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Acetylcholine imbalance

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https://www.readbyqxmd.com/read/30063976/evaluation-of-oxidative-stress-and-antioxidant-status-serum-trace-mineral-levels-and-cholinesterases-activity-in-cattle-infected-with-anaplasma-marginale
#1
Bijan Esmaeilnejad, Mousa Tavassoli, Awat Samiei, Nasser Hajipour, Abbas Imani-Baran, Farhad Farhang-Pajuh
This study was undertaken to assess the influence of an Anaplasma marginale infection on oxidative stress and antioxidant status, trace elements and cholinesterase as markers of the inflammatory process and biomarkers of oxidative imbalance. An infected group comprised of 35 crossbred Holstein cattle, about 2-3 years old, naturally infected with Anaplasma marginale, were divided into 4 subgroups according to their parasitemia rates (<1%, 1-10%, 10-20%, >20%) and also 10 healthy cattle as control were selected...
July 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30051417/postoperative-delirium-in-the-elderly-the-potential-neuropathogenesis
#2
REVIEW
Yiru Wang, Xia Shen
Postoperative delirium (POD) is a neurobehavioral syndrome caused by dysfunction of neural activity mainly in elderly people. POD is not uncommon, but under-recognized, and often serious. Multifactorial causes including aging, acetylcholine deficiency, sleep deprivation and intraoperative hypoxia have been proposed attempting to explain the processes leading to the development of POD. To date, however, no specific pathophysiologic mechanism has been identified. Here, we summarize the five most prominent theories (neuronal aging, neuroinflammation, neurotransmitter imbalance, neuroendocrine activation, and network connectivity change) to explain the development of delirium...
July 26, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/30031104/experimentally-induced-maternal-hypothyroidism-alters-enzyme-activities-and-the-sensorimotor-cortex-of-the-offspring-rats
#3
Juliana Tonietto Domingues, Carolinne Sayury Wajima, Patricia Acordi Cesconetto, Eduardo Benedetti Parisotto, Elisa Winkelmann-Duarte, Karin Dos Santos, Najla Saleh, Fabíola Branco Filippin-Monteiro, Guilherme Razzera, Fátima Regina Mena Barreto Silva, Regina Pessoa-Pureur, Ariane Zamoner
In this study, we used an experimental model of congenital hypothyroidism to show that deficient thyroid hormones (TH) disrupt different neurochemical, morphological and functional aspects in the cerebral cortex of 15-day-old offspring. Our results showing decreased glutamine synthetase (GS) activity and Ca2+ overload in the cerebral cortex of hypothyroid pups suggest misregulated glutamate metabolism associated with developmentally induced TH deficiency. The 14 C-MeAIB accumulation indicates upregulated System A activity and glutamine uptake by neurons...
July 18, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/30009813/additive-counteraction-by-%C3%AE-7-and-%C3%AE-4%C3%AE-2-nachrs-of-the-hypotension-and-cardiac-sympathovagal-imbalance-evoked-by-endotoxemia-in-male-rats
#4
Marwa Y Sallam, Sahar M El-Gowilly, Hanan M El-Gowelli, Mohammed A El-Lakany, Mahmoud M El-Mas
The cholinergic antiinflammatory pathway favorably influences end organ damage induced by inflammatory conditions. Here, we hypothesized that α7 and/or α4β2-nicotinic acetylcholine receptors (nAChRs) protect against cardiovascular and autonomic imbalances induced by endotoxemia in rats. We assessed dose-effect relationships of i.v. nicotine (25, 50, or 100 μg/kg), PHA-543613 (α7-nAChR agonist; 0.2 or 2.0 mg/kg), or 5-iodo-A-85380 (5IA, α4β2-nAChRs agonist; 0.01 or 0.1 mg/kg) on cardiovascular and inflammatory responses elicited by lipopolysaccharide (LPS, 10 mg/kg i...
