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Raju Vaishya, Amit Kumar Agarwal, Amish Shah, Vipul Vijay, Abhishek Vaish
Knee Osteoarthritis (OA) is a progressive degenerative joint disease affecting the quality of life of the elderly population. There is considerable evidence that nutraceuticals from natural herbs may play a significant role in inflammation and joint destruction in OA. We review the current status of some of the commonly used nutraceuticals in Indian market - Boswellia, Aflapin, Chondroitin sulphate, Glucosamine sulphate, Collagen peptide, Curcumin, Fish Oil, Ginger, Green tea, and Rosehip extract. We have summarized their mechanism of action, biological effects, toxicities and efficacy in the management of Knee OA...
October 2018: Journal of Clinical Orthopaedics and Trauma
Natalia Prieto Vidal, Oludoyin Adeseun Adigun, Thu Huong Pham, Abira Mumtaz, Charles Manful, Grace Callahan, Peter Stewart, Dwayne Keough, Raymond Horatio Thomas
Saponification is the process in which triglycerides are combined with a strong base to form fatty acid metal salts during the soap-making process. The distribution of unsaturated and saturated fatty acid determines the hardness, aroma, cleansing, lather, and moisturizing abilities of soaps. Plant extracts, such as rosemary, vegetable, and essential oils are frequently added to soaps to enhance quality and sensory appeal. Three natural soaps were formulated using cold saponification to produce a base or control bar (BB), hibiscus rosehip bar (H), and a forest grove bar (FG)...
September 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Zhiyong Lei, Zhijian Cao, Zaiwang Yang, Mingzhang Ao, Wenwen Jin, Longjiang Yu
Poor wound healing is a major and global threat to public health. Efforts have been made to better understand the underlying mechanisms and develop effective remedies, though the advancements that have been made are still limited. As there are no effective and generally applicable therapies available for skin injuries and fibrosis, it is urgent to develop new drugs and therapies that facilitate wound healing and effectively improve scars. In this study, GC-MS analysis was performed to identify the chemical composition of rosehip oil...
September 10, 2018: Planta Medica
Eszter Boldog, Trygve E Bakken, Rebecca D Hodge, Mark Novotny, Brian D Aevermann, Judith Baka, Sándor Bordé, Jennie L Close, Francisco Diez-Fuertes, Song-Lin Ding, Nóra Faragó, Ágnes K Kocsis, Balázs Kovács, Zoe Maltzer, Jamison M McCorrison, Jeremy A Miller, Gábor Molnár, Gáspár Oláh, Attila Ozsvár, Márton Rózsa, Soraya I Shehata, Kimberly A Smith, Susan M Sunkin, Danny N Tran, Pratap Venepally, Abby Wall, László G Puskás, Pál Barzó, Frank J Steemers, Nicholas J Schork, Richard H Scheuermann, Roger S Lasken, Ed S Lein, Gábor Tamás
We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1+ CCK+ , CNR1- SST- CALB2- PVALB- ) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex...
September 2018: Nature Neuroscience
Noémi Koczka, Éva Stefanovits-Bányai, Attila Ombódi
Background: Rosehips, the fruits of Rosa species, are well known for their various health benefits like strengthening the immune system and treating digestive disorders. Antioxidant, anti-inflammatory, and cell regenerative effects are also among their health enhancing impacts. Rosehips are rich in compounds having antioxidant properties, like vitamin C, carotenoids, and phenolics. Methods: Total polyphenol content (Folin-Ciocalteu's method), and in vitro total antioxidant capacity (ferric-reducing ability of plasma, FRAP) in rosehips of four Rosa species ( R...
August 4, 2018: Medicines (Basel, Switzerland)
Ahlam Al-Yafeai, Volker Böhm
Limited bioavailability of antioxidants present in food from fruits and vegetables matrices is determined by their low bioaccessibility due to the physical and chemical interactions of the antioxidants with the indigestible polysaccharides of cell walls. Therefore, this in vitro investigation aimed to assess the bioaccessibility of carotenoids and vitamin E from rosehips as well as from tomato paste and to investigate several aspects of effects of pectin contents and food processing on bioaccessibility. Following the addition of the enzyme mixture Fructozym P6-XL, the bioaccessibility of carotenoids from rosehips as well as from tomato paste significantly increased...
