Read by QxMD icon Read

Muscle volume MRI

Mark J Hamilton, John McLean, Sarah Cumming, Bob Ballantyne, Josephine McGhie, Ravi Jampana, Cheryl Longman, Jonathan J Evans, Darren G Monckton, Maria Elena Farrugia
Background: Central nervous system involvement in myotonic dystrophy type 1 (DM1) is associated with cognitive deficits, impaired social performance and excessive somnolence, which greatly impact quality of life. With the advent of clinical trials in DM1, there is a pressing need to identify outcome measures for quantification of central symptoms that are feasible and valid. In this context, we sought to evaluate neuropsychological and self-reported measures currently recommended by expert consensus, with particular reference to their specificity for central nervous system involvement in a moderate-sized DM1 cohort...
2018: Frontiers in Neurology
Olimpia Musumeci, Silvia Marino, Francesca Granata, Rosa Morabito, Lilla Bonanno, Teresa Brizzi, Viviana Lo Buono, Francesco Corallo, Marcello Longo, Antonio Toscano
BACKGROUND: Late Onset Pompe Disease (LOPD) is a rare, multisystem disorder, that is well established to mainly impair skeletal muscle function. Systematic studies exploring brain functions in LOPD are lacking. Aim of this study is to detect morphological and functional brain alterations as well as neuropsychological impairment in LOPD. MATERIALS AND METHODS: We studied 21 patients (10M, 11F, mean-age 49±18,4years), with defined diagnosis of LOPD, divided in two groups: one with presymptomatic hyperCKemia with no muscle weakness and the second with Limb-Girdle Muscle Weakness (LGMW group)...
October 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Zhen Xing, Hongjie Huang, Zebin Xiao, Xiefeng Yang, Yu Lin, Dairong Cao
OBJECTIVE: With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity. MATERIALS AND METHODS: This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed...
October 11, 2018: Skeletal Radiology
I Kalina, A Tóth, É Valcseva, P N Kaposi, N Ács, S Várbíró, V Bérczi
AIM: To evaluate the prognostic value of pretreatment pelvic magnetic resonance imaging (MRI) features in uterine artery embolisation (UAE) for symptomatic fibroids. MATERIALS AND METHODS: MRI characteristics of 109 fibroids (≥3 cm) in 70 patients were analysed retrospectively. Imaging was performed 1.8±1.3 (SD) months before and 6.6±1.8 months after UAE. On pretreatment images, signal intensity (SI) of fibroids was compared with that of the myometrium and skeletal muscle on T1- and T2-weighted sequences; the contrast enhancement pattern and localisation of fibroids were also analysed...
October 8, 2018: Clinical Radiology
Vincent Koppelmans, Jessica M Scott, Meghan E Downs, Kaitlin E Cassady, Peng Yuan, Ofer Pasternak, Scott J Wood, Yiri E De Dios, Nichole E Gadd, Igor Kofman, Roy Riascos, Patricia A Reuter-Lorenz, Jacob J Bloomberg, Ajitkumar P Mulavara, Lori L Ploutz-Snyder, Rachael D Seidler
PURPOSE: Spaceflight negatively affects sensorimotor behavior; exercise mitigates some of these effects. Head down tilt bed rest (HDBR) induces body unloading and fluid shifts, and is often used to investigate spaceflight effects. Here, we examined whether exercise mitigates effects of 70 days HDBR on the brain and if fitness and brain changes with HDBR are related. METHODS: HDBR subjects were randomized to no-exercise (n = 5) or traditional aerobic and resistance exercise (n = 5)...
2018: PloS One
Savio G Barreto, Ilse Dirkzwager, John A Windsor, Sanjay Pandanaboyana
BACKGROUND: Post-operative pancreatic fistulae (POPF) remain a major contributor to morbidity and mortality following pancreatic resection. Evidence for preoperative prediction of POPF based on cross-sectional imaging has not been systemically reviewed. This review aimed to determine whether preoperative imaging modalities can accurately predict the development of POPF. METHODS: A systematic review of major reference databases was undertaken, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, up to May 2018...
October 10, 2018: ANZ Journal of Surgery
Fitz-Roy E Curry, Torfinn Taxt, Cecilie Brekke Rygh, Tina Pavlin, Ronja Bjørnestad, Stein Ove Døskeland, Rolf K Reed
AIM: Epac1-/- mice, but not Epac2-/- mice have elevated baseline permeability to albumin. This study extends investigations of how Epac dependent pathways modulate transvascular exchange in response to the classical inflammatory agent histamine. It also evaluates limitations of models of blood-to-tissue exchange in transgenic mice in DCE-MRI measurements. METHODS: We measured DCE-MRI signal intensity in masseter muscle of wt and Epac1-/- mice with established approaches from capillary physiology to determine how changes in blood flow and vascular permeability contribute to overall changes of microvascular flux...
