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metabolomics hypertension

Alejandra Rodríguez, Päivi Pajukanta
Cardiovascular disease (CVD) is a broad definition for diseases of the heart and blood vessels with high mortality and morbidity worldwide. Atherosclerosis and hypertension are the most common causes of CVD, and multiple factors confer the susceptibility. Some of the predisposing factors are modifiable such as diet, smoking, and exercise, whereas others, including age, sex, and individual's genetic variations contributing to the CVD composition traits, are non-modifiable. This latter group includes serum lipid traits...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Mei-Xue Dong, Xia Feng, Xiao-Min Xu, Ling Hu, Yang Liu, Si-Yu Jia, Bo Li, Wei Chen, You-Dong Wei
Depression is a common comorbidity in Parkinson's disease (PD) but is underdiagnosed. We aim to investigate the altered metabolic pathways of Parkinson's disease-related depression (PDD) in plasma and to identify potential biomarkers for clinical diagnosis. Consecutive patients with PD were recruited, clinically assessed, and patients with PDD identified. Fasting plasma samples were collected from 99 patients and differentially expressed metabolites and proteins between patients with PDD and PD were identified using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and tandem mass tag (TMT)-based proteomics analysis, followed by an integrated analysis...
2018: Frontiers in Molecular Neuroscience
Jose L Izquierdo-Garcia, Teresa Arias, Yeny Rojas, Victoria Garcia-Ruiz, Arnoldo Santos, Silvia Martin-Puig, Jesus Ruiz-Cabello
A significant glycolytic shift in the cells of the pulmonary vasculature and right ventricle during pulmonary arterial hypertension (PAH) has been recently described. Due to the late complications and devastating course of any variant of this disease, there is a great need for animal models that reproduce potential metabolic reprograming of PAH. Our objective is to study, in situ , the metabolic reprogramming in the lung and the right ventricle of a mouse model of PAH by metabolomic profiling and molecular imaging...
2018: Frontiers in Cardiovascular Medicine
Michael La Frano, Johannes Fahrmann, Dmitry Grapov, Theresa Pedersen, John W Newman, Oliver Fiehn, Mark A Underwood, Karen K Mestan, Robin Steinhorn, Stephen Wedgwood
Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains a primary contributor to increased morbidity and mortality among preterm infants. Unfortunately, at the present time there are no reliable early predictive markers for BPD-associated PH. Considering its health consequences, understanding in utero perturbations that lead to the development of BPD and BPD-associated PH and identifying early predictive markers is of utmost importance. As part of the discovery phase, we applied a multi-platform metabolomics approach consisting of untargeted and targeted methodologies to screen for metabolic perturbations in umbilical cord blood (UCB) plasma from preterm infants that did (n=21; cases) or did not (n=21; controls) develop subsequent PH...
August 16, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Huan Zhao, Yijia Liu, Zhu Li, Yanqi Song, Xuemeng Cai, Yuechen Liu, Tianpu Zhang, Liu Yang, Lin Li, Shan Gao, Yubo Li, Chunquan Yu
BACKGROUND: In recent years, using metabolomics technology to study hypertension has made some progress. However, in actual clinical studies, there are few studies on hypertension related metabonomics with human urine as samples. In this study, the urine samples of patients with essential hypertension (EH) were studied by comparing with healthy people to explore the changes of urine metabolites between hypertensive patients and healthy people in order to find potential biomarkers and metabolic pathways...
August 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Qianru Bai, Baohua Peng, Xue Wu, Yunfeng Cao, Xiaoyu Sun, Mo Hong, Rongmei Na, Baiting Liu, Qianxiao Li, Zhu Li, Weiyi Fang, Ning Zhu, Chengguo Zong, Qin Yu
Hypertension is an increasingly serious public-health challenge worldwide. The traditional blood pressure measurement method could easily and reliably detect blood pressure. However, the delayed symptom onset may influence the screening of essential hypertension (EH). In addition, EH is significantly associated to cardiovascular disease, stroke and kidney disease. Hence, it is urgent to define associated biomarkers with early diagnosis potential for EH. A dried blood spot method integrated with direct infusion mass spectrometry (MS) metabolomic analysis was applied for the detection of metabolites toward 87 EH patients and 91 healthy controls (HC)...