July 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29851248/lactobacillus-fermentum-improves-tacrolimus-induced-hypertension-by-restoring-vascular-redox-state-and-improving-enos-coupling
#5
Marta Toral, Miguel Romero, Alba Rodríguez-Nogales, Rosario Jiménez, Iñaki Robles-Vera, Francesca Algieri, Natalia Chueca-Porcuna, Manuel Sánchez, Néstor de la Visitación, Mónica Olivares, Federico García, Francisco Pérez-Vizcaíno, Julio Gálvez, Juan Duarte
SCOPE: The aim is to analyze whether the probiotic Lactobacillus fermentum CECT5716 (LC40) can prevent endothelial dysfunction and hypertension induced by tacrolimus in mice. METHODS AND RESULTS: Tacrolimus increases systolic blood pressure (SBP) and impairs endothelium-dependent relaxation to acetylcholine and these effects are partially prevented by LC40. Endothelial dysfunction induced by tacrolimus is related to both increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) and uncoupled endothelial nitric oxide synthase (eNOS)-driven superoxide production and Rho-kinase-mediated eNOS inhibition...
May 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29782883/a-new-outlook-on-cholinergic-interneurons-in-parkinson-s-disease-and-l-dopa-induced-dyskinesia
#6
REVIEW
Melissa M Conti, Nicole Chambers, Christopher Bishop
Traditionally, dopamine (DA) and acetylcholine (ACh) striatal systems were considered antagonistic and imbalances or aberrant signaling between these neurotransmitter systems could be detrimental to basal ganglia activity and pursuant motor function, such as in Parkinson's disease (PD) and L-DOPA-induced dyskinesia (LID). Herein, we discuss the involvement of cholinergic interneurons (ChIs) in striatally-mediated movement in a healthy, parkinsonian, and dyskinetic state. ChIs integrate numerous neurotransmitter signals using intrinsic glutamate, serotonin, and DA receptors and convey the appropriate transmission onto nearby muscarinic and nicotinic ACh receptors to produce movement...
May 18, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29720657/structural-principles-of-distinct-assemblies-of-the-human-%C3%AE-4%C3%AE-2-nicotinic-receptor
#7
Richard M Walsh, Soung-Hun Roh, Anant Gharpure, Claudio L Morales-Perez, Jinfeng Teng, Ryan E Hibbs
Fast chemical communication in the nervous system is mediated by neurotransmitter-gated ion channels. The prototypical member of this class of cell surface receptors is the cation-selective nicotinic acetylcholine receptor. As with most ligand-gated ion channels, nicotinic receptors assemble as oligomers of subunits, usually as hetero-oligomers and often with variable stoichiometries 1 . This intrinsic heterogeneity in protein composition provides fine tunability in channel properties, which is essential to brain function, but frustrates structural and biophysical characterization...
May 2018: Nature
https://www.readbyqxmd.com/read/29655652/protective-role-of-rosmarinic-acid-on-amyloid-beta-42-induced-echoic-memory-decline-implication-of-oxidative-stress-and-cholinergic-impairment
#8
Deniz Kantar Gok, Enis Hidisoglu, Guzide Ayse Ocak, Hakan Er, Alev Duygu Acun, Piraye Yargıcoglu
In the present study, we examined whether rosmarinic acid (RA) reverses amyloid β (Aβ) induced reductions in antioxidant defense, lipid peroxidation, cholinergic damage as well as the central auditory deficits. For this purpose, Wistar rats were randomly divided into four groups; Sham(S), Sham + RA (SR), Aβ42 peptide (Aβ) and Aβ42 peptide + RA (AβR) groups. Rat model of Alzheimer was established by bilateral injection of Aβ42 peptide (2,2 nmol/10 μl) into the lateral ventricles. RA (50 mg/kg, daily) was administered orally by gavage for 14 days after intracerebroventricular injection...
September 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29569949/altered-expression-of-transcription-factors-irf4-and-irf8-in-peripheral-blood-b-cells-is-associated-with-clinical-severity-and-circulating-plasma-cells-frequency-in-patients-with-myasthenia-gravis
#9
Yong Zhang, Xiao Jia, Yan Xia, Hao Li, Fei Chen, Jie Zhu, Xiuying Zhang, Yanyan Zhang, YuZhong Wang, Yanan Xu, Meng Pan, Xiaoyu Huang, Tingyan Yu, Linlin Fu, Chenghua Xiao, Deqin Geng
Previous studies have shown that interferon regulatory factor-4 (IRF4) and IRF8 play critical but distinct roles in the differentiation of B cells into plasma cells (PCs). In the present study, we aimed to measure the expression levels of IRF4 and IRF8 in B cells from patients with myasthenia gravis (MG) and to investigate whether the expression of IRF4 and IRF8 associates with pathogenesis of MG. A total of 35 anti-acetylcholine receptor (AChR) antibody (Ab)-positive patients with MG [20 generalized MG (GMG) and 15 ocular MG (OMG) and 25 healthy donors were recruited in this study...
