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metabolomics hypertension

Mingxiao Yang, Zheng Yu, Xiaomin Chen, Zhenyu Guo, Shufang Deng, Lin Chen, Qiaofeng Wu, Fanrong Liang
The effect of active acupoints versus inactive acupoints in treating hypertension is not well documented. Metabolic phenotypes, depicted by metabolomics analysis, reflect the influence of external exposures, nutrition, and lifestyle on the integrated system of the human body. Therefore, we utilized high-performance liquid chromatography tandem mass spectrometry to compare the targeted metabolic phenotype changes induced by two different acupoint treatments. The clinical outcomes show that active acupoint treatment significantly lowers 24-hour systolic blood pressure but not diastolic blood pressure, as compared with inactive acupoint treatment...
December 13, 2018: Scientific Reports
Mark I Attard, Timothy J W Dawes, Antonio de Marvao, Carlo Biffi, Wenzhe Shi, John Wharton, Christopher J Rhodes, Pavandeep Ghataorhe, J Simon R Gibbs, Luke S G E Howard, Daniel Rueckert, Martin R Wilkins, Declan P O'Regan
Aims: We sought to identify metabolic pathways associated with right ventricular (RV) adaptation to pulmonary hypertension (PH). We evaluated candidate metabolites, previously associated with survival in pulmonary arterial hypertension, and used automated image segmentation and parametric mapping to model their relationship to adverse patterns of remodelling and wall stress. Methods and results: In 312 PH subjects (47.1% female, mean age 60.8 ± 15.9 years), of which 182 (50...
December 7, 2018: European Heart Journal Cardiovascular Imaging
Abdulwahab Alamri, Abdulhadi S Burzangi, Paul Coats, David G Watson
Pulmonary arterial hypertension (PAH) is a multi-factorial disease characterized by the hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). Excessive reactive oxygen species (ROS) formation resulted in alterations of the structure and function of pulmonary arterial walls, leading to right ventricular failure and death. Diabetes mellitus has not yet been implicated in pulmonary hypertension. However, recently, variable studies have shown that diabetes is correlated with pulmonary hypertension pathobiology, which could participate in the modification of pulmonary artery muscles...
November 30, 2018: Metabolites
Ivana Blaženović, Young Taek Oh, Fan Li, Jian Ji, Ahn-Khoi Nguyen, Benjamin Wancewicz, Jeffrey M Bender, Oliver Fiehn, Jang H Youn
SCOPE: High-sodium and low-potassium (HNaLK) content in Western diets increases the risk of hypertension and cardiovascular disease (CVD). We investigated if the dietary minerals interact with gut bacteria to modulate circulating levels of biogenic amines, which are implicated in various pathologies, including hypertension and CVD. METHODS AND RESULTS: Using a metabolomic approach to target biogenic amines, we examined the effects of gut-bacteria depletion and HNaLK intake on circulating levels of biogenic amines in rats...
December 4, 2018: Molecular Nutrition & Food Research
Ling-Yu Ruan, Ming-Hui Li, Yue-Xiao Xing, Wei Hong, Cheng Chen, Jian-Feng Chen, Han Xu, Wen-Long Zhao, Jun-Song Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Polygonum multiflorum Thund., a well-known and commonly-used TCM (Traditional Chinese Medicine) for treating hypertension, hyperlipidemia, premature graying of hair, and etc., has aroused wide concern for its reported potential liver toxicity. Due to its various active ingredients, the mechanisms underlying the hepatotoxicity of raw Polygonum multiflorum Thund (RPM) remain largely unknown. AIM OF THE STUDY: 1 H NMR metabolomics was used to study the mechanism of RPM induced hepatotoxicity and disclosed the existence of hepatotoxicity and hepatoprotection conversion during RPM administration in mice...
October 27, 2018: Journal of Ethnopharmacology
Pirro G Hysi, Anthony P Khawaja, Cristina Menni, Bani Tamraz, Nick Wareham, Kay-Tee Khaw, Paul J Foster, Leslie Z Benet, Tim D Spector, Chris J Hammond
Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Mechanisms involved in its homeostasis are not well understood, but associations between metabolic factors and IOP have been reported. To investigate the relationship between levels of circulating metabolites and IOP, we performed a metabolome-wide association using a machine learning algorithm, and then employing Mendelian Randomization models to further explore the strength and directionality of effect of the metabolites on IOP...
