles of patients with migraine and healthy volunteers...
February 22, 2024: Musculoskeletal Science & Practice
https://read.qxmd.com/read/38231594/successful-case-of-teprotumumab-treatment-in-an-adolescent-patient-with-thyroid-eye-disease
#3
JOURNAL ARTICLE
Nicholas Radulovich, Alexandra Van Brummen, Christopher Chambers, Matthew Zhang
A 16-year-old black female presented with a 4-month history of significant proptosis and diplopia in the setting of diagnosed Graves disease. The patient underwent 8 infusions of teprotumumab. She had migraines and diplopia that were resolved with treatment. There was also a dramatic improvement in her proptosis. The authors present the first reported case of successful teprotumumab treatment in an adolescent patient, describing outcomes and proposing a mechanism for her transient side effects.
January 17, 2024: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38111471/recurrent-multiple-eye-muscle-palsy-as-a-first-sign-of-sarcoidosis
#4
Isabel Deboutte, Daisy Godts, Michel Van Lint
PURPOSE: To report a case of (neuro)sarcoidosis presenting solely with recurrent cranial nerve palsies in a 57-year-old Caucasian female. METHODS: Case report with clinical imaging. RESULTS: A 57-year-old female first presented with a right sixth nerve palsy, which resolved spontaneously after 6 months. Three years later she was diagnosed with a sixth nerve palsy in the fellow eye followed by a complete palsy of the left third cranial nerve four months after...
2023: GMS Ophthalmology Cases
https://read.qxmd.com/read/38081745/varicella-zoster-virus-vasculopathy-in-a-patient-with-multiple-sclerosis-receiving-natalizumab
#5
JOURNAL ARTICLE
Anna Elmståhl, Fredrik Buchwald, Andreea Ilinca
We present a case of a woman in her 30s with relapsing-remitting multiple sclerosis, treated with natalizumab, who developed ophthalmic varicella zoster virus (VZV) infection, with subsequent vasculopathy causing cerebral ischaemic lesions. She was treated with acyclovir, prednisolone and acetylsalicylic acid and fully recovered. VZV vasculopathy is associated with stroke and immunomodulating treatments may increase the risks of these adverse events. To date, nine VZV-related vasculopathy cases in patients treated with natalizumab have been reported in English literature and are summarised in this paper...
December 11, 2023: BMJ Case Reports
https://read.qxmd.com/read/38043970/the-anatomy-of-head-pain
#6
REVIEW
Carrie E Robertson, Eduardo E Benarroch
Pain-sensitive structures in the head and neck, including the scalp, periosteum, meninges, and blood vessels, are innervated predominantly by the trigeminal and upper cervical nerves. The trigeminal nerve supplies most of the sensation to the head and face, with the ophthalmic division (V1) providing innervation to much of the supratentorial dura mater and vessels. This creates referral patterns for pain that may be misleading to clinicians and patients, as described by studies involving awake craniotomies and stimulation with electrical and mechanical stimuli...
2023: Handbook of Clinical Neurology
https://read.qxmd.com/read/37788937/clinical-reasoning-a-woman-with-progressive-painless-sequential-monocular-vision-loss
#7
JOURNAL ARTICLE
Joseph Ditrapani, Hayley Price, Christine Shrock, Shuodan Zhang, Patricia E Greenstein, Marc Bouffard
A 68-year-old woman with a history of diabetes mellitus type 2, depression, and migraines presented with painless, acute, consecutive vision loss affecting the right eye for 1 week and the left eye for 2 weeks. Neuro-ophthalmic examination was notable for visual acuities of finger-counting peripherally, a central scotoma, anterior uveitis, vitritis, and placoid macular pigmentary changes in each eye (OU). Proprioception was diminished in the bilateral lower extremities. Optical coherence tomography (OCT) revealed hyper-reflectivity and attenuation of the outer retina OU with normal inner retinal architecture and reflectivity...
November 21, 2023: Neurology
https://read.qxmd.com/read/37633167/quechers-assisted-ion-pair-chromatography-fluorescence-detection-method-for-determination-of-antimigraine-combination-therapy-in-rabbit-plasma-samples-application-to-a-pharmacokinetic-study
#8
JOURNAL ARTICLE
Azza H Rageh, Pakinaz Y Khashaba, Sally A El Zohny, Noha N Atia
Antimigraine combination therapy has shown significant effectiveness in relieving pain, as well as reducing the frequency, duration, and severity of migraine attacks if compared to a single migraine medication. This work represents the first analytical investigation for emphasizing the synergistic effect of combining ophthalmic beta blockers with triptans in migraine treatment. The presented study was conducted to investigate the pharmacokinetic profile of almotriptan (ALM), a serotonin (5-HT1B/1D ) receptor agonist used to treat migraine, when coadministered with timolol (TIM) or verapamil (VER) which are considered as an adjuvant therapy in migraine prevention...
