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Stroke prevention

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https://www.readbyqxmd.com/read/28944903/gpvi%C3%A2-fc%C3%A2-peg-improves-cerebral-infarct-volume-and-cerebral-thrombosis-in-mouse-model-with-cerebral-thrombosis
#1
Yimae Wufuer, Xuefeng Shan, Magaoweiya Sailike, Kamile Adilaimu, Songfeng Ma, Huguo Wang
Cerebral thrombosis is one of the most common causes of cerebral infarction, and anticoagulation therapy is a routine treatment in patients with hemorrhagic cerebral venous thrombosis. The hemostatic function of platelets is important for the anticoagulation therapy of thrombosis. Glycoprotein VI (GPVI) is reported as the major signaling receptor for collagen and is exclusively expressed on platelets and megakaryocytes, initiating platelet recruitment at sites of vascular injury and demonstrating numerous beneficial effects for patients with cerebral thrombosis...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944725/intermediate-risk-of-cardiac-events-and-recurrent-stroke-after-stroke-admission-in-young-adults
#2
Peter Jin, Ivan Matos Diaz, Laura Stein, Alison Thaler, Stanley Tuhrim, Mandip S Dhamoon
Background In older adults with stroke, there is an increased risk of cardiovascular events in the intermediate period, up to one year after stroke. The risk of cardiovascular events in this period in young adults after stroke has not been studied. We hypothesized that in the intermediate risk period, young adults with ischemic stroke have an increased risk of recurrent stroke and a smaller increase of cardiac events. Methods Using the National Readmissions Database during the year 2013, we identified ischemic stroke admissions among those aged 18-45 years using International Classification of Disease, Ninth Revision, Clinical Modification codes to identify index vascular events and risk factors...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28944218/diabetes-mitigates-the-role-of-memory-complaint-in-predicting-dementia-risk-results-from-the-prevention-of-alzheimer-s-disease-with-vitamin-e-and-selenium-study
#3
X Zhang, F A Schmitt, A M Caban-Holt, X Ding, R J Kryscio, E Abner
BACKGROUND: Subjective memory complaints (SMCs) are associated with increased risk of dementia in older adults, but the role of comorbidities in modifying this risk is unknown. OBJECTIVES: To assess whether comorbidities modify estimated dementia risk based on SMCs. DESIGN: The Prevention of Alzheimer's Disease with Vitamin E and Selenium Study (PREADVISE) was designed as an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a randomized, multi-center prostate cancer prevention trial with sites in the Unites States, Puerto Rico, and Canada...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28943006/outcomes-of-mini-incision-eversion-carotid-endarterectomy-combined-with-nontouch-isolation-technique-of-the-internal-carotid-artery
#4
Kota Shukuzawa, Takao Ohki, Yuji Kanaoka, Makoto Sumi, Koji Maeda, Naoki Toya, Hirotsugu Ozawa
OBJECTIVE: We developed a mini-incision eversion carotid endarterectomy (CEA) procedure (the Jikei method CEA) to prevent perioperative embolic stroke. The aim of this study was to retrospectively analyze perioperative and midterm outcomes after the Jikei method CEA. METHODS: We evaluated patients with the Jikei method CEA at our institution between January 2006 and June 2014. The primary end point was a major adverse event, which included death, stroke, intracranial hemorrhage, and myocardial infarction, within 30 days of CEA...
September 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942855/a-systematic-review-and-meta-analysis-of-factors-for-delirium-in-vascular-surgical-patients
#5
REVIEW
Christopher Oldroyd, Anna F M Scholz, Robert J Hinchliffe, Kathryn McCarthy, Jonathan Hewitt, Terrence J Quinn
BACKGROUND: Delirium is a common syndrome responsible for a large burden of morbidity and mortality. In surgical settings, research into risk factors for postoperative delirium has largely focused on elective orthopedic patients. We performed a systematic review and meta-analysis to evaluate the evidence surrounding risk factors for delirium in vascular surgical populations. METHODS: Two independent reviewers searched five databases (MEDLINE, Web of Science, Embase, Cumulative Index to Nursing and Allied Health Literature, and PsycINFO) from January 1987 to December 2015...
