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Gastro esophageal reflux disease

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https://www.readbyqxmd.com/read/27896423/long-term-outcomes-following%C3%A2-h-type-tracheoesophageal-fistula%C3%A2-repair-in-infants
#1
Augusto Zani, Luai Jamal, Giovanni Cobellis, Justyna M Wolinska, Samuel Fung, Evan J Propst, Priscilla P L Chiu, Agostino Pierro
PURPOSE: To evaluate outcomes following repair of H-type tracheoesophageal fistula (TEF). METHODS: Retrospective chart review of infants with H-type TEF treated at our institution between 2000 and 2014. Patient demographics, surgical management, and postoperative function were evaluated. RESULTS: Of the 268 patients with esophageal atresia/TEF treated at our center, 16 (6%) had an H-type TEF (10 males). Thirteen (81%) had associated anomalies...
November 28, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27896401/sleeve-gastrectomy-combined-with-the-simplified-hill-repair-in-the-treatment-of-morbid-obesity-and-gastro-esophageal-reflux-disease-preliminary-results-in-14-patients
#2
Daniel Gero, Lara Ribeiro-Parenti, Konstantinos Arapis, Jean-Pierre Marmuse
BACKGROUND: Our aim is to report our initial experience with a novel technique which addresses morbid obesity and gastro-esophageal reflux disease (GERD) simultaneously by combination of laparoscopic sleeve gastrectomy (LSG) and simplified laparoscopic Hill repair (sLHR). METHODS: Retrospective analysis of LSG+sLHR patients >5 months postoperatively includes demographics, GERD status, proton-pump inhibitor (PPI) use, body mass index (BMI), excess BMI loss (EBMIL), complications and GERD-Health Related Quality of Life (GERD-HRQL) questionnaire...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27862680/the-natural-history-of-gastro-esophageal-reflux-disease-a-comprehensive-review
#3
REVIEW
E Savarino, N de Bortoli, C De Cassan, M Della Coletta, O Bartolo, M Furnari, A Ottonello, E Marabotto, G Bodini, V Savarino
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology...
November 9, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27862259/the-association-between-gastroesophageal-reflux-disease-gerd-with-sleep-quality-depression-and-anxiety-in-a-cohort-study-of-australian-men
#4
Zhi Xiang On, Janet Grant, Zumin Shi, Anne W Taylor, Gary A Wittert, Phillip J Tully, Amie C Hayley, Sean Martin
BACKGROUND & AIM: Previous clinical studies have demonstrated a relationship between gastro-esophageal reflux disease (GERD) with anxiety and depression; however few population-based studies have controlled for sleep disorders. The current study aimed to assess the relationship between GERD and anxiety, depression, and sleep disorders in a community-based sample of Australian men. METHODS: Participants comprised a sub-set of 1,612 men (mean age: 60.7 years, range: 35 - 80) who participated in the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study during the years 2001-2012, who had complete GERD measures [Gastresophageal Reflux Disease Questionnaire (GerdQ)] and were not taking medications known to impact gastrointestinal function (excluding drugs taken for acid-related disorders)...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27855237/insulin-autoimmune-syndrome-a-rare-cause-of-postprandial-hypoglycemia
#5
Pooja Sahni, Nitin Trivedi, Abdulkadir Omer
: A 65-year-old obese Caucasian woman presented with symptomatic postprandial hypoglycemic episodes, resolution of symptoms with carbohydrate intake and significantly elevated anti-insulin antibody levels. She did not have any evidence for the use of oral antidiabetic medications, insulin, herbal substances, performing strenuous exercise or history of bariatric surgery. Fingerstick blood glucose readings revealed blood sugar of 35 mg/dL and 48 mg/dL, when she had these symptoms. Her medical history was significant for morbid obesity, hypothyroidism and gastro esophageal reflux disease...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27800536/gastrointestinal-headache-a-narrative-review
#6
REVIEW
Majid T Noghani, Hossein Rezaeizadeh, Sayed Mohammad Baqer Fazljoo, Mansoor Keshavarz
There are studies reporting primary headaches to be associated with gastrointestinal disorders, and some report resolution of headache following the treatment of the associated gastrointestinal disorder. Headache disorders are classified by The International Headache Society as primary or secondary; however, among the secondary headaches, those attributed to gastrointestinal disorders are not appreciated. Therefore, we aimed to review the literature to provide evidence for headaches, which originate from the gastrointestinal system...
