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Lloyd D Harvey, Mona Alotaibi, Hee-Jung Janice Kim, Yi-Yin Tai, Ying Tang, Wei Sun, Wadih El Khoury, Chen-Shan C Woodcock, Yassmin Al Aaraj, Claudette M St Croix, Donna B Stolz, Jiyoung Lee, Mary Hongying Cheng, Tae-Hwi Schwantes-An, Ankit A Desai, Michael W Pauciulo, William C Nichols, Amy Webb, Robert Lafyatis, Mehdi Nouraie, Haodi Wu, Jeffrey G McDonald, Caroline Chauvet, Susan Cheng, Ivet Bahar, Thomas Bertero, Raymond L Benza, Mohit Jain, Stephen Y Chan
Vascular inflammation critically regulates endothelial cell (EC) pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulation of lysosomal activity and cholesterol metabolism have known inflammatory roles in disease, but their relevance to PAH is unclear. In human pulmonary arterial ECs and in PAH, we found that inflammatory cytokine induction of the nuclear receptor coactivator 7 (NCOA7) both preserved lysosomal acidification and served as a homeostatic brake to constrain EC immunoactivation...
March 1, 2024: bioRxiv
#22
JOURNAL ARTICLE
Elham Alhathli, Thomas Julian, Zain Ul Abideen Girach, A A Roger Thompson, Christopher Rhodes, Stefan Gräf, Niamh Errington, Martin R Wilkins, Allan Lawrie, Dennis Wang, Johnathan Cooper-Knock
BACKGROUND: Pulmonary arterial hypertension (PAH) exhibits phenotypic heterogeneity and variable response to therapy. The metabolome has been implicated in the pathogenesis of PAH, but previous works have lacked power to implicate specific metabolites. Mendelian randomization (MR) is a method for causal inference between exposures and outcomes. METHODS AND RESULTS: Using genome-wide association study summary statistics, we implemented MR analysis to test for potential causal relationships between serum concentration of 575 metabolites and PAH...
March 8, 2024: Journal of the American Heart Association
#23
JOURNAL ARTICLE
Minna K Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J Neville, Natalie R van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O Mook-Kanamori, Ayse Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Christiana Kartsonaki, Liming Li, Kuang Lin, Fiona A Hagenbeek, Jouke Jan Hottenga, René Pool, M Arfan Ikram, Joyce van Meurs, Toomas Haller, Yuri Milaneschi, Mika Kähönen, Pashupati P Mishra, Peter K Joshi, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Ilhan E Acar, Carel B Hoyng, Yara T E Lechanteur, Lude Franke, Alexander Kurilshikov, Alexandra Zhernakova, Marian Beekman, Erik B van den Akker, Ivana Kolcic, Ozren Polasek, Igor Rudan, Christian Gieger, Melanie Waldenberger, Folkert W Asselbergs, Caroline Hayward, Jingyuan Fu, Anneke I den Hollander, Cristina Menni, Tim D Spector, James F Wilson, Terho Lehtimäki, Olli T Raitakari, Brenda W J H Penninx, Tonu Esko, Robin G Walters, J Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Ko Willems van Dijk, Fredrik Karpe, Mark I McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Markus Perola, Jaspal S Kooner, John C Chambers, Cornelia van Duijn, P Eline Slagboom, Dorret I Boomsma, John Danesh, Mika Ala-Korpela, Adam S Butterworth, Johannes Kettunen
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1-7 . This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8-11 . Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts...
March 6, 2024: Nature
#24
JOURNAL ARTICLE
Haichao Li, Lihua Wang, Hao Zhang, Wenchi Yu, Yunlun Li, Haiqing Jiang, Danyang Wang, Yu Wang
High blood pressure is a serious human health problem and one of the leading risk factors for fatal complications in cardiovascular disease. The ZXT granules were prepared based on the Zhengan-Xifeng-Tang (ZXT) decoction. However, the therapeutic effects of ZXT granules on spontaneous hypertension and the metabolic pathways in which they may intervene are unclear. The aim of this study was to investigate the antihypertensive effect of ZXT granules on spontaneously hypertensive rats (SHR) and to analyze the metabolic pathway of intervention through chemical composition characterization, pharmacodynamics, and serum metabolomics analysis...
