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https://www.readbyqxmd.com/read/27915028/catalytic-synthesis-of-%C3%AE-amino-chromone-phosphonates-and-their-antimicrobial-toxicity-and-potential-hiv-1-rt-inhibitors-based-on-silico-screening
#1
Abosede Oluwabukola Jaiyeola, K Anand, K Kasumbwe, M Ramesh, R M Gengan
The α-amino phosphonates exhibit a wide range of biological properties which create demand for simple and efficient synthetic routes of new molecules. In this study synthesis of a new series of derivatives of α-amino chromone phosphonates (ACPs) was reported using RhBT catalyst. The RhBT was first prepared by simply mixing boron nitride in a solution of rhodium acetate, under inert atmosphere for a week followed by filtration (yield: 92%). The catalyst can be re-used for up to four times and showed minimal loss of activity...
November 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27914926/metschnikowia-cf-typographi-and-other-pathogens-from-the-bark-beetle-ips-sexdentatus-prevalence-histological-and-ultrastructural-evidence-and-molecular-characterization
#2
Regina G Kleespies, Young Woon Lim, Cezary Tkaczuk, Marta Wrzosek, Bernhardt M Steinwender, Rudolf Wegensteiner
Ips sexdentatus (Six-spined engraver beetle) from Austria and Poland were dissected and examined for the presence of pathogens. Specimens collected in Austria were found to contain the ascomycetous fungus Metschnikowia cf. typographi. Infection rates ranged from 3.6% to 26.8% at different collection sites. M. cf. typographi infected midguts were investigated by histological, ultrastructural and molecular techniques. Extraordinary ultrastructural details are shown, such as ascospores with bilateral flattened flanks resembling alar rims at both sides of their attenuating tube-like ends...
November 30, 2016: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/27913891/biotransformation-of-2-4-dinitroanisole-by-a-fungal-penicillium-sp
#3
Hunter W Schroer, Kathryn L Langenfeld, Xueshu Li, Hans-Joachim Lehmler, Craig L Just
Insensitive munitions explosives are new formulations that are less prone to unintended detonation compared to traditional explosives. While these formulations have safety benefits, the individual constituents, such as 2,4-dinitroanisole (DNAN), have an unknown ecosystem fate with potentially toxic impacts to flora and fauna exposed to DNAN and/or its metabolites. Fungi may be useful in remediation and have been shown to degrade traditional nitroaromatic explosives, such as 2,4,6-trinitrotoluene and 2,4-dinitrotoluene, that are structurally similar to DNAN...
December 2, 2016: Biodegradation
https://www.readbyqxmd.com/read/27913420/multiple-evolutionary-trajectories-have-led-to-the-emergence-of-races-in-fusarium-oxysporum-f-sp-lycopersici
#4
Biju V Chellappan, Like Fokkens, Petra M Houterman, Martijn Rep, Ben J C Cornelissen
: Race 1 isolates of Fusarium oxysporum f. sp. lycopersici (Fol) are characterized by the presence of AVR1 in their genome. The product of this gene, Avr1, triggers resistance in tomato cultivars carrying resistance gene I In Fol race 2 and race 3 isolates, AVR1 is absent and hence they are virulent on tomato cultivars carrying I In this study, we analyze an approximately 100 kb genomic fragment containing the AVR1 locus of race 1 isolate Fol004, and compare it to the sequenced genome of Fol race 2 isolate 4287 (Fol4287)...
December 2, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27912907/bioactivity-guided-isolation-of-anti-inflammatory-triterpenoids-from-the-sclerotia-of-poria-cocos-using-lps-stimulated-raw264-7-cells
#5
Seoung Rak Lee, Seulah Lee, Eunjung Moon, Hye-Jin Park, Hyun Bong Park, Ki Hyun Kim
Poria cocos Wolf (Polyporaceae) has been used as a medicinal fungus to treat various diseases since ancient times. This study aimed to investigate the anti-inflammatory chemical constituents of the sclerotia of P. cocos. Based on bioassay-guided fractionation using lipopolysaccharide (LPS)-stimulated Raw264.7 cells, chemical investigation of the EtOH extract of the sclerotia of P. cocos resulted in the isolation and identification of eight compounds including six triterpenoids, namely poricoic acid A (1), 3-O-acetyl-16α-hydroxydehydrotrametenolic acid (2), polyporenic acid C (3), 3β-hydroxylanosta-7,9(11),24-trien-21-oic acid (4), trametenolic acid (5), and dehydroeburicoic acid (6), as well as (-)-pinoresinol (7) and protocatechualdehyde (8)...
