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Diabetic Cardiovascular Autonomic Neuropathy

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https://www.readbyqxmd.com/read/30548403/genetic-variants-in-dnmt1-and-the-risk-of-cardiac-autonomic-neuropathy-in-females-with-type-1-diabetes
#1
Daniele Pereira Santos-Bezerra, Sharon Nina Admoni, Rosana Cristina Mori, Tatiana Souza Pelaes, Ricardo Vesoni Perez, Cleide Guimarães Machado, Maria Beatriz Monteiro, Maria Candida Parisi, Elizabeth Joao Pavin, Marcia Silva Queiroz, Marisa Passarelli, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella
AIMS/INTRODUCTION: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications. MATERIAL AND METHODS: We assessed the frequency of 5 single nucleotide polymorphisms (SNPs) in the gene encoding DNA methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076) and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy (CAN) in 359 long-term Type 1 diabetes individuals...
December 11, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/30539026/implications-of-the-intestinal-microbiota-in-diagnosing-the-progression-of-diabetes-and-the-presence-of-cardiovascular-complications
#2
REVIEW
Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase
The prevalence of diabetes is steadily rising, and once it occurs, it can cause multiple complications with a negative impact on the whole organism. Complications of diabetes may be macrovascular: such as stroke and ischemic heart disease as well as peripheral vascular and microvascular diseases-retinopathy, nephropathy, and neuropathy. Key factors that cause cardiovascular disease in people with diabetes include hyperglycemia, dyslipidemia, obesity, insulin resistance, inflammation, hypertension, autonomic dysfunction, and decreased vascular response capacity...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/30511897/pulmonary-vein-ganglia-are-remodeled-in-the-diabetic-heart
#3
Guillaume Bassil, Mengmeng Chang, Audrys Pauza, Jesus Diaz Vera, Athanasios Tsalatsanis, Bruce G Lindsey, Sami F Noujaim
Background Cardiac autonomic neuropathy is thought to cause adverse cardiovascular effects in diabetes mellitus. Pulmonary vein ganglia ( PVG ), which have been implicated in normal and abnormal heart rhythm regulation, have not been fully investigated in type 1 diabetes mellitus (T1D). We examined the functional and anatomical effects of T1D on PVG and studied the details of T1D-induced remodeling on the PVG structure and function. Methods and Results We used a mouse model of T1D (Akita mouse), immunofluorescence, isolated Langendorff-perfused hearts, and mathematical simulations to explore the effects of T1D on PVG ...
December 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30481956/7-8-dihydroxyflavone-protects-high-glucose-damaged-neuronal-cells-against-oxidative-stress
#4
Suk Ju Cho, Kyoung Ah Kang, Mei Jing Piao, Yea Seong Ryu, Pincha Devage Sameera Madushan Fernando, Ao Xuan Zhen, Yu Jae Hyun, Mee Jung Ahn, Hee Kyoung Kang, Jin Won Hyun
Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent complications of diabetes, affect sensory, motor, and autonomic nerves. This study aimed to investigate whether 7,8-dihydroxyflavone (7,8-DHF) protects SH-SY5Y neuronal cells against high glucose-induced toxicity. In the current study, we found that diabetic patients exhibited higher lipid peroxidation caused by oxidative stress than healthy subjects...
November 27, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/30475825/the-prevalence-of-cardiovascular-autonomic-neuropathy-and-its-influence-on-post-induction-hemodynamic-variables-in-patients-with-and-without-diabetes-a-prospective-cohort-study
#5
Jorinde A W Polderman, Nicolaas H Sperna Weiland, Michel H Klaver, Judy Biginski, Marijn Horninge, Markus W Hollmann, J Hans DeVries, Rogier V Immink, Benedikt Preckel, Jeroen Hermanides
BACKGROUND: Cardiovascular autonomic neuropathy (CAN) is a known complication of diabetes, but is also diagnosed in patients without diabetes. CAN may be related to perioperative hemodynamic instability. Our objective was to investigate if patients with diabetes would have a higher prevalence of CAN compared to patients without diabetes undergoing surgery. We further studied its relation to changes in post-induction hemodynamic variables. METHODS: We prospectively included 82 adult patients, 55 with DM, 27 without DM, scheduled for major abdominal or cardiac surgery...
