Vorthon Sawaswong, Prangwalai Chanchaem, Pavit Klomkliew, Suwatchareeporn Rotcheewaphan, Suthirote Meesawat, Taratorn Kemthong, Mutchamon Kaewparuehaschai, Kirana Noradechanon, Monya Ekatat, Reka Kanitpun, Prapaporn Srilohasin, Saradee Warit, Angkana Chaiprasert, Suchinda Malaivijitnond, Sunchai Payungporn
Tuberculosis (TB) is an infectious disease caused by the Mycobacterium tuberculosis complex (Mtbc), which develops from asymptomatic latent TB to active stages. The microbiome was purposed as a potential factor affecting TB pathogenesis, but the study was limited. The present study explored the association between gut-pharyngeal microbiome and TB stages in cynomolgus macaques using the full-length 16S rDNA amplicon sequencing based on Oxford Nanopore Technologies. The total of 71 macaques was divided into TB (-) control, TB (+) latent and TB (+) active groups...
February 10, 2024: Scientific Reports