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Muscle volume MRI

Yan-Yan Zhang, Chao-Xu Zhang, Yu Li, Xuan Jiang, Yong-Fang Wang, Yang Sun, Jun Wang, Wan-Ying Ji, Yi Liu
AIM: To develop a novel rat model of heterogeneous hepatic injury. METHODS: Seventy male Sprague-Dawley rats were randomly divided into a control group ( n = 10) and a colchicine group ( n = 60). A 0.25% colchicine solution (0.4 mL/kg) was injected via the splenic vein in the colchicine group to develop a rat model of heterogeneous hepatic injury. An equal volume of normal saline was injected via the splenic vein in the control group. At days 3, 7, and 14 and weeks 4, 8, and 12 after the operation, at least seven rats of the colchicine group were selected randomly for magnetic resonance imaging (MRI) examinations, and then they were euthanized...
November 28, 2018: World Journal of Gastroenterology: WJG
Christelle Pons, Bhushan Borotikar, Marc Garetier, Valérie Burdin, Douraied Ben Salem, Mathieu Lempereur, Sylvain Brochard
AIMS: The aim of this study was to report the metrological qualities of techniques currently used to quantify skeletal muscle volume and 3D shape in healthy and pathological muscles. METHODS: A systematic review was conducted (Prospero CRD42018082708). PubMed, Web of Science, Cochrane and Scopus databases were searched using relevant keywords and inclusion/exclusion criteria. The quality of the articles was evaluated using a customized scale. RESULTS: Thirty articles were included, 6 of which included pathological muscles...
2018: PloS One
M Noorkoiv, N Theis, G Lavelle
INTRODUCTION: Muscle volume (MV) is an important parameter for understanding muscle morphology and adaptations to training, growth and pathology. In this study, we assessed the validity of freehand 3D ultrasound (3DUS) for measuring medial gastrocnemius MV in adults, typically developing children (TD) and children with cerebral palsy (CP). We also assessed the validity between our direct measures of MV and estimates derived from anatomical cross sectional area (ACSA) and muscle length (ML), using previously outlined methods...
November 27, 2018: Clinical Anatomy
Reza Farjam, Neelam Tyagi, Joseph O Deasy, Margie A Hunt
PURPOSE: To investigate the potential of an atlas-based approach in generation of synthetic CT for pelvis anatomy. METHODS: Twenty-three matched pairs of computed tomography (CT) and magnetic resonance imaging (MRI) scans were selected from a pool of prostate cancer patients. All MR scans were preprocessed to reduce scanner- and patient-induced intensity inhomogeneities and to standardize their intensity histograms. Ten (training dataset) of 23 pairs were then utilized to construct the coregistered CT-MR atlas...
November 26, 2018: Journal of Applied Clinical Medical Physics
Davide Ippolito, Anna Pecorelli, Simone Famularo, Davide Bernasconi, Eleonora Benedetta Orsini, Alessandro Giani, Fabrizio Romano, Cammillo Talei Franzesi, Sandro Sironi
AIM: To assess the efficacy of signal intensity in interstitial and hepatobiliary phase normalized for liver volume, on gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) study, for the evaluation of liver function through the comparison with Child-Pugh (CP), model for end-stage liver disease (MELD), and biochemical tests. METHODS: All dynamic Gd-EOB-DTPA MRI studies performed in patients with suspected liver lesions were retrospectively reviewed...
November 8, 2018: Abdominal Radiology
Willeke A Traa, Mark C van Turnhout, Kevin M Moerman, Jules L Nelissen, Aart J Nederveen, Gustav J Strijkers, Dan L Bader, Cees W J Oomens
Pressure ulcers occur due to sustained mechanical loading. Deep tissue injury is a severe type of pressure ulcer, which is believed to originate in subcutaneous tissues adjacent to bony prominences. In previous experimental-numerical studies the relationship between internal tissue state and damage development was investigated using a 2D analysis. However, recent studies suggest that a local analysis is not sufficient. In the present study we developed a method to create animal-specific 3D finite element models of an indentation test on the tibialis anterior muscle of rats based on MRI data...
November 6, 2018: Computer Methods in Biomechanics and Biomedical Engineering
Abir Massaad, Ayman Assi, Ziad Bakouny, Aren Joe Bizdikian, Wafa Skalli, Ismat Ghanem
Lower limb (LL) muscle morphology and growth are altered in children with cerebral palsy (CP). Muscle alterations differ with age and with severity of motor impairment, classified according to the gross motor classification system (GMFCS). Muscle alterations differ also with orthopedic intervention, frequently performed at the level of the shank muscles since an early age, such as the gastrocnemius. The aim was to investigate the alterations of treatment-naïve pelvis and thigh muscle lengths and volumes in children with GMFCS levels I and II, of varying ages...