2018: PloS One
https://www.readbyqxmd.com/read/30461290/prevalence-of-diabetic-neuropathy-in-young-adults-with-type-1-diabetes-and-the-association-with-insulin-pump-therapy
#6
Marie Mathilde Bjerg Christensen, Eva Elisabeth Hommel, Marit Eika Jørgensen, Bernt Johan von Scholten, Jesper Fleischer, Christian Stevns Hansen
AIMS: The aim was to investigate the prevalence of diabetic sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in a Danish population of young adults with type 1 diabetes (T1D) using both established and novel measuring modalities. Furthermore, to investigate the association between continuous subcutaneous insulin infusion (CSII) treatment and these complications. MATERIALS AND METHODS: CAN was assessed by cardiovascular autonomic reflex tests...
November 21, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/30455335/effects-of-severe-hypoglycemia-on-cardiovascular-outcomes-and-death-in-the-veterans-affairs-diabetes-trial
#7
Stephen N Davis, William Duckworth, Nicholas Emanuele, Rodney A Hayward, Wyndy L Wiitala, Lizy Thottapurathu, Domenic J Reda, Peter D Reaven
OBJECTIVE: To determine the risk factors for severe hypoglycemia and the association between severe hypoglycemia and serious cardiovascular adverse events and cardiovascular and all-cause mortality in the Veterans Affairs Diabetes Trial (VADT). RESEARCH DESIGN AND METHODS: This post hoc analysis of data from the VADT included 1,791 military veterans (age 60.5 ± 9.0 years) with suboptimally controlled type 2 diabetes (HbA1c 9.4 ± 2.0%) of 11.5 ± 7.5 years disease duration with or without known cardiovascular disease and additional cardiovascular risk factors...
November 19, 2018: Diabetes Care
https://www.readbyqxmd.com/read/30446479/the-association-of-diabetic-microvascular-and-macrovascular-disease-with-cutaneous-circulation-in-patients-with-type-2-diabetes-mellitus
#8
Ioanna Eleftheriadou, Anastasios Tentolouris, Pinelopi Grigoropoulou, Dimitrios Tsilingiris, Ioanna Anastasiou, Alexandros Kokkinos, Despoina Perrea, Nikolaos Katsilambros, Nikolaos Tentolouris
AIMS: To study the impact of diabetic neuropathy, both peripheral sensorimotor (DPN) and cardiac autonomic neuropathy (CAN), on transcutaneous oxygen tension (TcPO2 ) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 163 participants were recruited; 100 with T2DM and 63 healthy individuals. Peripheral arterial disease (PAD) was defined as ankle-brachial index (ABI) values ≤0.90. Diagnosis of DPN was based on neuropathy symptom score and neuropathy disability score (NDS), while diagnosis of CAN on the battery of the cardiovascular autonomic function tests...
October 12, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30430334/decreased-%C3%AE-cell-function-is-associated-with-cardiovascular-autonomic-neuropathy-in-chinese-patients-newly-diagnosed-with-type-2-diabetes
#9
Xubin Yang, Wen Xu, Yanhua Zhu, Hongrong Deng, Ying Tan, Longyi Zeng, Jianping Weng
The influence of β-cell function on cardiovascular autonomic neuropathy (CAN), an important diabetes-related complication, is still unclear. In this study, we aimed to investigate the association between residual β-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN+ group (diabetic patients with CAN, n = 20) and a CAN- group (diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests...
November 15, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/30409691/co-occurrence-of-early-diabetes-related-complications-in-adolescents-and-young-adults-with-type-1-diabetes-an-observational-cohort-study
#10
Katherine A Sauder, Jeanette M Stafford, Elizabeth J Mayer-Davis, Elizabeth T Jensen, Sharon Saydah, Amy Mottl, Lawrence M Dolan, Richard F Hamman, Jean M Lawrence, Catherine Pihoker, Santica Marcovina, Ralph B D'Agostino, Dana Dabelea
BACKGROUND: One in three adolescents and young adults with type 1 diabetes have at least one early diabetes-related complication or comorbidity. We aimed to examine the prevalence and pattern of co-occurring complications in this population, as well as the related risk factors. METHODS: This observational cohort study includes data from individuals diagnosed with type 1 diabetes before age 20 years who participated in the SEARCH for Diabetes in Youth Study across five sites in the USA...