November 23, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27912176/novel-designed-vmct1-analogs-with-increased-antimicrobial-activity
#6
Cibele Nicolaski Pedron, Marcelo Der Torossian Torres, Julia Aparecida da Silva Lima, Pedro Ismael Silva, Fernanda Dias Silva, Vani Xavier Oliveira
Antimicrobial peptides are biologically active molecules produced by a wide range of organisms as an essential component of the innate immune response. They have recently attracted great interest, since they have antimicrobial activity against a broad spectrum of microorganisms. VmCT1 is a cationic peptide from the venom of Vaejovis mexicanus smithi scorpions, which presents antibacterial activity and tends to helical structures. Its analogs were synthesized, characterized and the conformational studies were performed by circular dichroism...
November 24, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27911737/the-conservation-of-phosphate-binding-residues-among-pht1-transporters-suggests-that-distinct-transport-affinities-are-unlikely-to-result-from-differences-in-the-phosphate-binding-site
#7
REVIEW
S Antony Ceasar, Alison Baker, Stephen P Muench, S Ignacimuthu, Stephen A Baldwin
The plant PHosphate Transporter 1 (PHT1) family of membrane proteins belongs to the major facilitator super family and plays a major role in the acquisition of inorganic phosphate (Pi) from the soil and its transport within the plant. These transporters have been well characterized for expression patterns, localization, and in some cases affinity. Furthermore, the crystal structure of a high-affinity eukaryotic phosphate transporter from the fungus Piriformospora indica (PiPT) has revealed important information on the residues involved in Pi transport...
October 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27910789/methoxyflavones-from-new-lingzhi-medicinal-mushroom-ganoderma-lingzhi-agaricomycetes
#8
Kuniyoshi Shimizu, Yhiya M Amen, Satoru Kaifuchi
Ganoderma lingzhi is one of the most famous medicinal fungi in the world. It has been used in folk medicine, especially in East Asian countries. It is also a white-rot fungus with strong wood degradation ability, especially against lignin. Different classes of bioactive natural products have been reported in Ganoderma, including triterpenes, polysaccharides, sterols, and peptides. The triterpenes and polysaccharides are the primary bioactive compounds of Ganoderma. We report for the first time the presence of 3 methoxyflavones as minor constituents in G...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910757/free-radical-scavenging-activities-of-cultured-mycelia-of-paecilomyces-hepiali-ascomycetes-extracts-and-structural-characterization-of-bioactive-components-by-nuclear-magnetic-resonance-spectroscopy
#9
Lucia Ungvarska Mal'ucka, Jarmila Harvanova, Martin Pavlik, Martin Rajtar, Lukas Jarosciak
Current research is focused on testing the cultivation of Paecilomyces hepiali mycelia on various plant substrates and producing fungus or mycelial biomass with qualitatively interesting substances. P. hepiali mycelia was cultivated using solid-state fermentation of different substrates. Mycelial biomass was then analyzed, and antioxidant activity was evaluated using the DPPH radical scavenging method for different ethanolic extracts based on a millet substrate (extract 1) or a chickpea substrate (extract 2)...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910702/a-new-isoquinolone-alkaloid-from-an-endophytic-fungus-r22-of-nerium-indicum
#10
Yang-Min Ma, Ke Qiao, Yang Kong, Meng-Yun Li, Lin-Xin Guo, Zhi Miao, Chao Fan
A new isoquinolone alkaloid named 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (3), together with two known quinolinone alkaloids 3-O-methylviridicatin (1) and viridicatol (2) were isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Their structures were elucidated by NMR, IR and MS data, and were also confirmed by comparing with the reported data in the literature. Meanwhile, the antibacterial and antifungal activities of all compounds were tested, and the results showed that three compounds had strong antifungal activity...
