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Irritable bowel syndrome, ibs, functional dyspepsia

Nicola Poloni, Marta Ielmini, Ivano Caselli, Francesca Ceccon, Lucia Bianchi, Celeste Isella, Camilla Callegari
Introduction: "Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. Materials and Methods: This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Socio-demographic and clinical variables were evaluated: gender, age, diagnosis or diagnostic hypothesis, presence of psychiatric comorbidities, psychiatric evaluation, pharmacological treatment, number of admissions/visits...
2018: Frontiers in Psychiatry
Vladimir Ivashkin, Arkady Sheptulin, Oleg Shifrin, Elena Poluektova, Chavdar Pavlov, Konstantin Ivashkin, Alexandra Drozdova, Olga Lyashenko, Alexandr Korolev
BACKGROUND AND AIM: physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the '7x7' questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of functional gastrointestinal disorders, using the Clinical Global Impressions scale as the reference standard. METHODS: fifty inpatients aged from 18 to 64 with a confirmed diagnosis of irritable bowel syndrome (26 patients, 52%), functional dyspepsia (15 patients, 30%) or both (9 patients, 18%) were prospectively enrolled in the study...
November 21, 2018: Journal of Gastroenterology and Hepatology
Renato Tambucci, Paolo Quitadamo, Michela Ambrosi, Paola De Angelis, Giulia Angelino, Stefano Stagi, Albero Verrotti, Annamaria Staiano, Giovanni Farello
OBJECTIVE: Although emerging data indicate that obese/overweight children are more likely to develop functional gastrointestinal disorders (FGIDs) than normal-weight peers, contrasting results have been reported. The present observational, case-control study aimed at estimating the prevalence of FGIDs in obese/overweight children compared to normal-weight peers. METHODS: Consecutive obese and overweight children aged 4-18 years attending the obesity outpatient clinic were enrolled as study cases...
November 15, 2018: Journal of Pediatric Gastroenterology and Nutrition
Grace Burns, Georgia Carroll, Andrea Mathe, Jay Horvat, Paul Foster, Marjorie M Walker, Nicholas J Talley, Simon Keely
BACKGROUND: Subtle histopathologic features such as eosinophilia and increased mast cells have been observed in functional gastrointestinal disorders (FGIDs), including functional dyspepsia (FD) and the irritable bowel syndrome (IBS). The mechanisms that drive recruitment of these cells to the gastrointestinal tract remain unexplained, largely due to the heterogeneity in phenotypes among patients diagnosed with such conditions. We aimed to systematically review the literature and collate the evidence for immune activation in FD and IBS, and where possible, detail the nature of activation...
November 14, 2018: American Journal of Gastroenterology
Nicola de Bortoli, Salvatore Tolone, Marzio Frazzoni, Irene Martinucci, Giulia Sgherri, Eleonora Albano, Linda Ceccarelli, Cristina Stasi, Massimo Bellini, Vincenzo Savarino, Edoardo V Savarino, Santino Marchi
Several studies have indicated an overlap between gastroesophageal reflux disease (GERD) and various functional gastrointestinal disorders (FGIDs). The overlapping conditions reported have mainly been functional dyspepsia (FD) and irritable bowel syndrome (IBS). The available literature is frequently based on symptomatic questionnaires or endoscopic procedures to diagnose GERD. Rarely, among patients with heartburn, pathophysiological evaluations have been considered to differentiate those with proven GERD from those without...
November 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Moritz von Wulffen, Nicholas J Talley, Johann Hammer, Jessica McMaster, Graeme Rich, Ayesha Shah, Natasha Koloski, Bradley J Kendall, Mike Jones, Gerald Holtmann
BACKGROUND: According to Rome IV criteria, functional dyspepsia (FD) and irritable bowel syndrome (IBS) are distinct functional gastrointestinal disorders (FGID); however, overlap of these conditions is common in population-based studies, but clinical data are lacking. AIMS: To determine the overlap of FD and IBS in the clinical setting and define risk factors for the overlap of FD/IBS. METHODS: A total of 1127 consecutive gastroenterology outpatients of a tertiary center were recruited and symptoms assessed with a standardized validated questionnaire...