November 5, 2018: Lancet Child & Adolescent Health
https://www.readbyqxmd.com/read/30401911/impaired-nocturnal-blood-pressure-dipping-in-patients-with-type-2-diabetes-mellitus
#11
Yu-Sok Kim, Shyrin C A T Davis, Wim J Stok, Frans J van Ittersum, Johannes J van Lieshout
Hypertension is a common comorbidity of type 2 diabetes mellitus (T2DM). Both conditions are associated with an increased cardiovascular risk, which is reduced by tight blood pressure (BP) and glycemic control. However, nondipping BP status continues to be an enduring cardiovascular risk factor in T2DM. Cardiovascular autonomic neuropathy and endothelial dysfunction have been proposed as potential mechanisms. This study tested the hypothesis that microvascular disease rather than cardiovascular autonomic neuropathy interferes with the physiological nocturnal BP reduction...
November 6, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/30361834/blood-pressure-variability-and-autonomic-dysfunction
#12
REVIEW
Vincenza Spallone
PURPOSE OF REVIEW: This review considers the relationship between abnormal blood pressure (BP) variability and autonomic dysfunction through an attempt to answer questions about its clinical relevance and pertinence to diabetes and cardiovascular autonomic neuropathy (CAN) and which therapeutic measures can lessen its cardiovascular impact. RECENT FINDINGS: Office, ambulatory, and home BP monitoring identify posture-related, circadian, short-term, and long-term BP variabilities...
October 25, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30355473/left-ventricular-remodelling-and-cardiac-chamber-sizes-in-long-term-normoalbuminuric-type-1-diabetes-patients-with-and-without-cardiovascular-autonomic-neuropathy
#13
Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Ulrik M Mogensen, Helle Corinth, Peter Rossing, Lars Køber, Klaus F Kofoed
AIMS: Type 1 diabetes is associated with increased cardiovascular (CV) morbidity and mortality, and cardiovascular autonomic neuropathy (CAN) is an important CV risk factor. The study aimed to explore associations between CAN and altered cardiac chamber sizes in persons with type 1 diabetes. METHODS: This was a cross-sectional study of 71 asymptomatic, normoalbuminuric participants with long-term type 1 diabetes (39 with CAN, determined by >1 abnormal autonomic function test) examined with cardiac multi detector computed tomography scans, which allowed measurements of left ventricular mass and all four cardiac chamber volumes...
October 11, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30345796/generalised-arterial-calcification-in-normoalbuminuric-patients-with-type-1-diabetes-with-and-without-cardiovascular-autonomic-neuropathy
#14
Henrik Øder Hjortkjær, Tonny Jensen, Jannik Hilsted, Ulrik Madvig Mogensen, Peter Rossing, Lars Køber, Klaus Fuglsang Kofoed
BACKGROUND: Type 1 diabetes is associated with increased risk of cardiovascular disease and the diabetic complication cardiovascular autonomic neuropathy in itself entails increased cardiovascular risk by mechanisms not yet fully understood. Arterial calcification is an important predictor of cardiovascular events; the aim of this study was to investigate the level of generalised arterial calcification in patients with long-term, normoalbuminuric type 1 diabetes and the association with cardiovascular autonomic neuropathy, as these factors have not been investigated in type 1 diabetes...
October 20, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/30345631/the-association-between-glycemic-variability-in-continuous-glucose-monitoring-and-cardiovascular-autonomic-neuropathy-independent-of-mean-glucose-in-adults-with-type-1-diabetes-importance-of-level-2-hypoglycemia
#15
Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Ji Yeon Ahn, Gyuri Kim, Kyu Yeon Hur, Moon-Kyu Lee, Sang-Man Jin, Jae Hyeon Kim
BACKGROUND: The purpose of this study was to establish the association between continuous glucose monitoring (CGM)-defined glycemic variability (GV) and cardiovascular autonomic neuropathy (CAN) in type 1 diabetes independent of mean glucose and to examine the relative contribution of each internationally standardized CGM parameter to this association. MATERIALS AND METHODS: This study included 80 adults with type 1 diabetes who underwent 3-day CGM and autonomic function tests within 3 months...