October 27, 2018: Journal of Biomechanics
Christopher Grunseich, Ram Miller, Therese Swan, David J Glass, Mohamed El Mouelhi, Mara Fornaro, Olivier Petricoul, Igor Vostiar, Ronenn Roubenoff, Matthew N Meriggioli, Angela Kokkinis, Robert D Guber, Maher S Budron, John Vissing, Gianni Soraru, Tahseen Mozaffar, Albert Ludolph, John T Kissel, Kenneth H Fischbeck
BACKGROUND: Spinal and bulbar muscular atrophy is an X-linked neuromuscular disease caused by CAG repeat expansion in the androgen receptor gene. Patients with this disease have low concentrations of insulin-like growth factor-1 (IGF-1), and studies of overexpression and administration of IGF-1 showed benefit in a transgenic model; thus the IGF-1 pathway presents as a potential treatment target. We assessed safety, tolerability, and preliminary efficacy of BVS857, an IGF-1 mimetic, in patients with spinal and bulbar muscular atrophy...
October 15, 2018: Lancet Neurology
Mark J Hamilton, John McLean, Sarah Cumming, Bob Ballantyne, Josephine McGhie, Ravi Jampana, Cheryl Longman, Jonathan J Evans, Darren G Monckton, Maria Elena Farrugia
Background: Central nervous system involvement in myotonic dystrophy type 1 (DM1) is associated with cognitive deficits, impaired social performance and excessive somnolence, which greatly impact quality of life. With the advent of clinical trials in DM1, there is a pressing need to identify outcome measures for quantification of central symptoms that are feasible and valid. In this context, we sought to evaluate neuropsychological and self-reported measures currently recommended by expert consensus, with particular reference to their specificity for central nervous system involvement in a moderate-sized DM1 cohort...
2018: Frontiers in Neurology
Olimpia Musumeci, Silvia Marino, Francesca Granata, Rosa Morabito, Lilla Bonanno, Teresa Brizzi, Viviana Lo Buono, Francesco Corallo, Marcello Longo, Antonio Toscano
BACKGROUND: Late Onset Pompe Disease (LOPD) is a rare, multisystem disorder, that is well established to mainly impair skeletal muscle function. Systematic studies exploring brain functions in LOPD are lacking. Aim of this study is to detect morphological and functional brain alterations as well as neuropsychological impairment in LOPD. MATERIALS AND METHODS: We studied 21 patients (10M, 11F, mean-age 49±18,4years), with defined diagnosis of LOPD, divided in two groups: one with presymptomatic hyperCKemia with no muscle weakness and the second with Limb-Girdle Muscle Weakness (LGMW group)...
October 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Zhen Xing, Hongjie Huang, Zebin Xiao, Xiefeng Yang, Yu Lin, Dairong Cao
OBJECTIVE: With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity. MATERIALS AND METHODS: This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed...
October 11, 2018: Skeletal Radiology
I Kalina, A Tóth, É Valcseva, P N Kaposi, N Ács, S Várbíró, V Bérczi
AIM: To evaluate the prognostic value of pretreatment pelvic magnetic resonance imaging (MRI) features in uterine artery embolisation (UAE) for symptomatic fibroids. MATERIALS AND METHODS: MRI characteristics of 109 fibroids (≥3 cm) in 70 patients were analysed retrospectively. Imaging was performed 1.8±1.3 (SD) months before and 6.6±1.8 months after UAE. On pretreatment images, signal intensity (SI) of fibroids was compared with that of the myometrium and skeletal muscle on T1- and T2-weighted sequences; the contrast enhancement pattern and localisation of fibroids were also analysed...
October 9, 2018: Clinical Radiology
Vincent Koppelmans, Jessica M Scott, Meghan E Downs, Kaitlin E Cassady, Peng Yuan, Ofer Pasternak, Scott J Wood, Yiri E De Dios, Nichole E Gadd, Igor Kofman, Roy Riascos, Patricia A Reuter-Lorenz, Jacob J Bloomberg, Ajitkumar P Mulavara, Lori L Ploutz-Snyder, Rachael D Seidler
PURPOSE: Spaceflight negatively affects sensorimotor behavior; exercise mitigates some of these effects. Head down tilt bed rest (HDBR) induces body unloading and fluid shifts, and is often used to investigate spaceflight effects. Here, we examined whether exercise mitigates effects of 70 days HDBR on the brain and if fitness and brain changes with HDBR are related. METHODS: HDBR subjects were randomized to no-exercise (n = 5) or traditional aerobic and resistance exercise (n = 5)...