December 2, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27909927/fungal-biomass-as-biosorbent-for-the-removal-of-acid-blue-161-dye-in-aqueous-solution
#11
Mayerly Johana Puchana-Rosero, Eder C Lima, Santiago Ortiz-Monsalve, Bianca Mella, Dimitrius da Costa, Eduardo Poll, Mariliz Gutterres
Physical and thermal treatment was used to inactivate Trametes sp. SC-10 fungus. The resulting biomass was named BTV, characterized by analytical techniques such as SEM, EDX, FTIR, BET, and Barrett-Joyner-Halenda (BJH) model. pH, kinetic, and equilibrium adsorption studies with the Acid Blue 161 (AB-161) dye were investigated at 303.15 K. The kinetics of the biosorption process were examined at 600.00 and 1300 mg L(-1), using pseudo-first-order, pseudo-second-order, and Avrami fractional-order models. The maximum biosorption capacity of BTV for AB-161 dye was 221...
December 2, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27909822/generation-of-lycopene-overproducing-strains-of-the-fungus-mucor-circinelloides-reveals-important-aspects-of-lycopene-formation-and-accumulation
#12
Yingtong Zhang, Haiqin Chen, Eusebio Navarro, Sergio López-García, Yong Q Chen, Hao Zhang, Wei Chen, Victoriano Garre
OBJECTIVES: To generate lycopene-overproducing strains of the fungus Mucor circinelloides with interest for industrial production and to gain insight into the catalytic mechanism of lycopene cyclase and regulatory process during lycopene overaccumulation. RESULTS: Three lycopene-overproducing mutants were generated by classic mutagenesis techniques from a β-carotene-overproducing strain. They carried distinct mutations in the carRP gene encoding lycopene cyclase that produced loss of enzymatic activity to different extents...
December 1, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27908773/does-the-effect-of-a-metarhizium-anisopliae-isolate-on-rhipicephalus-microplus-depend-on-the-tick-population-evaluated
#13
Anelise Webster, Endrigo Pradel, Ugo Araújo Souza, João Ricardo Martins, José Reck, Augusto Schrank, Guilherme Klafke
The filamentous fungus Metarhizium anisopliae is an arthropod pathogen used in the biological control of pests in agriculture and livestock. The effect of the fungus M. anisopliae on ticks has been shown in experiments in vitro. The aim of the present study was to compare the susceptibility of different field isolates of Rhipicephalus microplus to M. anisopliae. A total of 67 field isolates were evaluated. Rhipicephalus microplus larvae were immersed in an M. anisopliae suspension (10(8) conidia/mL) for 5min...
November 24, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27907207/optimized-jasmonic-acid-production-by-lasiodiplodia-theobromae-reveals-formation-of-valuable-plant-secondary-metabolites
#14
Felipe Eng, Sven Haroth, Kirstin Feussner, Dorothea Meldau, Dmitrij Rekhter, Till Ischebeck, Florian Brodhun, Ivo Feussner
Jasmonic acid is a plant hormone that can be produced by the fungus Lasiodiplodia theobromae via submerged fermentation. From a biotechnological perspective jasmonic acid is a valuable feedstock as its derivatives serve as important ingredients in different cosmetic products and in the future it may be used for pharmaceutical applications. The objective of this work was to improve the production of jasmonic acid by L. theobromae strain 2334. We observed that jasmonic acid formation is dependent on the culture volume...
2016: PloS One
https://www.readbyqxmd.com/read/27907048/chemical-defence-in-a-millipede-evaluation-and-characterization-of-antimicrobial-activity-of-the-defensive-secretion-from-pachyiulus-hungaricus-karsch-1881-diplopoda-julida-julidae
#15
Slaviša Stanković, Ivica Dimkić, Ljubodrag Vujisić, Sofija Pavković-Lučić, Zvezdana Jovanović, Tatjana Stević, Ivana Sofrenić, Bojan Mitić, Vladimir Tomić
The chemical defence of the millipede Pachyiulus hungaricus is reported in the present paper, in which a chemical characterization is given and antimicrobial activity is determined. In total, independently of sex, 44 compounds were identified. All compounds belong to two groups: quinones and pentyl and hexyl esters of long-chain fatty acids. The relative abundances of quinones and non-quinones were 94.7% vs. 5.3% (males) and 87.3% vs. 12.7% (females), respectively. The two dominant quinones in both sexes were 2-methyl-1,4,-benzoquinone and 2-methoxy-3-methyl-1,4-benzoquinone...