April 18, 2018: Journal of Agricultural and Food Chemistry
Gül Dinç Ata, Osman Gokay, Arzu Müjdeci, Tugba Congara Kivrak, Armin Mokhtari Tavana
PURPOSE: To investigate the effect of various teas on color stability of resin composites. METHODS: Two methacrylate-based (Arabesk Top, Grandio) and a silorane-based (Filtek Silorane) resin composites were used. 110 cylindrical samples of each resin composite were prepared (2 mm thickness and 8 mm diameter), polished and stored in distilled water (37°C for 24 hours). They were randomly divided into 11 groups (n= 10) and color measurements were taken. Then the samples were immersed in tap water (control), a black tea, a green tea or one of the eight herbal-fruit teas (37°C for 1 week) and subsequently subjected to the final color measurements...
December 2017: American Journal of Dentistry
Huri İlyasoğlu, Tuba Eda Arpa
The aim of this study was to investigate the effects of brewing conditions (infusion time and temperature) on the antioxidant properties of rosehip tea beverage. The ascorbic acid content, total phenolic content (TPC), and ferric reducing antioxidant power (FRAP) of rosehip tea beverage were analysed. A two-factor and three-level central composite design was applied to evaluate the effects of the variables on the responses. The best quadratic models were obtained for all responses. The generated models were validated under the optimal conditions...
October 2017: Journal of Food Science and Technology
Ahlam Al-Yafeai, Angelika Malarski, Volker Böhm
The hips of Rosa species have gained more attention in recent years due to their high contents of antioxidant compounds. This study was designed to compare rosehips of the two roses species Rosa rugosa and Rosa canina, including different products, on carotenoid contents, including phytoene and phytofluene, as well as vitamin E. The investigation allowed the identification and quantification of types of (Z)-isomers of lycopene and rubixanthin in both rosehips and focused also on isomerisation of both carotenoids...
March 1, 2018: Food Chemistry
A Nagatomo, M Oguri, N Nishida, M Ogawa, A Ichikawa, Y Tanaka-Azuma
Rose hip is the fruit of the rose plant, which is widely used in food, cosmetics and as a traditional medicine. Therefore, rose hip is considered safe and has a sufficient history of consumption as food. However, few studies have reported on the safety of rose hip extracts in toxicological analyses. Thus, to evaluate the safety of rosehip polyphenol MJ (RHPMJ), an aqueous ethanol extract standardized with the trans-tiliroside content, we performed genotoxicity and 90-day repeated oral dose toxicity studies in compliance with the Organisation for Economic Co-operation and Development-Good Laboratory Practice...
July 2018: Human & Experimental Toxicology
Apurva Bhave, Vera Schulzova, Hana Chmelarova, Libor Mrnka, Jana Hajslova
In this study, an in-depth analysis of the unique set of rosehip samples from 71 Rosa genotypes was conducted with the aim to identify the most suitable ones for applications in the food and pharmaceutical industries based on the content of biologically active compounds. In the first part of our experiments, the antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl assay and the genotypes with the highest values were selected for the follow-up analysis. In the second part of experiments, the major classes of biologically active compounds in rosehips such as carotenoids, tocopherols, flavonoids, and triterpenoic acids were further quantified using liquid chromatography-based techniques...
July 2017: Journal of Food and Drug Analysis
Mayram Hacioglu, Sibel Dosler, Ayse Seher Birteksoz Tan, Gulten Otuk
BACKGROUND: Because of increasing antibiotic resistance, herbal teas are the most popular natural alternatives for the treatment of infectious diseases, and are currently gaining more importance. We examined the antimicrobial activities of 31 herbal teas both alone and in combination with antibiotics or antifungals against some standard and clinical isolates of Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, methicillin susceptible/resistant Staphylococcus aureus and Candida albicans...
2017: PeerJ
Margret Moré, Joerg Gruenwald, Ute Pohl, Ralf Uebelhack
The special formulation MA212 (Rosaxan) is composed of rosehip ( Rosa canina L.) puree/juice concentrate, nettle ( Urtica dioica L.) leaf extract, and devil's claw ( Harpagophytum procumbens DC. ex Meisn. or Harpagophytum zeyheri Decne.) root extract and also supplies vitamin D. It is a food for special medical purposes ([EU] No 609/2013) for the dietary management of pain in patients with gonarthritis.This 12-week randomized, placebo-controlled double-blind parallel-design study aimed to investigate the efficacy and safety of MA212 versus placebo in patients with gonarthritis...