August 19, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/37309334/sporadic-hemiplegic-migraine
#9
Tina Kana, Saraf Mehjabeen, Nirav Patel, Ahmed Kawamj, Zaineb Shamim
An uncommon presentation of a migraine headache is hemiplegic migraine, which can clinically imitate other conditions including transient ischemic attacks and stroke with unilateral muscle weakness or hemiplegia. We present a 46-year-old female patient who was admitted with symptoms of a unilateral occipital headache, dysphagia and left-sided motor weakness. Diffusion magnetic resonance imaging (MRI) and brain tomography results were normal. A diagnosis of sporadic hemiplegic migraine was made after extensive workup and managed conservatively with solumedrol...
May 2023: Curēus
https://read.qxmd.com/read/37285496/benign-episodic-mydriasis-as-a-cause-of-isolated-anisocoria
#10
JOURNAL ARTICLE
Alyssa Seibold, Jonathan Barnett, Lawrence Stack, Charles Lei
CASE PRESENTATION: A 22-year-old female presented to the emergency department with a dilated right pupil and mild blurry vision. Physical examination revealed a dilated, sluggishly reactive right pupil, without other ophthalmic or neurologic abnormalities. Neuroimaging was normal. The patient was diagnosed with unilateral benign episodic mydriasis (BEM). DISCUSSION: BEM is a rare cause of acute anisocoria with an underlying pathophysiology that is not well understood...
May 2023: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/37179452/optic-neuritis-related-to-chronic-sphenoid-sinusitis-as-an-uncommon-cause-of-vision-loss-a-case-report-and-literature-review
#11
REVIEW
Barbara Nowacka, Wojciech Lubiński, Jakub Lubiński
BACKGROUND Optic neuritis is a rare but possible complication of sphenoid sinusitis. CASE REPORT We present a case of a young woman with recurrent optic neuritis associated with chronic sphenoid sinusitis. A 29-year-old woman with visual impairment of the left eye to Snellen distance best-corrected visual acuity (DBCVA) of 0.5 and migraine headaches accompanied by vomiting and dizziness reported to the ophthalmic emergency room. The preliminary diagnosis was demyelinating optic neuritis. On head computed tomography, a polypoid lesion of the sphenoid sinus was found and qualified for elective endoscopic treatment...
May 14, 2023: American Journal of Case Reports
https://read.qxmd.com/read/37176658/predictors-of-response-to-fremanezumab-in-migraine-patients-with-at-least-three-previous-preventive-failures-post-hoc-analysis-of-a-prospective-multicenter-real-world-greek-registry
#12
JOURNAL ARTICLE
Andreas A Argyriou, Emmanouil V Dermitzakis, Georgia Xiromerisiou, Dimitrios Rallis, Panagiotis Soldatos, Pantelis Litsardopoulos, Michail Vikelis
OBJECTIVE: To define, in a real-world population of patients with high-frequency episodic (HFEM) or chronic migraine (CM), the predictive role of socio-demographic or phenotypic profiling of responders to fremanezumab. PATIENTS AND METHODS: Two-hundred and four adult fremanezumab-treated patients with either HFEM or CM, who failed to at least three preventive treatments, provided data at baseline on several individual socio-demographic and phenotypic variables. These variables were analyzed for their ability to independently predict the response (50-74% response rates) or super-response (≥ 75% response rates) to fremanezumab...
April 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36937196/risk-factors-associated-with-keratoconus-in-an-iranian-population
#13
JOURNAL ARTICLE
Hossein Mohammad-Rabei, Shahrokh Ramin, Sahar Lotfi, Hamideh Sabbaghi, Farid Karimian, Saeid Abdi, Mohammad Hasan Shahriari, Bahareh Kheiri, Kourosh Sheibani, Mohammad Ali Javadi
PURPOSE: To determine associated factors for keratoconus (KCN) in the Iranian population. METHODS: In this retrospective case-control study, 100 KCN patients and 200 age- and sex-matched individuals, who were either candidates for photorefractive keratectomy or healthy referrals from the Torfeh Eye Hospital, were included as the case and control groups, respectively. KCN patients were all registered at the Iranian National Registry of Keratoconus (KCNRegⓇ)...
2023: Journal of Ophthalmic & Vision Research
https://read.qxmd.com/read/36902751/disturbances-of-ocular-circulation-in-color-doppler-imaging-retinal-changes-and-electrophysiological-tests-with-neuro-ophthalmological-clinical-symptoms-in-the-course-of-cadasil-syndrome-a-case-report
#14
Monika Modrzejewska, Patrycja Woźniak, Wiktoria Bosy-Gąsior, Adam Kaniewski
The authors present a new paper examining the disturbances in ocular circulation and electrophysiological changes in the presence of neuro-ophthalmic manifestations in a patient with cerebral autosomal dominant arteriopathy with subcortical infracts and leucoencephalopathy (CADASIL). Symptoms reported by the patient included: transient vision loss (TVL), migraines, diplopia, bilateral peripheral visual field loss and convergence insufficiency. CADASIL was confirmed by the presence of NOTCH3 gene mutation (p...