October 9, 2018: Acta Physiologica
Lena Trinh, Pernilla Peterson, Håkan Brorson, Sven Månsson
BACKGROUND: In patients with arm or leg lymphedema, more fat has been found in the epifascial compartment of the edematous limb compared to the healthy limb. However, not much is known about subfascial fat accumulation in these patients. This study aims to investigate the intramuscular and intermuscular fat and muscle/water volume in lymphedema patients. The excess of intramuscular and intermuscular fat volume was also compared to the excess epifascial fat volume, the excess limb volume, and the duration of lymphedema...
October 6, 2018: Lymphatic Research and Biology
Ellankavi Ramasamy, Okan Avci, Beate Dorow, Sook-Yee Chong, Leonardo Gizzi, Günter Steidle, Fritz Schick, Oliver Röhrle
The lack of an efficient modelling-simulation-analysis workflow for creating and utilising detailed subject-specific computational models is one of the key reasons why simulation-based approaches for analysing socket-stump interaction have not yet been successfully established. Herein, we propose a novel and efficient modelling-simulation-analysis workflow that uses commercial software for generating a detailed subject-specific, three-dimensional finite element model of an entire residual limb from Diffusion Tensor MRI images in <20 min...
2018: Frontiers in Bioengineering and Biotechnology
Hans C Dreyer, Erin C Owen, Lisa A Strycker, Keith Smolkowski, Jonathan B Muyskens, Tessa K Kirkpatrick, Anita D Christie, Kerry S Kuehl, Brick A Lantz, Steven N Shah, Craig G Mohler, Brian A Jewett
Background: Substantial muscle atrophy occurs after total knee arthroplasty (TKA), resulting in decreased strength and impaired mobility. We sought to determine whether perioperative supplementation with essential amino acids (EAA) would attenuate muscle atrophy following TKA and whether the supplements were safe for ingestion in an older surgical population. Methods: We performed a double-blind, placebo-controlled, randomized trial of 39 adults (age range, 53 to 76 years) undergoing primary unilateral TKA who ingested 20 g of EAA (n = 19) or placebo (n = 20) twice daily for 7 days preoperatively and for 6 weeks postoperatively...
June 28, 2018: JB & JS open access
Kayla Md Cornett, Elizabeth Wojciechowski, Amy D Sman, Terri Walker, Manoj P Menezes, Paula Bray, Mark Halaki, Joshua Burns
INTRODUCTION: Biomarkers of disease severity in Charcot-Marie-Tooth disease (CMT) are required to evaluate early responses to treatment. The study aimed to evaluate the relationship between muscle volume and intramuscular fat accumulation by magnetic resonance imaging (MRI) and weakness, disability and impaired gait in affected children and adolescents. METHODS: 55 participants underwent MRI of the anterior compartment of the lower leg. Muscle and fat volumes were calculated...
September 28, 2018: Muscle & Nerve
Takashi Abe, Scott J Dankel, Samuel L Buckner, Matthew B Jessee, Kevin T Mattocks, J Grant Mouser, Zachary W Bell, Jeremy P Loenneke
OBJECTIVES: To investigate the skeletal muscle mass to fat-free mass (SM-FFM) ratio in female and male athletes, as well as to examine the relationship between ultrasound predicted SM and magnetic resonance imaging (MRI)-measured SM. METHODS: Seven female track and field athletes (Female), 8 male collegiate swimmers (Male-G1) and 8 male collegiate Olympic weightlifters (Male-G2) volunteered. Whole-body SM volume was measured using MRI images obtained from the first cervical vertebra to the ankle joints...
September 27, 2018: Journal of Sports Medicine and Physical Fitness
Víctor Illera-Domínguez, Sergi Nuell, Gerard Carmona, Josep M Padullés, Xavier Padullés, Mario Lloret, Roser Cussó, Xavier Alomar, Joan A Cadefau
Purpose: To assess early changes in muscle function and hypertrophy, measured as increases in muscle cross-sectional areas (CSAs) and total volume, over a 4 weeks inertial resistance training (RT) program. Methods: Ten young RT-naive volunteers (age 23.4 ± 4.1 years) underwent 10 training sessions (2-3 per week) consisting of five sets of 10 flywheel squats (moment of inertia 900 kg⋅cm2 ). Magnetic resonance imaging (MRI) scans of both thighs were performed before (PRE), and after 2 (IN) and 4 (POST) weeks of training to compute individual muscle volumes and regional CSAs...
2018: Frontiers in Physiology
Joseph L Demer, Robert A Clark
We employed magnetic resonance imaging (MRI) to quantify human extraocular muscle contractility during centered target fusion, and fusional divergence repeated with each eye viewing monocularly at 20 cm through 8Δ, and at 400 cm through 4Δ base in prism. Contractility, indicated by posterior partial volume (PPV) change, was analyzed in transverse rectus and in medial and lateral superior oblique (SO) muscle compartments, and by cross sectional area change in the inferior oblique (IO). At 20 cm, 3.1±0.5° (SEM) diverging eye abduction in 10 subjects was associated with 4...