October 13, 2018: Redox Biology
Ghislaine Scelo, Tricia L Larose
The purpose of this narrative review is to summarize evidence of the epidemiology of and risk factors for kidney cancer with a focus on renal cell carcinoma in adults. The etiology of kidney cancer is largely unknown and the main epidemiologic determinants are large geographic and temporal variations in incidence rates. Established risk factors include tobacco smoking, body size, and history of hypertension and chronic kidney disease. Other suspected risk factors require additional investigation, as do the underlying biologic mechanisms that are responsible for disease occurrence...
October 29, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Saroj Chakraborty, Sarah Galla, Xi Cheng, Ji-Youn Yeo, Blair Mell, Vishal Singh, BengSan Yeoh, Piu Saha, Anna V Mathew, Matam Vijay-Kumar, Bina Joe
Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark. We hypothesized that dietary salt impacts metabolism in a salt-sensitive model of hypertension. An untargeted metabolomic approach demonstrates lower circulating levels of the ketone body, beta-hydroxybutyrate (βOHB), in high salt-fed hypertensive rats. Despite the high salt intake, specific rescue of βOHB levels by nutritional supplementation of its precursor, 1,3-butanediol, attenuates hypertension and protects kidney function...
October 16, 2018: Cell Reports
Anna Hernández-Aguilera, Salvador Fernández-Arroyo, Noemí Cabre, Fedra Luciano-Mateo, Gerard Baiges-Gaya, Montserrat Fibla, Vicente Martín-Paredero, Javier A Menendez, Jordi Camps, Jorge Joven
Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated with other highly prevalent and related conditions, such as diabetes, dyslipidemia, and hypertension. We have measured energy-balance-associated metabolite concentrations in the plasma of PAD patients segregated by the severity of the disease and in plasma of healthy volunteers using a quantitative and targeted metabolomic approach...
2018: Mediators of Inflammation
Yamin Liu, Ting-Li Han, Xiaofang Luo, Yuxiang Bai, Xuehai Chen, Wei Peng, Xi Xiong, Philip N Baker, Chao Tong, Hongbo Qi
Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks' gestation and is a leading cause of maternal and neonatal morbidity and mortality. The pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental implantation. However, the exact underlying mechanisms remain unclear. Placental LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR, and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry (GC-MS)...
September 2018: Genes & Diseases
Alejandra Rodríguez, Päivi Pajukanta
Cardiovascular disease (CVD) is a broad definition for diseases of the heart and blood vessels with high mortality and morbidity worldwide. Atherosclerosis and hypertension are the most common causes of CVD, and multiple factors confer the susceptibility. Some of the predisposing factors are modifiable such as diet, smoking, and exercise, whereas others, including age, sex, and individual's genetic variations contributing to the CVD composition traits, are non-modifiable. This latter group includes serum lipid traits...
2018: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Mei-Xue Dong, Xia Feng, Xiao-Min Xu, Ling Hu, Yang Liu, Si-Yu Jia, Bo Li, Wei Chen, You-Dong Wei
Depression is a common comorbidity in Parkinson's disease (PD) but is underdiagnosed. We aim to investigate the altered metabolic pathways of Parkinson's disease-related depression (PDD) in plasma and to identify potential biomarkers for clinical diagnosis. Consecutive patients with PD were recruited, clinically assessed, and patients with PDD identified. Fasting plasma samples were collected from 99 patients and differentially expressed metabolites and proteins between patients with PDD and PD were identified using non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and tandem mass tag (TMT)-based proteomics analysis, followed by an integrated analysis...
2018: Frontiers in Molecular Neuroscience
Jose L Izquierdo-Garcia, Teresa Arias, Yeny Rojas, Victoria Garcia-Ruiz, Arnoldo Santos, Silvia Martin-Puig, Jesus Ruiz-Cabello
A significant glycolytic shift in the cells of the pulmonary vasculature and right ventricle during pulmonary arterial hypertension (PAH) has been recently described. Due to the late complications and devastating course of any variant of this disease, there is a great need for animal models that reproduce potential metabolic reprograming of PAH. Our objective is to study, in situ , the metabolic reprogramming in the lung and the right ventricle of a mouse model of PAH by metabolomic profiling and molecular imaging...
