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https://www.readbyqxmd.com/read/30326469/gab2-ablation-reverses-the-stemness-of-her2-overexpressing-breast-cancer-cells
#1
Peng Zhang, Yiying Chen, Miaomiao Gong, Zhumei Zhuang, Yueyue Wang, Lin Mu, Tianjiao Wang, Jinjin Pan, Yanan Liu, Jianming Xu, Rui Liang, Yuhui Yuan
BACKGROUND/AIMS: HER2 has been implicated in mammary tumorigenesis as well as aggressive tumor growth and metastasis. Its overexpression is related to a poor prognosis and chemoresistance in breast cancer patients. Although Grb2-associated binding protein 2 (Gab2) is important in the development and progression of human cancer, its effects and mechanisms in HER2-overexpressing breast cancer are unclear. METHODS: Clone formation and MTT assays were used to examine cell proliferation...
October 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30326434/integrative-analysis-of-pectin-methylesterase-pme-and-pme-inhibitors-in-tomato-solanum-lycopersicum-identification-tissue-specific-expression-and-biochemical-characterization
#2
Ho Young Jeong, Hong Phuong Nguyen, Seok Hyun Eom, Chanhui Lee
Although previous studies have demonstrated that the degree of demethylesterification of pectin polysaccharides is modulated during tomato fruit ripening, its involvement in vegetative organ development has been seldom investigated. As a first step in understanding the importance of pectin modification during vegetative stages, we used chemical, biochemical, and molecular approaches to analyze PMEs and PMEIs in tomato plants. We found that tomato cell walls isolated from vegetative tissues as well as the fruit contain substantial quantities of pectin, and different degrees of methylesterification were evident in different tissues...
October 9, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30326377/ldl-apheresis-to-decrease-sflt-1-during-early-severe-preeclampsia-report-of-two-cases-from-a-discontinued-phase-ii-trial
#3
Bassam Haddad, Guillaume Lefèvre, Alexandra Rousseau, Thomas Robert, Samir Saheb, Cedric Rafat, Marie Bornes, Camille Petit-Hoang, Frédéric Richard, Edouard Lecarpentier, Vassilis Tsatsaris, Jean Guibourdenche, Anthony Corchia, Eric Rondeau, Tabassome Simon, Alexandre Hertig
OBJECTIVE: Severe preeclampsia may require the delivery of the placenta to avoid life-threatening complications for the mother. Before 26 weeks of gestation, this often results in perinatal death. A decrease in soluble fms-like tyrosine kinase 1 (sFlt1), an anti-angiogenic factor central to the pathophysiology of the maternal syndrome, has been reported after LDL- apheresis. The present study tested whether LDL-apheresis could be used to allow women with early and severe preeclampsia to reach a gestational age where the baby had a viable chance of survival...
September 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/30326371/computer-aided-drug-discovery-of-myc-max-inhibitors-as-potential-therapeutics-for-prostate-cancer
#4
Lavinia A Carabet, Nada Lallous, Eric Leblanc, Fuqiang Ban, Helene Morin, Sam Lawn, Fariba Ghaidi, Joseph Lee, Ian G Mills, Martin E Gleave, Paul S Rennie, Artem Cherkasov
While Myc is an essential regulator of growth in normal cells, it is also frequently associated with cancer progression, therapy-resistance and lethal outcomes in most human cancers. In prostate cancer (PCa), Myc transcription factors are implicated in the pathogenesis and progression of the full spectrum of PCa, from adenocarcinoma to advanced castration-resistant and neuroendocrine phenotypes. Though a high-value therapeutic target, clinically approved anti-Myc drugs have yet to be discovered. To elicit its oncogenic effects, Myc must form a heterodimer with its partner Max, which together bind DNA and activate transcription of a spectrum of target genes that promote cell growth, proliferation, metabolism, and apoptosis while blocking differentiation...
September 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/30326333/fast-growing-willows-significantly-reduce-invasive-knotweed-spread
#5
Fanny Dommanget, André Evette, Vincent Breton, Nathan Daumergue, Olivier Forestier, Philippe Poupart, François-Marie Martin, Marie-Laure Navas
Competitive interactions seem to play a major role in invasive plant success. However, they have mostly been addressed through the invader impacts on other species of the plant community and rarely through the way plant communities can contain alien species. Understanding such mechanisms would help in designing restoration projects using plant community competitive properties to control invasive populations. In this study, we looked at the role of competitive interactions in the success of Fallopia japonica (Houtt...