October 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28942782/eighth-annual-intermacs-report-special-focus-on-framing-the-impact-of-adverse-events
#6
James K Kirklin, Francis D Pagani, Robert L Kormos, Lynne W Stevenson, Elizabeth D Blume, Susan L Myers, Marissa A Miller, J Timothy Baldwin, James B Young, David C Naftel
BACKGROUND: The Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database now includes >20,000 patients from >180 hospitals. METHODS: The eighth annual report of INTERMACS updates the first decade of patient enrollment. RESULTS: In the current era, >95% of implants are continuous flow devices. Overall survival continues to remain >80% at 1 year and 70% at 2 years. Review of major adverse events shows minimal advantage for patients with ambulatory heart failure pre-implant...
October 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28942764/ocular-manifestations-of-obstructive-sleep-apnea
#7
Matthew Santos, R Jeffrey Hofmann
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) incurs a host of systemic side effects. The eyes are particularly susceptible to both mechanical and vascular sequelae of the disease. This paper outlines the ocular manifestations of sleep apnea. The authors hope to increase awareness of the ocular complications of this common disorder and increase communication and co-management between eye-care providers and sleep specialists alike. METHODS: Data were collected from PubMed and the Brown University Library Collection...
September 20, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28942553/clinacanthus-nutans-mitigates-neuronal-apoptosis-and-ischemic-brain-damage-through-augmenting-the-c-ebp%C3%AE-driven-ppar-%C3%AE-transcription
#8
Jui-Sheng Wu, Mei-Han Kao, Hsin-Da Tsai, Wai-Mui Cheung, Jin-Jer Chen, Wei-Yi Ong, Grace Y Sun, Teng-Nan Lin
Clinacanthus nutans Lindau (C. nutans) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies including snake and insect bites, skin rashes, viral infections, and cancer. However, the underlying molecular mechanisms for its action and whether C. nutans can offer protection on stroke damage in brain remain largely unknown. In the present study, we demonstrated protective effects of C. nutans extract to ameliorate neuronal apoptotic death in the oxygen-glucose deprivation model and to reduce infarction and mitigate functional deficits in the middle cerebral artery occlusion model, either administered before or after hypoxic/ischemic insult...
September 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28942438/retraction-statement-paper-low-dose-vitamin-d-prevents-muscular-atrophy-and-reduces-falls-and-hip-fractures-in-women-after-stroke-a-randomized-controlled-trial-by-sato-et-al-cerebrovasc-dis-2005-20-187-192
#9
https://www.readbyqxmd.com/read/28942389/left-atrial-appendage-occlusion
#10
Fabian Nietlispach, Igal Moarof, Maurizio Taramasso, Francesco Maisano, Bernhard Meier
Left atrial appendage occlusion (LAAO) is a first-line therapy for stroke prevention in patients suffering from atrial fibrillation (AF). While patients at high risk for bleeding or patients with previous bleeding have the highest relative risk reduction from LAAO, it is the younger patients with a high lifetime bleeding risk who benefit from the highest absolute risk reduction after LAAO. Therefore, LAAO should be discussed with every AF patient, as an alternative to lifelong oral anticoagulation. The patient needs to be informed about the risks and benefits of each treatment strategy in order to take an informed treatment decision...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942115/quality-of-life-and-patient-satisfaction-in-patients-with-atrial-fibrillation-on-stable-vitamin-k-antagonist-treatment-or-switched-to-a-non-vitamin-k-antagonist-oral-anticoagulant-during-a-1-year-follow-up-a-prefer-in-af-registry-substudy
#11
Raffaele De Caterina, Bernd Brüggenjürgen, Harald Darius, Sabine Köhler, Markus Lucerna, Ladislav Pecen, Giulia Renda, Richard John Schilling, Tessa Schliephacke, José Luis Zamorano, Jean-Yves Le Heuzey, Paulus Kirchhof
BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) are being introduced for stroke prevention in non-valvular Atrial Fibrillation (AF), and promise to be accepted better than Vitamin K Antagonists (VKAs) by patients, improving their Quality of Life (QoL). AIM: To assess to what extent patient-related factors influence decisions to switch from a VKA to a NOAC. METHODS: The PREFER in AF Registry collected data at baseline in 2012 - at the beginning of NOAC prescriptions - and at 1-year follow-up, in 6412 patients in seven Western European countries...
