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https://www.readbyqxmd.com/read/30121936/timp-1-promotes-oligodendrocyte-differentiation-through-receptor-mediated-signaling
#1
Alexandra M Nicaise, Kasey M Johnson, Cory M Willis, Rosa M Guzzo, Stephen J Crocker
The extracellular protein tissue inhibitor of metalloproteinase (TIMP)-1 is both a matrix metalloproteinase (MMP) inhibitor and a trophic factor. Mice lacking TIMP-1 exhibit delayed central nervous system myelination during postnatal development and impaired remyelination following immune-mediated injury in adulthood. We have previously determined that the trophic action of TIMP-1 on oligodendrocyte progenitor cells (OPCs) to mature into oligodendrocytes is independent of its MMP inhibitory function. However, the mechanism by which TIMP-1 promotes OPC differentiation is not known...
August 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30121903/the-arbuscular-mycorrhizal-fungus-rhizophagus-irregularis-mucl-41833-increases-the-phosphorus-uptake-and-biomass-of-medicago-truncatula-a-benzo-a-pyrene-tolerant-plant-species
#2
Maryline Calonne-Salmon, Katia Plouznikoff, Stéphane Declerck
The accumulation of phosphorus (P) in plants increases their biomass and resistance/tolerance to organic pollutants. Both characteristics are mandatory for the utilization of plants in phytoremediation. Arbuscular mycorrhizal (AM) fungi improve plant P nutrition, and thus growth. However, only a few studies have focused on the dynamics of inorganic P (Pi) uptake in AM fungal-colonized plants in the presence of organic pollutants. Indeed, most of the results so far were obtained after harvesting the plants, thus by evaluating P concentration and content at a single time point...
August 18, 2018: Mycorrhiza
https://www.readbyqxmd.com/read/30121899/fusobacterium-nucleatum-promotes-m2-polarization-of-macrophages-in-the-microenvironment-of-colorectal-tumours-via-a-tlr4-dependent-mechanism
#3
Ting Chen, Qing Li, Jiao Wu, Yaxin Wu, Wei Peng, Huan Li, Jianmei Wang, Xiaowei Tang, Yan Peng, Xiangsheng Fu
Fusobacterium nucleatum (Fn) has been shown to promote colorectal cancer (CRC) development by inhibiting host anti-tumour immunity. However, the impact of Fn infection on macrophage polarization and subsequent intestinal tumour formation as well as the underlying molecular pathways has not been investigated. We investigated the impact of Fn infection on macrophage polarization in human CRCs and cultured macrophages as well as the effects on macrophage phenotype and intestinal tumour formation in ApcMin/+ mice...
August 18, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/30121877/behavioral-trajectories-during-middle-childhood-differential-effects-of-the-school-wide-positive-behavior-support-model
#4
Mari-Anne Sørlie, Thormod Idsoe, Terje Ogden, Asgeir Røyrhus Olseth, Torbjørn Torsheim
The aims of this study were to assess the longitudinal trajectories of externalizing problem behavior during middle childhood among typically developing children and to examine subgroup differences in the effectiveness of the School-Wide Positive Behavior Support (SWPBS) model, called N-PALS in Norway. Participants were approximately 3000 students, and behavioral assessments were performed by class head teachers at four time points from the 4th or 5th grade through the 7th grade. Using a combination of latent class growth analyses (LCGA) and growth mixture modeling (GMM), four distinct trajectory classes were identified, i...
August 18, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/30121803/presence-of-anaerobic-bacteria-in-the-urinary-tract-of-catheterized-icu-patients
#5
Keren Lee Rozenfeld, Orna Nitzan, Avi Peretz
The purpose of our study was to examine the extent of anaerobic bacteriuria in catheterized patients in the intensive care unit (ICU) and to search for risk factors for anaerobic bacteriuria. A urine culture was collected from each patient every 2 days during their ICU stay and incubated under aerobic and anaerobic conditions. Aerobic and anaerobic blood cultures were collected as well. Demographic, clinical, and laboratory data were collected from patient files. Ninety patients were included in this study, 32 women (35...
