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George Sarosi

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https://www.readbyqxmd.com/read/30471171/carborane-based-analogues-of-5-lipoxygenase-inhibitors-co-inhibit-heat-shock-protein-90-in-hct-116-cells
#1
Evamarie Hey-Hawkins, Robert Kuhnert, Menyhárt-Botond Sárosi, Sven George, Peter Lönnecke, Bettina Hofmann, Dieter Steinhilber, Sara Steinmann, Regine Schneider-Stock, Blagoje Murganic, Sanja Mijatovic, Danijelа Maksimovic-Ivanic
5-Lipoxygenase converts arachidonic acid to leukotrienes that are involved in inflammation and angiogenesis. The introduction of carboranes can improve the pharmacokinetic behavior of metabolically less stable pharmaceutics. We here report the syntheses of several carborane-based inhibitors of the 5-lipoxygenase pathway. The isosteric replacement of phenyl rings by carboranes leads to improved cytotoxicity for several melanoma and colon cancer cell lines. For the colon cancer cell line HCT-116 the co-inhibition of heat shock protein 90 could be detected...
November 24, 2018: ChemMedChem
https://www.readbyqxmd.com/read/30177356/gender-diversity-in-general-surgery-residency-leadership
#2
Anne-Marie Carpenter, Sanda A Tan, Kelly Costopoulos, Lou Ann Cooper, George A Sarosi, Christiana M Shaw
OBJECTIVE: This study aimed to evaluate the proportion and characteristics of women who serve in general surgery program director (PD) and associate program director (APD) positions in the United States. DESIGN: General surgery programs (n = 276) and directors were identified using the Association for Program Directors in Surgery website; information was cross-referenced with American Medical Association FREIDA and Accreditation Council for Graduate Medical Education databases, current to July 1, 2017...
August 31, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/30172359/packed-red-blood-cell-donor-age-affects-overall-survival-in-transfused-patients-undergoing-hepatectomy-for-non-hepatocellular-malignancy
#3
Tyler J Loftus, Alexandra N Lopez, Thomas K Jenkins, Edward M Downey, James R Sikora, J Peter R Pelletier, Ivan R Zendejas, George A Sarosi, Ryan M Thomas
BACKGROUND: Patients undergoing hepatectomy often require packed red blood cell (PRBC) transfusion, which has been associated with worse oncologic outcomes. However, limited data exist regarding the impact of PRBC donor factors. We hypothesized that PRBC donor age impacts survival after hepatectomy for non-hepatocellular malignancies. METHODS: Patients who underwent hepatectomy for non-hepatocellular malignancy from 2005 to 2014 were retrospectively evaluated. Impact of clinicopathologic and PRBC factors on oncologic outcomes were assessed...
August 27, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29937017/postoperative-surgical-trainee-opioid-prescribing-practices-post-opp-an-institutional-study
#4
Kevin R Olsen, David J Hall, Juan C Mira, Patrick W Underwood, Ajay B Antony, Terrie Vasilopoulos, George A Sarosi
BACKGROUND: Increasing mortality from opioid overdoses has prompted increased focus on prescribing practices of physicians. Unfortunately, resident physicians rarely receive formal education in effective opioid prescribing practices or postoperative pain management. Data to inform surgical training programs regarding the utility and feasibility of formal training are lacking. METHODS: Following Institutional Review Board approval, a single institution's resident physicians who had completed at least one surgical rotation were surveyed to assess knowledge of pain management and evaluate opioid prescribing practices...
September 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29710280/reducing-surgical-resident-attrition
#5
Christiana Shaw, George A Sarosi
No abstract text is available yet for this article.
August 1, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29518379/cavitary-lung-diseases-a-clinical-radiologic-algorithmic-approach
#6
REVIEW
Khalid Gafoor, Shalin Patel, Francis Girvin, Nishant Gupta, David Naidich, Stephen Machnicki, Kevin K Brown, Atul Mehta, Bryan Husta, Jay H Ryu, George A Sarosi, Tomás Franquet, Johny Verschakelen, Takeshi Johkoh, William Travis, Suhail Raoof
Cavities occasionally are encountered on thoracic images. Their differential diagnosis is large and includes, among others, various infections, autoimmune conditions, and primary and metastatic malignancies. We offer an algorithmic approach to their evaluation by initially excluding mimics of cavities and then broadly classifying them according to the duration of clinical symptoms and radiographic abnormalities. An acute or subacute process (< 12 weeks) suggests common bacterial and uncommon nocardial and fungal causes of pulmonary abscesses, necrotizing pneumonias, and septic emboli...
