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https://www.readbyqxmd.com/read/28926847/probing-the-stochastic-property-of-endoreduplication-in-cell-size-determination-of-arabidopsis-thaliana-leaf-epidermal-tissue
#1
Kensuke Kawade, Hirokazu Tsukaya
Cell size distribution is highly reproducible, whereas the size of individual cells often varies greatly within a tissue. This is obvious in a population of Arabidopsis thaliana leaf epidermal cells, which ranged from 1,000 to 10,000 μm2 in size. Endoreduplication is a specialized cell cycle in which nuclear genome size (ploidy) is doubled in the absence of cell division. Although epidermal cells require endoreduplication to enhance cellular expansion, the issue of whether this mechanism is sufficient for explaining cell size distribution remains unclear due to a lack of quantitative understanding linking the occurrence of endoreduplication with cell size diversity...
2017: PloS One
https://www.readbyqxmd.com/read/28926139/the-synonymous-nucleotide-substitution-rhd-1056c-g-alters-mrna-splicing-associated-with-serologically-weak-d-phenotype
#2
Sejong Chun, Jae Won Yun, Geon Park, Duck Cho
BACKGROUND: D antigen is one of the most clinically significant blood group antigens. Variation of the RHD gene can cause weak D or partial D phenotypes. While most variations are missense substitutions with amino acid changes, those without are called "silent" or "synonymous" substitutions. Synonymous substitutions often have little effect on the protein, not altering the phenotype. However, effect on splicing can affect end-product protein. We report a new synonymous variation, RHD 1056C>G, that resulted in weak D phenotype, and predicted its effect with various in silico methods...
September 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28925699/ab-initio-computation-of-energy-deposition-during-electron-ionization-of-molecules
#3
Karl K Irikura
The dissociative ionization of molecules under electron impact forms the basis for analytical mass spectrometry of volatile compounds. It is also important in other situations, notably plasmas. Although qualitative theory for mass spectrometry was developed long ago, progress toward predictive theory has been slow. A major obstacle has been ignorance of the amount of energy deposited in the molecular ion, prior to its fragmentation. Here, we consider the Binary-Encounter Bethe (BEB) theory, which was originally developed for predicting total ionization cross sections...
September 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28925156/-plant-metabolomics-approach-for-age-discrimination-of-mountain-cultivated-ginseng-using-uplc-q-tof-ms
#4
Xiang-Wei Chang, Bo-Ran Wang, Tong Wang, De-Kun Li, Ying Zhao, Yu-Ling Zhang, Da-Zheng Zhou, Zheng-Liang Ye
Growth year is one of the important factors for the quality of mountain cultivated ginseng (MCG). For age differentiation of MCG, rhizome extracts of ginseng aged from 11 to 15 years were analyzed using a non-targeted approach with ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS)-based on plant metabolomics technique. Multivariate statistical methods such as principal component analysis (PCA) and orthogonal partial least squared discrimination analysis (OPLS-DA) were used to compare the derived patterns among the samples...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925149/-research-on-modeling-method-to-analyze-lonicerae-japonicae-flos-extraction-process-with-online-mems-nir-based-on-two-types-of-error-detection-theory
#5
Chen-Zhao Du, Zhi-Sheng Wu, Na Zhao, Zheng Zhou, Xin-Yuan Shi, Yan-Jiang Qiao
To establish a rapid quantitative analysis method for online monitoring of chlorogenic acid in aqueous solution of Lonicera Japonica Flos extraction by using micro-electromechanical near infrared spectroscopy (MEMS-NIR). High performance liquid chromatography(HPLC) was used as reference method.Kennard-Stone (K-S) algorithm was used to divide sample sets, and partial least square(PLS) regression was adopted to establish the multivariate analysis model between the HPLC analysis contents and NIR spectra. The synergy interval partial least squares (SiPLS) was used to selected modeling waveband to establish PLS models...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28924502/factors-influencing-healthcare-provider-respondent-fatigue-answering-a-globally-administered-in-app-survey
#6
Vikas N O'Reilly-Shah
BACKGROUND: Respondent fatigue, also known as survey fatigue, is a common problem in the collection of survey data. Factors that are known to influence respondent fatigue include survey length, survey topic, question complexity, and open-ended question type. There is a great deal of interest in understanding the drivers of physician survey responsiveness due to the value of information received from these practitioners. With the recent explosion of mobile smartphone technology, it has been possible to obtain survey data from users of mobile applications (apps) on a question-by-question basis...
2017: PeerJ
https://www.readbyqxmd.com/read/28923297/quick-analysis-of-organic-matter-in-soil-by-energy-dispersive-x-ray-fluorescence-and-multivariate-analysis
#7
Franslley Morona, Felipe R Dos Santos, André M Brinatti, Fábio L Melquiades
The rapid, simple and accurate determination of soil quality indicators is fundamental for improvements in precision agriculture and consequently in production efficiency. The objectives of this study were to determine the organic matter (OM) and total organic carbon (TOC) concentrations in agricultural soil and to discriminate soil provenance by energy-dispersive X-ray fluorescence (EDXRF) combined with principal component analysis and partial least square regression. The conventional methods used for the determination of OM and TOC concentrations are the gravimetric and Walkley-Black methods, respectively...