October 13, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/30326275/gold-nanobranched-shell-based-drug-vehicles-with-ultrahigh-photothermal-efficiency-for-chemo-photothermal-therapy
#6
Yanping Liu, Xuwu Zhang, Liyao Luo, Lei Li, Rui Yan Zhu, Anshuo Li, Yuchu He, Weiwei Cao, Kang Niu, Huan Liu, Jingyue Yang, Dawei Gao
Development of combined chemo-photothermal nanoplatform is of great interest for enhancing antitumor efficacy. Herein, a multifunctional drug delivery system was synthesized based on gold-nanobranched coated betulinic acid liposomes (GNBS-BA-Lips) for chemo-photothermal synergistic therapy. In this system, GNBS-BA-Lips exhibited broad near-infrared (NIR) absorption, preferable photothermal response and good photostability under NIR irradiation. Importantly, the gold-nanobranched nanostructure possessed high photothermal conversion efficiency (η=55...
October 13, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/30326253/stabilization-of-mirnas-in-esophageal-cancer-contributes-to-radioresistance-and-limits-efficacy-of-therapy
#7
REVIEW
Akshay Malhotra, Uttam Sharma, Shyamly Puhan, Naga Chandra Bandari, Anjali Kharab, P P Arifa, Lovlesh Thakur, Hridayesh Prakash, Karen M Vasquez, Aklank Jain
The five-year survival rate of esophageal cancer patients is less than 20%. This may be due to increased resistance (acquired or intrinsic) of tumor cells to chemo/radiotherapies, often caused by aberrant cell cycle, deregulated apoptosis, increases in growth factor signaling pathways, and/or changes in the proteome network. In addition, deregulation in non-coding RNA-mediated signaling pathways may contribute to resistance to therapies. At the molecular level, these resistance factors have now been linked to various microRNA (miRNAs), which have recently been shown to control cell development, differentiation and neoplasia...
October 13, 2018: Biochimie
https://www.readbyqxmd.com/read/30326162/interventions-for-preventing-and-treating-cardiac-complications-in-duchenne-and-becker-muscular-dystrophy-and-x-linked-dilated-cardiomyopathy
#8
REVIEW
John P Bourke, Teofila Bueser, Rosaline Quinlivan
BACKGROUND: The dystrophinopathies include Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and X-linked dilated cardiomyopathy (XLDCM). In recent years, co-ordinated multidisciplinary management for these diseases has improved the quality of care, with early corticosteroid use prolonging independent ambulation, and the routine use of non-invasive ventilation signficantly increasing survival. The next target to improve outcomes is optimising treatments to delay the onset or slow the progression of cardiac involvement and so prolong survival further...
October 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30326046/incidence-and-early-course-of-retinopathy-of-prematurity-secondary-analysis-of-the-postnatal-growth-and-retinopathy-of-prematurity-g-rop-study
#9
Graham E Quinn, Gui-Shuang Ying, Edward F Bell, Pamela K Donohue, David Morrison, Lauren A Tomlinson, Gil Binenbaum
Importance: The current guidelines for retinopathy of prematurity (ROP) detection programs in the United States include a range of birth weights (BWs) and gestational ages and likely require examinations of many premature infants who are at low risk for developing serious retinopathy. Objective: To determine the incidence, onset, and early course of ROP in what to our knowledge is the largest cohort to date that is representative of infants who are undergoing ROP screening...
September 20, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/30325750/nicu-discharge-feeding-bundle-improves-accuracy-of-postdischarge-feeding-preparation-and-potentially-prevents-readmission
#10
Kimberly Vollrath, Adam Rosenberg, Lisbeth Gabrielski, Jane Deacon, Susan Marshall, Andrew Rihn, Theresa Grover
BACKGROUND: Hospitalized infants often need fortified human milk and formulas for growth in the neonatal intensive care unit and postdischarge. Parents must learn how to properly mix infant feedings.At the initial Children's Hospital Colorado follow-up visit, baseline data revealed a 50% rate of mixing inaccuracy of discharge feeding recipes and identified the readmission of 2 infants with life-threatening hypernatremia. A gap in discharge teaching was identified. A quality improvement project was implemented at 2 affiliated neonatal intensive care units...