October 27, 2018: Digestive Diseases and Sciences
Shravan Kumar Porika, Krishna Chaitanya Veligandla, Shashi Kanth Muni, Shivani Acharya, Suyog C Mehta, Akhilesh D Sharma
INTRODUCTION: Functional dyspepsia (FD) is a highly prevalent condition which reduces patients' quality of life (QoL) and imparts a significant economic burden on the healthcare system. Acotiamide is a novel prokinetic agent useful in treatment of FD, and this study evaluated the effectiveness of acotiamide hydrochloride hydrate in management of FD over a 4-week period in a real-world setting. METHODS: This study was a prospective, observational, real-world data collection of 132 patients (85 male, 47 female) over 18 years of age diagnosed with FD as per Rome III criteria and treated with acotiamide for 4 weeks at a gastroenterology unit of a medical school in India...
October 22, 2018: Advances in Therapy
Ivana Trivić, Iva Hojsak
Purpose: The aim of this study was to describe functional gastrointestinal disorders (FGID) presented in a tertiary medical center, characteristics of patients and results of the diagnostic work-up together with an outcome during the follow up. Methods: This was a retrospective, single center, observational study including all patients who were diagnosed with FGID based on Rome III criteria from January to December 2015 in tertiary medical center. Results: Overall 294 children were included (mean age, 8...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
Kichul Yoon, Nayoung Kim, Ju Yup Lee, Dong Hyun Oh, A Young Seo, Chang Yong Yun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
BACKGROUND/AIMS: Abdominal bloating is a troublesome complaint due to insufficient understanding of the pathophysiology. The aim of this study was to evaluate the efficacy of rifaximin in reducing bloating associated with functional gastrointestinal disorders (FGIDs). METHODS: A total of 63 patients were treated with rifaximin for FGIDs with bloating or gas-related symptoms between 2007 and 2013 at Seoul National University Bundang Hospital. Rifaximin was administered at a dose between 800 mg/day and 1,200 mg/day for 5 to 14 days...
September 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Larry Miller, Aydin Farajidavar, Anil Vegesna
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for >40% of patients seen in gastroenterology clinics and affect >20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail...
September 24, 2018: Cold Spring Harbor Perspectives in Medicine
Åsa V Keita, Johan D Söderholm
The intestinal mucosa is constantly exposed to harmful luminal content, and uptake is closely controlled and regulated by neuro-immune factors. If control is broken, it might lead to ongoing enhanced mucosal permeability, potentially resulting in functional gastrointestinal disorders. The importance of mast cells in the regulation of the mucosal barrier has become obvious, and increased numbers and more activated mast cells have been observed in irritable bowel syndrome, functional dyspepsia and gastroesophageal reflux disease...
September 11, 2018: Current Opinion in Pharmacology
Wei-Yi Lei, Wei-Chuan Chang, Ming-Wun Wong, Jui-Sheng Hung, Shu-Hui Wen, Chih-Hsun Yi, Tso-Tsai Liu, Jiann-Hwa Chen, Ching-Sheng Hsu, Tsung-Cheng Hsieh, Chien-Lin Chen
BACKGROUND/AIMS: We aimed to investigate gastrointestinal symptoms, clinical characteristics, and psychological factors in subjects with and without sleep disturbance (SD) in a health screening cohort. METHODS: We enrolled 2,752 consecutive subjects during their health checkups. All participants underwent an evaluation with questionnaires. Demographic characteristics and biochemical data were recorded. SD was confirmed when Pittsburgh Sleep Quality Index score was greater than 5...
September 4, 2018: Digestion
M Masudur Rahman, Uday Chand Ghoshal, Shamima Sultana, Md Golam Kibria, Nigar Sultana, Zeenat Arefin Khan, Faruque Ahmed, Mahmud Hasan, Tahmeed Ahmed, Shafiqul Alam Sarker
BACKGROUND: Postinfection irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD), though reported from the temperate countries, have not been studied in the tropics; PI-malabsorption syndrome (MAS), which mimics PI-IBS, is reported from the tropics. No report till date on PI-IBS excluded PI-MAS. We studied: (i) the frequency of continuing bowel dysfunction after acute gastroenteritis (AG), (ii) its predictors, and (iii) PI-MAS among patients with PI-IBS. METHODS: 345 consecutive subjects each, with AG and age- and gender-matched healthy controls were followed up 3-monthly for 12 months using a translated-validated questionnaire and functional gastrointestinal disorders (FGIDs) were diagnosed by Rome III criteria...
August 31, 2018: American Journal of Gastroenterology
Zahid Hussain, Da Hyun Jung, Young Ju Lee, Hyojin Park
Background/Aims: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing diarrhea-dominant IBS, however its effect on overlap syndrome (OS) patients has not been reported. Therefore, we investigated the effect of trimebutine on the model of OS in guinea pigs. Methods: Male guinea pigs were used to evaluate the effects of trimebutine in corticotropin-releasing factor (CRF) induced OS model...