October 21, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/30339460/diabetes-mellitus-attenuates-the-pressure-response-against-hypotensive-stress-by-impairing-the-sympathetic-regulation-of-the-baroreflex-afferent-arc
#16
Kazuhiro Kamada, Keita Saku, Takeshi Tohyama, Toru Kawada, Hiroshi Mannoji, Kiyokazu Abe, Takuya Nishikawa, Genya Sunagawa, Takuya Kishi, Kenji Sunagawa, Hiroyuki Tsutsui
Patients with diabetes mellitus (DM) often show arterial pressure (AP) lability associated with cardiovascular autonomic neuropathy. Since the arterial baroreflex tightly regulates AP via sympathetic nerve activity (SNA), we investigated the systematic baroreflex function considering the control theory in DM by an open-loop analysis. We used Zucker Diabetic Fatty (ZDF)-Fatty rats as a type 2 DM model. Under general anesthesia, we isolated the carotid sinuses from systemic circulation, changed intra-carotid sinus pressure (CSP), and recorded SNA and AP responses...
October 19, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30305347/risk-factors-for-the-presence-and-progression-of-cardiovascular-autonomic-neuropathy-in-type-2-diabetes-addition-denmark
#17
Signe T Andersen, Daniel R Witte, Jesper Fleischer, Henning Andersen, Torsten Lauritzen, Marit E Jørgensen, Troels S Jensen, Rodica Pop-Busui, Morten Charles
OBJECTIVE: To examine the course of cardiovascular autonomic neuropathy (CAN) and related cardiometabolic risk factors in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: CAN and cardiometabolic risk factors were assessed in the Danish arm of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Denmark) at 6-year ( n = 777) and 13-year ( n = 443) follow-up examinations. Cardiovascular autonomic reflex tests (CARTs)-that is, lying to standing, deep breathing, and the Valsalva maneuver-and 2-min resting heart rate variability (HRV) indices were obtained as the main measures of CAN...
December 2018: Diabetes Care
https://www.readbyqxmd.com/read/30302965/cardiovascular-autonomic-neuropathy-predicts-higher-hba1c-variability-in-subjects-with-type-2-diabetes-mellitus
#18
Yeoree Yang, Eun Young Lee, Jae Hyoung Cho, Yong Moon Park, Seung Hyun Ko, Kun Ho Yoon, Moo Il Kang, Bong Yun Cha, Seung Hwan Lee
BACKGROUND: This study aimed to investigate the association between the presence and severity of cardiovascular autonomic neuropathy (CAN) and development of long-term glucose fluctuation in subjects with type 2 diabetes mellitus. METHODS: In this retrospective cohort study, subjects with type 2 diabetes mellitus who received cardiovascular autonomic reflex tests (CARTs) at baseline and at least 4-year of follow-up with ≥6 measures of glycosylated hemoglobin (HbA1c) were included...
September 28, 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/30289492/microvascular-complications-of-posttransplant-diabetes-mellitus-in-kidney-transplant-recipients-a-longitudinal-study-posttransplant-diabetes-complications
#19
Thizá Massaia Londero, Luana Seminotti Giaretta, Luisa Penso Farenzena, Roberto Manfro, Luis Henrique Canani, Daniel Lavinsky, Cristiane Bauermann Leitão, Andrea Carla Bauer
Objective: to assesses microvascular complications in renal transplant recipients with posttransplant diabetes mellitus (PTDM). Research Design and Methods: in this observational study, patients with ≥ 5 years of PTDM were included from a cohort of 895 kidney recipients transplanted in 2000-2011. Diabetic retinopathy was evaluated by fundus photographs and optical coherence tomography (OCT). Diabetes kidney disease was evaluated by protein to creatinine ratio (PCR) and estimated glomerular filtration rate (eGFR)...
October 4, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30281621/a-cardiac-risk-score-based-on-sudomotor-function-to-evaluate-cardiovascular-autonomic-neuropathy-in-asymptomatic-chinese-patients-with-diabetes-mellitus
#20
Tao Yuan, Jiapei Li, Yong Fu, Tao Xu, Juan Li, Xiangqing Wang, Ying Zhou, Yingyue Dong, Weigang Zhao
BACKGROUNDS: Cardiac autonomic neuropathy is a common but always overlooked. More convenient diagnostic methods are needed. HYPOTHESIS: Cardiac autonomic neuropathy risk score evaluated by SUDOSCAN has a fine diagnostic efficacy detecting cardiac autonomic neuropathy. METHODS: This is a cross-sectional study among patients with diabetes mellitus. Subjects undertook SUDOSCAN tests and cardiac autonomic reflex tests, including heart rate variability due to Valsalva maneuver, heart rate response due to deep breathing and heart rate response due to standing up...
2018: PloS One
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