March 1, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
#25
JOURNAL ARTICLE
Jing-Jing Song, Jun Cai, Wen-Jun Ma, Ying Lou, Jin Bian, Beibei Zhao, Xuhui She, Xiao-Ning Liu
Metabolite profiling has the potential to comprehensively bridge phenotypes and complex heterogeneous physiological and pathological states. We performed a metabolomics study using parallel liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis to screen for biomarkers of primary aldosteronism (PA) from a cohort of 111 PA patients and 218 primary hypertension (PH) patients. Hydrophilic interaction chromatography and reversed-phase liquid chromatography separations were employed to obtain a global plasma metabolome of endogenous metabolites...
March 5, 2024: Biomedical Chromatography: BMC
#26
JOURNAL ARTICLE
Zhao Yao, Xueqing Jia, Zhuoneng Chen, Tianfang Zhang, Xin Li, Liming Zhang, Fenfen Chen, Jingyun Zhang, Ziwei Zhang, Zuyun Liu, Zuobing Chen
Objective : To examine the associations of dietary patterns with frailty and whether metabolic signatures (MSs) mediate these associations. Methods : We used UK Biobank data to examine (1) the associations of four dietary patterns ( i.e. , alternate Mediterranean diet [aMED], Recommended Food Score [RFS], Dietary Approaches to Stop Hypertension [DASH] and Mediterranean-DASH Intervention for Neurodegenerative Delay [MIND] diet) with frailty (measured by the frailty phenotype and the frailty index) using multivariable logistic regression (analytic sample 1: N = 124 261; mean age = 57...
March 5, 2024: Food & Function
#27
JOURNAL ARTICLE
Guning Liu, Ngoc Quynh H Nguyen, Kari E Wong, Sunil K Agarwal, Eric Boerwinkle, Patricia P Chang, Brian L Claggett, Laura R Loehr, Jianzhong Ma, Kunihiro Matsushita, Carlos J Rodriguez, Joseph S Rossi, Stuart D Russell, R Brandon Stacey, Amil M Shah, Bing Yu
BACKGROUND: Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. This study aimed to identify metabolites associated with incident HF, HFpEF, and HF with reduced ejection fraction and examine risk prediction in older adults. METHODS: Untargeted metabolomic profiling was performed in Black and White adults from the ARIC study (Atherosclerosis Risk in Communities) visit 5 (n=3719; mean age, 75 years)...
March 1, 2024: Circulation. Heart Failure
#28
JOURNAL ARTICLE
Ying Zhang, Bing Yu, Qibin Qi, Ali Azarbarzin, Han Chen, Neomi A Shah, Alberto R Ramos, Phyllis C Zee, Jianwen Cai, Martha L Daviglus, Eric Boerwinkle, Robert Kaplan, Peter Y Liu, Susan Redline, Tamar Sofer
Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals...
February 28, 2024: Nature Communications
#29
JOURNAL ARTICLE
Yuqing Zhang, Hui Zhao, Jinhui Zhao, Wangjie Lv, Xueni Jia, Xin Lu, Xinjie Zhao, Guowang Xu
The co-occurrence of multiple chronic metabolic diseases is highly prevalent, posing a huge health threat. Clarifying the metabolic associations between them, as well as identifying metabolites which allow discrimination between diseases, will provide new biological insights into their co-occurrence. Herein, we utilized targeted serum metabolomics and lipidomics covering over 700 metabolites to characterize metabolic alterations and associations related to seven chronic metabolic diseases (obesity, hypertension, hyperuricemia, hyperglycemia, hypercholesterolemia, hypertriglyceridemia, fatty liver) from 1626 participants...