August 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30121779/influence-of-human-induced-pressures-on-dissolved-and-particulate-metal-concentrations-in-a-south-american-estuary
#6
Noelia S La Colla, Sandra E Botté, Vanesa L Negrin, Analía V Serra, Jorge E Marcovecchio
Coastal areas are urbanized and industrialized environments, affected by dredging operations, discharges of untreated municipal wastewaters, and farming. Developing countries are in continuous growth and will deal, in a close future, with the highest rate of coastal transformation, posing serious risks for the ecological and environmental value of ecosystem assets. This research aims to study the dissolved and particulate Cr, Ni, Pb and Zn values within an argentinean estuarine environment which is currently under human-induced pressures...
August 18, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/30121547/embryotropic-effects-of-vascular-endothelial-growth-factor-on-porcine-embryos-produced-by-in-vitro-fertilization
#7
Dibyendu Biswas, Kyoung Ha So, Seon Ung Hwang, Junchul David Yoon, Mirae Kim, Dae Young Kim, Sang Hwan Hyun
Current research suggests that supplementing in vitro culture (IVC) media with vascular endothelial growth factor (VEGF) may have beneficial effects on the development of porcine embryos in vitro. However, the molecular signaling mechanisms underlying this effect are unclear. Therefore, we aimed to investigate the effects of VEGF on molecular signaling events during in vitro embryonic development of porcine embryos. Porcine oocytes matured in vitro were fertilized, and the resultant zygotes were cultured with 5 ng/mL of VEGF supplemented with or without fetal bovine serum from day 4 till day 7...
August 16, 2018: Theriogenology
https://www.readbyqxmd.com/read/30121527/the-effects-of-elevated-fibroblast-growth-factor-23-on-mandibular-growth-in-rats
#8
Yanan Wu, Jinkai Zhang, Fengshan Chen
OBJECTIVE: The aim of this study is to elucidate the local effects of fibroblast growth factor 23 (FGF23) in on mandibular condylar growth in growing rats. DESIGN: Growing Sprague-Dawley rats received intra-temporomandibular joint injections of phosphate buffer solution (PBS), adenovirus-mediated green fluorescent protein (Ad-GFP) or adenovirus-mediated fibroblast growth factor 23 (Ad-FGF23), which were marked as groups A, B, and C, respectively. In vitro, we treated rat mandibular cartilage chondrocytes with PBS, Ad-GFP, and Ad-FGF23...
August 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30121512/phytotoxicity-and-bioaccumulation-of-zinc-oxide-nanoparticles-in-rice-oryza-sativa-l
#9
Jing Chen, Runzhi Dou, Zhongzhou Yang, Tingting You, Xiang Gao, Li Wang
This work focused on the toxicity evaluation of ZnO NPs and their uptake and transportation in a significant crop plant, Rice (Oryza sativa L.). Under hydroponic condition, 25, 50 and 100 mg/L ZnO NPs could inhibit the growth of rice seedlings by reducing their biomass comparing with Zn2+ (13.82 mg/L) treatment and the control. In addition, physiological index was determined, involving the decrease of the chlorophyll content, which was further confirmed by the down-regulation of photosynthetic pigment related genes...
August 14, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30121494/mmb-triazole-analogs-are-potent-nf-%C3%AE%C2%BAb-inhibitors-and-anti-cancer-agents-against-both-hematological-and-solid-tumor-cells
#10
Venumadhav Janganati, Jessica Ponder, Meenakshisundaram Balasubramaniam, Poornima Bhat-Nakshatri, Eli E Bar, Harikrishna Nakshatri, Craig T Jordan, Peter A Crooks
Triazole derivatives of melampomagnolide B (MMB) have been synthesized via click chemistry methodologies and screened against a panel of 60 human cancer cell lines. Several derivatives showed promising anti-cancer activity, affording growth inhibition (GI50 ) values in the nanomolar range (GI50  = 0.02-0.99 μM). Lead compound 7h exhibited EC50 values of 400 nM and 700 nM, respectively, against two AML clinical specimens. Compound 7h was significantly more potent than parthenolide as an inhibitor of p65 phosphorylation in both hematological and solid tumor cell lines, indicating its ability to inhibit the NF-κB pathway...
