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Zuzana Sipkova, Elizabeth A Insull, Joel David, Helen E Turner, Shay Keren, Jonathan H Norris
OBJECTIVES: The current first-line treatment for management of active thyroid eye disease (TED) is high-dose intravenous corticosteroids, which have the potential for serious adverse effects. Our aim was to evaluate the effect of steroid-sparing agents (SSAs) in patients with moderate-to-severe active TED, using methotrexate as first-line. METHODS: Presented is a retrospective, four-year, single-centre, consecutive case series of patients with moderate-to-severe TED treated using the Oxford protocol...
August 13, 2018: Clinical Endocrinology
Gabriel Levin, Amihai Rottenstreich, David Shveiky, Nilli Yanai, Shay Porat
No abstract text is available yet for this article.
August 10, 2018: Journal of Minimally Invasive Gynecology
Sophie G Shay, Jonathan D Chrin, Marilene B Wang, Abie H Mendelsohn
OBJECTIVES/HYPOTHESIS: To objectively assess the initial and long-term retention of robotic surgical skills of otolaryngology residents. STUDY DESIGN: This study was performed in an academic otolaryngology residency training program. Between October 2015 and November 2016, residents were invited to complete a prospective, multiphase robotic surgical skills training course: 1) online da Vinci Surgical System Assessment and didactic, 2) faculty-supervised robotic simulator training, 3) robotic docking and draping training, 4) robotic dry-lab exercises...
August 10, 2018: Laryngoscope
Themistocles S Protopsaltis, Bassel G Diebo, Renaud Lafage, Jensen K Henry, Justin S Smith, Justin K Scheer, Daniel M Sciubba, Peter G Passias, Han Jo Kim, D Kojo Hamilton, Alexandra Soroceanu, Eric O Klineberg, Christopher P Ames, Christopher I Shaffrey, Shay Bess, Robert A Hart, Frank J Schwab, Virginie Lafage
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To define thoracic compensation and investigate its association with postoperative reciprocal thoracic kyphosis and proximal junctional kyphosis (PJK) SUMMARY OF BACKGROUND DATA.: Adult spinal deformity (ASD) patients recruit compensatory mechanisms like pelvic retroversion and knee flexion. However, thoracic hypokyphosis is a less recognized compensatory mechanism. METHODS: Patients enrolled in a multicenter ASD registry undergoing fusions to the pelvis with UIV between T9-L1 were included...
August 9, 2018: Spine
Muhammad Jbara, Shay Laps, Michael Morgan, Guy Kamnesky, Guy Mann, Cynthia Wolberger, Ashraf Brik
Organic chemistry allows for the modification and chemical preparation of protein analogues for various studies. The thiolate side chain of the Cys residue has been a key functionality in these ventures. In order to generate complex molecular targets, there is a particular need to incorporate orthogonal protecting groups of the thiolated amino acids to control the directionality of synthesis and modification site. Here, we demonstrate the tuning of palladium chemoselectivity in aqueous medium for on-demand deprotection of several Cys-protecting groups that are useful in protein synthesis and modification...
August 8, 2018: Nature Communications
Irene Scarfò, Maria Ormhøj, Matthew J Frigault, Ana P Castano, Selena Lorrey, Amanda A Bouffard, Alexandria van Scoyk, Scott J Rodig, Alexandra J Shay, Jon C Aster, Frederic I Preffer, David M Weinstock, Marcela V Maus
Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment for patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell therapy has effected impressive clinical responses in B-cell acute lymphoblastic leukemia (ALL) and diffuse large B-cell lymphoma (DLBCL). However, not all patients respond, and relapse with antigen loss has been observed in all patient subsets. Here, we report on the design and optimization of a novel CAR directed to the surface antigen CD37, which is expressed in B-cell non-Hodgkin Lymphomas, in chronic lymphocytic leukemia (CLL) and in some cases of cutaneous and peripheral T-cell lymphomas (CTCL and PTCL, respectively)...
August 8, 2018: Blood
Shay Golan, Meital Nidam, Hanna Bernstine, Jack Baniel, David Groshar
OBJECTIVES: To test the ability of dynamic 11C-PET / CT to discriminate cancerous tissue from background tissue in patients with localized prostate cancer. MATERIALS AND METHODS: Twenty-four consecutive patients with prostate cancer were prospectively evaluated with dynamic 11C-choline PET / CT prior to radical prostatectomy. The PET / CT scan was divided into 18 sequences of 5 seconds each, followed by 9 sequences of 60 seconds each. Whole-mount sections of harvested prostates served as reference standards...