February 26, 2024: Journal of Proteome Research
#30
JOURNAL ARTICLE
Liwei Chen, Jin Dai, Guoqi Yu, Wei Wei Pang, Mohammad L Rahman, Xinyue Liu, Oliver Fiehn, Claire Guivarch, Zhen Chen, Cuilin Zhang
Objective: the aim of this study was to identify plasma metabolomic markers of Dietary Approaches to Stop Hypertension (DASH) dietary patterns in pregnant women. Methods: This study included 186 women who had both dietary intake and metabolome measured from a nested case-control study within the NICHD Fetal Growth Studies-Singletons cohort (FGS). Dietary intakes were ascertained at 8-13 gestational weeks (GW) using the Food Frequency Questionnaire (FFQ) and DASH scores were calculated based on eight food and nutrient components...
February 8, 2024: Nutrients
#31
JOURNAL ARTICLE
Sarah Al Ashmar, Najeha Rizwana Anwardeen, Gulsen Guliz Anlar, Shona Pedersen, Mohamed A Elrayess, Asad Zeidan
INTRODUCTION: Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others. OBJECTIVE: The precise mechanisms driving the progression of hypertension remain unknown...
2024: Frontiers in Cardiovascular Medicine
#32
JOURNAL ARTICLE
Ting Xu, Yueqi Lu, Bangwei Chen, Chenxin Deng, Yucong Zhang, Mei Wang, Huifen Ling, Yi Huang, Jing Yuan, Xin Jin, Lei Ruan, Tao Li, Cun-Tai Zhang
PURPOSE: The Tongji Cardiovascular Health Study aimed to further explore the onset and progression mechanisms of cardiovascular disease (CVD) through a combination of traditional cohort studies and multiomics analysis, including genomics, metabolomics and metagenomics. STUDY DESIGN AND PARTICIPANTS: This study included participants aged 20-70 years old from the Geriatric Health Management Centre of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology...
February 15, 2024: BMJ Open
#33
JOURNAL ARTICLE
Miyesaier Abudureyimu, Xuanming Luo, Lingling Jiang, Xuejuan Jin, Cuizhen Pan, Wei Yu, Junbo Ge, Yingmei Zhang, Jun Ren
AIMS: Heart failure with preserved ejection fraction (HFpEF) is a devastating health issue although limited knowledge is available for its pathogenesis and therapeutics. Given the perceived involvement of mitochondrial dysfunction in HFpEF, this study was designed to examine the role of mitochondrial dynamics in the etiology of HFpEF. METHOD AND RESULTS: Adult mice were placed on a high fat diet plus l-NAME in drinking water ('two-hit' challenge to mimic obesity and hypertension) for 15 consecutive weeks...
April 2024: Redox Biology
#34
JOURNAL ARTICLE
Elizabeth Costello, Jesse A Goodrich, William B Patterson, Douglas I Walker, Jiawen Carmen Chen, Brittney O Baumert, Sarah Rock, Frank D Gilliland, Michael I Goran, Zhanghua Chen, Tanya L Alderete, David V Conti, Lida Chatzi
The assessment of "omics" signatures may contribute to personalized medicine and precision nutrition. However, the existing literature is still limited in the homogeneity of participants' characteristics and in limited assessments of integrated omics layers. Our objective was to use post-prandial metabolomics and fasting proteomics to identify biological pathways and functions associated with diet quality in a population of primarily Hispanic young adults. We conducted protein and metabolite-wide association studies and functional pathway analyses to assess the relationships between a priori diet indices, Healthy Eating Index-2015 (HEI) and Dietary Approaches to Stop Hypertension (DASH) diets, and proteins ( n = 346) and untargeted metabolites ( n = 23,173), using data from the MetaAIR study ( n = 154, 61% Hispanic)...
January 31, 2024: Nutrients
#35
JOURNAL ARTICLE
Yaling Ding, Mengxin Yao, Jiafeng Liu, Wanyi Fu, Xiaoyan Zhu, Yelin He, Qiuping Ma, Chunhua Zhang, Jieyun Yin
Pre-eclampsia is a complex multi-system pregnancy disorder with limited treatment options. Therefore, we aimed to screen for metabolites that have causal associations with preeclampsia and to predict target-mediated side effects based on Mendelian randomization (MR) analysis. A two-sample MR analysis was firstly conducted to systematically assess causal associations of blood metabolites with pre-eclampsia, by using metabolites related large-scale genome-wide association studies (GWASs) involving 147,827 European participants, as well as GWASs summary data about pre-eclampsia from the FinnGen consortium R8 release data that included 182,035 Finnish adult female subjects (5922 cases and 176,113 controls)...