August 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30121426/fluoropolymers-for-intracellular-and-in-vivo-protein-delivery
#11
Jia Lv, Bingwei He, Jingwen Yu, Yitong Wang, Changping Wang, Song Zhang, Hui Wang, Jingjing Hu, Qiang Zhang, Yiyun Cheng
The design of efficient and universal carriers to transport proteins into cells is highly desirable in the development of biotherapeutics. However, intracellular protein delivery remains a major challenge owing to the multiple barriers in protein delivery process, such as protein encapsulation, endocytosis, endosomal escape and intracellular protein release. Recently, it was reported that fluorination on polymers is beneficial for their self-assembly and intracellular trafficking. We hypothesize the fluoropolymers can be used to encapsulate proteins and developed as a new class of carriers to break down the barriers during intracellular protein delivery...
August 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/30121393/an-integrative-analysis-of-transcriptome-and-epigenome-features-of-ascl1-positive-lung-adenocarcinomas
#12
Naoya Miyashita, Masafumi Horie, Hiroshi I Suzuki, Masahito Yoshihara, Dijana Djureinovic, Johan Persson, Hans Brunnström, Cecilia Lindskog, Hedvig Elfving, Patrick Micke, Akira Saito, Takahide Nagase
A subgroup of lung adenocarcinoma shows neuroendocrine differentiation and expression of achaete-scute complex homolog 1 (ASCL1), common to high-grade neuroendocrine tumors, small cell lung cancer and large cell neuroendocrine carcinoma. The aim of this study was to characterize clinical and molecular features of ASCL1-positive lung adenocarcinoma by utilizing recent transcriptome profiling in multiple patient cohorts and genome-wide epigenetic profiling including data from The Cancer Genome Atlas (TCGA). The ASCL1-positive subtype of lung adenocarcinoma developed preferentially in current or former smokers and usually did not harbor epidermal growth factor receptor (EGFR) mutations...
August 16, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/30121374/fabrication-of-heterogeneous-porous-bilayered-nanofibrous-vascular-grafts-by-two-step-phase-separation-technique
#13
Weizhong Wang, Wei Nie, Xiaojun Zhou, Wei Feng, Liang Chen, Qianqian Zhang, Zhengwei You, Qiusheng Shi, Chen Peng, Chuanglong He
Innterconnected porous architecture is critical for tissue engineering scaffold as well as biomimetic nanofibrous structure. In addition, a paradigm shift is recently taking place in the scaffold design from homogeneous porous scaffold to heterogeneous porous scaffold for the complex tissues. In this study, a versatile and simple one-pot method, dual phase separation, is developed to fabricate macroporous nanofibrous scaffold by phase separating the mixture solutions of immiscible polymer blends without using porogens...
August 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/30121372/recurrent-rttn-mutation-leading-to-severe-microcephaly-polymicrogyria-and-growth-restriction
#14
Mara Cavallin, Amandine Bery, Camille Maillard, Laurent J Salomon, Christine Bole, Madeline Louise Reilly, Patrick Nitschké, Nathalie Boddaert, Nadia Bahi-Buisson
Autosomal recessive missense Rotatin (RTTN) mutations are responsible for syndromic forms of malformation of cortical development, ranging from isolated polymicrogyria to microcephaly associated with primordial dwarfism and other major malformations. We identified, by trio based whole exome sequencing, a homozygous missense mutation in the RTTN gene (c.2953A > G; p.(Arg985Gly)) in one Moroccan patient from a consanguineous family. The patient showed early onset primary microcephaly, detected in the fetal period, postnatal growth restriction, encephalopathy with hyperkinetic movement disorders and self-injurious behavior with sleep disturbance...
August 16, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/30121312/delivery-of-superparamagnetic-polymeric-micelles-loaded-with-quercetin-to-hepatocellular-carcinoma-cells
#15
Korawith Srisa-Nga, Samlee Mankhetkorn, Siriporn Okonogi, Ruttiros Khonkarn
The aim of this study was to develop co-encapsulation of quercetin (QCT) and superparamagnetic iron oxide nanoparticles (SPIONs) into methoxy-poly(ethylene glycol)-b-oligo(ɛ-caprolactone), mPEG750-b-OCL-Bz micelles (QCT-SPIONs-loaded micelles) for inhibition of hepatitis B virus-transfected hepatocellular carcinoma (HepG2.2.15) cell growth. QCT-SPIONs-loaded micelles were prepared using film hydration method. They were spherical in shape with average size of 22-55 nm. The best QCT-SPIONs-loaded micelles showed entrapment efficiency and loading capacity of QCT at 70% and 3...