July 30, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Theodore W James, Jessica E S Shay, David Furfaro, Burak Ozseker, Stuart D Russell, Aliaksei Pustavoitau, Nicole Rizkalla, Behnam Saberi, Benjamin Philosophe, Andrew M Cameron, Ahmet Gurakar
OBJECTIVES: Each year in the United States, approximately 40000 patients with a liver disorder will progress to end-stage liver disease and about 30000 of those patients will subsequently die from this condition. Liver transplant remains the definitive treatment option for end-stage liver disease, and understanding the causes of posttransplant mortality is an ongoing area of investigation. MATERIALS AND METHODS: In this retrospective cohort study, patients who underwent orthotopic liver transplant between January 2012 and January 2015 at the Johns Hopkins Hospital Liver Transplant Program were reviewed by a single reviewer for cardiac events in the 30 days after transplant or during the index admission...
August 6, 2018: Experimental and Clinical Transplantation
Andrew T Ludlow, Mandy Sze Wong, Jerome D Robin, Kimberly Batten, Laura Yuan, Tsung-Po Lai, Nicole Dahlson, Lu Zhang, Ilgen Mender, Enzo Tedone, Mohammed E Sayed, Woodring E Wright, Jerry W Shay
Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing factors that enhance or silence FL hTERT is lacking. We identified splicing factors that reduced telomerase activity and shortened telomeres using a siRNA minigene reporter screen and a lung cancer cell bioinformatics approach. A lead candidate, NOVA1, when knocked down resulted in a shift in hTERT splicing to non-catalytic isoforms, reduced telomerase activity, and progressive telomere shortening...
August 6, 2018: Nature Communications
Thomas J Buell, Davis G Taylor, Ching-Jen Chen, Christopher I Shaffrey, Justin S Smith, Shay Bess
No abstract text is available yet for this article.
August 3, 2018: Journal of Neurosurgery. Spine
Xiangdong Zhao, Faliang Xu, Nestor Prieto Dominguez, Yuanping Xiong, Zhongxun Xiong, Hong Peng, Chloe Shay, Yong Teng
Although genetic amplification and overexpression of the fibroblast growth factor 19 (FGF19) gene are found in human breast cancer, mechanisms that contribute to such functional alterations remain elusive. We report here that high expression of FGF19 is associated with the aggressive malignant behavior and poor survival outcome of breast cancer patients. FGF19 is particularly highly expressed in luminal molecular subtype of breast tumors and its expression levels are positively associated with its secretion levels from breast cancer cells...
August 3, 2018: Molecular Carcinogenesis
Ravi Verma, Renaud Lafage, Justin Scheer, Justin Smith, Peter Passias, Richard Hostin, Christopher Ames, Gregory Mundis, Douglas Burton, Han Jo Kim, Shay Bess, Eric Kleinberg, Frank Schwab, Virginie Lafage
STUDY DESIGN: A retrospective review of a prospective, multicenter adult spinal deformity (ASD) database. OBJECTIVE: Our objective was to quantify the change in disability reported for patients with radiculopathy as compared with patients with back pain only following ASD realignment surgery. SUMMARY OF BACKGROUND DATA: Studies utilizing patient-reported outcomes (PROs) have shown that ASD patients suffer from significant pain and disability...
July 31, 2018: Spine
Mikhail Kazachkov, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Bat-El Bar-Aluma, Christy L Spalink, Erin P Barnes, Nancy E Amoroso, Stamatela M Balou, Shay Bess, Arun Chopra, Rany Condos, Ori Efrati, Kathryn Fitzgerald, David Fridman, Ronald M Goldenberg, Ayelet Goldhaber, David A Kaufman, Sanjeev V Kothare, Jeremiah Levine, Joseph Levy, Anthony S Lubinsky, Channa Maayan, Libia C Moy, Pedro J Rivera, Alcibiades J Rodriguez, Gil Sokol, Mark F Sloane, Tina Tan, Horacio Kaufmann
BACKGROUND: Familial dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type-III) is a rare genetic disease caused by impaired development of sensory and afferent autonomic nerves. As a consequence, patients develop neurogenic dysphagia with frequent aspiration, chronic lung disease, and chemoreflex failure leading to severe sleep disordered breathing. The purpose of these guidelines is to provide recommendations for the diagnosis and treatment of respiratory disorders in familial dysautonomia...
August 2018: Respiratory Medicine
Jacqueline V Brady, Ryan M Troyer, Stephen A Ramsey, Haley Leeper, Liping Yang, Claudia S Maier, Cheri P Goodall, Carl E Ruby, Hassan A M Albarqi, Oleh Taratula, Shay Bracha
Circulating cancer exosomes are microvesicles which originate from malignant cells and other organs influenced by the disease and can be found in blood. The exosomal proteomic cargo can often be traced to the cells from which they originated, reflecting the physiological status of these cells. The similarities between cancer exosomes and the tumor cells they originate from exhibit the potential of these vesicles as an invaluable target for liquid biopsies. Exosomes were isolated from the serum of eight osteosarcoma-bearing dogs, five healthy dogs, and five dogs with traumatic fractures...