2018: Frontiers in Cardiovascular Medicine
Michael La Frano, Johannes Fahrmann, Dmitry Grapov, Theresa Pedersen, John W Newman, Oliver Fiehn, Mark A Underwood, Karen K Mestan, Robin Steinhorn, Stephen Wedgwood
Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains a primary contributor to increased morbidity and mortality among preterm infants. Unfortunately, at the present time there are no reliable early predictive markers for BPD-associated PH. Considering its health consequences, understanding in utero perturbations that lead to the development of BPD and BPD-associated PH and identifying early predictive markers is of utmost importance. As part of the discovery phase, we applied a multi-platform metabolomics approach consisting of untargeted and targeted methodologies to screen for metabolic perturbations in umbilical cord blood (UCB) plasma from preterm infants that did (n=21; cases) or did not (n=21; controls) develop subsequent PH...
August 16, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
Huan Zhao, Yijia Liu, Zhu Li, Yanqi Song, Xuemeng Cai, Yuechen Liu, Tianpu Zhang, Liu Yang, Lin Li, Shan Gao, Yubo Li, Chunquan Yu
BACKGROUND: In recent years, using metabolomics technology to study hypertension has made some progress. However, in actual clinical studies, there are few studies on hypertension related metabonomics with human urine as samples. In this study, the urine samples of patients with essential hypertension (EH) were studied by comparing with healthy people to explore the changes of urine metabolites between hypertensive patients and healthy people in order to find potential biomarkers and metabolic pathways...
November 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Qianru Bai, Baohua Peng, Xue Wu, Yunfeng Cao, Xiaoyu Sun, Mo Hong, Rongmei Na, Baiting Liu, Qianxiao Li, Zhu Li, Weiyi Fang, Ning Zhu, Chengguo Zong, Qin Yu
Hypertension is an increasingly serious public-health challenge worldwide. The traditional blood pressure measurement method could easily and reliably detect blood pressure. However, the delayed symptom onset may influence the screening of essential hypertension (EH). In addition, EH is significantly associated to cardiovascular disease, stroke and kidney disease. Hence, it is urgent to define associated biomarkers with early diagnosis potential for EH. A dried blood spot method integrated with direct infusion mass spectrometry (MS) metabolomic analysis was applied for the detection of metabolites toward 87 EH patients and 91 healthy controls (HC)...
August 9, 2018: IUBMB Life
Xiushi Zhou, Renping Wang, Tian Zhang, Fei Liu, Wei Zhang, Guili Wang, Guorong Gu, Qinqi Han, Demin Xu, Chenling Yao, Daqiao Guo, Weiguo Fu, Yunpeng Qi, Lixin Wang
OBJECTIVES: Acute aortic dissection (AAD) is a severe clinical emergency with a high mortality, and is easily misdiagnosed in its early stage. This study aimed at discovering serum metabolomic markers with the potential to diagnose AAD and distinguish between two subtypes of AAD. MATERIALS AND METHODS: Thirty-five patients with AAD, including 20 with Stanford type A and 15 with Stanford type B were enrolled in this study, together with 20 healthy controls. All patients with AAD were admitted within 72 h of onset...
August 4, 2018: European Journal of Vascular and Endovascular Surgery
Martin R Wilkins, Jurjan Aman, Lars Harbaum, Anna Ulrich, John Wharton, Christopher J Rhodes
Pulmonary arterial hypertension (PAH) is a rare disorder with a high mortality rate. Treatment options have improved in the last 20 years, but patients still die prematurely of right heart failure. Though rare, it is heterogeneous at the genetic and molecular level, and understanding and exploiting this is key to the development of more effective treatments. BMPR2 , encoding bone morphogenetic receptor type 2, is the most commonly affected gene in both familial and non-familial PAH, but rare mutations have been identified in other genes...
2018: F1000Research
Jacquelyn M Walejko, Seungbum Kim, Ruby Goel, Eileen M Handberg, Elaine M Richards, Carl J Pepine, Mohan K Raizada
BACKGROUND: Black Americans have greater rates, severity and resistance to treatment of hypertension than White Americans. The gut microbiota and its metabolites may contribute to this. This concept was tested in a pilot study. METHODS: Subjects with high (HBP, >140/80 mm Hg) and normal (NBP, <120/80 mm Hg) blood pressure (BP) provided stool and blood samples for whole genome sequencing (WGS) of gut microbiota and global untargeted metabolomics of serum...
November 15, 2018: International Journal of Cardiology
Takehiro Suzuki, Takaaki Abe
Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein...
August 2018: Kidney International
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