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Diabetic Cardiovascular Autonomic Neuropathy

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https://www.readbyqxmd.com/read/30087063/is-there-an-association-between-non-dipping-blood-pressure-and-measures-of-glucose-variability-in-type-1-diabetes
#1
Mamta Jaiswal, Lynn Ang, Kara Mizokami-Stout, Rodica Pop-Busui
AIM: To assess the relationship between glucose variability (GV) and non-dipping of blood pressure (BP) as a marker of cardiovascular autonomic neuropathy (CAN) among patients with type 1 diabetes (T1D). METHODS: Forty-one subjects with T1D (age 34 ± 13 years, duration 13 ± 6 years, HbA1c 8 ± 1.2%) without cardiovascular disease, dyslipidemia, or hypertension at baseline were enrolled in a 3-year observational cohort study. Subjects were phenotyped for CAN with heart rate variability, cardiovascular autonomic reflex tests, and 24-h BP profiles at baseline and during follow-up...
July 31, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30084083/involvement-of-p2y-12-receptor-of-stellate-ganglion-in-diabetic-cardiovascular-autonomic-neuropathy
#2
Jingjing Guo, Xuan Sheng, Yu Dan, Yurong Xu, Yuanruohan Zhang, Huihong Ji, Jiayue Wang, Zixi Xu, Hongyu Che, Guodong Li, Shangdong Liang, Guilin Li
Diabetes as a chronic epidemic disease with obvious symptom of hyperglycemia is seriously affecting human health globally due to the diverse diabetic complications. Diabetic cardiovascular autonomic neuropathy (DCAN) is a common complication of both type 1 and type 2 diabetes and incurs high morbidity and mortality. However, the underlying mechanism for DCAN is unclear. It is well known that purinergic signaling is involved in the regulation of cardiovascular function. In this study, we examined whether the P2Y12 receptor could mediate DCAN-induced sympathetic reflexes...
August 6, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/30071872/progression-of-cardiovascular-autonomic-neuropathy-and-cardiovascular-disease-in-type-2-diabetes
#3
Jae-Seung Yun, Yong-Moon Park, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
BACKGROUND: To examine whether the progression rate of cardiovascular autonomic neuropathy (CAN) stage is an independent predictive factor for cardiovascular disease (CVD) in type 2 diabetes. METHODS: Standardized cardiovascular autonomic reflex tests (CARTs) using traditional Ewing method were performed at baseline. The follow-up CARTs was recommended once every two years. We estimated the primary CVD endpoint, defined as coronary artery disease and ischemic stroke...
August 2, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/30006307/time-and-frequency-domain-measures-of-heart-rate-variability-predict-cardiovascular-outcome-in-patients-with-type-2-diabetes
#4
Seon-Ah Cha, Yong-Moon Park, Jae-Seung Yun, Seung-Hwan Lee, Yu-Bae Ahn, Sung-Rae Kim, Seung-Hyun Ko
AIMS: To evaluate the association between impaired heart rate variability (HRV) and cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM). METHODS: A total of 655 patients with T2DM who underwent cardiovascular autonomic function testing were consecutively recruited and followed up prospectively. Time- and frequency-domain HRV were assessed for 5 min by beat-to-beat heart rate recording. We estimated the development of CVD events during a follow-up period...
July 10, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29999549/cardiovascular-autonomic-neuropathy-and-bone-metabolism-in-type-1-diabetes
#5
C S Hansen, S Theilade, M Lajer, T W Hansen, P Rossing
AIM: To investigate the association between cardiovascular autonomic neuropathy and bone metabolism in people with Type 1 diabetes. METHODS: We assessed cardiovascular autonomic neuropathy in 329 people with Type 1 diabetes according to heart rate response to deep breathing, to standing and to the Valsalva manoeuvre, and 2-min resting heart rate. More than one pathological non-resting test was defined as cardiovascular autonomic neuropathy. Bone mineral density of the femoral neck (BMDfn) was assessed by dual energy X-ray absorptiometry...
July 12, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29937880/qtc-prolongation-in-black-diabetic-subjects-with-cardiac-autonomic-neuropathy
#6
Ogba J Ukpabi, Basden Jc Onwubere
Background: Prolonged corrected QT (QTc) has been identified as a risk factor for malignant arrhythmias and sudden cardiac death. Caucasian studies have shown a definite relationship between QTc prolongation and Cardiac Autonomic Neuropathy (CAN) in diabetic subjects. Objective: To determine the prevalence of prolonged QTc in Black diabetic individuals with CAN and to ascertain how prolonged QTc correlated with the severity of CAN among these patients. Methods: A total of 176 adult diabetic subjects were studied, 87 males and 89 females...