August 9, 2018: IUBMB Life
Xiushi Zhou, Renping Wang, Tian Zhang, Fei Liu, Wei Zhang, Guili Wang, Guorong Gu, Qinqi Han, Demin Xu, Chenling Yao, Daqiao Guo, Weiguo Fu, Yunpeng Qi, Lixin Wang
OBJECTIVES: Acute aortic dissection (AAD) is a severe clinical emergency with a high mortality, and is easily misdiagnosed in its early stage. This study aimed at discovering serum metabolomic markers with the potential to diagnose AAD and distinguish between two subtypes of AAD. MATERIALS AND METHODS: Thirty-five patients with AAD, including 20 with Stanford type A and 15 with Stanford type B were enrolled in this study, together with 20 healthy controls. All patients with AAD were admitted within 72 h of onset...
August 4, 2018: European Journal of Vascular and Endovascular Surgery
Martin R Wilkins, Jurjan Aman, Lars Harbaum, Anna Ulrich, John Wharton, Christopher J Rhodes
Pulmonary arterial hypertension (PAH) is a rare disorder with a high mortality rate. Treatment options have improved in the last 20 years, but patients still die prematurely of right heart failure. Though rare, it is heterogeneous at the genetic and molecular level, and understanding and exploiting this is key to the development of more effective treatments. BMPR2 , encoding bone morphogenetic receptor type 2, is the most commonly affected gene in both familial and non-familial PAH, but rare mutations have been identified in other genes...
2018: F1000Research
Jacquelyn M Walejko, Seungbum Kim, Ruby Goel, Eileen M Handberg, Elaine M Richards, Carl J Pepine, Mohan K Raizada
BACKGROUND: Black Americans have greater rates, severity and resistance to treatment of hypertension than White Americans. The gut microbiota and its metabolites may contribute to this. This concept was tested in a pilot study. METHODS: Subjects with high (HBP, >140/80 mm Hg) and normal (NBP, <120/80 mm Hg) blood pressure (BP) provided stool and blood samples for whole genome sequencing (WGS) of gut microbiota and global untargeted metabolomics of serum...
November 15, 2018: International Journal of Cardiology
Takehiro Suzuki, Takaaki Abe
Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein...
August 2018: Kidney International
Wenjuan Lin, Zerong Liu, Xuewei Zheng, Meng Chen, Dan Gao, Zhongmin Tian
Genetic background and high-salt diet are considered key factors contributing to the development of hypertension and its associated metabolic disorders. Metabolomics is an emerging powerful tool to analyze the low-molecular weight metabolites in plasma and tissue. This study integrated metabolomics and correlation network analysis to investigate the metabolic profiles of plasma and muscle of Dahl salt-sensitive (SS) rats and SS.13BN rats (control) under normal and high-salt diet. The hub metabolites, which could play important roles in the metabolic changes, were identified by correlation network analysis...
October 2018: Amino Acids
Ioanna Tzoulaki, Aikaterini Iliou, Emmanuel Mikros, Paul Elliott
PURPOSE OF THE REVIEW: This review presents the analytical techniques, processing and analytical steps used in metabolomics phenotyping studies, as well as the main results from epidemiological studies on the associations between metabolites and high blood pressure. RECENT FINDINGS: A variety of metabolomic approaches have been applied to a range of epidemiological studies to uncover the pathophysiology of high blood pressure. Several pathways have been suggested in relation to blood pressure including the possible role of the gut microflora, inflammatory, oxidative stress, and lipid pathways...
July 10, 2018: Current Hypertension Reports
B Fatemeh Nobakht M Gh
Preeclampsia is a multifactorial disorder defined by hypertension and increased urinary protein excretion during pregnancy. It is a significant cause of maternal and neonatal deaths worldwide. Despite various research efforts to clarify pathogenies of preeclampsia and predict this disease before beginning of symptoms, the pathogenesis of preeclampsia is unclear. Early prediction and diagnosis of women at risk of preeclampsia has not markedly improved. Therefore, the objective of this study was to perform a review on metabolomic articles assessing predictive and diagnostic biomarkers of preeclampsia...