February 8, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
#36
JOURNAL ARTICLE
Ya Luo, Xianmei Qi, Zhenxi Zhang, Jiawei Zhang, Bolun Li, Ting Shu, Xiaona Li, Huiyuan Hu, Jinqiu Li, Qihao Tang, Yitian Zhou, Mingyao Wang, Tianfei Fan, Wenjun Guo, Ying Liu, Jin Zhang, Junling Pang, Peiran Yang, Ran Gao, Wenhui Chen, Chen Yan, Yanjiang Xing, Wenjing Du, Jing Wang, Chen Wang
BACKGROUND: Pulmonary hypertension (PH) is a progressive cardiopulmonary disease with a high mortality rate. Although growing evidence has revealed the importance of dysregulated energetic metabolism in the pathogenesis of PH, the underlying cellular and molecular mechanisms are not fully understood. In this study, we focused on ME1 (malic enzyme 1), a key enzyme linking glycolysis to the tricarboxylic acid cycle. We aimed to determine the role and mechanistic action of ME1 in PH. METHODS: Global and endothelial-specific ME1 knockout mice were used to investigate the role of ME1 in hypoxia- and SU5416/hypoxia (SuHx)-induced PH...
February 5, 2024: Circulation
#37
JOURNAL ARTICLE
Rami Al-Jafar, Rui Climaco Pinto, Paul Elliott, Konstantinos K Tsilidis, Abbas Dehghan
BACKGROUND: The dramatic change in lifestyle associated with Ramadan fasting raises questions about its effect on metabolism and health. Metabolites, as the end product of metabolism, are excellent candidates to be studied in this regard. OBJECTIVE: This study aims to investigate the effect of Ramadan fasting on the metabolic profile and risk of chronic diseases. METHODS: The London Ramadan study (LORANS) is an observational study in which 2 blood samples were collected from 72 participants a few days before and after the fasting month of Ramadan...
February 1, 2024: American Journal of Clinical Nutrition
#38
JOURNAL ARTICLE
Shuang-Yan Zhang, Yu-Qing Peng, Gui-Sheng Xiang, Wan-Ling Song, Lei Feng, Xin-Yue Jiang, Xue-Jiao Li, Si-Mei He, Sheng-Chao Yang, Yan Zhao, Guang-Hui Zhang
The oxidosqualene cyclases (OSCs) generating triterpenoid skeletons in Cyclocarya paliurus were identified for the first time, and two uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyzing the glycosylation of flavonoids were characterized. Cyclocarya paliurus, a native rare dicotyledonous plant in China, contains an abundance of triterpenoid saponins and flavonoid glycosides that exhibit valuable pharmaceutical effects in preventing hypertension, hyperlipidemia, and diabetes. However, the molecular mechanism explaining the biosynthesis of triterpenoid saponin and flavonoid glycoside in C...
January 29, 2024: Planta
#39
JOURNAL ARTICLE
Kartikeya Makker, Xiaobin Wang
No abstract text is available yet for this article.
September 2023: Precis Nutr
#40
REVIEW
Sandra Cabała, Małgorzata Ożgo, Agnieszka Herosimczyk
A well-balanced diet is integral for overall health, aiding in managing key risk factors for kidney damage like hypertension while supplying necessary precursors for metabolite production. Dietary choices directly influence the composition and metabolic patterns of the gut microbiota, showing promise as therapeutic tools for addressing various health conditions, including chronic kidney diseases (CKD). CKD pathogenesis involves a decline in the glomerular filtration rate and the retention of nitrogen waste, fostering gut dysbiosis and the excessive production of bacterial metabolites...
January 22, 2024: Metabolites
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