November 2016: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/27784575/the-appropriate-use-of-proton-pump-inhibitors-ppis-need-for-a-reappraisal
#7
REVIEW
Vincenzo Savarino, Pietro Dulbecco, Nicola de Bortoli, Andrea Ottonello, Edoardo Savarino
The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has revolutionized the management of acid-related diseases and has minimized the role of surgery. The major and universally recognized indications for their use are represented by treatment of gastro-esophageal reflux disease, eradication of Helicobacter pylori infection in combination with antibiotics, therapy of H. pylori-negative peptic ulcers, healing and prophylaxis of non-steroidal anti-inflammatory drug-associated gastric ulcers and control of several acid hypersecretory conditions...
October 23, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27759771/late-evaluation-of-patients-operated-for-gastroesophageal-reflux-disease-by-nissen-fundoplication
#8
Maxwel Capsy Boga Ribeiro, Amanda Bueno de Araújo, Juverson Alves Terra-Júnior, Eduardo Crema, Nelson Adami Andreollo
Background: Surgical treatment of GERD by Nissen fundoplication is effective and safe, providing good results in the control of the disease. However, some authors have questioned the efficacy of this procedure and few studies on the long-term outcomes are available in the literature, especially in Brazil. Aim: To evaluate patients operated for gastro-esophageal reflux disease, for at least 10 years, by Nissen fundoplication. Methods: Thirty-two patients were interviewed and underwent upper digestive endoscopy, esophageal manometry, 24 h pH monitoring and barium esophagogram, before and after Nissen fundoplication...
July 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27736035/role-of-non-acid-gastro-esophageal-reflux-in-children-with-respiratory-symptoms
#9
Letizia Zenzeri, Paolo Quitadamo, Renato Tambucci, Dario Ummarino, Antonio Poziello, Erasmo Miele, Annamaria Staiano
OBJECTIVES: Respiratory symptoms are a possible atypical clinical picture of gastro-esophageal reflux disease (GERD). However, a significant number of patients with GERD-related respiratory symptoms do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. The aim of our study is to assess the pH-impedance features of GER inducing airway symptoms, compared with GER inducing typical gastro-intestinal (GI) symptoms...
October 13, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27727466/parents-reported-reduced-symptoms-and-improved-satisfaction-after-fundoplication-and-their-perceptions-were-an-important-outcome-measure
#10
Martina Heinrich, Alexandra Kain, Florian Bergmann, Dietrich von Schweinitz
AIM: Fundoplication is required for children with chronic recurrent gastro-oesophageal reflux disease (GERD). The aim of this study was to report parental perceptions of symptoms and overall satisfaction with the long-term course following fundoplication with special reference to patients with GERD risk factors. METHODS: We studied 34 patients, with a median age of 6.5 ± 4.9 years, who received fundoplication between 2001 and 2005. Clinical information and surgical complications were recorded...