September 20, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28941763/oral-anticoagulants-to-prevent-stroke-in-nonvalvular-atrial-fibrillation-in-patients-with-ckd-stage-5d-an-nkf-kdoqi-controversies-report
#12
Vinod K Bansal, Charles A Herzog, Mark J Sarnak, Michael J Choi, Ravindra Mehta, Bernard G Jaar, Michael V Rocco, Holly Kramer
Stroke risk may be more than 3-fold higher among patients with chronic kidney disease stage 5D (CKD-5D) compared to the general population, with the highest stroke rates noted among those 85 years and older. Atrial fibrillation (AF), a strong risk factor for stroke, is the most common arrhythmia and affects >7% of the population with CKD-5D. Warfarin use is widely acknowledged as an important intervention for stroke prevention with nonvalvular AF in the general population. However, use of oral anticoagulants for stroke prevention in patients with CKD-5D and nonvalvular AF continues to be debated by the nephrology community...
September 20, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28940001/dabigatran-induced-massive-spontaneous-hemothorax
#13
Jing Huang, Wei Lin, Dan Lv, Li Yu, Lun Wu, Haiying Jin, Zaichun Deng, Qunli Ding
Spontaneous hemothorax due to anticoagulant use is extremely rare in clinical practice. Dabigatran is a novel anticoagulant to prevent stroke or thromboembolic episodes in patients with nonvalvular atrial fibrillation. We report on an 83-year-old man who received dabigatran therapy (110 mg twice daily) for 7 months and developed massive spontaneous hemothorax and acute renal failure. The patient was admitted to the hospital with complaint of a dull ache in the chest and dyspnea. Chest computed tomography scan revealed massive pleural effusion in the left hemithorax with atelectasis...
September 22, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/28939672/cha2ds2-vasc-score-for-identifying-truly-low-risk-atrial-fibrillation-for-stroke-a-korean-nationwide-cohort-study
#14
Tae-Hoon Kim, Pil-Sung Yang, Daehoon Kim, Hee Tae Yu, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
BACKGROUND AND PURPOSE: As the threshold of stroke risk for initiating oral anticoagulants is lowered after the introduction of the nonvitamin K antagonist oral anticoagulants, the focus of stroke prevention in patients with nonvalvular atrial fibrillation has shifted away from predicting high-risk patients toward initially identifying patients with a truly low risk of ischemic stroke, who do not need antithrombotic therapy. We tested the predictive ability of the congestive heart failure, hypertension, age ≥75, diabetes mellitus, prior stroke or transient ischemic attack (doubled; CHADS2), congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65 to 74, female (CHA2DS2-VASc), and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) risk stratification schemes in oral anticoagulants naive patients with atrial fibrillation in a Korean nationwide sample cohort...