December 2017: African Health Sciences
https://www.readbyqxmd.com/read/29793518/a-dose-response-study-of-aerobic-training-for-oxygen-uptake-oxidative-stress-and-cardiac-autonomic-function-in-type-2-diabetes-mellitus-study-protocol-for-a-randomized-controlled-trial
#7
Shalini Verma, Jamal Ali Moiz, Shahnawaz Anwer, Ahmad H Alghadir, Mohammed Ejaz Hussain
BACKGROUND: Cardiac autonomic neuropathy is a commonly overlooked complication of type 2 diabetes mellitus (T2DM) characterized by an imbalance between sympathetic and parasympathetic supply to the heart, which contributes to cardiovascular morbidity and mortality. T2DM has also been shown to negatively influence oxygen kinetics and increase oxidative stress, which may be linked to the development of various chronic complications. Aerobic training has been reported to improve oxygen uptake, antioxidant defense, and cardiac autonomic function in T2DM; however, the effects of varying doses of exercise on these variables are not known...
May 24, 2018: Trials
https://www.readbyqxmd.com/read/29775674/the-prognostic-value-of-the-frontal-qrs-t-angle-is-comparable-to-cardiovascular-autonomic-neuropathy-regarding-long-term-mortality-in-people-with-diabetes-a-population-based-study
#8
O May, C B Graversen, M Ø Johansen, H Arildsen
Cardiovascular autonomic neuropathy (CAN) is a well known prognostic marker in diabetes. A large angle between the QRS- and the T-wave vector (QRS-T angle) in the electrocardiogram (ECG) has recently been introduced as another marker of poor prognosis. AIM: To assess and compare the long-term predictive power of the frontal plane QRS-T angle with CAN in people with diabetes. METHODS: In 1992-93 people with diabetes in the municipality of Horsens, Denmark, were identified by the prescription method andan age and gender stratified sample of 240 individuals with diabetes were randomly selected...
June 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29725320/cardiovascular-autonomic-neuropathy-and-glucose-variability-in-patients-with-type-1-diabetes-is-there-an-association
#9
Szabolcs Nyiraty, Fruzsina Pesei, Andrea Orosz, Sara Coluzzi, Orsolya Eszter Vági, Csaba Lengyel, György Ábrahám, Simona Frontoni, Peter Kempler, Tamás Várkonyi
Introduction: The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV. Patients and methods: Twenty type 1 diabetic patients were involved (age: 39.5 ± 3.4 years, duration of diabetes: 17.5 ± 2.5 years; HbA1c: 8...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29693021/predictors-of-cardiovascular-autonomic-neuropathy-onset-and-progression-in-a-cohort-of-type-1-diabetic-patients
#10
M Matta, A Pavy-Le Traon, S Perez-Lloret, C Laporte, I Berdugo, N Nasr, H Hanaire, J M Senard
Aim: The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Methods: 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29679631/possible-early-detection-of-coronary-artery-calcium-progression-in-type-1-diabetes-a-case-control-study-of-normoalbuminuric-type-1-diabetes-patients-and-matched-controls
#11
Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Helle Corinth, Ulrik M Mogensen, Lars Køber, Andreas Fuchs, Børge G Nordestgaard, Klaus F Kofoed
AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression. METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC...
July 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29675928/differential-cardiac-sympatho-inhibitory-responses-produced-by-the-agonists-b-ht-933-quinpirole-and-immepip-in-normoglycaemic-and-diabetic-pithed-rats
#12
Eduardo Rivera-Mancilla, Alain H Altamirano-Espinoza, Guadalupe Manrique-Maldonado, Belinda Villanueva-Castillo, Carlos M Villalón
This study compared the cardiac sympatho-inhibitory responses produced by agonists at α2 -adrenergic (B-HT 933), dopamine D2 -like (quinpirole) and histamine H3 /H4 (immepip) receptors between normoglycaemic and streptozotocin-pretreated (diabetic) pithed rats. Intravenous (i.v.) continuous infusions of B-HT 933, quinpirole or immepip were used in normoglycaemic and diabetic pithed rats to analyse their sympatho-inhibitory effects on the electrically-stimulated cardioaccelerator sympathetic outflow. Both in normoglycaemic and diabetic animals, B-HT 933 (until 100 μg/kg per minute) and quinpirole (until 10 μg/kg per minute) inhibited the tachycardic responses to electrical sympathetic stimulation, but not those to i...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29643979/cardiac-autonomic-neuropathy-as-a-result-of-mild-hypercaloric-challenge-in-absence-of-signs-of-diabetes-modulation-by-antidiabetic-drugs
#13
Ola Al-Assi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Nahed Mougharbil, Ali H Eid, Fouad A Zouein, Ahmed F El-Yazbi
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident. The cause of CAN remains elusive and cannot be directly linked to hyperglycemia. Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action. Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of interfering effects of hyperglycemia, glucose intolerance, or obesity...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29608603/heart-rate-variability-in-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#14
REVIEW
Thomas Benichou, Bruno Pereira, Martial Mermillod, Igor Tauveron, Daniela Pfabigan, Salwan Maqdasy, Frédéric Dutheil
BACKGROUND: Cardiac autonomic neuropathy in type 2 dibetes mellitus (T2DM) patients is frequent and associated with high cardiovascular mortality. Heart rate variability (HRV) is the gold standard to measure cardiac autonomic neuropathy. We aimed to conduct a systematic review and meta-analysis to evaluate the impact of T2DM on HRV parameters. METHODS: The PubMed, Cochrane Library, Embase and Science Direct databases were searched on 1st October 2017 using the keywords "diabetes" AND ("heart rate variability" OR "HRV")...