May 2018: Autoimmunity
https://www.readbyqxmd.com/read/29512464/insight-into-the-emerging-role-of-striatal-neurotransmitters-in-the-pathophysiology-of-parkinson-s-disease-and-huntington-s-disease-a-review
#10
Sumit Jamwal, Puneet Kumar
Alteration in neurotransmitters signaling in basal ganglia has been consistently shown to significantly contribute to the pathophysiological basis of Parkinson's disease and Huntington's disease. Dopamine is important neurotransmitter which play critical role in coordinated body movements. Alteration in level of brain dopamine and receptor radically contribute to irregular movements, glutamate mediated excitotoxic neuronal death and further leads to imbalance in the levels of other neurotransmitters viz. GABA, adenosine, acetylcholine and endocannabinoids...
March 1, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29492663/the-striatal-cholinergic-system-in-l-dopa-induced-dyskinesias
#11
REVIEW
X A Perez, T Bordia, M Quik
Cholinergic signaling plays a key role in regulating striatal function. The principal source of acetylcholine in the striatum is the cholinergic interneurons which, although low in number, densely arborize to modulate striatal neurotransmission. This modulation occurs via strategically positioned nicotinic and muscarinic acetylcholine receptors that influence striatal dopamine, GABA and other neurotransmitter release. Cholinergic interneurons integrate multiple striatal synaptic inputs and outputs to regulate motor activity under normal physiological conditions...
August 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29405352/an-imbalance-between-regulatory-t-cells-and-t-helper-17-cells-in-acetylcholine-receptor-positive-myasthenia-gravis-patients
#12
REVIEW
Jose Adolfo Villegas, Jérôme Van Wassenhove, Rozen Le Panse, Sonia Berrih-Aknin, Nadine Dragin
A chronic autoimmune disease, myasthenia gravis (MG) is characterized in 85% of patients by antibodies directed against the acetylcholine receptor (AChR) located at the neuromuscular junction. The functional and effective balance between regulatory T cells (Treg cells) and effector T cells (Teff cells) is lost in the hyperplastic thymus of MG patients with antibodies specific for the AChR (AChR+ MG patients). The objective of this review is to describe how Treg cells and inflammatory T cells participate in this imbalance and contribute to induce a chronic inflammatory state in the MG thymus...
February 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29397207/cholinergic-imbalance-in-lumbar-spinal-cord-of-a-rat-model-of-multiple-sclerosis
#13
Chunling Liu, Hui Liu, Hongjun Jin, Xuyi Yue, Zonghua Luo, Zhude Tu
Cholinergic dysfunction in the central nervous system is an important characteristic of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). By using a rat EAE model, upregulation of vesicular acetylcholine transporter (VAChT) level in the EAE rat lumbar spinal cord was detected by western blot and immunostaining, and was associated with lymphocyte filtration and glial activation. Ex vivo and in vitro autoradiography studies with [18 F]VAT, a VAChT-specific radioligand, also revealed increased tracer uptake in EAE rat lumbar spinal cord compared with shams...
May 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29306322/curcumin-attenuates-collagen-induced-inflammatory-response-through-the-gut-brain-axis
#14
Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai
BACKGROUND: Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of curcumin. METHODS: The collagen-induced arthritis (CIA) rat model was induced by immunization with an emulsion of collagen II and complete Freund's adjuvant. Sympathetic and parasympathetic tones were measured by electrocardiographic recordings...