June 2018: Chest
https://www.readbyqxmd.com/read/29198770/preoperative-enteral-access-is-not-necessary-prior-to-multimodality-treatment-of-esophageal-cancer
#7
Thomas K Jenkins, Alexandra N Lopez, George A Sarosi, Kfir Ben-David, Ryan M Thomas
BACKGROUND: Surgical enteral access prior to multimodality treatment for esophageal cancer is controversial as dysphagia is often used for feeding tube referral. We hypothesized that enteral access before neoadjuvant chemoradiation for esophageal cancer provides no benefit compared to that placed during definitive esophagectomy. METHODS: Patients undergoing esophagectomy for esophageal malignancy from 2007 - 2014 were retrospectively identified. Clinicopathologic factors were recorded including preoperative enteral access, weight change, nutritional laboratory works, and perioperative complications...
April 2018: Surgery
https://www.readbyqxmd.com/read/29183501/improvement-in-resident-robotic-surgical-perception-with-a-cadaver-training-lab-a-pilot-study
#8
Atif Iqbal, Ilya Sakharuk, Sanda Tan, Steven J Hughes, George Sarosi
No abstract text is available yet for this article.
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28679001/perspective-of-residency-program-directors-on-accreditation-council-for-graduate-medical-education-changes-in-resident-work-environment-and-duty-hours
#9
Michael O Meyers, George A Sarosi, Karen J Brasel
No abstract text is available yet for this article.
October 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28409378/percutaneous-cholecystostomy-prognostic-factors-and-comparison-to-cholecystectomy
#10
Tyler J Loftus, Elisha M Collins, Camille G Dessaigne, Amber N Himmler, Alicia M Mohr, Ryan M Thomas, Charles E Hobson, George A Sarosi, William J Zingarelli
BACKGROUND: Data regarding long-term outcomes following percutaneous cholecystostomy (PC) are limited, and comparisons to cholecystectomy (CCY) are lacking. We hypothesized that chronic disease burden would predict 1-year mortality following PC, and that outcomes following PC and CCY would be similar when controlling for preprocedural risk factors. METHODS: We performed a 10-year retrospective cohort analysis of patients with acute cholecystitis managed by PC (n = 114) or CCY (n = 234)...
November 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28177861/disseminated-blastomycosis
#11
Anjum S Kaka, George A Sarosi
A 39-year-old man presented with acute hemoptysis and chills. Computed tomography (CT) of his chest showed an infiltrate in the right upper lobe (Panel A), and he was treated with levofloxacin. One month after this presentation, his 5-year-old son pulled on his left ring finger, which caused pain..
February 9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28099380/predicting-appendiceal-tumors-among-patients-with-appendicitis
#12
Tyler J Loftus, Steven L Raymond, George A Sarosi, Chasen A Croft, R Stephen Smith, Philip A Efron, Frederick A Moore, Scott C Brakenridge, Alicia M Mohr, Janeen R Jordan
BACKGROUND: As nonoperative management of appendicitis gains popularity, vigilance for appendiceal tumors becomes increasingly important. We hypothesized that, among patients presenting with acute appendicitis, those with advanced age, multiple comorbidities, atypical presentation, and complicated appendicitis would be more likely to have underlying appendiceal tumors. METHODS: We performed a 4-year retrospective cohort analysis of 677 consecutive adult patients who underwent appendectomy for appendicitis at our tertiary care center...
April 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28050668/antibiotics-may-be-safely-discontinued-within-one-week-of-percutaneous-cholecystostomy
#13
Tyler J Loftus, Scott C Brakenridge, Camille G Dessaigne, George A Sarosi, William J Zingarelli, Frederick A Moore, Janeen R Jordan, Chasen A Croft, R Stephen Smith, Phillip A Efron, Alicia M Mohr
BACKGROUND: For patients with acute cholecystitis managed with percutaneous cholecystostomy (PC), the optimal duration of post-procedural antibiotic therapy is unknown. Our objective was to compare short versus long courses of antibiotics with the hypothesis that patients with persistent signs of systemic inflammation 72 h following PC would receive prolonged antibiotic therapy and that antibiotic duration would not affect outcomes. METHODS: We performed a retrospective cohort analysis of 81 patients who underwent PC for acute cholecystitis at two hospitals during a 41-month period ending November 2014...
May 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/27932030/a-clinically-applicable-muscular-index-predicts-long-term-survival-in-resectable-pancreatic-cancer
#14
Daniel Delitto, Sarah M Judge, Thomas J George, George A Sarosi, Ryan M Thomas, Kevin E Behrns, Steven J Hughes, Andrew R Judge, Jose G Trevino
BACKGROUND: The relationship between myopenia, nutritional status, and long-term oncologic outcomes remains poorly characterized in patients with clinically resectable pancreatic cancer. We sought to reliably quantify prognostic indicators of preoperative cachexia in a manner applicable to any clinical setting. METHODS: Preoperative computed tomographies were available electronically and suitable for analysis in 73 of 82 consecutive patients with pancreatic cancer undergoing pancreatoduodenectomy between November 2010 and February 2014...