October 1, 2018: Journal of Neurogastroenterology and Motility
Rabia Miray Kisla Ekinci, Sibel Balcı, Okkes Ozgur Mart, Gokhan Tumgor, Sibel Yavuz, Halil Celik, Dilek Dogruel, Derya Ufuk Altintas, Mustafa Yilmaz
Henoch-Schönlein purpura (HSP), the most common childhood vasculitis is characterized by non-thrombocytopenic palpable purpura, arthritis/arthralgia, abdominal pain and renal involvement. Functional gastrointestinal disorders (FGIDs) are heterogeneous disease spectrum with unclear etiology and include the most common subtypes: functional dyspepsia, irritable bowel syndrome (IBS), functional abdominal pain and functional constipation. Formerly, FGIDs were known as non-organic disorders; however, recent advances revealed that low-grade inflammation may also play a role...
August 12, 2018: Rheumatology International
Ruben J Colman, Neal Bryan S Rosario, Analydia Gutierrez Bonilla, Gabriela Benavidez Alvarez, Joel Benavidez Alvarez, Vincent P Uy, Paulo R Pina, David H Rubin
OBJECTIVE: Functional gastrointestinal (GI) disorders (FGIDs), such as irritable bowel syndrome, functional abdominal pain and dyspepsia, are common causes of chronic GI symptoms in children. Prior studies found high comorbidity of FGID and asthma. This study aimed to assess the prevalence and comorbidities of FGID among pediatric patients with asthma at a university-affiliated urban community hospital. METHODS: This prospective, cross-sectional study assessed FGID prevalence, asthma control and symptoms of anxiety among pediatric patients with persistent asthma...
August 9, 2018: Journal of Digestive Diseases
Sarah Ballou, Eaman Alhassan, Elise Hon, Cara Lembo, Vikram Rangan, Prashant Singh, William Hirsch, Thomas Sommers, Johanna Iturrino, Judy Nee, Anthony Lembo
BACKGROUND: Poor sleep quality is common among patients with gastrointestinal (GI) disorders. However, few studies have assessed the presence of insomnia or reported circadian preferences and none have directly compared sleep between common GI conditions. AIMS: To compare clinical sleep characteristics in patients presenting to a tertiary care GI clinic for irritable bowel syndrome (IBS), functional dyspepsia (FD), inflammatory bowel disease (IBD), gastroesophageal reflux disease (GERD), and celiac disease (CD)...
November 2018: Digestive Diseases and Sciences
Craig Friesen, Meenal Singh, Vivekanand Singh, Jennifer V Schurman
Headaches and abdominal pain are among the most common pediatric pain conditions. Mast cells have been implicated in the pathophysiology of migraines, as well as functional dyspepsia (FD) and irritable bowel syndrome (IBS). The primary aims of the current study were to assess headache prevalence in patients with FD and to assess the association between headaches and mucosal mast cells and eosinophils. An additional aim was to explore associations of headache with other symptoms.We conducted a cross-sectional retrospective chart review of 235 consecutive patients with chronic abdominal pain...
July 2018: Medicine (Baltimore)
F W Ismail, S Abid, S Awan, F Lubna
BACKGROUND AND STUDY AIMS: Food hypersensitivity (FH), irritable bowel syndrome (IBS) and functional dyspepsia (FD) have many overlapping symptoms, including abdominal discomfort, bloating, and altered bowel habits. We aimed to determine the frequency of FH in patients with IBS and functional FD. PATIENTS AND METHODS: Adult patients of either gender diagnosed with IBS and/or FD as per the Rome III criteria were recruited. Patients underwent serological testing against 6 food allergens: beef, shrimp, egg white, milk, peanut, and soy-bean...
April 2018: Acta Gastro-enterologica Belgica
P Enck, N Mazurak
While it is generally accepted that gastrointestinal infections can cause functional disturbances in the upper and lower gastrointestinal tract-known as postinfectious irritable bowel syndrome (PI-IBS) and functional dyspepsia (PI-FD)-it has still not been widely recognized that such an infection can also initiate functional non-intestinal diseases, and that non-intestinal infections can provoke both intestinal and non-intestinal functional disturbances. We conducted a scoping review of the respective literature and-on the basis of these data-hypothesize that medically unexplained functional symptoms and syndromes following an infection may have a biological (genetic, endocrine, microbiological) origin, and that psychological and social factors, which may contribute to the disease "phenotype," are secondary to this biological cause...
June 28, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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