October 11, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27692155/clinical-characteristics-in-patients-with-asymmetric-idiopathic-pulmonary-fibrosis
#11
Sean J Callahan, Meng Xia, Susan Murray, Kevin R Flaherty
BACKGROUND: A group of patients with idiopathic pulmonary fibrosis (IPF) presents with disease affecting one lung markedly more than the other. At this time, it is unclear how this population differs from those who present with more symmetric disease. We sought to explain the characteristics of the asymmetric group and how their disease progresses. METHODS: In this retrospective case-control study we accessed an interstitial lung disease (ILD) database and identified 14 asymmetric IPF cases via high-resolution computed tomography (HRCT) scoring of each lung lobe's disease severity...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27682990/reflux-monitoring-in-children
#12
REVIEW
M M J Singendonk, M A Benninga, M P van Wijk
Recently, multichannel intraluminal impedance (MII) monitoring was added to the repertoire of tests to evaluate the (patho)physiology of gastroesophageal reflux (GER) in children. Its advantage above the sole monitoring of the esophageal pH lies in the ability of the detection of both acid and nonacid GER and to discern between liquid and gas GER. Currently, combined 24 h pH-MII monitoring is recommended for evaluation of gastro-esophageal reflux disease (GERD) and its relation to symptoms in infants and children, despite the lack of reference values in these age groups...
October 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27652174/downward-trend-in-the-prevalence-of-helicobacter-pylori-infections-and-corresponding-frequent-upper-gastrointestinal-diseases-profile-changes-in-southeastern-china-between-2003-and-2012
#13
Jian-Xia Jiang, Qing Liu, Xin-Yi Mao, Hai-Han Zhang, Guo-Xin Zhang, Shun-Fu Xu
This present study aims to determine trends in the prevalence of H. pylori infections in Southeastern China between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. This retrospective study screened 196,442 patients with a mean age of 47.49 ± 14.47 years (age range 5-100 years) in Southeastern China, and a total of 134,812 cases of an endoscopy-referral patient population with digestive symptoms between 2003 and 2012 were enrolled. Based on esophago-gastro-duodenoscopy and pathology, patients diagnosed with chronic gastritis, peptic ulcer, gastric cancer or reflux esophagitis were included in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27644924/-complications-and-reoperations-following-laparoscopic-antireflux-surgery
#14
Örs Péter Horváth, Gábor Varga, Zsanett Biró, András Papp, Laura Bognár, András Vereczkei
Laparoscopic antireflux surgery is an effective treatment for patients with gastro-esophageal reflux disease, when it is refractory to conservative management. In experienced centers the procedure is safe, although complications may develop either during surgery or in the early or late postoperative period, which may necessitate revisional surgery. Between 1998 and 2015 a total of 407 patients underwent laparoscopic antireflux surgery at the Department of Surgery, University of Pécs. This interval was divided into two periods...
September 2016: Magyar Sebészet
https://www.readbyqxmd.com/read/27638345/pneumatosis-intestinalis-during-chemotherapy-with-nilotinib-in-a-patient-with-chronic-myeloid-leukemia-who-tested-positive-for-anti-topoisomerase-i-antibodies
#15
Akihito Fujimi, Hiroki Sakamoto, Yuji Kanisawa, Shinya Minami, Yasuhiro Nagamachi, Naofumi Yamauchi, Soushi Ibata, Junji Kato
A 55-year-old man with several comorbidities including idiopathic interstitial pneumonia under long-term corticosteroid therapy, longstanding myocardial infarction, chronic heart failure, paroxysmal atrial fibrillation, gastro-esophageal reflux disease, constipation, and history of paralytic ileus, was diagnosed with chronic myelogenous leukemia (CML) in the chronic phase. He also tested positive for anti-topoisomerase I antibodies without clinical diagnosis of any connective tissue disease, including systemic sclerosis...