July 2, 2018: Systems Biology in Reproductive Medicine
Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections. Objective: The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern. Design: We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329)...
August 1, 2018: American Journal of Clinical Nutrition
Judith Aron-Wisnewsky, Edi Prifti, Eugeni Belda, Farid Ichou, Brandon D Kayser, Maria Carlota Dao, Eric O Verger, Lyamine Hedjazi, Jean-Luc Bouillot, Jean-Marc Chevallier, Nicolas Pons, Emmanuelle Le Chatelier, Florence Levenez, Stanislav Dusko Ehrlich, Joel Dore, Jean-Daniel Zucker, Karine Clément
OBJECTIVES: Decreased gut microbial gene richness (MGR) and compositional changes are associated with adverse metabolism in overweight or moderate obesity, but lack characterisation in severe obesity. Bariatric surgery (BS) improves metabolism and inflammation in severe obesity and is associated with gut microbiota modifications. Here, we characterised severe obesity-associated dysbiosis (ie, MGR, microbiota composition and functional characteristics) and assessed whether BS would rescue these changes...
June 13, 2018: Gut
Anna R Hemnes
Pulmonary arterial hypertension (PAH) is a devastating disease for which there is no cure. Presently this condition is differentiated from other diseases of the pulmonary vasculature by a practitioner's history, physical examination, and clinical studies with clinical markers of disease severity primarily guiding therapeutic choices. New technologies such as next generation DNA sequencing, high throughput RNA sequencing, metabolomics and proteomics have greatly enhanced the amount of data that can be studied efficiently in patients with PAH and other rare diseases...
2018: Frontiers in Medicine
Brian B Graham, Rahul Kumar, Claudia Mickael, Biruk Kassa, Dan Koyanagi, Linda Sanders, Li Zhang, Mario Perez, Daniel Hernandez-Saavedra, Carolyn Valencia, Kandice Dixon, Julie Harral, Zoe Loomis, David Irwin, Travis Nemkov, Angelo D'Alessandro, Kurt R Stenmark, Rubin M Tuder
Optimal right ventricular (RV) function in pulmonary hypertension (PH) requires structural and functional coupling between the RV cardiomyocyte and its adjacent capillary network. Prior investigations have indicated that RV vascular rarefaction occurs in PH, which could contribute to RV failure by reduced delivery of oxygen or other metabolic substrates. However, it has not been determined if rarefaction results from relative underproliferation in the setting of tissue hypertrophy or from actual loss of vessels...
October 2018: American Journal of Respiratory Cell and Molecular Biology
Ana Liu, Yan-Jun Chu, Xiaoming Wang, Ruixue Yu, Haiqiang Jiang, Yunlun Li, Honglei Zhou, Li-Li Gong, Wen-Qing Yang, Jianqing Ju
Our previous studies have shown that Uncaria has an important role in lowering blood pressure, but its intervention mechanism has not been clarified completely in the metabolic level. Therefore, in this study, a combination method of HPLC-TOF/MS-based metabolomics and multivariate statistical analyses was employed to explore the mechanism and evaluate the antihypertensive effect of Uncaria . Serum samples were analyzed and identified by HPLC-TOF/MS, while the acquired data was further processed by partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA) to discover the perturbed metabolites...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He, Ping Yang
BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare systemic disorder associated with considerable metabolic dysfunction. Although enormous metabolomic studies on PAH have been emerging, research remains lacking on metabolic reprogramming in experimental PAH models. We aim to evaluate the metabolic changes in PAH and provide new insight into endogenous metabolic disorders of PAH. METHOD: A single subcutaneous injection of monocrotaline (MCT) (60 mg kg- 1 ) was used for rats to establish PAH model...
May 11, 2018: Respiratory Research
Donna K Arnett, Steven A Claas
Essential hypertension is a common, complex disorder affecting ≤1 billion adults globally. Blood pressure is a highly heritable trait, with ≤50% of the variation between individuals accounted for by familial relationships. Despite this strong heritability, determining the genetic architecture of hypertension in humans has proved challenging. Recent technological and methodological developments have given rise to what is now known as omics-a domain of study that includes genomics, as well as epigenomics, transcriptomics, proteomics, and metabolomics...
May 11, 2018: Circulation Research
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