September 19, 2018: Journal of Neurophysiology
Faes D Kerkhof, Timo van Leeuwen, Evie E Vereecke
How changes in anatomy affect joint biomechanics can be studied using musculoskeletal modelling, making it a valuable tool to explore joint function in healthy and pathological joints. However, gathering the anatomical, geometrical and physiological data necessary to create a model can be challenging. Very few integrated datasets exist and even less raw data is openly available to create new models. Therefore, the goal of the present study is to create an integrated digital forearm and make the raw data available via an open-access database...
September 17, 2018: Journal of Anatomy
Alexandra Grimm, Heiko Meyer, Marcel D Nickel, Mathias Nittka, Esther Raithel, Oliver Chaudry, Andreas Friedberger, Michael Uder, Wolfgang Kemmler, Klaus Engelke, Harald H Quick
BACKGROUND: Changes in muscle fat composition as for example observed in sarcopenia or muscular dystrophy affect physical performance and muscular function, like strength and power. The purpose of the present study is to measure the repeatability of Dixon magnetic resonance imaging (MRI) for assessing muscle volume and fat in the thigh. Furthermore, repeatability of magnetic resonance spectroscopy (MRS) for assessing muscle fat is determined. METHODS: A prototype 6-point Dixon MRI method was used to measure muscle volume and muscle proton density fat fraction (PDFF) in the left thigh...
September 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
Ismail Turkmen, Guray Altun
PURPOSE: The aim of this study was to determine the effect of changes in deltoid muscle volume (DMV) on the clinical outcomes of patients who underwent arthroscopic repair due to chronic rotator cuff rupture. METHODS: A total of 54 patients (35 females, 19 males) between 40 and 70 years of age who underwent single-row arthroscopic repair due to chronic rotator cuff tears were compared via preoperative (preop) and postoperative (postop) (6-12 months) magnetic resonance imaging (MRI) to determine the total DMV (tDMV)...
September 8, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Joshua Burns, Amy D Sman, Kayla M D Cornett, Elizabeth Wojciechowski, Terri Walker, Manoj P Menezes, Melissa R Mandarakas, Kristy J Rose, Paula Bray, Hugo Sampaio, Michelle Farrar, Kathryn M Refshauge, Jacqueline Raymond
BACKGROUND: Exercise is potentially therapeutic for neuromuscular disorders, but a risk of harm exists due to overwork weakness. We aimed to assess the safety and efficacy of progressive resistance exercise for foot dorsiflexion weakness in children with Charcot-Marie-Tooth disease. METHODS: We did this randomised, double-blind, sham-controlled trial across the Sydney Children's Hospitals Network (NSW, Australia). Children aged 6-17 years with Charcot-Marie-Tooth disease were eligible if they had foot dorsiflexion weakness (negative Z score based on age-matched and sex-matched normative reference values)...
October 2017: Lancet Child & Adolescent Health
Jian-Zhong Lin, Guang-Dong Shi, Hong-Fei Wu, Hong-Bo Yu, He-Tong Zhou, Xin Hu, Hao Wang
Objective: To investigate the diagnosis and treatment of ejaculatory duct cyst. METHODS: This study included 2 male patients present at the hospital for hemospermia and abnormal sensation in the perineal region in July and August 2014. Both underwent transrectal ultrasonography, routine semen examination, CT, MRI, cystoscopy, and vesiculography before transurethral fenestration of the cysts and pathological examination of the cyst wall specimens. Analyses were made on the clinical presentations, imaging features, pathological characteristics, differential diagnosis and treatment of ejaculatory duct cyst and relevant literature was reviewed...
March 2018: Zhonghua Nan Ke Xue, National Journal of Andrology
Lorenzo Ball, Anja Braune, Peter Spieth, Moritz Herzog, Karthikka Chandrapatham, Volker Hietschold, Marcus J Schultz, Nicolò Patroniti, Paolo Pelosi, Marcelo Gama de Abreu
Background: Computed tomography is the gold standard for lung aeration assessment, but exposure to ionizing radiation limits its application. We assessed the ability of magnetic resonance imaging (MRI) to detect changes in lung aeration in ex vivo isolated swine lung and the potential of translation of the findings to human MRI scans. Methods: We performed MRI scans in 11 isolated non-injured and injured swine lungs, as well as 6 patients both pre- and post-operatively. Images were obtained using a 1.5 T MRI scanner, with T1 - weighted volumetric interpolated breath-hold examination (VIBE) and T2 - weighted half-Fourier acquisition single-shot turbo spin-echo (HASTE) sequences...
2018: Frontiers in Physiology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"