2018: PloS One
Savio G Barreto, Ilse Dirkzwager, John A Windsor, Sanjay Pandanaboyana
BACKGROUND: Post-operative pancreatic fistulae (POPF) remain a major contributor to morbidity and mortality following pancreatic resection. Evidence for preoperative prediction of POPF based on cross-sectional imaging has not been systemically reviewed. This review aimed to determine whether preoperative imaging modalities can accurately predict the development of POPF. METHODS: A systematic review of major reference databases was undertaken, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, up to May 2018...
October 10, 2018: ANZ Journal of Surgery
Fitz-Roy E Curry, Torfinn Taxt, Cecilie Brekke Rygh, Tina Pavlin, Ronja Bjønrstad, Stein Ove Døskeland, Rolf K Reed
AIM: Epac1-/- mice, but not Epac2-/- mice have elevated baseline permeability to albumin. This study extends the investigations of how Epac-dependent pathways modulate transvascular exchange in response to the classical inflammatory agent histamine. It also evaluates the limitations of models of blood-to-tissue exchange in transgenic mice in DCE-MRI measurements. METHODS: We measured DCE-MRI signal intensity in masseter muscle of wt and Epac1-/- mice with established approaches from capillary physiology to determine how changes in blood flow and vascular permeability contribute to overall changes of microvascular flux...
October 9, 2018: Acta Physiologica
Lena Trinh, Pernilla Peterson, Håkan Brorson, Sven Månsson
BACKGROUND: In patients with arm or leg lymphedema, more fat has been found in the epifascial compartment of the edematous limb compared to the healthy limb. However, not much is known about subfascial fat accumulation in these patients. This study aims to investigate the intramuscular and intermuscular fat and muscle/water volume in lymphedema patients. The excess of intramuscular and intermuscular fat volume was also compared to the excess epifascial fat volume, the excess limb volume, and the duration of lymphedema...
October 6, 2018: Lymphatic Research and Biology
Ellankavi Ramasamy, Okan Avci, Beate Dorow, Sook-Yee Chong, Leonardo Gizzi, Günter Steidle, Fritz Schick, Oliver Röhrle
The lack of an efficient modelling-simulation-analysis workflow for creating and utilising detailed subject-specific computational models is one of the key reasons why simulation-based approaches for analysing socket-stump interaction have not yet been successfully established. Herein, we propose a novel and efficient modelling-simulation-analysis workflow that uses commercial software for generating a detailed subject-specific, three-dimensional finite element model of an entire residual limb from Diffusion Tensor MRI images in <20 min...
2018: Frontiers in Bioengineering and Biotechnology
Hans C Dreyer, Erin C Owen, Lisa A Strycker, Keith Smolkowski, Jonathan B Muyskens, Tessa K Kirkpatrick, Anita D Christie, Kerry S Kuehl, Brick A Lantz, Steven N Shah, Craig G Mohler, Brian A Jewett
Background: Substantial muscle atrophy occurs after total knee arthroplasty (TKA), resulting in decreased strength and impaired mobility. We sought to determine whether perioperative supplementation with essential amino acids (EAA) would attenuate muscle atrophy following TKA and whether the supplements were safe for ingestion in an older surgical population. Methods: We performed a double-blind, placebo-controlled, randomized trial of 39 adults (age range, 53 to 76 years) undergoing primary unilateral TKA who ingested 20 g of EAA (n = 19) or placebo (n = 20) twice daily for 7 days preoperatively and for 6 weeks postoperatively...
June 28, 2018: JB & JS open access
Kayla Md Cornett, Elizabeth Wojciechowski, Amy D Sman, Terri Walker, Manoj P Menezes, Paula Bray, Mark Halaki, Joshua Burns
INTRODUCTION: Biomarkers of disease severity in Charcot-Marie-Tooth disease (CMT) are required to evaluate early responses to treatment. The study aimed to evaluate the relationship between muscle volume and intramuscular fat accumulation by magnetic resonance imaging (MRI) and weakness, disability and impaired gait in affected children and adolescents. METHODS: 55 participants underwent MRI of the anterior compartment of the lower leg. Muscle and fat volumes were calculated...
September 28, 2018: Muscle & Nerve
Takashi Abe, Scott J Dankel, Samuel L Buckner, Matthew B Jessee, Kevin T Mattocks, J Grant Mouser, Zachary W Bell, Jeremy P Loenneke
OBJECTIVES: To investigate the skeletal muscle mass to fat-free mass (SM-FFM) ratio in female and male athletes, as well as to examine the relationship between ultrasound predicted SM and magnetic resonance imaging (MRI)-measured SM. METHODS: Seven female track and field athletes (Female), 8 male collegiate swimmers (Male-G1) and 8 male collegiate Olympic weightlifters (Male-G2) volunteered. Whole-body SM volume was measured using MRI images obtained from the first cervical vertebra to the ankle joints...
September 27, 2018: Journal of Sports Medicine and Physical Fitness
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