January 6, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29298542/the-role-of-alpha7-nicotinic-acetylcholine-receptors-in-inflammatory-bowel-disease-involvement-of-different-cellular-pathways
#15
Mohammad Seyedabadi, Reza Rahimian, Jean-Eric Ghia
Autonomic imbalance plays a pivotal role in the pathophysiology of inflammatory bowel diseases (IBD). The central nervous system (CNS) cooperates dynamically with the immune system to regulate inflammation through humoral and neural pathways. In particular, acetylcholine (Ach), the main neurotransmitter in the vagus nerve, decreases the production of pro-inflammatory cytokines through a mechanism dependent on the α7 nicotinic Ach receptors (α7nAChRs). Areas covered: Here, we review the evidence for involvement of the cholinergic anti-inflammatory pathway (CAP) in IBD...
February 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29071918/-development-of-researches-on-mechanisms-of-acupuncture-intervention-in-improving-myocar-dial-ischemia-by-balancing-interaction-between-%C3%AE-adrenergic-receptor-and-acetylcholinergic-receptor-signal-transduction-pathway-of-myocardiocytes
#16
REVIEW
Li Shi, Jun-Hong Gao, Ji-Ping Zhao, Bing Zhu, Xiao-Chun Yu, Pei-Jing Rong
The imbalance of autonomic nervous function after myocardial ischemia (MI) accelerates the development of ischemic myocardial injury. The beta-adrenergic receptor (β-AR) and muscarinic acetylcholine receptor (M-AChR) are the main receptor types of the cardiomyocyte and the binding sites of the cardiac sympathetic and parasympathetic transmitters. In the present paper, the authors review recent progress of experimental researches on the mechanisms of acupuncture therapy in the prevention and treatment of MI, mainly focusing on the signaling of β1 -AR and M2 -AChR subtypes...
June 25, 2016: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/28842344/allosteric-modulation-of-nicotinic-and-gaba-a-receptor-subtypes-differentially-modify-autism-like-behaviors-in-the-btbr-mouse-model
#17
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Narielle L Ayala, Timothy Johnstone, Andrew J Dunnigan, Timothy K Gee, Kelvin W Gee
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acidA (GABAA ) and α7 nicotinic acetylcholine receptors (nAChRs) significantly impact E/I...
November 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28771182/new-targets-for-schizophrenia-treatment-beyond-the-dopamine-hypothesis
#18
REVIEW
Albert C Yang, Shih-Jen Tsai
Schizophrenia has been primarily associated with dopamine dysfunction, and treatments have been developed that target the dopamine pathway in the central nervous system. However, accumulating evidence has shown that the core pathophysiology of schizophrenia might involve dysfunction in dopaminergic, glutamatergic, serotonergic, and gamma-aminobutyric acid (GABA) signaling, which may lead to aberrant functioning of interneurons that manifest as cognitive, behavioral, and social dysfunction through altered functioning of a broad range of macro- and microcircuits...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28584127/dynamic-changes-in-murine-forebrain-mir-211-expression-associate-with-cholinergic-imbalances-and-epileptiform-activity
#19
Uriya Bekenstein, Nibha Mishra, Dan Z Milikovsky, Geula Hanin, Daniel Zelig, Liron Sheintuch, Amit Berson, David S Greenberg, Alon Friedman, Hermona Soreq
Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures. Epileptogenesis may develop due to genetic or pharmacological origins or following injury, but it remains unclear how the unaffected brain escapes this susceptibility to seizures. Here, we report that dynamic changes in forebrain microRNA (miR)-211 in the mouse brain shift the threshold for spontaneous and pharmacologically induced seizures alongside changes in the cholinergic pathway genes, implicating this miR in the avoidance of seizures...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28547815/balancing-the-autonomic-nervous-system-to-reduce-inflammation-in-rheumatoid-arthritis
#20
REVIEW
F A Koopman, M A van Maanen, M J Vervoordeldonk, P P Tak
Imbalance in the autonomic nervous system (ANS) has been observed in many established chronic autoimmune diseases, including rheumatoid arthritis (RA), which is a prototypic immune-mediated inflammatory disease (IMID). We recently discovered that autonomic dysfunction precedes and predicts arthritis development in subjects at risk of developing seropositive RA. In addition, RA patients with relatively high vagus nerve tone (higher parasympathetic parameters, measured by heart rate variability) respond better to antirheumatic therapies...
July 2017: Journal of Internal Medicine
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