July 24, 2018: Translational Oncology
Mareen Engel, Carola Eggert, Paul M Kaplick, Matthias Eder, Simone Röh, Lisa Tietze, Christian Namendorf, Janine Arloth, Peter Weber, Monika Rex-Haffner, Shay Geula, Mira Jakovcevski, Jacob H Hanna, Dena Leshkowitz, Manfred Uhr, Carsten T Wotjak, Mathias V Schmidt, Jan M Deussing, Elisabeth B Binder, Alon Chen
N6 -methyladenosine (m6 A) and N6 ,2'-O-dimethyladenosine (m6 Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6 A/m, in the stress response in the adult brain in vivo is currently unknown. Here, we provide a detailed analysis of the stress epitranscriptome using m6 A/m-seq, global and gene-specific m6 A/m measurements. We show that stress exposure and glucocorticoids region and time specifically alter m6 A/m and its regulatory network...
July 25, 2018: Neuron
Jing Xu, Guangqiu Jin, Hongwu Tang, Pei Zhang, Shen Wang, You-Gan Wang, Ling Li
To assess the quality of a water environment, an in-depth analysis of temporal patterns of contaminant concentrations in water body should be carried out based on unbiased water quality datasets. In this study, we developed a modified log-linear model to account for non-stationary seasonal variations of contaminant concentrations over multiple periods. The model was applied to analyze temporal changes of the Ammonia Nitrogen (AN) concentration at Middle Reaches of Huaihe River (MRHR) and two major tributaries, Shaying River (SR) and Guo River (GR)...
November 15, 2018: Science of the Total Environment
Lixia Gao, Xiangdong Zhao, Liwei Lang, Chloe Shay, W Andrew Yeudall, Yong Teng
The functional relationship between apoptosis and autophagy in anticancer drug treatment is extremely complex, and the molecular machinery is obscure. This study aims to investigate the efficacy of CYT997, a novel microtubule-disrupting agent, in head and neck squamous cell carcinomas (HNSCCs) and complete the autophagy-apoptosis puzzle involved in drug action. We report here that CYT997 exhibits anticancer activity by triggering oxidative stress-associated apoptosis in HNSCC cells. Interestingly, upregulation of autophagy by mTOR-dependent pathways appears to have a cytoprotective role in preventing apoptosis by inhibiting CYT997-induced excessively high levels of reactive oxygen species (ROS)...
July 18, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Jin Wang, Tianfang Wang, Micah A Bishop, John F Edwards, Hang Yin, Stephen Dalton, Laura K Bryan, Shaying Zhao
Extreme intestinal polyposis in pet dogs has not yet been reported in literature. We identified a dog patient who developed numerous intestinal polyps, with the severity resembling human classic familial adenomatous polyposis (FAP), except the jejunum-ileum junction being the most polyp-dense. We investigated this dog, in comparison with 22 other dogs with spontaneous intestinal tumors but no severe polyposis, and with numerous published human cancers. We found, not APC mutation, but three other alteration pathways as likely reasons of this canine extreme polyposis...
June 26, 2018: Oncotarget
Ilgen Mender, Ryan LaRanger, Krishna Luitel, Michael Peyton, Luc Girard, Tsung-Po Lai, Kimberly Batten, Crystal Cornelius, Maithili P Dalvi, Michael Ramirez, Wenting Du, Lani F Wu, Steven J Altschuler, Rolf Brekken, Elisabeth D Martinez, John D Minna, Woodring E Wright, Jerry W Shay
Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2'-deoxyguanosine (6-thio-dG), to target telomerase-expressing non-small cell lung cancer cells resistant to EGFR-inhibitors and commonly used chemotherapy combinations. Colony formation assays, human xenografts as well as syngeneic and genetically engineered immune competent mouse models of lung cancer were used to test the effect of 6-thio-dG on targeted therapy- and chemotherapy-resistant lung cancer human cells and mouse models...
August 2018: Neoplasia: An International Journal for Oncology Research
Peter G Passias, Cole A Bortz, Frank A Segreto, Samantha R Horn, Renaud Lafage, Virginie Lafage, Justin S Smith, Breton Line, Han Jo Kim, Robert Eastlack, D Kojo Hamilton, Themistocles Protopsaltis, Richard A Hostin, Eric O Klineberg, Douglas C Burton, Robert A Hart, Frank J Schwab, Shay Bess, Christopher I Shaffrey, Christopher P Ames
STUDY DESIGN: Retrospective review OBJECTIVE.: Develop a simplified frailty index for CD patients SUMMARY OF BACKGROUND DATA.: To improve preoperative risk stratification for surgical cervical deformity (CD) patients, a CD frailty index (CD-FI) incorporating 40 health deficits was developed. While novel, the CD-FI is clinically impractical due to the large number of factors needed for its calculation. To increase clinical utility, a simpler, modified CD-FI (mCD-FI) is necessary. METHODS: CD patients (C2-C7 Cobb>10°, CL>10°, cSVA>4 cm, or CBVA>25°) >18yr with preoperative CD-FI component factors...
July 12, 2018: Spine
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