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https://www.readbyqxmd.com/read/30536593/oral-health-related-quality-of-life-in-patients-with-disorders-of-nutrition
#1
Boaz Shay, Orly Ben Ami, Dana Levy Ianculovici, Avraham Zini, Clariel Ianculovici, Galit Almoznino
BACKGROUND: Researchers demonstrated a correlation between nutrition and health-related quality-of-life (HRQoL). Little is known about the correlation between disorders of nutrition (DON) and Oral HRQoL (OHRQoL). OBJECTIVES: 1) to measure OHRQoL in DON patients compared to patients attending nutritional counseling for other reasons (e.g. systemic diseases or general dietary counseling) (NCOR) and to healthy controls attending routine dental screenings.(2) analyze associations between OHRQoL and demographics, health-related behaviors and nutritional practices...
December 11, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/30534605/rapid-characterization-of-secreted-recombinant-proteins-by-native-mass-spectrometry
#2
Gili Ben-Nissan, Shay Vimer, Shira Warszawski, Aliza Katz, Meital Yona, Tamar Unger, Yoav Peleg, David Morgenstern, Hadas Cohen-Dvashi, Ron Diskin, Sarel J Fleishman, Michal Sharon
Characterization of overexpressed proteins is essential for assessing their quality, and providing input for iterative redesign and optimization. This process is typically carried out following purification procedures that require pronounced cost of time and labor. Therefore, quality assessment of recombinant proteins with no prior purification offers a major advantage. Here, we report a native mass spectrometry method that enables characterization of overproduced proteins directly from culture media. Properties such as solubility, molecular weight, folding, assembly state, overall structure, post-translational modifications and binding to relevant biomolecules are immediately revealed...
2018: Communications biology
https://www.readbyqxmd.com/read/30534479/improving-outcome-in-immediate-alloplastic-breast-reconstruction-an-algorithm-for-operative-decision-making
#3
Tamir Shay, Avi A Cohen, Dean Ad-El
Supplemental Digital Content is available in the text.
October 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/30533193/inducing-rapid-telomere-irreparable-damage-in-telomerase-expressing-cancers
#4
EDITORIAL
Gao Zhang, Jerry W Shay
No abstract text is available yet for this article.
November 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/30532719/heroic-helping-the-effects-of-priming-superhero-images-on-prosociality
#5
Daryl R Van Tongeren, Rachel Hibbard, Megan Edwards, Evan Johnson, Kirstin Diepholz, Hanna Newbound, Andrew Shay, Russell Houpt, Athena Cairo, Jeffrey D Green
Two experiments examined how exposure to superhero images influences both prosociality and meaning in life. In Experiment 1 ( N = 246) exposed individuals to scenes with superhero images or neutral images. Individuals primed with superhero images reported greater helping intentions relative to the control group, which, in turn, were associated with increased meaning in life (indirect effect only; no direct effect). In Experiment 2 ( N = 123), individuals exposed to a superhero poster helped an experimenter in a tedious task more than those exposed to a bicycle poster, though no differences were found for meaning in life...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30530636/breast-cancer-risk-in-neurofibromatosis-type-1-is-a-function-of-the-type-of-nf1-gene-mutation-a-new-genotype-phenotype-correlation
#6
Ian M Frayling, Victor-Felix Mautner, Rick van Minkelen, Roope A Kallionpaa, Safiye Aktaş, Diana Baralle, Shay Ben-Shachar, Alison Callaway, Harriet Cox, Diana M Eccles, Salah Ferkal, Holly LaDuca, Conxi Lázaro, Mark T Rogers, Aaron J Stuenkel, Pia Summerour, Ali Varan, Yoon Sim Yap, Ouidad Zehou, Juha Peltonen, Gareth D Evans, Pierre Wolkenstein, Meena Upadhyaya
BACKGROUND: Neurofibromatosis type 1 (NF1) predisposes to breast cancer (BC), but no genotype-phenotype correlations have been described. METHODS: Constitutional NF1 mutations in 78 patients with NF1 with BC (NF1-BC) were compared with the NF1 Leiden Open Variation Database (n=3432). RESULTS: No cases were observed with whole or partial gene deletions (HR 0.10; 95% CI 0.006 to 1.63; p=0.014, Fisher's exact test). There were no gross relationships with mutation position...