September 8, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28922296/trajectories-of-glycemic-change-in-a-national-cohort-of-adults-with-previously-controlled-type-2-diabetes
#8
Rozalina G McCoy, Che Ngufor, Holly K Van Houten, Brian Caffo, Nilay D Shah
BACKGROUND: Individualized diabetes management would benefit from prospectively identifying well-controlled patients at risk of losing glycemic control. OBJECTIVES: To identify patterns of hemoglobin A1c (HbA1c) change among patients with stable controlled diabetes. RESEARCH DESIGN: Cohort study using OptumLabs Data Warehouse, 2001-2013. We develop and apply a machine learning framework that uses a Bayesian estimation of the mixture of generalized linear mixed effect models to discover glycemic trajectories, and a random forest feature contribution method to identify patient characteristics predictive of their future glycemic trajectories...
September 15, 2017: Medical Care
https://www.readbyqxmd.com/read/28921989/universal-calibration-of-computationally-predicted-n-1s-binding-energies-for-interpretation-of-xps-experimental-measurements
#9
Jing Zhao, Fei Gao, Sidharam Pundlik Pujari, Han Zuilhof, Andrew Teplyakov
Computationally predicted N 1s core level energies are commonly used to interpret the experimental measurements obtained with X-ray photoelectron spectroscopy. This work compares the application of Koopmans' theorem to core electrons using the B3LYP functional with two commonly used basis sets, analyses the factors relevant to the comparison of the computational with experimental data, and presents several correlations that allow an accurate prediction of the N 1s binding energy. The first correlation is obtained with a series of known nitrogen-containing functional groups on well-characterized organic monolayers...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28920894/electro-thermal-equivalent-3d-finite-element-model-of-a-single-neuron
#10
I Cinelli, M Destrade, M Duffy, P McHugh
OBJECTIVE: We propose a novel approach for modelling the inter-dependence of electrical and mechanical phenomena in nervous cells, by using electro-thermal equivalences in finite element (FE) analysis so that existing thermo-mechanical tools can be applied. METHODS: First, the equivalence between electrical and thermal properties of the nerve materials is established, and results of a pure heat conduction analysis performed in Abaqus CAE Software 6.13-3 are validated with analytical solutions for a range of steady and transient conditions...
September 14, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28918699/effects-of-weapons-on-aggressive-thoughts-angry-feelings-hostile-appraisals-and-aggressive-behavior-a-meta-analytic-review-of-the-weapons-effect-literature
#11
Arlin J Benjamin, Sven Kepes, Brad J Bushman
Guns are associated with aggression. A landmark 1967 study showed that simply seeing a gun can increase aggression-called the "weapons effect." This meta-analysis integrates the findings of weapons effect studies conducted from 1967 to 2017. It includes 162 effect-size estimates from 78 independent studies involving 7,668 participants. The theoretical framework used to explain the weapons effect was the General Aggression Model (GAM), which proposes three routes to aggression-cognitive, affective, and arousal...
September 1, 2017: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/28918548/tumor-and-serum-dna-methylation-in-women-receiving-preoperative-chemotherapy-with-or-without-vorinostat-in-tbcrc008
#12
Roisin M Connolly, Mary Jo Fackler, Zhe Zhang, Xian C Zhou, Matthew P Goetz, Judy C Boughey, Bridget Walsh, John T Carpenter, Anna Maria Storniolo, Stanley P Watkins, Edward W Gabrielson, Vered Stearns, Saraswati Sukumar
BACKGROUND: Methylated gene markers have shown promise in predicting breast cancer outcomes and treatment response. We evaluated whether baseline and changes in tissue and serum methylation levels would predict pathological complete response (pCR) in patients with HER2-negative early breast cancer undergoing preoperative chemotherapy. METHODS: The TBCRC008 trial investigated pCR following 12 weeks of preoperative carboplatin and albumin-bound paclitaxel + vorinostat/placebo (n = 62)...
September 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28917963/an-efficient-computational-fluid-particle-dynamics-method-to-predict-deposition-in-a-simplified-approximation-of-the-deep-lung
#13
P G Koullapis, P Hofemeier, J Sznitman, S C Kassinos
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to predict particle deposition in a simplified approximation of the deep lung during a full breathing cycle. The geometrical model employed consists of an idealised bronchial tree that represents generations 10 to 19 of the conducting zone and an heterogeneous acinar model created using a space-filling algorithm...