October 15, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/30325734/thyroid-dysfunction-in-children-with-leukemia-over-the-first-year-after-hematopoietic-stem-cell-transplantation
#11
Yoon-Ji Lee, Hyun Young Lee, Moon Bae Ahn, Seong-Koo Kim, Won Kyoung Cho, Jae-Wook Lee, Nack-Gyun Chung, Bin Cho, Byung-Kyu Suh
Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0.8-21.8) years old] were reviewed retrospectively. Results In children with leukemia, T3 decreased at 1 month (p<0.001) and recovered 9 months to the levels before HSCT. TSH decreased at 1 month (p<0.001), recovered at 3 months and increased at 12 months (p<0...
October 16, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30325569/rapid-establishment-of-a-flowering-cline-in-medicago-polymorpha-after-invasion-of-north-america
#12
Emily E Helliwell, Joshua Faber-Hammond, Zoie C Lopez, Aaron Garoutte, Eric von Wettberg, Maren L Friesen, Stephanie S Porter
To establish and spread in a new location, an invasive species must be able to carry out its life cycle in novel environmental conditions. A key trait underlying fitness is the shift from vegetative to reproductive growth through floral development. In this study, we used a common garden experiment and genotyping-by-sequencing to test whether the latitudinal flowering cline of the North American invasive plant Medicago polymorpha was translocated from its European native range through multiple introductions, or whether the cline rapidly established due to evolution following a genetic bottleneck...
October 16, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/30325501/mifepristone-mediates-anti-proliferative-effect-on-ovarian-mesenchymal-stem-stromal-cells-from-female-brca-1-2-carriers
#13
Sakthivignesh Ponandai-Srinivasan, Parameswaran G Lalitkumar, Laura Garcia, Suby Jo Varghese, Joseph W Carlson, Kristina Gemzell-Danielsson, Angelique Floter Radestad
INTRODUCTION: Women with hereditary mutation in breast cancer associated genes (BRCA1-/2- ) have higher lifetime risk for developing ovarian cancer. Here, we aimed to investigate the effect of mifepristone, a selective progesterone receptor modulator on ovarian mesenchymal stem/stromal cells (MSC) from BRCA1-/2- carriers. MATERIAL AND METHODS: Ovarian BRCA1-/2- MSC were positively selected using markers CD90, CD73 and CD105 from nine healthy women. Effect of dose response and combination treatment with mifepristone and analogues of progesterone- or glucocorticoid- receptors were investigated on BRCA1-/2- MSC in vitro using panel of markers for proliferation (ki67, BrdU, CDK2, p21CIP ), apoptosis (BAX, BCL2, CASPASE3), tumor suppression (TP53, PTEN) and cell survival (PI3KCA, MAPK3,mTOR)...
October 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30325439/the-role-of-transposable-elements-in-the-evolution-of-aluminum-resistance-in-plants
#14
Jorge F Pereira, Peter R Ryan
Aluminium (Al) toxicity can severely reduce root growth and consequently affect plant development and yield. A widespread mechanism by which many species resist the toxic effects of Al relies on the efflux of organic anions (OA) from the root apices via OA transporters. Several of the genes encoding these OA transporters contain transposable elements (TEs) in the coding sequences or in flanking regions. Some of the TE-induced mutations impact Al resistance by modifying the level and/or location of gene expression so that OA efflux from the roots is increased...