December 10, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/30513757/infection-with-a-nonencapsulated-bacillus-anthracis-strain-in-rabbits-the-role-of-bacterial-adhesion-and-the-potential-for-a-safe-live-attenuated-vaccine
#7
Itai Glinert, Shay Weiss, Assa Sittner, Elad Bar-David, Amir Ben-Shmuel, Josef Schlomovitz, David Kobiler, Haim Levy
Nonencapsulated (∆pXO2) Bacillus anthracis strains are commonly used as vaccines and for anthrax research, mainly in the mouse model. Previously, we demonstrated that the infection of rabbits, intranasally or subcutaneously, with the spores of a fully virulent strain results in the systemic dissemination of the bacteria, meningitis, and death, whereas ∆pXO2 strains are fully attenuated in this animal model. We used the intravenous inoculation of rabbits to study the pathogenicity of the ∆pXO2 strain infection...
December 1, 2018: Toxins
https://www.readbyqxmd.com/read/30513059/in-response-to-ersatz-ultrasonographic-measurements-for-the-knee-joint
#8
Itzhak Siev-Ner, Myriam D Stern, Shay Tenenbaum, Alexander Blankstein, Aviva Zeev, Nili Steinberg
No abstract text is available yet for this article.
December 4, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/30507686/histopathologic-analysis-in-the-diagnosis-and-management-of-chronic-rhinosinusitis
#9
Aryan D Shay, Bobby A Tajudeen
PURPOSE OF REVIEW: New research in the pathogenesis of chronic rhinosinusitis has shed light on an emerging classification system based on endotypes, which help to explain the individualized mechanism of disease in patients suffering from chronic rhinosinusitis with and without nasal polyps. The purpose of this review is to advocate the use of structured histopathologic analysis in the diagnosis and management of patients affected by chronic rhinosinusitis with and without polyps. RECENT FINDINGS: Numerous studies have demonstrated the role of inflammation in chronic rhinosinusitis and the ensuing histopatholgic changes...
November 30, 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/30502048/relation-of-neutrophil-to-lymphocyte-ratio-to-risk-of-incident-atrial-fibrillation
#10
Anat Berkovitch, Arwa Younis, Yoni Grossman, Shlomo Segev, Shaye Kivity, Yechezkel Sidi, Roy Beinart, Ilan Goldenberg, Elad Maor
Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2...
November 7, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30497324/a-university-based-mental-health-center-for-veterans-and-their-families-challenges-and-opportunities
#11
Ari Lowell, Andrea Lopez-Yianilos, Matthew Ryba, Shay Arnon, Benjamin Suarez-Jimenez, Amit Lazarov, Prudence W Fisher, John C Markowitz, Yuval Neria
The Military Family Wellness Center at Columbia University Irving Medical Center provides cost-free, confidential mental health services to military service members, veterans, and their families in a nongovernmental setting, with an emphasis on addressing gaps in available care. Partnerships with academic institutions and collaboration with veteran organizations, regional stakeholders, and local Veterans Administration centers facilitate cross-site referrals, enhance knowledge and expertise, and advance shared goals...
November 30, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/30488553/telomere-length-and-telomerase-activity-in-t-cells-are-biomarkers-of-high-performing-centenarians
#12
Enzo Tedone, Ejun Huang, Ryan O'Hara, Kimberly Batten, Andrew T Ludlow, Tsung-Po Lai, Beatrice Arosio, Daniela Mari, Woodring E Wright, Jerry W Shay
It is generally recognized that the function of the immune system declines with increased age and one of the major immune changes is impaired T-cell responses upon antigen presentation/stimulation. Some "high-performing" centenarians (100+ years old) are remarkably successful in escaping, or largely postponing, major age-related diseases. However, the majority of centenarians ("low-performing") have experienced these pathologies and are forced to reside in long-term nursing facilities. Previous studies have pooled all centenarians examining heterogeneous populations of resting/unstimulated peripheral blood mononuclear cells (PBMCs)...
November 28, 2018: Aging Cell
https://www.readbyqxmd.com/read/30482279/proton-radiation-induced-cancer-progression
#13
Krishna Luitel, Ronald Bozeman, Aadil Kaisani, Sang Bum Kim, Summer Barron, James A Richardson, Jerry W Shay
There are considerable health risks related to ionizing and proton radiation exposure. While there is a long history of health risks associated with ionizing (photon) radiation exposure, there is a limited understanding of the long-term health risks associated with proton radiation exposure. Since proton radiation is becoming more common in cancer therapy, the long-term biological effects of proton radiation remain less well characterized in terms of radiotherapy and well as for astronauts during deep space explorations...