April 2017: Surgery
https://www.readbyqxmd.com/read/27893641/routine-surveillance-cholangiography-after-percutaneous-cholecystostomy-delays-drain-removal-and-cholecystectomy
#15
COMPARATIVE STUDY
Tyler J Loftus, Scott C Brakenridge, Frederick A Moore, Camille G Dessaigne, George A Sarosi, William J Zingarelli, Janeen R Jordan, Chasen A Croft, R Stephen Smith, Philip A Efron, Alicia M Mohr
INTRODUCTION: Percutaneous cholecystostomy (PC) is often performed for patients with acute cholecystitis who are at high risk for operative morbidity and mortality. However, the necessity for routine cholangiography after PC remains unclear. We hypothesized that routine surveillance cholangiography (RSC) after PC would provide no benefit compared to on-demand cholangiography (ODC) triggered by signs or symptoms of biliary pathology. METHODS: We performed a 3-year retrospective cohort analysis of patients managed with PC for acute cholecystitis at two tertiary care hospitals...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27627680/comparative-effectiveness-of-preoperative-treatment-regimens-in-patients-with-potentially-resectable-esophageal-cancer
#16
LETTER
Jennifer M Duff, H Charles Peters, William Zingarelli, Kfir Ben-David, George A Sarosi, Ryan M Thomas
No abstract text is available yet for this article.
January 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/27419155/diagnostic-delay-and-antibiotic-overuse-in-acute-pulmonary-blastomycosis
#17
Jonathan D Alpern, Nathan C Bahr, Gabriela Vazquez-Benitez, David R Boulware, Jonathan S Sellman, George A Sarosi
The diagnosis of blastomycosis is often delayed. We identified 28 cases of pulmonary blastomycosis in a retrospective chart review. Most patients received multiple antibiotic courses before being diagnosed, and the sputum KOH smear was rarely used. Diagnostic delay can be decreased with higher suspicion for pulmonary blastomycosis and early use of the sputum KOH smear.
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27260793/standardization-of-surgical-care-in-a-high-volume-center-improves-survival-in-resected-pancreatic-head-cancer
#18
Daniel Delitto, Brian S Black, Holly B Cunningham, Sarunas Sliesoraitis, Xiaomin Lu, Chen Liu, George A Sarosi, Ryan M Thomas, Jose G Trevino, Steven J Hughes, Thomas J George, Kevin E Behrns
BACKGROUND: Durable clinical gains in surgical care are frequently reliant on well-developed standardization of practices. We hypothesized that the standardization of surgical management would result in improved long-term survival in pancreatic cancer. METHODS: Seventy-seven consecutive, eligible patients representing all patients who underwent pancreaticoduodenectomy and received comprehensive, long-term postoperative care at the University of Florida were analyzed...
August 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27142633/oncologic-and-perioperative-outcomes-following-selective-application-of-laparoscopic-pancreaticoduodenectomy-for-periampullary-malignancies
#19
Daniel Delitto, Casey M Luckhurst, Brian S Black, John L Beck, Thomas J George, George A Sarosi, Ryan M Thomas, Jose G Trevino, Kevin E Behrns, Steven J Hughes
BACKGROUND: Data are sparse regarding patient selection criteria or evaluating oncologic outcomes following laparoscopic pancreaticoduodenectomy (LPD). Having prospectively limited LPD to patients with resectable disease defined by National Comprehensive Cancer Network (NCCN) criteria, we evaluated perioperative and long-term oncologic outcomes of LPD compared to a similar cohort of open pancreaticoduodenectomy (OPD). METHODS: Consecutive patients (November 2010-February 2014) undergoing pancreaticoduodenectomy (PD) for periampullary adenocarcinoma were reviewed...
July 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/26667487/nicotine-reduces-survival-via-augmentation-of-paracrine-hgf-met-signaling-in-the-pancreatic-cancer-microenvironment
#20
Daniel Delitto, Dongyu Zhang, Song Han, Brian S Black, Andrea E Knowlton, Adrian C Vlada, George A Sarosi, Kevin E Behrns, Ryan M Thomas, Xiaomin Lu, Chen Liu, Thomas J George, Steven J Hughes, Shannon M Wallet, Jose G Trevino
PURPOSE: The relationship between smoking and pancreatic cancer biology, particularly in the context of the heterogeneous microenvironment, remains incompletely defined. We hypothesized that nicotine exposure would lead to the augmentation of paracrine growth factor signaling between tumor-associated stroma (TAS) and pancreatic cancer cells, ultimately resulting in accelerated tumor growth and metastasis. EXPERIMENTAL DESIGN: The effect of tobacco use on overall survival was analyzed using a prospectively maintained database of surgically resected patients with pancreatic cancer...
April 1, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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