September 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28939569/recording-a-diagnosis-of-stroke-transient-ischaemic-attack-or-myocardial-infarction-in-primary-healthcare-and-the-association-with-dispensation-of-secondary-preventive-medication-a-registry-based-prospective-cohort-study
#15
Cecilia Dahlgren, Lukas Geary, Jan Hasselström, Clas Rehnberg, Karin Schenck-Gustafsson, Per Wändell, Mia von Euler
OBJECTIVES: The aim of this study was to explore whether recording in primary care of a previously recorded hospital diagnosis was associated with increased patient utilisation of recommended medications. DESIGN: Registry-based prospective cohort study. SETTING AND PARTICIPANTS: 19 072 patients with a hospital discharge diagnosis of transient ischaemic attack (TIA), stroke or acute coronary syndrome from hospitals in Stockholm County 2010-2013 were included in the study...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28939540/long-term-patency-of-posterior-auricular-artery-middle-cerebral-artery-bypass-for-adult-onset-moyamoya-disease-case-report-and-review-of-literature
#16
Seiei Torazawa, Hirotaka Hasegawa, Taichi Kin, Hiroaki Sato, Shigeo Sora
BACKGOUND: Direct extracranial-intracranial (EC-IC) bypass is one of the fundamental techniques to prevent recurrent stroke in patients with adult-onset ischemic moyamoya disease. When the standard superficial temporal artery (STA) cannot be used for a graft, the posterior auricular artery (PAA) can be a potential surrogate graft. CASE DESCRIPTION: In this article, the authors reported a 34-year-old female patient suffering from ischemic moyamoya disease. To widely revascularize the anterior half of the hemisphere, direct double EC-IC bypass was considered beneficial; however, she had only a single-branched STA but had a prominent branch of the PAA...
September 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28939005/antidiabetic-drugs-and-stroke-risk-current-evidence
#17
REVIEW
Luis Castilla-Guerra, María Del Carmen Fernandez-Moreno, David Leon-Jimenez, Eduardo Carmona-Nimo
Cardiovascular disease (CVD) is the major cause of morbidity and mortality for individuals with type 2 diabetes (T2D). In particular, the risk for stroke is twice that of patients without diabetes, and diabetes may be responsible for >8% of first ischemic strokes. Therefore, the way to prevent stroke in these patients has become an important issue. Traditionally, glucose-lowering drugs had not been shown to protect against stroke. Moreover, several antidiabetic drugs (i.e., sulfonylureas, rosiglitazone) have been reported to be associated with increased risks of CVD and stroke...
September 20, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28938505/-treatment-targets-in-hypertension
#18
Rainer Düsing
The optimal target blood pressure (BP) in the treatment of hypertensive patients remains controversial. Recently, the systolic blood pressure trial (SPRINT) has proposed that a target systolic blood pressure of < 120 mmHg provides prognostic benefit in elderly hypertensive patients at high cardiovascular risk. The results of SPRINT contrast with several other intervention trials which have investigated the effect of intense BP lowering (Secondary Prevention of Small Subcortical Strokes [SPS3], Action to Control Cardiovascular Risk in Diabetes [ACCORD], Heart Outcomes Prevention Evaluation [HOPE]-3)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938240/atrial-fibrillation-bleeding-and-coronary-intervention-current-recommendations
#19
Serdar Farhan, Roxana Mehran
The patient population with the need for oral anticoagulation to reduce stroke risk associated with atrial fibrillation (AF) and dual antiplatelet therapy to prevent stent thrombosis and myocardial infarction after percutaneous coronary intervention is increasing. However, patients treated with a triple therapy consisting of oral anticoagulation, aspirin, and a P2Y12 inhibitor have been demonstrated to be at high bleeding risk. The best combination of these agents and the duration of the different therapies are still uncertain...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28937581/thrombosis-on-a-left-atrial-appendage-occluder-device-the-double-edged-sword-of-stroke-prevention-strategies-in-atrial-fibrillation
#20
Giuseppe Ciconte, Manuel Conti, Mario Baldi, Massimo Saviano, Gabriele Vicedomini, Carlo Pappone
: A huge thrombus, developing after percutaneous left atrial appendage occlusion, has been successfully treated with dabigatran and aspirin as combination therapy.Although novel oral anticoagulants alone may be effective in thrombus dissolution, the association of an antiplatelet drug may safely enhance this process.
September 20, 2017: Journal of Cardiovascular Medicine
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