November 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/30481223/correction-castle-classification-of-single-cells-by-transfer-learning-harnessing-the-power-of-publicly-available-single-cell-rna-sequencing-experiments-to-annotate-new-experiments
#14
https://www.readbyqxmd.com/read/30480633/sensory-changes-in-periocular-skin-after-upper-eyelid-surgery
#15
Tal Koval, Shay Ofir, Avner Belkin, Ori Segal, Achia Nemet, Arie Y Nemet
The aim of this interventional, prospective study is to estimate the change in periocular cutaneous sensation after upper eyelid surgery. The trial included 48 eyes of 24 patients undergoing upper eyelid blepharoplasty or upper eyelid blepharoplasty and blepharoptosis repair. Eyelid sensation was measured using a Cochet-Bonnet filament-type esthesiometer at 4 predetermined anatomical locations in the upper eyelid. The mean esthesiometry reading was calculated at the preoperative visit (4.06 cm), at 2-week postoperative visit (4...
November 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/30472130/clinical-features-and-outcomes-in-young-adults-with-oral-tongue-cancer
#16
Courtney Miller, Aryan Shay, Bobby Tajudeen, Neilayan Sen, Mary Fidler, Kerstin Stenson, Paolo Gattuso, Samer Al-Khudari
OBJECTIVE: To evaluate outcomes and survival in young patients with oral tongue cancer (OTC). METHODS: Retrospective chart review of patients aged 18-40 with OTC treated between 2000 and 2016. Tumor characteristics of p16 expression, perineural invasion (PNI), and lymph-vascular invasion (LVI) were evaluated. Recurrence-free (RFS) and overall survival (OS) data were analyzed according to Kaplan-Meier method with univariate analysis. RESULTS: A total of 23 patients were identified: 12 with early stage disease (ESD, stage I), and 11 with advanced stage disease (ASD, stage III or IV), (17 men and 6 women)...
October 2, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/30459103/tranexamic-acid-in-coronary-artery-surgery-one-year-results-of-the-aspirin-and-tranexamic-acid-for-coronary-artery-surgery-atacas-trial
#17
Paul S Myles, Julian A Smith, Jessica Kasza, Brendan Silbert, Mohandas Jayarajah, Thomas Painter, D James Cooper, Silvana Marasco, John McNeil, Jean S Bussières, Shay McGuinness, Kelly Byrne, Matthew T V Chan, Giovanni Landoni, Sophie Wallace, Andrew Forbes
BACKGROUND: Tranexamic acid reduces blood loss and transfusion requirements in cardiac surgery but may increase the risk of coronary graft thrombosis. We previously reported the 30-day results of a trial evaluating tranexamic acid for coronary artery surgery. Here we report the 1-year clinical outcomes. METHODS: Using a factorial design, we randomly assigned patients undergoing coronary artery surgery to receive aspirin or placebo and tranexamic acid or placebo...
October 19, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30455703/myeloid-cell-hypoxia-inducible-factors-promote-resolution-of-inflammation-in-experimental-colitis
#18
Nan Lin, Jessica E S Shay, Hong Xie, David S M Lee, Nicolas Skuli, Qiaosi Tang, Zilu Zhou, Andrew Azzam, Hu Meng, Haichao Wang, Garret A FitzGerald, M Celeste Simon
Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of the inflamed colon, suggesting that myeloid cell functions in colitis are HIF-dependent. By depleting ARNT (the obligate heterodimeric binding partner for both HIFα subunits) in a murine model, we demonstrate here that myeloid HIF signaling promotes the resolution of acute colitis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30451785/grading-of-complications-after-cervical-deformity-corrective-surgery-are-existing-classification-systems-applicable
#19
Cole A Bortz, Peter G Passias, Frank A Segreto, Samantha R Horn, Renaud Lafage, Justin S Smith, Breton G Line, Gregory M Mundis, Michael P Kelly, Paul Park, Daniel M Sciubba, D Kojo Hamilton, Jeffrey L Gum, Douglas C Burton, Robert A Hart, Frank J Schwab, Shay Bess, Christopher Shaffrey, Eric O Klineberg
STUDY DESIGN: This is a retrospective review of prospective multicenter cervical deformity (CD) database. OBJECTIVE: Assess the impact of complication type and Clavien complication (Cc) grade on clinical outcomes of surgical CD patients BACKGROUND:: Validated for general surgery, the Clavien-Dindo complication classification system allows for broad comparison of postoperative complications; however, the applicability of this system is unclear in CD-specific populations...
November 16, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/30450343/is-there-an-association-between-hyperbaric-oxygen-therapy-and-improved-outcome-of-deep-chemical-peeling-a-randomized-pilot-clinical-study
#20
Itay Wiser, Averbuch Sagie Roni, Ella Ziv, Mony Friedman, Shay Efraty, Lior Heller, Marina Landau, Tali Friedman
Background: Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events. Methods: This is a pilot randomized controlled clinical study. Women following PCP underwent 5 consecutive daily HBOT sessions, compared with PCP alone. Pain, pruritus, erythema, crusting, scaling, and edema were daily evaluated up to 28 days following PCP...
November 2018: Plastic Surgery
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