December 2017: Planta Medica
Hidetomo Kikuchi, Satomi Kogure, Rie Arai, Kouki Saino, Atsuko Ohkubo, Tadashi Tsuda, Katsuyoshi Sunaga
Rosehip, the fruit of Rosa canina L., has traditionally been used to treat urate metabolism disorders; however, its effects on such disorders have not been characterized in detail. Therefore, the present study investigated the effects of hot water, ethanol and ethyl acetate extracts of rosehip on xanthine oxidase (XO) activity in vitro. In addition, the serum urate lowering effects of the rosehip hot water extract in a mouse model of hyperuricemia (male ddY mice, which were intraperitoneally injected with potassium oxonate) were investigated...
May 2017: Biomedical Reports
Sandra Jiménez, Nerea Jiménez-Moreno, Asunción Luquin, Mariano Laguna, María Jesús Rodríguez-Yoldi, Carmen Ancín-Azpilicueta
It is important to explore new sources of natural additives because the demand for these compounds by consumers is increasing. These products also provide health benefits and help in food preservation. An unexplored source of nutrients and antioxidant compounds is rosehip, the fleshy fruit of roses. This work compares the antioxidant compound (vitamin C, neutral phenols and acidic phenols) content of four Rosa species rosehips: R. pouzinii, R. corymbifera, R. glauca and R. canina from different geographical zones...
July 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Domingo Martínez-Romero, Pedro J Zapata, Fabián Guillén, Diego Paladines, Salvador Castillo, Daniel Valero, María Serrano
The effect of Aloe vera gel (AV) and Aloe arborescens gel (AA) alone or in combination with rosehip oil (RO) at 2% on ethylene production, respiration rate, quality parameters, bioactive compounds and antioxidant activity during plum postharvest storage was studied. Coated plums showed a delay in ethylene production and respiration rate at 20°C and during cold storage and subsequent shelf life, the main effect being observed for those fruits coated with AA+RO. Quality parameters such as softening, colour and maturity index was also delayed during storage by the use of the coatings, which led to a 2-fold increase in plum storability...
February 15, 2017: Food Chemistry
Gulzhan T Zhamanbayeva, Araylim N Aralbayeva, Maira K Murzakhmetova, Sultan T Tuleukhanov, Michael Danilenko
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy with poor prognosis and limited treatment options. Sea buckthorn (Hippophae rhamnoides) berries, dog rose (Rosa canina) rosehips, and garden sage (Salvia officinalis) and oregano (Origanum vulgare) aerial parts are widely used in traditional medicine and exhibit antitumor effects in preclinical models. However, these plants remain scarcely tested for antileukemic activity. Here, we show that their water-ethanol leaf extracts reduced the growth and viability of AML cells and, at non-cytotoxic doses, potentiated cell differentiation induced by a low concentration of 1α,25-dihydroxyvitamin D3, the hormonal form of vitamin D, in a cell type-dependent manner...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sandra Jiménez, Sonia Gascón, Asunción Luquin, Mariano Laguna, Carmen Ancin-Azpilicueta, María Jesús Rodríguez-Yoldi
The in vitro antiproliferative and antioxidant effects of different fractions of Rosa canina hips on human colon cancer cell lines (Caco-2) was studied. The compounds tested were total extract (fraction 1), vitamin C (fraction 2), neutral polyphenols (fraction 3) and acidic polyphenols (fraction 4). All the extracts showed high cytotoxicity after 72 h, both low and high concentrations. The flow cytometric analysis revealed that all the fractions produce disturbances in the cell cycle resulting in a concomitant cell death by an apoptotic pathway...
2016: PloS One
Firas Jumaah, Merichel Plaza, Victor Abrahamsson, Charlotta Turner, Margareta Sandahl
In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as well as the number of hydroxyl groups in the structure of the studied carotenoids determines their differences in the physiochemical properties and thus the separation that is achieved on this column...
August 2016: Analytical and Bioanalytical Chemistry
Małgorzata Tańska, Beata Roszkowska, Sylwester Czaplicki, Eulalia Julitta Borowska, Justyna Bojarska, Aneta Dąbrowska
Fruit pomace remaining after juice extraction is still a source of bioactive compounds. Especially rich in these compounds is the pomace from blackcurrant fruit and from fruits of little-known horticultural plants, like: rowan, rosehip and elderberry. The addition of fruit pomace to bakery and confectionery products, especially to those made of white flour, may significantly enrich their composition with dietary fiber, vitamins and phenolic compounds. This study was aimed at determining the effect of 20 % addition of fruit pomace from rosehip, rowan, blackcurrant and elderberry on the properties of shortbread cookies...
September 2016: Plant Foods for Human Nutrition
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