October 16, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/30325408/liver-tumorigenesis-is-promoted-by-a-high-saturated-fat-diet-specifically-in-male-mice-and-is-associated-with-hepatic-expression-of-the-proto-oncogene-agap2-and-enrichment-of-the-intestinal-microbiome-with-coprococcus
#15
Kim B Pedersen, Casey F Pulliam, Aarshvi Patel, Fabio Del Piero, Tatiane T N Watanabe, Umesh D Wankhade, Kartik Shankar, Chindo Hicks, Martin J Ronis
Liver cancer results in a high degree of mortality, especially among men. Since fatty liver disease is a risk factor for development of hepatocellular carcinoma, we investigated the role of dietary fat type in tumor promotion by high fat diets in mice after initiation with the chemical carcinogen diethyl nitrosamine. Tumor incidence and multiplicity was significantly greater in males than in females. In males, fat type had complex effects on tumorigenesis. Preneoplastic foci were most prevalent in mice fed a polyunsaturated fat diet enriched in docosahexaenoic acid (DHA), while carcinomas and large visible liver tumors were significantly greater in mice fed a saturated fat diet made with cocoa butter relative to mice fed mono- or polyunsaturated fats...
October 16, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/30325394/graphene-oxide-silver-nanocomposites-modulate-biofilm-formation-and-extracellular-polymeric-substance-eps-production
#16
Shima Liu, Shuting Cao, Jingyang Guo, Liqiang Luo, Yi Zhou, Chenglie Lin, Jiye Shi, Chunhai Fan, Min Lv, Lihua Wang
Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of an antibacterial graphene oxide-silver nanoparticles (GO-AgNPs) composite on Pseudomonas aeruginosa biofilm formation. We found that GO-AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 μg mL-1...
October 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/30325154/effects-of-vertically-rotary-sub-soiling-tillage-on-water-utilization-and-yield-of-potato-in-semi-arid-area-of-northwest-china
#17
Xu Cheng Zhang, Yi Fan Ma, Xian Feng Yu, Hui Zhi Hou, Hong Li Wang, Yan Jie Fang
To examine the effects of vertically rotary sub-soiling tillage (VRT) on stage water consumption, individual and population development, yield, water use efficiency, and economic profit of potato is helpful to find the optimized tillage method which could increase crop drought-resistant, yield, and resource use efficiency. With randomized block design, the field experiment involved in three treatments, 1) vertically rotary sub-soiling tillage for 40 cm depth (VRT), 2) deep loosing tillage for 40 cm (DLT), and 3) rotary tillage for 15 cm (TT)...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/30325149/regulatory-effects-of-bundled-straw-covering-on-winter-wheat-yield-and-soil-thermal-moisture-utilization-in-dryland
#18
Chang Gang Yang, Shou Xi Chai
Bundled straw covering (BSC), using corn whole straw for partial coverage planting, is a novel dryland cultivation technique. To examine the effects of BSC on the thermal-moisture status and winter wheat yield under typical arid and semiarid conditions in the Loess Plateau of Northwest China, soil temperature, soil water content and consumption, grain yield and water-use efficiency were compared for four treatments, including no-tillage with straw mulch (NTS), whole field plastic mulching with soil covering on the top of the plastic mulch and bunch-seeding (PFM), open field cultivation (CK) and BSC during three growing seasons from 2013 to 2016...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/30325143/effects-of-soil-in-larch-plantations-on-the-growth-of-picea-koraiensis-and-p-crassifolia-seedlings
#19
Hui Dong, Li Xue Yang
In addition to soil fertility decline, larch plantation had difficulty in natural regeneration, which challenges the healthy development and sustainable management. A greenhouse experiment was conducted with two kinds of shade-tolerant conifer species (Picea koraiensis and P. crassifolia) to examine the responses of seedling growth of two spruce species on sterilization treatment of larch plantation soils (except spruce biological characteristics), which would provide scientific basis for the transformation, regeneration and multi-storied forest cultivation of larch...
October 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/30325048/development-of-the-cerebral-cortex-and-the-effect-of-the-intrauterine-environment
#20
Sebastian Quezada, Margie Castillo-Melendez, David W Walker, Mary Tolcos
KEY POINTS: Normal folding of the cerebral cortex (gyrification) is fundamental for neurodevelopment. Some molecular mechanisms of gyrification during fetal development have been identified, but the impact of maternal health and the intrauterine environment has been largely overlooked. Recent evidence suggests that the intrauterine environment has a significant impact on the normal folding of the fetal cerebral cortex. This article reviews evidence for the effect of the most common intrauterine alterations on the normal development of the cortical folding in the fetus...
October 16, 2018: Journal of Physiology
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