March 1, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36804335/idiopathic-intracranial-hypertension-in-female-to-male-transgender-patients-on-exogenous-testosterone-therapy
#15
JOURNAL ARTICLE
Naomi E Gutkind, David T Tse, Thomas E Johnson, Brian C Tse
PURPOSE: To present four female-to-male (FTM) transgender patients on testosterone therapy diagnosed with idiopathic intracranial hypertension (IIH). METHODS: The authors report 4 consecutive FTM transgender patients on exogenous testosterone diagnosed with IIH at a single institution. RESULTS: Patient 1 presented with progressive blurred vision and a central scotoma 10 weeks after starting testosterone cypionate injections for hormonal gender transition...
February 21, 2023: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/36705344/characterization-of-trigeminal-c-fiber-reactivity-through-capsaicin-induced-release-of-calcitonin-gene-related-peptide
#16
JOURNAL ARTICLE
Hauke Basedau, Thalea Oppermann, Elisa Gundelwein Silva, Kuan-Po Peng, Arne May
OBJECTIVE: We hypothesized that the response of trigeminal dermal blood flow (DBF) in the trigeminal system and consecutive expansion of flare response to capsaicin would differ from the somatosensory system (arm). We also investigated whether there are differences between patients with migraine and healthy controls (HC). BACKGROUND: Functional differences between the trigeminal and extracephalic somatosensory systems may partly explain the susceptibility for headaches in patients with migraine...
January 27, 2023: Headache
https://read.qxmd.com/read/36516150/evaluation-of-factors-associated-with-interhospital-transfers-to-pediatric-and-adult-tertiary-level-of-care-a-study-of-acute-neurological-disease-cases
#17
JOURNAL ARTICLE
Stanca Iacob, Yanzhi Wang, Susan C Peterson, Sven Ivankovic, Salil Bhole, Patrick T Tracy, Patrick W Elwood
INTRODUCTION: Patient referrals to tertiary level of care neurological services are often potentially avoidable and result in inferior clinical outcomes. To decrease transfer burden, stakeholders should acquire a comprehensive perception of specialty referral process dynamics. We identified associations between patient sociodemographic data, disease category and hospital characteristics and avoidable transfers, and differentiated factors underscoring informed decision making as essential care management aspects...
2022: PloS One
https://read.qxmd.com/read/36259130/pharmacological-modulation-of-ventral-tegmental-area-neurons-elicits-changes-in-trigeminovascular-sensory-processing-and-is-accompanied-by-glycemic-changes-implications-for-migraine
#18
JOURNAL ARTICLE
Margarida Martins-Oliveira, Simon Akerman, Philip R Holland, Isaura Tavares, Peter J Goadsby
BACKGROUND: Imaging migraine premonitory studies show increased midbrain activation consistent with the ventral tegmental area, an area involved in pain modulation and hedonic feeding. We investigated ventral tegmental area pharmacological modulation effects on trigeminovascular processing and consequent glycemic levels, which could be involved in appetite changes in susceptible migraine patients. METHODS: Serotonin and pituitary adenylate cyclase-activating polypeptide receptors immunohistochemistry was performed in ventral tegmental area parabrachial pigmented nucleus of male Sprague Dawley rats...
October 18, 2022: Cephalalgia: An International Journal of Headache
https://read.qxmd.com/read/36166802/sharp-edge-eye-syndrome-a-case-report-and-survey-of-self-identified-individuals
#19
JOURNAL ARTICLE
Merrick S Reynolds, Bradley J Katz, Kathleen B Digre, Ben J Brintz, Lenora M Olson, Judith E A Warner
BACKGROUND: Sharp edge eye syndrome (SEES), sometimes known as visual looming syndrome, is a condition in which the patient experiences ocular pain or discomfort when viewing or mentally picturing sharp objects and edges. Patients may present for medical care because they perceive the condition to represent an ophthalmic problem or a sign of a more serious underlying condition. An individual case report of SEES is included to aid in illustrating syndrome characteristics. Our aim is to describe the syndrome, vision-related quality of life (VRQOL), and psychosocial characteristics in patients with self-identified SEES...
December 1, 2022: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/36147764/an-ocular-chameleon
#20
Mohamed Shaffi, Nick Saad, Jennifer Arnold, Geoffrey Parker, Daniel Nguyen, Behzad Eftekhar
Patients presenting with transient visual loss is common in emergency departments. Neurologists, ophthalmologists and emergency care physicians may be called upon to evaluate such patients. Monocular visual loss should be differentiated from the binocular involvement as the oetologies, investigations and management of such patients differ considerably. We report a case of monocular visual loss that involved predominantly one eye but affected the other side independently, albeit less frequently. A meticulous history, thorough general, neurological and ophthalmological examinations are necessary in such patients to identify the cause and to treat appropriately...
October 2022: Neurohospitalist
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