September 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28917795/portable-near-infrared-spectroscopy-applied-to-quality-control-of-brazilian-coffee
#14
Radigya M Correia, Flavia Tosato, Eloilson Domingos, Rayza R T Rodrigues, Luiz Felipe M Aquino, Paulo R Filgueiras, Valdemar Lacerda, Wanderson Romão
The use of portable micro-spectrometers such as a micro near infrared region (microNIR) spectrometer is a promising technique for solving analytical problems in several areas of science. This work evaluated the potential of microNIR in quality control of Arabica coffee. Arabica coffee has a high commercial value product, motivating the development of analytical methods with high sensitivity and accuracy for detection of its adulteration. Herein, microNIR was successfully used to determine the quality of Arabica coffee by identification and quantification of adulterations such as Robusta coffee (in different roasting levels), as well as corn, peels, and sticks...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917770/applicability-of-the-direct-injection-liquid-chromatographic-tandem-mass-spectrometric-analytical-approach-to-the-sub-ngl-1-determination-of-perfluoro-alkyl-acids-in-waste-surface-ground-and-drinking-water-samples
#15
Lorenzo Ciofi, Lapo Renai, Daniele Rossini, Claudia Ancillotti, Alida Falai, Donatella Fibbi, Maria Concetta Bruzzoniti, José Juan Santana-Rodriguez, Serena Orlandini, Massimo Del Bubba
The applicability of a direct injection UHPLC-MS/MS method for the analysis of several perfluoroalkyl acids (PFAAs) in a wide range of water matrices was investigated. The method is based on the direct injection of 100µL of centrifuged water sample, without any other sample treatment. Very good method detection limits (0.014-0.44ngL(-1)) and excellent intra and inter-day precision (RSD% values in the range 1.8-4.4% and 2.7-5.7%, respectively) were achieved, with a total analysis time of 20min per sample. A high number of samples - i...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916927/genetic-test-risk-prediction-and-counseling
#16
Maggie Haitian Wang, Haoyi Weng
Advancement in technology has nurtured the new era of genetic tests for personalized medicine. In this chapter, we will introduce the current development, challenges, and the outlook of genetic test, disease risk prediction, and genetic counseling. In the first section, we will present the success cases in the areas of molecular classification of tumors, pharmacogenomics, and Mendelian disorders, and the challenges of genetic tests implementations. In the second section, common methods for genetic risk prediction models and evaluation measures will be introduced, as well as challenges in feature reliability, risk model stability, and clinical utility...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28916393/towards-a-chromatographic-similarity-index-to-establish-localised-quantitative-structure-retention-relationships-for-retention-prediction-iii-combination-of-tanimoto-similarity-index-logp-and-retention-factor-ratio-to-identify-optimal-analyte-training-sets
#17
Soo Hyun Park, Paul R Haddad, Ruth I J Amos, Mohammad Talebi, Roman Szucs, Christopher A Pohl, John W Dolan
Retention prediction for unknown compounds based on Quantitative Structure-Retention Relationships (QSRR) can lead to rapid "scoping" method development in chromatography by simplifying the selection of chromatographic parameters. The use of retention factor ratio (or k-ratio) as a chromatographic similarity index can be a potent method to cluster similar compounds into a training set to generate an accurate predictive QSRR model provided that its limitation - that the method is impractical for retention prediction for unknown compounds - is successfully addressed...
September 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28915732/virial-coefficients-and-equations-of-state-for-hard-polyhedron-fluids
#18
M Eric Irrgang, Michael Engel, Andrew J Schultz, David A Kofke, Sharon C Glotzer
Hard polyhedra are a natural extension of the hard sphere model for simple fluids, but no general scheme exists for predicting the effect of shape on thermodynamic properties, even in fluids of moderate density. Only the second virial coefficient is known analytically for general convex shapes, so higher order equations of state have been elusive. Here we investigate high-precision state functions in the fluid phase of 14 representative polyhedra with different assembly behaviors. We discuss historic efforts in analytically approximating virial coefficients up to $B_4$ and numerically evaluating them to $B_8$ Using virial coefficients as inputs, we show the convergence properties for four equations of state for hard convex bodies...
September 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28914928/multi-resonant-lugiato-lefever-model
#19
Matteo Conforti, Fabio Biancalana
We introduce a new model that extends the Lugiato-Lefever equation to the description of multiple resonances in Kerr optical cavities. It perfectly agrees quantitatively (in both stationary and dynamical regimes) with the exact Ikeda map, even when using a small number of resonances. Our model predicts the onset of complex phenomena such as the recently observed super-cavity solitons and the coexistence of multiple nonlinear states. It will be of crucial importance for the analytical understanding of new nonlinear phenomena in Kerr cavities when the intensities or nonlinearities are high enough to be able to excite more than one cavity resonance...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28914402/analytical-modeling-of-the-mechanics-of-early-invasion-of-a-merozoite-into-a-human-erythrocyte
#20
Tamer Abdalrahman, Thomas Franz
In this study, we used a continuum model based on contact mechanics to understand the mechanics of merozoite invasion into human erythrocytes. This model allows us to evaluate the indentation force and work as well as the contact pressure between the merozoite and erythrocyte for an early stage of invasion (γ = 10%). The model predicted an indentation force of 1.3e (-11)N and an indentation work of 1e (-18)J. The present analytical model can be considered as a useful tool not only for investigations in mechanobiology and biomechanics but also to explore novel therapeutic targets for malaria and other parasite infections...
September 15, 2017: Journal of Biological Physics
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