2018: PloS One
https://www.readbyqxmd.com/read/29593644/autonomic-neuropathy-a-prospective-cohort-study-of-symptoms-and-e-i-ratio-in-normal-glucose-tolerance-impaired-glucose-tolerance-and-type-2-diabetes
#15
Malin Zimmerman, Kaveh Pourhamidi, Olov Rolandsson, Lars B Dahlin
Background: Autonomic neuropathy in diabetes, in addition to causing a range of symptoms originating from the autonomic nervous system, may increase cardiovascular morbidity. Our aim was to study the progression of autonomic neuropathy, based on symptom score and evaluation of an autonomic test, in persons with normal and impaired glucose tolerance and in patients with type 2 diabetes (T2D). Methods: Participants were recruited in 2003/2004 with a follow-up in 2014...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29559406/perioperative-management-of-adult-diabetic-patients-preoperative-period
#16
Gaëlle Cheisson, Sophie Jacqueminet, Emmanuel Cosson, Carole Ichai, Anne-Marie Leguerrier, Bogdan Nicolescu-Catargi, Alexandre Ouattara, Igor Tauveron, Paul Valensi, Dan Benhamou
In diabetic patients undergoing surgery, we recommend assessing glycaemic control preoperatively by assessing glycated haemoglobin (HbA1c) levels and recent capillary blood sugar (glucose) levels, and to adjust any treatments accordingly before surgery, paying particular attention to specific complications of diabetes. Gastroparesis creates a risk of stasis and aspiration of gastric content at induction of anaesthesia requiring the use of a rapid sequence induction technique. Cardiac involvement can be divided into several types...
June 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29514695/glycemic-variability-in-continuous-glucose-monitoring-is-inversely-associated-with-baroreflex-sensitivity-in-type-2-diabetes-a-preliminary-report
#17
Daisuke Matsutani, Masaya Sakamoto, Hiroyuki Iuchi, Souichirou Minato, Hirofumi Suzuki, Yosuke Kayama, Norihiko Takeda, Ryuzo Horiuchi, Kazunori Utsunomiya
BACKGROUND: It is presently unclear whether glycemic variability (GV) is associated with baroreflex sensitivity (BRS), which is an early indicator of cardiovascular autonomic neuropathy. The present study is the first to examine the relationships between BRS and GV measured using continuous glucose monitoring (CGM). METHODS: This was a multicenter, prospective, open-label clinical trial. A total of 102 patients with type 2 diabetes were consecutively recruited for this study...
March 7, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29504257/correlation-of-retinal-neurodegeneration-with-measures-of-peripheral-autonomic-neuropathy-in-type-1-diabetes
#18
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29500542/cardiac-autonomic-function-in-children-with-type-1-diabetes
#19
Kotb Abbass Metwalley, Sherifa Ahmed Hamed, Hekma Saad Farghaly
Cardiovascular autonomic neuropathy (CAN) is a major complication of type 1 diabetes (T1D). This study aimed to evaluate cardiac autonomic nervous system (ANS) function in children with T1D and its relation to different demographic, clinical and laboratory variable. This cross-sectional study included 60 children with T1D (mean age = 15.1 ± 3.3 years; duration of diabetes = 7.95 ± 3.83 years). The following 8 non-invasive autonomic testing were used for evaluation: heart rate at rest and in response to active standing (30:15 ratio), deep breathing and Valsalva maneuver (indicating parasympathetic function); blood pressure response to standing (orthostatic hypotension or OH), sustained handgrip and cold; and heart rate response to standing or positional orthostatic tachycardia syndrome or POTs (indicating sympathetic function)...
June 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29453140/serum-apolipoprotein-a-1-concentrations-and-the-prevalence-of-cardiovascular-autonomic-neuropathy-in-individuals-with-type-2-diabetes
#20
Jin Ook Chung, Seon-Young Park, Ji Hyun Han, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
OBJECTIVE: To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. METHODS: In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of a cardiovascular reflex test. Serum apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) levels were measured. RESULTS: Serum apoA-1 levels were significantly low in individuals with CAN, but there was no significant association between serum apoB levels and CAN...
April 2018: Journal of Diabetes and its Complications
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