August 16, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/30121012/deletion-of-the-t-box-transcription-factor-gene-tbx1-in-mice-induces-differential-expression-of-genes-associated-with-cleft-palate-in-humans
#16
Noriko Funato, Hiromi Yanagisawa
OBJECTIVE: We examined the function of the T-box transcription factor 1 (TBX1) in palatogenesis. DESIGN: Tbx1-knockout mice were histologically examined by hematoxylin and eosin staining. Next, secondary palatal shelves dissected from wild type or Tbx1-knockout mice embryos at embryonic day 13.5 were investigated with microarray analysis, gene ontology analysis, and real-time quantitative polymerase chain reaction. We performed gene profiling of developing palatal shelves from wild type and Tbx1-knockout embryos...
August 9, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/30121008/tumor-cell-autonomous-ron-receptor-expression-promotes-prostate-cancer-growth-under-conditions-of-androgen-deprivation
#17
Nicholas E Brown, Andrew M Paluch, Madison A Nashu, Kakajan Komurov, Susan E Waltz
Current treatment strategies provide minimal results for patients with castration-resistant prostate cancer (CRPC). Attempts to target the androgen receptor have shown promise, but resistance ultimately develops, often due to androgen receptor reactivation. Understanding mechanisms of resistance, including androgen receptor reactivation, is crucial for development of more efficacious CRPC therapies. Here, we report that the RON receptor tyrosine kinase is highly expressed in the majority of human hormone-refractory prostate cancers...
August 14, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/30120980/functional-role-of-peroxiredoxin-6-in-the-eye
#18
REVIEW
Stephen Wahlig, Matthew Lovatt, Jodhbir S Mehta
Peroxiredoxin 6 (Prdx6) is the only mammalian 1-Cys member of the Prdx family, a group of enzymes which share the ability to reduce peroxides. In addition to its peroxidase function, Prdx6 also demonstrates phospholipase A2 and lysophosphatidylcholine acyl transferase (LPCAT) activities. These enzymatic activities play an important role in regenerating oxidized membrane phospholipids and maintaining an appropriate balance of intracellular reactive oxygen species. Development of clinical pathologies, including those within the eye, have been linked to dysregulation of Prdx6 function...
August 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/30120975/long-non-coding-rna-linc01617-promotes-proliferation-and-metastasis-of-esophageal-cancer-cells-through-akt-pathway
#19
Dan Zhang, Wei Yang, Shuwei Wang, Fei Wang, Dayong Liu, Jingjing Dong, Nan Zhao, Yunye Wang, Haiyan Zhang
OBJECTIVE: To investigate the clinical significance of long non-coding RNA LINC01617 in esophageal cancer and explore the effect of LINC01617 on the proliferation and metastasis of esophageal cancer cells. METHODS: Real time fluorescence PCR was used to detect the expression of LINC01617 in 142 cases of esophageal cancer and adjacent tissues. The relationship between the expression level of LINC01617 and the survival rate of esophageal cancer patients was analyzed...
August 15, 2018: Gene
https://www.readbyqxmd.com/read/30120860/lncrna-fendrr-mediates-vegfa-to-promote-the-apoptosis-of-brain-microvascular-endothelial-cells-via-regulating-mir-126-in-mice-with-hypertensive-intracerebral-hemorrhage
#20
Baizhuo Dong, Zhigang Sun, Bin Zhou, Shengming Huang, Liang Han, Honghua Nie, Guohui Chen, Shibing Liu, Yanna Zhang, Ning Bao, Xiaolong Yang, Hongwei Feng
BACKGROUND: LncRNA-FENDRR is a kind of endothelial genes critical for vascular development. Moreover, miR-126 and vascular endothelial growth factor A (VEGFA) are also involved in the physiological process of vascular endothelial cells. This study aimed to the underlying mechanism of FENDRR involving miR-126 and VEGFA in hypertensive intracerebral hemorrhage (HICH). METHODS: C57BL/6 mice were chosen to establish HICH model. The expression of FENDRR, miR-126 and VEGFA at mRNA level were determined by qRT-PCR...
August 18, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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