2016: PloS One
https://www.readbyqxmd.com/read/27906500/phylogenetic-studies-gene-cluster-analysis-and-enzymatic-reaction-support-anthrahydroquinone-reduction-as-the-physiological-function-of-fungal-17%C3%AE-hydroxysteroid-dehydrogenase
#16
Leon Fürtges, David Conradt, Michael A Schätzle, Shailesh Kumar Singh, Nada Kraševec, Tea Lanišnik Rižner, Michael Müller, Syed Masood Husain
17β-Hydroxysteroid dehydrogenase (17β-HSDcl) from the filamentous fungus Curvularia lunata (teleomorph Cochliobolus lunatus) catalyzes NADP(H)-dependent oxidoreductions of androgens and estrogens. Despite detailed biochemical and structural characterization of 17β-HSDcl, its physiological function remains unknown. On the basis of amino acid sequence alignment, phylogenetic studies, and the recent identification of the physiological substrates of the homologous MdpC from Aspergillus nidulans and AflM from Aspergillus parasiticus, we propose an anthrahydroquinone as the physiological substrate of 17β-HSDcl...
December 1, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27905295/desensitization-of-idiopathic-pulmonary-fibrosis-fibroblasts-to-alternaria-alternata-extract-mediated-necrotic-cell-death
#17
Jintaek Im, Kyutae Kim, Ji Young Yhee, Scott M O'Grady, Richard S Nho
Alternaria alternata is an allergenic fungus and known to cause an upper respiratory tract infection and asthma in humans with compromised immunity. Although A. alternata's effect on airway epithelial cells has previously been examined, the potential role of A. alternata on lung fibroblast viability is not understood. Since lung fibroblasts derived from patients with idiopathic pulmonary fibrosis (IPF) display a distinct phenotype that is resistant to stress and cell death inducing conditions, the investigation of the role of Alternaria on pathological IPF fibroblasts provides a better understanding of the fibrotic process induced by an allergenic fungus...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27904463/digital-infrared-thermal-imaging-of-crape-myrtle-leaves-infested-with-sooty-mold
#18
Jiyeon Kim, Si-Gyun Kweon, Junhyung Park, Harim Lee, Ki Woo Kim
The spatial patterns for temperature distribution on crape myrtle leaves infested with sooty mold were investigated using a digital infrared thermal imaging camera. The mean temperatures of the control and sooty regions were 26.98°C and 28.44°C, respectively. In the thermal images, the sooty regions appeared as distinct spots, indicating that the temperatures in these areas were higher than those in the control regions on the same leaves. This suggests that the sooty regions became warmer than their control regions on the adaxial leaf surface...
December 2016: Plant Pathology Journal
https://www.readbyqxmd.com/read/27904462/overexpression-of-a-pathogenesis-related-protein-10-enhances-biotic-and-abiotic-stress-tolerance-in-rice
#19
Jingni Wu, Sang Gon Kim, Kyu Young Kang, Ju-Gon Kim, Sang-Ryeol Park, Ravi Gupta, Yong Hwan Kim, Yiming Wang, Sun Tae Kim
Pathogenesis-related proteins play multiple roles in plant development and biotic and abiotic stress tolerance. Here, we characterize a rice defense related gene named "jasmonic acid inducible pathogenesis-related class 10" (JIOsPR10) to gain an insight into its functional properties. Semi-quantitative RT-PCR analysis showed up-regulation of JIOsPR10 under salt and drought stress conditions. Constitutive over-expression JIOsPR10 in rice promoted shoot and root development in transgenic plants, however, their productivity was unaltered...
December 2016: Plant Pathology Journal
https://www.readbyqxmd.com/read/27904208/verrucous-onychomycosis-caused-by-curvularia-in-a-patient-with-congenital-pterygium
#20
Mary Vineetha, Seena Palakkal, K Sobhanakumari, M I Celine, V Letha
A 57 year healthy farmer with congenital nail pterygium presented with a verrucous growth on nail bed since 8 months. He was not diabetic and HIV rapid card test negative. Our clinical diagnosis was chromoblastomycosis but culture showed growth of curvularia species on two occasions and histopathology showed hyphal and yeast forms of the pigmented fungus. After excision biopsy patient was started on oral itraconazole. This case is reported due to rarity of verrucous cutaneous lesions caused by curvularia in immunocompetent individuals...
November 2016: Indian Journal of Dermatology
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