December 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27631208/prevalence-of-chronic-cough-and-possible-causes-in-the-general-population-based-on-the-korean-national-health-and-nutrition-examination-survey
#16
Hyeon-Kyoung Koo, Ina Jeong, Sei Won Lee, Jinkyeong Park, Joo-Hee Kim, So Young Park, Hye Yun Park, Chin Kook Rhee, Yee Hyung Kim, Ji Ye Jung, Sung-Kyoung Kim, Yong Hyun Kim, Eun Young Choi, Ji-Yong Moon, Jong-Wook Shin, Jin Woo Kim, Kyung Hoon Min, Sei Won Kim, Kwang Ha Yoo, Je Hyeong Kim, Seung Hun Jang, Hyoung Kyu Yoon, Hui Jung Kim, Ki-Suck Jung, Deog Kyeom Kim
Although chronic cough is very common, its prevalence and causes have been rarely reported in the large general population including smokers. This study aimed to identify the prevalence of possible causes of chronic cough and their clinical impact.From Korean National Health and Nutrition Examination Survey (KNHANES) data including 119,280 adults aged over 40 years, 302 individuals with chronic cough were recruited irrespective of smoking status. Data from questionnaire, laboratory tests including spirometry, chest radiographs, and otorhinolaryngologic examination were analyzed...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27623934/opportunities-for-preventing-esophageal-adenocarcinoma
#17
John Maret-Ouda, Hashem El-Serag, Jesper Lagergren
Esophageal adenocarcinoma is rapidly increasing in incidence in many Western societies, requires demanding treatment and is associated with a poor prognosis, therefore preventive measures are highly warranted. To assess the opportunities for prevention, we reviewed the available literature and identified seven main potentially preventive targets. Preventive effects were found based on medium level observational evidence following treatment of gastroesophageal reflux disease (both using medication and surgery) and tobacco smoking cessation, which should be clinically recommended among exposed patients...
September 13, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27598861/ilaprazole-for-the-treatment-of-gastro-esophageal-reflux
#18
Edoardo Savarino, Andrea Ottonello, Irene Martinucci, Pietro Dulbecco, Vincenzo Savarino
INTRODUCTION: Despite the undoubted benefit of proton pump inhibitors (PPIs), they have several shortcomings, such as a slow onset of action and a remarkable inter-individual variability, that limit the complete success of these drugs. Recently, a new PPI, ilaprazole, has been developed and used in GERD patients. AREAS COVERED: The present review provides an update on the following points: current knowledge of GERD mechanisms; limitations of actual therapies; pharmacokinetic profile and metabolism of ilaprazole; initial studies on the therapeutic efficacy of ilaprazole in GERD...
October 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27577963/proton-pump-inhibitor-monotherapy-and-the-risk-of-cardiovascular-events-in-patients-with-gastro-esophageal-reflux-disease-a-meta-analysis
#19
S Sun, Z Cui, M Zhou, R Li, H Li, S Zhang, Y Ba, G Cheng
BACKGROUND AND PURPOSE: Proton pump inhibitors (PPIs) are commonly used as potent gastric acid secretion antagonists for gastro-esophageal disorders and their overall safety in patients with gastro-esophageal reflux disease (GERD) is considered to be good and they are well-tolerated. However, recent studies have suggested that PPIs may be a potential independent risk factor for cardiovascular adverse events. The aim of our meta-analysis was to examine the association between PPI monotherapy and cardiovascular events in patients with GERD...
August 30, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27574989/esomeprazole-immediate-release-tablets-gastric-mucosa-ex-vivo-permeation-absorption-and-antisecretory-activity-in-conscious-rats
#20
Camillo Benetti, Lisa Flammini, Valentina Vivo, Paolo Colombo, Gaia Colombo, Lisa Elviri, Carmelo Scarpignato, Francesca Buttini, Ruggero Bettini, Elisabetta Barocelli, Alessandra Rossi
The aim of this work was to study the esomeprazole activity on the control of gastric secretion after administration of a novel immediate release tablet. The ex vivo permeation of esomeprazole across porcine gastric mucosa from immediate release tablets, containing sodium carbonate or magnesium oxide as alkalinizing agents, was firstly assessed. Pharmacokinetics and pharmacodynamics studies in conscious rats following the administration of immediate release tablets with sodium carbonate, in comparison with delayed-release tablets having the same formula, were also conducted...
October 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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